LLPS-Mum-2168
Igf2bp3

▼ OVERVIEW

Status: Reviewed
Protein Name: Insulin-like growth factor 2 mRNA-binding protein 3
Gene Name: Igf2bp3, Vickz3
Ensembl Gene: ENSMUSG00000029814.10
Ensembl Protein: ENSMUSP00000031838.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Chromatoid body
"...The list of 88 CB proteins identified in at least three separate experiments."
Round spermatids24554440
P-body, Stress granulePredicted from orthologsN/A(View)

▼ FUNCTION

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNKLYIGNLS  DHAGPADLES  VFKDAKIPVA  GPFLVKTGYA  FVDCPDEGWA  LKAIEALSGK  60
61    MELHGKPMEV  EHSVPKRQRI  RKLQIRNIPP  HLQWEVLDSL  LVQYGVVESC  EQVNTDSETA  120
121   VVNVTYSSKD  QARQALDKLN  GFQLENFTLK  VAYIPDETAA  QQNPSPQLRG  RRGPGQRGSS  180
181   RQASPGSVSK  QKPCDLPLRL  LVPTQFVGAI  IGKEGATIRN  ITKQTQSKID  VHRKENTGAA  240
241   EKSITILSTP  EGTSAACKSI  LEIMHKEAQD  IKFTEEIPLK  ILAHNNFVGR  LIGKEGRNLK  300
301   KIEQDTDTKI  TISPLQELTL  YNPERTITVK  GSVETCAKAE  EEIMKKIRES  YENDIASMNL  360
361   QAHLIPGLNL  NALGLFPPTS  GMPPPTSGPP  STLTPPYPQF  EQSETETVHL  FIPALSVGAI  420
421   IGKQGQHIKQ  LSRFAGASIK  IAPAEAPDAK  VRMVIITGPP  EAQFKAQGRI  YGKIKEENFV  480
481   SPKEEVKLEA  HIRVPSFAAG  RVIGKGGKTV  NELQSLSSAE  VVVPRDQTPD  ENDQVVVKIT  540
541   GHFYACQVAQ  RKIQEILTQV  KQHQQQKALQ  SGPPQSRRK  579
Nucleotide CDS Sequence (FASTA)
1     ATGAACAAAT  TGTACATCGG  GAACCTCAGC  GACCACGCCG  GCCCCGCGGA  CCTGGAAAGT  60
61    GTCTTCAAGG  ACGCTAAGAT  CCCGGTGGCG  GGCCCCTTCC  TGGTGAAGAC  GGGCTACGCG  120
121   TTCGTGGACT  GCCCGGACGA  GGGCTGGGCC  CTCAAGGCCA  TCGAGGCGCT  TTCAGGTAAA  180
181   ATGGAACTAC  ATGGGAAACC  GATGGAAGTT  GAGCACTCGG  TCCCTAAACG  GCAGAGGATT  240
241   CGTAAACTTC  AGATACGAAA  TATCCCGCCC  CACTTACAAT  GGGAGGTGCT  GGATAGTTTA  300
301   CTAGTCCAGT  ATGGAGTGGT  GGAGAGCTGT  GAGCAAGTGA  ACACGGATTC  GGAAACGGCA  360
361   GTTGTAAATG  TAACCTATTC  CAGTAAGGAC  CAAGCTAGAC  AAGCCTTAGA  CAAACTGAAT  420
421   GGATTCCAGT  TAGAGAACTT  CACCTTGAAG  GTTGCCTACA  TCCCAGATGA  AACTGCTGCC  480
481   CAGCAAAATC  CCTCGCCACA  GCTCCGGGGG  CGCCGGGGGC  CAGGGCAGCG  GGGCTCATCC  540
541   AGGCAGGCGT  CTCCAGGATC  GGTGTCCAAG  CAGAAACCCT  GTGACCTGCC  ACTGCGCCTG  600
601   CTGGTTCCCA  CCCAGTTTGT  TGGAGCCATT  ATAGGAAAAG  AAGGTGCTAC  CATTCGCAAC  660
661   ATCACAAAGC  AGACCCAGTC  TAAAATCGAT  GTCCATCGTA  AGGAGAATAC  AGGGGCCGCG  720
721   GAGAAGTCCA  TTACTATCCT  CTCTACCCCT  GAAGGCACCT  CTGCAGCTTG  TAAGTCTATT  780
781   CTGGAGATTA  TGCATAAGGA  AGCTCAAGAT  ATAAAATTCA  CAGAGGAGAT  TCCCTTGAAG  840
841   ATCTTAGCTC  ACAATAACTT  TGTAGGCCGT  CTCATTGGTA  AAGAAGGAAG  AAACCTTAAA  900
901   AAAATCGAGC  AAGACACGGA  CACTAAAATC  ACAATATCTC  CATTGCAGGA  ACTGACGCTG  960
961   TACAATCCGG  AACGCACCAT  TACAGTGAAA  GGCAGTGTTG  AGACGTGTGC  CAAGGCGGAG  1020
1021  GAGGAAATAA  TGAAGAAGAT  CAGGGAGTCT  TATGAAAATG  ATATTGCTTC  CATGAATCTT  1080
1081  CAAGCACATT  TAATCCCTGG  ATTAAATCTG  AATGCCTTGG  GTCTGTTCCC  ACCCACGTCA  1140
1141  GGGATGCCAC  CTCCCACCTC  AGGGCCCCCT  TCAACCCTGA  CTCCTCCCTA  CCCACAATTT  1200
1201  GAGCAATCAG  AGACGGAGAC  TGTGCATCTG  TTTATTCCCG  CCCTGTCCGT  TGGCGCCATC  1260
1261  ATTGGCAAGC  AGGGCCAACA  CATCAAACAG  CTTTCTCGCT  TTGCGGGAGC  TTCGATTAAG  1320
1321  ATCGCTCCAG  CCGAAGCACC  AGATGCTAAA  GTGCGGATGG  TGATTATCAC  TGGACCACCA  1380
1381  GAGGCTCAGT  TCAAGGCTCA  GGGAAGAATT  TATGGAAAAA  TTAAAGAAGA  AAACTTTGTT  1440
1441  AGTCCTAAAG  AAGAGGTGAA  ACTTGAAGCT  CACATCAGAG  TGCCGTCCTT  TGCTGCTGGC  1500
1501  AGAGTTATTG  GGAAAGGAGG  CAAAACGGTG  AATGAGCTCC  AGAGTTTATC  AAGTGCTGAA  1560
1561  GTTGTCGTCC  CCCGTGACCA  GACACCTGAT  GAGAATGATC  AAGTAGTTGT  CAAAATAACT  1620
1621  GGCCACTTCT  ATGCTTGCCA  GGTTGCCCAG  AGGAAAATTC  AGGAAATTCT  GACTCAGGTA  1680
1681  AAGCAGCACC  AGCAGCAGAA  AGCTCTGCAG  AGTGGACCAC  CTCAGTCAAG  GCGGAAGTAA  1740

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Isopeptide bond
mRNA transport
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Translation regulation
Transport
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
MRNA 3'-UTR binding
Molecular Function
MRNA 5'-UTR binding
Biological Process
MRNA transport
Biological Process
Regulation of translation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-2644Rattus norvegicus98.790.01048
LLPS-Chs-0393Chlorocebus sabaeus97.730.0 843
LLPS-Mea-2808Mesocricetus auratus97.580.01037
LLPS-Gog-0802Gorilla gorilla97.50.0 919
LLPS-Loa-0017Loxodonta africana96.930.0 834
LLPS-Cas-1681Carlito syrichta96.720.01033
LLPS-Man-0610Macaca nemestrina96.720.01035
LLPS-Rhb-1756Rhinopithecus bieti96.720.01035
LLPS-Dio-2043Dipodomys ordii96.720.01033
LLPS-Paa-2454Papio anubis96.720.01035
LLPS-Mal-2735Mandrillus leucophaeus96.720.01035
LLPS-Maf-2548Macaca fascicularis96.720.01035
LLPS-Cea-2285Cercocebus atys96.720.01035
LLPS-Ict-1370Ictidomys tridecemlineatus96.550.01035
LLPS-Hos-0450Homo sapiens96.550.01033
LLPS-Pap-1727Pan paniscus96.550.01033
LLPS-Pat-2918Pan troglodytes96.550.01033
LLPS-Otg-1122Otolemur garnettii96.550.01033
LLPS-Mup-2288Mustela putorius furo96.550.01026
LLPS-Caf-1401Canis familiaris96.370.01027
LLPS-Fec-2984Felis catus96.370.01028
LLPS-Tut-0918Tursiops truncatus96.370.01027
LLPS-Fud-4235Fukomys damarensis96.370.01030
LLPS-Aim-0738Ailuropoda melanoleuca96.20.01024
LLPS-Aon-2023Aotus nancymaae95.850.01028
LLPS-Caj-0815Callithrix jacchus95.850.01027
LLPS-Bot-2750Bos taurus95.520.01013
LLPS-Eqc-3998Equus caballus95.510.01022
LLPS-Ova-3141Ovis aries95.340.01012
LLPS-Nol-0298Nomascus leucogenys94.880.01019
LLPS-Cap-1505Cavia porcellus94.810.0 884
LLPS-Orc-1391Oryctolagus cuniculus94.640.0 898
LLPS-Sus-2217Sus scrofa93.930.0 894
LLPS-Myl-1504Myotis lucifugus92.130.0 821
LLPS-Urm-1667Ursus maritimus89.550.0 931
LLPS-Lac-3837Latimeria chalumnae85.473e-92 298
LLPS-Gaga-1414Gallus gallus82.890.0 903
LLPS-Ora-3552Ornithorhynchus anatinus82.590.0 916
LLPS-Meg-0967Meleagris gallopavo82.160.0 811
LLPS-Tag-2519Taeniopygia guttata82.020.0 912
LLPS-Anp-0172Anas platyrhynchos82.020.0 912
LLPS-Anc-2969Anolis carolinensis81.680.0 907
LLPS-Fia-3378Ficedula albicollis81.140.0 739
LLPS-Pes-0216Pelodiscus sinensis80.340.0 887
LLPS-Xet-3234Xenopus tropicalis77.930.0 880
LLPS-Leo-1210Lepisosteus oculatus77.840.0 879
LLPS-Scf-1131Scleropages formosus75.60.0 840
LLPS-Pof-1260Poecilia formosa74.020.0 808
LLPS-Orn-3674Oreochromis niloticus74.020.0 817
LLPS-Sah-3273Sarcophilus harrisii73.830.0 685
LLPS-Mam-0303Macaca mulatta73.333e-63 220
LLPS-Mod-2544Monodelphis domestica73.250.0 819
LLPS-Ten-2252Tetraodon nigroviridis73.210.0 801
LLPS-Icp-0316Ictalurus punctatus73.20.0 826
LLPS-Asm-0137Astyanax mexicanus72.910.0 809
LLPS-Dar-3094Danio rerio72.730.0 804
LLPS-Orl-1228Oryzias latipes71.890.0 797
LLPS-Tar-0940Takifugu rubripes71.870.0 803
LLPS-Gaa-1861Gasterosteus aculeatus71.560.0 791
LLPS-Xim-0141Xiphophorus maculatus71.40.0 773
LLPS-Poa-3164Pongo abelii71.160.0 818
LLPS-Scm-2998Scophthalmus maximus68.840.0 754
LLPS-Cii-1213Ciona intestinalis45.471e-150 453
LLPS-Cis-1321Ciona savignyi44.871e-149 450
LLPS-Drm-0212Drosophila melanogaster39.41e-101 328
LLPS-Put-0762Puccinia triticina27.211e-1273.9
LLPS-Glm-0179Glycine max26.571e-0655.5
LLPS-Zem-1601Zea mays26.479e-1270.9
LLPS-Sot-2299Solanum tuberosum26.256e-1478.6
LLPS-Mua-0180Musa acuminata26.061e-1377.8
LLPS-Sem-0439Selaginella moellendorffii26.03e-1271.2
LLPS-Crn-0314Cryptococcus neoformans25.665e-1374.7
LLPS-Cae-0606Caenorhabditis elegans25.366e-1995.1
LLPS-Sol-2190Solanum lycopersicum25.336e-1272.4
LLPS-Gas-0344Galdieria sulphuraria25.262e-1480.1
LLPS-Mae-1043Manihot esculenta24.214e-1168.6
LLPS-Dac-2239Daucus carota24.071e-1274.3
LLPS-Brr-0292Brassica rapa23.972e-1169.7
LLPS-Blg-0342Blumeria graminis23.643e-1169.3
LLPS-Coc-0243Corchorus capsularis23.472e-1170.5
LLPS-Vir-1928Vigna radiata22.764e-1273.2