LLPS-Mum-2503
Spty2d1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein SPT2 homolog; SPT2 domain-containing protein 1 |
| Gene Name: | Spty2d1 |
| Ensembl Gene: | ENSMUSG00000049516.9 |
| Ensembl Protein: | ENSMUSP00000059457.7 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|
▼ FUNCTION
| Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000061639.9 | ENSMUSP00000059457.7 |
| UniProt | Q68FG3, SPT2_MOUSE, Q8BIR1 | |
| GeneBank | BC079859, AK030869 | BAC27165.1, AAH79859.1 |
| RefSeq | NM_175318.4 | NP_780527.2 |
| Entrez | 101685 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDFREILLIA SKGQGVNHVP KRYSLAVGPP KKDPKVKGVQ SAAVQAFLRR KEEELRQKAL 60 61 EEKKRKEELV KKRIELKHDK KARAMAKRTK DNFHGYDGIP VEEKTKKKQL VESHLNQGTD 120 121 QEYDVEEEDF IDYNQAELDQ DYEEEQEPPK AESKPKAPLK SAPSPMNFTD LLRLAEKKQF 180 181 EPVEIKVVKK AEDRPLTAEE LREREFLERK HRKKKPEPDA KLPPPVLKKA PSHKDIMGTK 240 241 PSRGAGDRQL ASKGLPFPQA EKKFRPSTAS EKQAALSSPK SLPGERTKVG SGSSTQPSLR 300 301 EGHNRPVFNG AGKPRPSTCS PSVPKTPASG TQKSASEHKA KKPLPSHPSH SKPGPTVLSH 360 361 NKSKSPGVRQ PGSNSGSAPG QPNPGTARPT LSSGPVPRRQ NGSSSSGPEQ SAGGIRKLAS 420 421 NSHLSGRTLN GTNGPGRPAS SSSGPGRPIS GSAGSGRPVG SSGGPGQPVN NPHDLRRPMN 480 481 SLSSPGRAVS GPGRSISGSI PAGRTVNSGP GRPVSSLGPG RAVSNPGLPT KPRCTVVSET 540 541 ISSKNIISRS SNGQINGMKP LLSGYRSAQG PQRLPFPTGY KRPREYEEDD DDEYDSEMDD 600 601 FIEDEGEPQE EISKHIREIF GYDRKKYKDE SDYALRYMES SWKEQQKEEA KSLRLGMQED 660 661 LEEMRREEEE LKRRKAKKLK RH 682 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACTTCA GGGAAATCCT CTTGATCGCT TCCAAAGGAC AAGGTGTCAA CCACGTACCG 60 61 AAAAGGTACA GTTTGGCGGT GGGGCCTCCA AAGAAAGACC CAAAAGTGAA AGGTGTCCAG 120 121 TCGGCAGCTG TGCAAGCTTT CCTTAGGCGG AAAGAAGAGG AGCTTAGACA AAAAGCCTTG 180 181 GAAGAGAAAA AAAGGAAAGA GGAACTAGTG AAAAAGCGAA TTGAGCTCAA ACATGACAAA 240 241 AAAGCAAGAG CCATGGCCAA GAGGACAAAG GACAATTTTC ATGGTTACGA TGGGATTCCT 300 301 GTTGAGGAAA AGACAAAGAA GAAGCAGCTG GTGGAGAGCC ACCTGAACCA GGGAACTGAC 360 361 CAGGAGTATG ATGTGGAGGA GGAAGACTTC ATAGACTACA ATCAGGCTGA GCTGGACCAG 420 421 GACTATGAGG AGGAGCAAGA GCCACCCAAG GCTGAAAGCA AACCAAAGGC CCCCCTTAAA 480 481 AGTGCCCCGT CACCCATGAA CTTCACTGAC TTACTGAGGC TAGCTGAGAA GAAGCAGTTT 540 541 GAACCAGTGG AGATCAAGGT AGTGAAGAAA GCAGAAGACC GGCCCCTGAC TGCAGAGGAA 600 601 CTGAGGGAGC GAGAGTTTCT TGAACGAAAG CATAGGAAAA AGAAACCTGA ACCCGATGCC 660 661 AAACTACCTC CACCCGTGTT GAAAAAGGCG CCCTCTCATA AAGACATCAT GGGTACAAAG 720 721 CCCAGCAGAG GTGCTGGGGA CAGGCAGCTT GCTTCCAAAG GATTGCCCTT TCCTCAAGCT 780 781 GAGAAGAAAT TCAGACCCAG CACGGCCAGT GAGAAACAAG CAGCTTTGTC TTCACCCAAA 840 841 TCCCTGCCAG GCGAGAGGAC CAAGGTAGGG TCTGGCAGTA GCACCCAGCC CTCACTTCGG 900 901 GAGGGTCACA ACAGGCCTGT CTTCAATGGG GCTGGAAAGC CCCGCCCCAG CACCTGTTCA 960 961 CCAAGTGTCC CAAAGACTCC TGCTAGCGGG ACTCAGAAAT CTGCTTCTGA GCACAAAGCC 1020 1021 AAAAAACCTC TTCCTTCTCA TCCGAGCCAT TCCAAGCCTG GACCCACGGT TCTCTCACAC 1080 1081 AACAAATCTA AGAGTCCAGG TGTCAGACAA CCAGGCAGCA ACTCTGGCTC TGCTCCTGGG 1140 1141 CAGCCTAACC CAGGGACAGC TCGACCCACA CTTAGTTCTG GCCCTGTGCC CAGGCGCCAG 1200 1201 AACGGCAGCT CCAGCTCAGG ACCTGAGCAG TCAGCCGGTG GGATCAGAAA GCTGGCCAGC 1260 1261 AATTCACATC TCTCCGGACG AACACTCAAC GGCACAAATG GTCCTGGACG ACCTGCAAGC 1320 1321 AGCTCAAGTG GCCCTGGGCG ACCCATCAGT GGATCTGCTG GTTCTGGGAG ACCTGTGGGC 1380 1381 AGTTCTGGAG GCCCCGGGCA GCCTGTAAAC AATCCACATG ACCTTCGACG ACCAATGAAC 1440 1441 AGTCTTAGCT CTCCTGGGCG GGCAGTCAGT GGCCCTGGGA GATCCATAAG TGGTTCCATT 1500 1501 CCAGCTGGAC GAACTGTCAA TTCAGGCCCT GGAAGACCAG TGAGCAGCCT AGGCCCTGGA 1560 1561 CGAGCAGTTA GTAACCCAGG CCTCCCCACA AAGCCCAGAT GTACTGTTGT CTCAGAAACA 1620 1621 ATTTCTTCAA AGAATATTAT TAGTCGGTCA AGTAATGGAC AGATAAATGG AATGAAACCT 1680 1681 CTCCTCTCTG GCTACAGATC TGCTCAAGGT CCTCAAAGGC TTCCCTTCCC TACTGGCTAC 1740 1741 AAAAGGCCTC GAGAGTATGA AGAAGATGAT GATGATGAAT ATGACTCGGA AATGGATGAT 1800 1801 TTCATCGAAG ATGAAGGAGA ACCTCAGGAA GAAATATCCA AGCACATTCG AGAAATCTTT 1860 1861 GGCTATGACC GAAAAAAATA TAAAGATGAA AGTGACTATG CCTTACGTTA CATGGAGAGC 1920 1921 AGTTGGAAGG AGCAGCAGAA GGAGGAAGCC AAGAGTTTAA GACTTGGTAT GCAAGAGGAC 1980 1981 TTAGAGGAAA TGAGGCGTGA AGAGGAGGAA CTGAAACGTC GAAAAGCCAA GAAGCTGAAG 2040 2041 CGACACTAG 2049 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleolus | |
Molecular Function | DNA binding | |
Molecular Function | Histone binding | |
Molecular Function | RNA polymerase I core binding | |
Biological Process | Histone exchange | |
Biological Process | Nucleosome assembly | |
Biological Process | Regulation of chromatin assembly | |
Biological Process | Regulation of transcription, DNA-templated |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0371 | Rattus norvegicus | 90.58 | 0.0 | 774 |
| LLPS-Ict-3997 | Ictidomys tridecemlineatus | 81.54 | 0.0 | 633 |
| LLPS-Nol-4499 | Nomascus leucogenys | 79.31 | 0.0 | 605 |
| LLPS-Cas-2794 | Carlito syrichta | 79.31 | 0.0 | 574 |
| LLPS-Hos-3120 | Homo sapiens | 79.15 | 0.0 | 584 |
| LLPS-Pat-3407 | Pan troglodytes | 79.12 | 0.0 | 583 |
| LLPS-Gog-0447 | Gorilla gorilla | 79.0 | 0.0 | 583 |
| LLPS-Poa-2339 | Pongo abelii | 79.0 | 0.0 | 574 |
| LLPS-Pap-3427 | Pan paniscus | 78.85 | 0.0 | 581 |
| LLPS-Rhb-3882 | Rhinopithecus bieti | 78.85 | 0.0 | 582 |
| LLPS-Maf-0213 | Macaca fascicularis | 78.67 | 0.0 | 578 |
| LLPS-Mam-0885 | Macaca mulatta | 78.67 | 0.0 | 578 |
| LLPS-Aon-2489 | Aotus nancymaae | 78.52 | 0.0 | 573 |
| LLPS-Cea-3557 | Cercocebus atys | 78.52 | 0.0 | 575 |
| LLPS-Paa-4495 | Papio anubis | 78.52 | 0.0 | 577 |
| LLPS-Mal-3657 | Mandrillus leucophaeus | 78.52 | 0.0 | 575 |
| LLPS-Caj-1884 | Callithrix jacchus | 78.43 | 0.0 | 577 |
| LLPS-Man-0695 | Macaca nemestrina | 78.37 | 0.0 | 572 |
| LLPS-Chs-2263 | Chlorocebus sabaeus | 78.1 | 0.0 | 592 |
| LLPS-Mea-3412 | Mesocricetus auratus | 77.64 | 0.0 | 654 |
| LLPS-Orc-3874 | Oryctolagus cuniculus | 77.26 | 0.0 | 575 |
| LLPS-Cap-3430 | Cavia porcellus | 77.01 | 0.0 | 592 |
| LLPS-Fud-1639 | Fukomys damarensis | 76.36 | 0.0 | 592 |
| LLPS-Dio-2319 | Dipodomys ordii | 76.36 | 0.0 | 580 |
| LLPS-Sus-0704 | Sus scrofa | 76.25 | 0.0 | 602 |
| LLPS-Ova-3694 | Ovis aries | 76.17 | 0.0 | 554 |
| LLPS-Bot-0970 | Bos taurus | 75.98 | 2e-180 | 536 |
| LLPS-Ora-3553 | Ornithorhynchus anatinus | 75.58 | 2e-28 | 125 |
| LLPS-Tar-3306 | Takifugu rubripes | 75.44 | 1e-21 | 103 |
| LLPS-Fec-2985 | Felis catus | 74.7 | 0.0 | 586 |
| LLPS-Caf-0274 | Canis familiaris | 74.63 | 0.0 | 567 |
| LLPS-Urm-1386 | Ursus maritimus | 74.56 | 0.0 | 572 |
| LLPS-Loa-1807 | Loxodonta africana | 74.55 | 0.0 | 564 |
| LLPS-Orl-2307 | Oryzias latipes | 74.14 | 4e-21 | 102 |
| LLPS-Scm-1483 | Scophthalmus maximus | 74.14 | 1e-20 | 100 |
| LLPS-Tut-0126 | Tursiops truncatus | 73.94 | 0.0 | 569 |
| LLPS-Eqc-3844 | Equus caballus | 73.61 | 0.0 | 592 |
| LLPS-Gaga-4015 | Gallus gallus | 73.55 | 8e-39 | 156 |
| LLPS-Mup-3035 | Mustela putorius furo | 72.55 | 2e-177 | 529 |
| LLPS-Pof-0756 | Poecilia formosa | 72.41 | 9e-21 | 101 |
| LLPS-Aim-3781 | Ailuropoda melanoleuca | 72.24 | 0.0 | 541 |
| LLPS-Gaa-0683 | Gasterosteus aculeatus | 70.69 | 1e-20 | 100 |
| LLPS-Anp-0228 | Anas platyrhynchos | 70.48 | 2e-40 | 161 |
| LLPS-Meg-1541 | Meleagris gallopavo | 70.3 | 1e-38 | 156 |
| LLPS-Tag-3466 | Taeniopygia guttata | 69.87 | 7e-42 | 165 |
| LLPS-Fia-3001 | Ficedula albicollis | 69.62 | 3e-40 | 160 |
| LLPS-Pes-0521 | Pelodiscus sinensis | 69.28 | 5e-38 | 154 |
| LLPS-Myl-2824 | Myotis lucifugus | 69.24 | 0.0 | 554 |
| LLPS-Otg-3854 | Otolemur garnettii | 67.06 | 1e-166 | 501 |
| LLPS-Anc-2829 | Anolis carolinensis | 65.66 | 6e-37 | 150 |
| LLPS-Lac-1982 | Latimeria chalumnae | 61.94 | 4e-32 | 136 |
| LLPS-Xet-2018 | Xenopus tropicalis | 59.49 | 2e-30 | 129 |
| LLPS-Mod-0880 | Monodelphis domestica | 57.58 | 1e-117 | 374 |
| LLPS-Dar-3257 | Danio rerio | 56.58 | 5e-25 | 114 |
| LLPS-Scf-1850 | Scleropages formosus | 56.41 | 1e-26 | 119 |
| LLPS-Orn-0367 | Oreochromis niloticus | 55.63 | 2e-25 | 115 |
| LLPS-Leo-3187 | Lepisosteus oculatus | 54.9 | 6e-27 | 120 |
| LLPS-Sah-0295 | Sarcophilus harrisii | 54.51 | 1e-124 | 393 |
| LLPS-Asm-0278 | Astyanax mexicanus | 53.53 | 2e-27 | 122 |
| LLPS-Drm-2380 | Drosophila melanogaster | 51.67 | 2e-07 | 58.5 |
| LLPS-Ten-3573 | Tetraodon nigroviridis | 51.39 | 2e-22 | 106 |
| LLPS-Icp-3195 | Ictalurus punctatus | 50.47 | 2e-23 | 109 |
| LLPS-Cii-2272 | Ciona intestinalis | 47.46 | 1e-06 | 52.4 |
| LLPS-Xim-3491 | Xiphophorus maculatus | 46.19 | 2e-20 | 100 |
| LLPS-Cis-1115 | Ciona savignyi | 45.76 | 4e-06 | 52.8 |