LLPS-Mum-2738
Ybx2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Y-box-binding protein 2; FRGY2 homolog; Germ cell-specific Y-box-binding protein |
| Gene Name: | Ybx2, Msy2 |
| Ensembl Gene: | ENSMUSG00000018554.13 |
| Ensembl Protein: | ENSMUSP00000018698.5 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Chromatoid body | "...The loss of PAPOLB had no impact either on the abundance of CB components such as PIWIL1, TDRD6, YBX2, and piRNAs, or on retrotransposon expression." | Round spermatids | 29109362 |
| Chromatoid body | "...The list of 88 CB proteins identified in at least three separate experiments." | Round spermatids | 24554440 |
▼ FUNCTION
| Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000018698.11 | ENSMUSP00000018698.5 |
| Ensembl | ENSMUST00000149194.7 | ENSMUSP00000136684.1 |
| Ensembl | ENSMUST00000108601.2 | ENSMUSP00000104242.2 |
| UniProt | Q9Z2C8, YBOX2_MOUSE, Q5NCW8, Q5NCW9, Q9Z2C7 | |
| GeneBank | AF073955, AL596185, AF073954 | AAC98673.1, CAI35156.1, CAI35155.1, AAC98674.1 |
| Entrez | 53422 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSEAEASVVA TAAPAATVPA TAAGVVAVVV PVPAGEPQKA GGGAGGGGGA ASGPAAGTPS 60 61 APGPRTPGNQ ATAASGTPAP PARSQADKPV LAIQVLGTVK WFNVRNGYGF INRNDTKEDV 120 121 FVHQTAIKRN NPRKFLRSVG DGETVEFDVV EGEKGAEAAN VTGPGGVPVK GSRYAPNRRR 180 181 FRRFIPRPRP AAPPPMVAEA PSGGTEPGSE GERAEDSGQR PRRRRPPPFF YRRRFVRGPR 240 241 PPNQQQPIEG SDGVEPKETA PLEGDQQQGD ERVPPPRFRP RYRRPFRPRP PQQPTTEGGD 300 301 GETKPSQGPT DGSRPEPQRP RNRPYFQRRR QQPPGPRQPI AAETSAPINS GDPPTTILE 359 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCGAGG CGGAGGCGTC AGTGGTGGCG ACAGCGGCCC CCGCGGCGAC GGTGCCCGCG 60 61 ACGGCGGCGG GGGTGGTAGC GGTGGTGGTA CCGGTGCCCG CGGGAGAGCC GCAGAAAGCA 120 121 GGCGGCGGGG CGGGCGGCGG GGGCGGAGCC GCCTCTGGCC CCGCTGCTGG GACCCCCTCA 180 181 GCGCCCGGCC CTCGCACCCC TGGCAACCAG GCGACGGCGG CCTCGGGGAC TCCCGCGCCC 240 241 CCGGCCCGGA GTCAGGCGGA CAAGCCGGTG CTGGCAATCC AAGTCCTGGG CACAGTCAAA 300 301 TGGTTCAACG TCCGGAATGG TTACGGATTC ATCAACAGGA ATGACACCAA GGAGGATGTC 360 361 TTTGTTCACC AGACAGCTAT TAAGAGAAAC AACCCCAGGA AGTTTCTGCG GAGTGTTGGA 420 421 GATGGGGAGA CTGTGGAGTT TGATGTCGTG GAAGGAGAGA AGGGTGCAGA AGCTGCTAAT 480 481 GTCACTGGGC CTGGGGGGGT ACCAGTGAAG GGCAGCCGCT ATGCCCCTAA TCGACGTAGG 540 541 TTCCGGAGGT TCATTCCTCG GCCTCGCCCA GCTGCCCCAC CACCTATGGT GGCAGAGGCT 600 601 CCCTCAGGTG GGACAGAACC TGGCAGCGAA GGGGAGCGGG CAGAGGACTC GGGGCAGCGA 660 661 CCTAGACGAC GGCGCCCACC ACCCTTCTTC TATCGAAGGC GGTTTGTGCG AGGCCCTCGG 720 721 CCCCCCAACC AGCAACAGCC CATAGAGGGC TCTGATGGGG TAGAACCCAA GGAGACAGCA 780 781 CCATTGGAGG GTGATCAACA GCAGGGAGAT GAACGGGTGC CCCCACCCAG ATTCCGGCCC 840 841 AGGTACCGAA GGCCTTTCCG CCCCAGGCCA CCCCAACAGC CTACCACAGA AGGTGGGGAT 900 901 GGAGAGACCA AGCCCAGCCA AGGCCCCACT GATGGCTCCC GGCCTGAGCC CCAGCGTCCA 960 961 CGAAACCGTC CCTACTTCCA GCGGCGTCGG CAGCAGCCCC CTGGCCCCCG GCAGCCTATA 1020 1021 GCCGCAGAGA CCTCCGCGCC TATCAACAGT GGGGACCCCC CCACCACCAT ACTGGAGTGA 1080 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Fibrillar center | |
Cellular Component | Polysome | |
Cellular Component | Ribonucleoprotein complex | |
Molecular Function | Chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | Lipid binding | |
Molecular Function | MRNA 3'-UTR binding | |
Molecular Function | MRNA binding | |
Molecular Function | Ribonucleoprotein complex binding | |
Molecular Function | Translation regulator activity | |
Biological Process | MRNA stabilization | |
Biological Process | Negative regulation of binding | |
Biological Process | Negative regulation of translation | |
Biological Process | Oogenesis | |
Biological Process | Positive regulation of cold-induced thermogenesis | |
Biological Process | Spermatid development |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2674 | Rattus norvegicus | 99.66 | 5e-95 | 294 |
| LLPS-Mea-2846 | Mesocricetus auratus | 99.28 | 1e-94 | 293 |
| LLPS-Pes-3613 | Pelodiscus sinensis | 98.77 | 2e-47 | 168 |
| LLPS-Fec-4560 | Felis catus | 97.83 | 2e-91 | 285 |
| LLPS-Ict-0702 | Ictidomys tridecemlineatus | 97.78 | 6e-86 | 268 |
| LLPS-Sus-4743 | Sus scrofa | 97.47 | 5e-92 | 286 |
| LLPS-Dio-3402 | Dipodomys ordii | 97.39 | 2e-84 | 265 |
| LLPS-Otg-0300 | Otolemur garnettii | 97.01 | 2e-83 | 261 |
| LLPS-Cap-4129 | Cavia porcellus | 96.75 | 2e-88 | 278 |
| LLPS-Fia-1814 | Ficedula albicollis | 95.0 | 2e-29 | 119 |
| LLPS-Chs-0756 | Chlorocebus sabaeus | 94.92 | 4e-29 | 118 |
| LLPS-Man-1094 | Macaca nemestrina | 94.58 | 2e-89 | 280 |
| LLPS-Maf-0452 | Macaca fascicularis | 94.58 | 2e-89 | 280 |
| LLPS-Cea-4503 | Cercocebus atys | 94.58 | 2e-89 | 280 |
| LLPS-Rhb-3092 | Rhinopithecus bieti | 94.22 | 4e-89 | 279 |
| LLPS-Paa-2916 | Papio anubis | 94.22 | 8e-89 | 278 |
| LLPS-Aon-3000 | Aotus nancymaae | 94.22 | 2e-86 | 271 |
| LLPS-Bot-1725 | Bos taurus | 94.09 | 3e-73 | 239 |
| LLPS-Ova-0478 | Ovis aries | 93.83 | 2e-45 | 164 |
| LLPS-Mal-1198 | Mandrillus leucophaeus | 93.75 | 3e-45 | 162 |
| LLPS-Fud-0454 | Fukomys damarensis | 93.75 | 3e-45 | 162 |
| LLPS-Ere-0690 | Erinaceus europaeus | 93.67 | 3e-43 | 157 |
| LLPS-Eqc-3135 | Equus caballus | 93.59 | 4e-69 | 228 |
| LLPS-Myl-1700 | Myotis lucifugus | 93.44 | 4e-29 | 118 |
| LLPS-Caf-3894 | Canis familiaris | 93.31 | 2e-89 | 280 |
| LLPS-Tut-1822 | Tursiops truncatus | 93.22 | 6e-28 | 115 |
| LLPS-Mod-0720 | Monodelphis domestica | 93.16 | 2e-77 | 249 |
| LLPS-Nol-4020 | Nomascus leucogenys | 92.78 | 5e-88 | 274 |
| LLPS-Sah-2119 | Sarcophilus harrisii | 92.77 | 9e-46 | 164 |
| LLPS-Tag-2137 | Taeniopygia guttata | 92.59 | 4e-44 | 159 |
| LLPS-Urm-1616 | Ursus maritimus | 92.59 | 1e-43 | 159 |
| LLPS-Anp-0056 | Anas platyrhynchos | 92.59 | 3e-44 | 160 |
| LLPS-Tar-2337 | Takifugu rubripes | 92.59 | 2e-43 | 158 |
| LLPS-Ora-1678 | Ornithorhynchus anatinus | 92.59 | 7e-45 | 157 |
| LLPS-Loa-3878 | Loxodonta africana | 92.42 | 5e-90 | 281 |
| LLPS-Mup-2651 | Mustela putorius furo | 91.87 | 9e-54 | 184 |
| LLPS-Gaga-1285 | Gallus gallus | 91.86 | 1e-47 | 170 |
| LLPS-Mam-0740 | Macaca mulatta | 91.86 | 2e-48 | 171 |
| LLPS-Pap-2974 | Pan paniscus | 91.86 | 5e-48 | 171 |
| LLPS-Pat-2291 | Pan troglodytes | 91.86 | 3e-47 | 169 |
| LLPS-Dar-0000 | Danio rerio | 91.86 | 1e-47 | 169 |
| LLPS-Gog-3395 | Gorilla gorilla | 91.86 | 5e-48 | 171 |
| LLPS-Asm-2173 | Astyanax mexicanus | 91.86 | 7e-48 | 170 |
| LLPS-Icp-1045 | Ictalurus punctatus | 91.86 | 1e-47 | 170 |
| LLPS-Caj-0273 | Callithrix jacchus | 91.86 | 5e-48 | 171 |
| LLPS-Leo-0622 | Lepisosteus oculatus | 91.86 | 3e-47 | 169 |
| LLPS-Meg-2868 | Meleagris gallopavo | 91.57 | 3e-43 | 157 |
| LLPS-Aim-0749 | Ailuropoda melanoleuca | 91.57 | 1e-45 | 164 |
| LLPS-Poa-0320 | Pongo abelii | 90.8 | 7e-46 | 166 |
| LLPS-Hos-1533 | Homo sapiens | 90.8 | 8e-46 | 166 |
| LLPS-Xet-0584 | Xenopus tropicalis | 90.7 | 1e-47 | 169 |
| LLPS-Ten-2306 | Tetraodon nigroviridis | 90.7 | 2e-46 | 166 |
| LLPS-Orn-3181 | Oreochromis niloticus | 90.7 | 8e-47 | 167 |
| LLPS-Pof-0441 | Poecilia formosa | 90.7 | 2e-46 | 166 |
| LLPS-Scm-3098 | Scophthalmus maximus | 90.7 | 3e-46 | 166 |
| LLPS-Xim-0400 | Xiphophorus maculatus | 90.7 | 1e-46 | 167 |
| LLPS-Scf-2612 | Scleropages formosus | 90.7 | 6e-47 | 168 |
| LLPS-Orl-1337 | Oryzias latipes | 90.7 | 3e-46 | 166 |
| LLPS-Orc-3089 | Oryctolagus cuniculus | 90.57 | 5e-23 | 101 |
| LLPS-Lac-0903 | Latimeria chalumnae | 89.66 | 1e-45 | 164 |
| LLPS-Cas-1101 | Carlito syrichta | 89.53 | 2e-45 | 163 |
| LLPS-Gaa-0176 | Gasterosteus aculeatus | 89.53 | 3e-46 | 166 |
| LLPS-Cis-0133 | Ciona savignyi | 79.12 | 4e-40 | 150 |
| LLPS-Drm-0134 | Drosophila melanogaster | 77.65 | 5e-36 | 139 |
| LLPS-Cii-0715 | Ciona intestinalis | 75.86 | 3e-36 | 139 |
| LLPS-Cae-0552 | Caenorhabditis elegans | 73.56 | 1e-36 | 137 |
| LLPS-Hea-0003 | Helianthus annuus | 55.84 | 1e-15 | 79.3 |
| LLPS-Sob-2420 | Sorghum bicolor | 52.0 | 2e-13 | 73.2 |
| LLPS-Amt-0048 | Amborella trichopoda | 51.95 | 8e-14 | 73.9 |
| LLPS-Tru-1227 | Triticum urartu | 51.35 | 2e-14 | 74.3 |
| LLPS-Tra-0466 | Triticum aestivum | 51.35 | 2e-14 | 74.7 |
| LLPS-Brd-1096 | Brachypodium distachyon | 51.25 | 2e-14 | 75.5 |
| LLPS-Ors-1342 | Oryza sativa | 50.67 | 9e-13 | 71.2 |
| LLPS-Orb-2063 | Oryza barthii | 50.67 | 1e-12 | 70.5 |
| LLPS-Ori-0909 | Oryza indica | 50.67 | 1e-13 | 71.6 |
| LLPS-Viv-2145 | Vitis vinifera | 50.65 | 4e-14 | 75.1 |
| LLPS-Abg-0907 | Absidia glauca | 50.63 | 6e-14 | 73.9 |
| LLPS-Pot-1689 | Populus trichocarpa | 50.0 | 6e-14 | 73.6 |
| LLPS-Osl-0594 | Ostreococcus lucimarinus | 47.56 | 9e-15 | 74.3 |
| LLPS-Hov-1117 | Hordeum vulgare | 47.56 | 1e-14 | 77.0 |
| LLPS-Sot-0749 | Solanum tuberosum | 44.87 | 4e-13 | 70.5 |