LLPS-Mum-2411
Tsks

▼ OVERVIEW

Status: Reviewed
Protein Name: Testis-specific serine kinase substrate
Gene Name: Tsks, Stk22s1
Ensembl Gene: ENSMUSG00000059891.14
Ensembl Protein: ENSMUSP00000079122.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A18495105

▼ FUNCTION

May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASVVVKTIW  QSKEIHEAGD  PPAGVESRAQ  LVPEAPGGVT  SPAKGITKKK  KAVSFHGVEP  60
61    RMSHEPMHWC  LNLKRSSACT  NVSLLNLAAV  EPDSSGTDST  TEDSGPLALP  GPPASPTTPW  120
121   APEDPDITEL  LSGVNSGLVR  AKDSITSLKE  KTTRVNQHVQ  TLQSECSVLS  ENLERRRQEA  180
181   EELEGYCSQL  KGPRPDVLTQ  ENCRKVTRSV  EDAEIKTNVL  KQNSALLEEK  LRYLQQQLQD  240
241   ETPRRQEAEL  QELEQKLEAG  LSRHGLSPAT  PIQGCSGPPG  SPEEPPRQRG  LSSSGWGMAV  300
301   RTGEGPSLSE  QELQKVSTGL  EELRREVSSL  AARWHQEEGA  VQEALRLLGG  LGGRLDGFLG  360
361   QWERAQREQA  QSARGLQELR  GRADELCTMV  ERSAVSVASL  RSELEALGPV  KPILEELGRQ  420
421   LQNSRRGADH  VLNLDRSAQG  PCARCASQGQ  QLSTESLQQL  LERALTPLVD  EVKQKGLAPA  480
481   CPSCQRLHKK  ILELERQALA  KHVRAEALSS  TLRLAQDEAV  RAKNLLLTDK  MKPEEKVATL  540
541   DYMHLKMCSL  HDQLSHLPLE  GSTGAMGGGS  NGGAPPKRGS  PGSEQ  585
Nucleotide CDS Sequence (FASTA)
1     ATGGCAAGCG  TGGTGGTGAA  GACAATCTGG  CAATCCAAAG  AGATCCACGA  AGCGGGGGAC  60
61    CCACCTGCGG  GGGTAGAAAG  CCGTGCCCAG  CTGGTCCCCG  AGGCTCCCGG  GGGGGTGACC  120
121   AGCCCTGCCA  AAGGGATAAC  GAAAAAAAAG  AAGGCTGTGT  CCTTCCATGG  GGTGGAGCCC  180
181   CGGATGTCCC  ACGAGCCGAT  GCACTGGTGC  CTGAACCTCA  AGCGGTCCTC  TGCCTGCACC  240
241   AACGTGTCCT  TGCTCAACCT  GGCTGCCGTG  GAGCCCGACT  CCTCGGGCAC  AGACTCGACC  300
301   ACAGAGGACA  GTGGTCCACT  GGCACTGCCA  GGGCCACCTG  CTTCCCCTAC  AACACCCTGG  360
361   GCTCCAGAGG  ACCCTGACAT  CACAGAACTA  CTGAGTGGGG  TCAACAGTGG  ATTGGTACGT  420
421   GCCAAAGACT  CCATCACCAG  CTTGAAGGAA  AAGACCACGC  GGGTTAATCA  GCACGTTCAG  480
481   ACTCTGCAGA  GCGAGTGCTC  TGTGCTGAGT  GAGAATCTGG  AAAGAAGACG  GCAGGAGGCA  540
541   GAAGAGTTGG  AGGGGTACTG  CAGTCAGTTG  AAGGAGAACT  GCCGCAAGGT  GACCCGTTCA  600
601   GTGGAAGACG  CTGAAATCAA  AACCAATGTC  CTGAAGCAGA  ACTCTGCCTT  GCTGGAGGAG  660
661   AAGCTAAGAT  ACCTCCAGCA  GCAACTGCAG  GATGAGACGC  CCCGGAGACA  GGAGGCCGAG  720
721   TTGCAGGAGT  TGGAGCAAAA  ACTGGAGGCT  GGCCTCTCCC  GACATGGTCT  GAGCCCTGCC  780
781   ACTCCCATTC  AGGGCTGCTC  GGGTCCTCCT  GGCAGCCCCG  AGGAACCCCC  GCGGCAGCGA  840
841   GGCCTGTCCT  CCAGTGGCTG  GGGCATGGCA  GTCCGCACAG  GGGAGGGACC  CTCGCTGAGC  900
901   GAGCAGGAGT  TGCAGAAGGT  CTCCACCGGC  CTGGAGGAGC  TGAGGAGGGA  GGTGTCCTCG  960
961   CTGGCAGCCC  GGTGGCATCA  GGAGGAGGGG  GCAGTGCAGG  AGGCCCTGAG  GTTGCTGGGA  1020
1021  GGCCTTGGCG  GCCGTCTGGA  TGGCTTCCTG  GGCCAGTGGG  AGCGGGCGCA  GCGGGAACAG  1080
1081  GCACAGTCCG  CAAGGGGCTT  GCAGGAGCTG  CGAGGACGAG  CAGATGAGTT  GTGCACTATG  1140
1141  GTGGAGAGGT  CAGCAGTGTC  TGTCGCCTCA  CTGAGGAGTG  AACTGGAGGC  ACTGGGCCCA  1200
1201  GTAAAACCCA  TTCTGGAGGA  GCTGGGACGG  CAACTTCAGA  ACTCCCGGAG  GGGAGCTGAC  1260
1261  CATGTCTTGA  ACTTGGATCG  GTCTGCCCAA  GGCCCCTGTG  CGCGCTGTGC  CAGCCAGGGG  1320
1321  CAGCAGTTAT  CCACGGAGTC  CCTGCAGCAG  CTGCTGGAAC  GTGCGCTGAC  CCCGCTGGTG  1380
1381  GATGAGGTGA  AGCAGAAGGG  TCTGGCTCCT  GCCTGCCCCA  GTTGCCAGAG  GCTACACAAG  1440
1441  AAGATTCTGG  AGCTGGAGCG  CCAGGCCTTG  GCCAAACACG  TCAGGGCAGA  GGCCCTGAGC  1500
1501  TCCACCCTTC  GGTTGGCCCA  AGACGAGGCC  GTTCGGGCCA  AGAACCTACT  GCTGACGGAC  1560
1561  AAGATGAAGC  CGGAGTGA  1578

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Acrosomal vesicle
Cellular Component
Centriole
Molecular Function
Protein kinase binding
Biological Process
Negative regulation of phosphatase activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4522Rattus norvegicus96.070.0 847
LLPS-Mea-0207Mesocricetus auratus91.492e-167 488
LLPS-Dio-0900Dipodomys ordii91.430.0 817
LLPS-Sus-1440Sus scrofa90.020.0 796
LLPS-Nol-3564Nomascus leucogenys89.874e-116 355
LLPS-Caf-0166Canis familiaris89.660.0 785
LLPS-Otg-0746Otolemur garnettii89.150.0 780
LLPS-Eqc-0829Equus caballus88.770.0 765
LLPS-Urm-0182Ursus maritimus87.520.0 798
LLPS-Loa-3189Loxodonta africana87.210.0 748
LLPS-Mup-1088Mustela putorius furo86.990.0 785
LLPS-Ict-2474Ictidomys tridecemlineatus86.920.0 733
LLPS-Bot-1177Bos taurus86.820.0 661
LLPS-Aim-2277Ailuropoda melanoleuca86.270.0 775
LLPS-Fec-3236Felis catus85.560.0 746
LLPS-Poa-1418Pongo abelii85.380.0 576
LLPS-Ova-0873Ovis aries85.050.0 767
LLPS-Myl-2270Myotis lucifugus84.220.0 739
LLPS-Cas-3103Carlito syrichta83.840.0 754
LLPS-Cea-0011Cercocebus atys82.270.0 742
LLPS-Rhb-2173Rhinopithecus bieti82.270.0 734
LLPS-Mal-3774Mandrillus leucophaeus82.090.0 740
LLPS-Maf-0935Macaca fascicularis82.090.0 739
LLPS-Mam-1061Macaca mulatta82.090.0 739
LLPS-Man-0252Macaca nemestrina82.090.0 739
LLPS-Pap-0778Pan paniscus81.910.0 728
LLPS-Caj-2980Callithrix jacchus81.850.0 719
LLPS-Gog-3205Gorilla gorilla81.380.0 724
LLPS-Pat-0729Pan troglodytes81.380.0 723
LLPS-Hos-0479Homo sapiens79.690.0 720
LLPS-Aon-3010Aotus nancymaae78.90.0 711
LLPS-Cap-1471Cavia porcellus78.40.0 720
LLPS-Fud-2167Fukomys damarensis77.260.0 684
LLPS-Chs-2613Chlorocebus sabaeus76.10.0 679
LLPS-Paa-4131Papio anubis75.530.0 673
LLPS-Mod-2036Monodelphis domestica73.220.0 665
LLPS-Anc-0960Anolis carolinensis42.376e-81 272
LLPS-Lac-2273Latimeria chalumnae31.242e-32 134