LLPS-Mum-1960
Wdr46

▼ OVERVIEW

Status: Reviewed
Protein Name: WD repeat-containing protein 46; WD repeat-containing protein BING4
Gene Name: Wdr46, Bing4
Ensembl Gene: ENSMUSG00000024312.10
Ensembl Protein: ENSMUSP00000025170.9
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs

▼ FUNCTION

Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

▼ SEQUENCE

Protein Sequence (FASTA)
1     METAPKPGRG  VPPKRDKPQA  KRKKPRRYWE  EETTPAAVAT  SPGPPRKKAR  TGESRPPRSK  60
61    SAHIAQKSRF  SKKPPISKTA  PDWKKPQRTL  SGAQDPFPGP  VPAPLEEARK  FCRIDKSKTL  120
121   PHSKPKTQSK  LEKAEAQEEE  ASVRAARAEL  LLAEEPGFLV  GEDGEDTAKI  LQTDIVEAVD  180
181   IASAAKHFDL  NLRQFGPYRL  NYSRTGRHLA  LGGRRGHVAA  LDWVTKKLMC  EINVMEAVRD  240
241   IHFLHSEALL  AVAQNRWLYI  YDNQGIELHC  IRRCDRVTRL  EFLPFHFLLA  TTSETGFLTY  300
301   LDVSVGKIVT  ALNVRAGRLS  VMAQNPYNAV  IHLGHSNGTV  SLWSPAVKEP  LAKILCHRGG  360
361   VRAVAVDSTG  TYMATSGLDH  QLKIFDLRGT  FQPLSSRTLP  QGAGHLAFSQ  RGLLVAGMGD  420
421   VVNIWAGQGK  ASPPSLEQPY  LTHRLSGHVH  GLQFCPFEDV  LGVGHSGGFT  SMLVPGAAEP  480
481   NFDGLENNPY  RSRKQRQEWE  VKALLEKVPA  ELICLNPRAL  AEVDVVTLEQ  QKKERIERLG  540
541   YDPDAKAAFQ  PKAKQKGRSS  TASLVKRKKK  VMDQEHRDKV  RQSLEQQQQK  KKQDMAMPPG  600
601   ARPSALDRFV  RRAREGGLQV  DP  622
Nucleotide CDS Sequence (FASTA)
1     ATGGAGACAG  CCCCCAAGCC  GGGTAGGGGT  GTCCCACCCA  AGAGAGACAA  GCCTCAGGCC  60
61    AAGAGGAAGA  AACCGCGGCG  CTACTGGGAG  GAGGAGACCA  CCCCGGCCGC  CGTCGCCACC  120
121   TCCCCGGGGC  CGCCTCGGAA  GAAGGCGAGG  ACTGGGGAGT  CGCGACCCCC  GAGGTCCAAG  180
181   AGCGCGCACA  TCGCCCAGAA  GTCCCGGTTC  TCCAAGAAGC  CCCCGATCTC  AAAGACCGCT  240
241   CCAGACTGGA  AGAAGCCTCA  GAGGACGCTG  TCGGGGGCTC  AGGACCCGTT  CCCAGGACCC  300
301   GTCCCCGCCC  CCCTGGAGGA  GGCCCGGAAG  TTTTGTCGAA  TTGACAAGTC  CAAAACGCTC  360
361   CCACATTCGA  AGCCTAAAAC  TCAAAGCAAA  CTCGAGAAGG  CTGAAGCGCA  AGAGGAAGAG  420
421   GCAAGCGTCA  GAGCCGCCCG  CGCTGAGCTG  CTGCTTGCAG  AGGAACCTGG  GTTTCTGGTA  480
481   GGAGAAGATG  GGGAAGACAC  GGCAAAAATC  CTGCAGACAG  ACATCGTGGA  GGCTGTGGAC  540
541   ATCGCCAGTG  CTGCCAAGCA  CTTTGACCTG  AATCTAAGAC  AGTTCGGACC  CTACAGACTG  600
601   AATTACTCTC  GAACAGGGAG  ACACCTGGCT  TTAGGAGGGC  GTCGGGGTCA  CGTGGCTGCC  660
661   CTCGACTGGG  TGACCAAGAA  GCTCATGTGT  GAGATCAACG  TCATGGAAGC  AGTACGGGAC  720
721   ATCCACTTCC  TCCATTCTGA  GGCTCTGCTC  GCAGTCGCTC  AGAACCGCTG  GCTTTATATC  780
781   TACGACAACC  AAGGCATCGA  GCTTCACTGC  ATCCGCCGCT  GTGACCGAGT  GACCCGGCTT  840
841   GAGTTCCTCC  CCTTCCACTT  CCTCCTGGCC  ACCACTTCAG  AGACAGGGTT  TCTGACCTAC  900
901   CTGGATGTGT  CAGTGGGGAA  GATCGTGACA  GCTCTGAACG  TGCGGGCGGG  ACGGCTCAGT  960
961   GTCATGGCTC  AGAACCCCTA  CAATGCTGTT  ATCCACCTGG  GACACAGTAA  TGGCACAGTG  1020
1021  TCTTTATGGA  GTCCAGCAGT  GAAGGAGCCA  CTGGCGAAGA  TTCTGTGTCA  CCGTGGTGGG  1080
1081  GTGCGTGCTG  TGGCAGTAGA  TTCTACAGGC  ACGTACATGG  CCACCTCTGG  TCTGGACCAC  1140
1141  CAGCTGAAGA  TCTTTGACTT  GCGAGGGACA  TTCCAGCCCC  TGAGTTCCCG  GACCTTGCCC  1200
1201  CAGGGAGCAG  GGCACTTGGC  CTTTTCCCAG  CGGGGACTGT  TAGTTGCGGG  AATGGGTGAT  1260
1261  GTGGTCAACA  TATGGGCAGG  GCAGGGCAAG  GCCAGCCCAC  CCTCCCTGGA  GCAGCCCTAC  1320
1321  CTCACCCACC  GGCTCTCAGG  CCACGTGCAT  GGGCTCCAGT  TCTGCCCCTT  TGAAGACGTG  1380
1381  TTGGGGGTGG  GGCACAGTGG  AGGCTTCACC  AGCATGCTGG  TCCCTGGGGC  TGCGGAGCCT  1440
1441  AACTTTGATG  GTTTGGAGAA  TAACCCATAC  CGGAGCCGGA  AGCAGCGCCA  GGAATGGGAG  1500
1501  GTGAAGGCCC  TGCTGGAGAA  GGTACCTGCA  GAGCTCATTT  GTTTGAACCC  CCGAGCCCTG  1560
1561  GCAGAGGTGG  ATGTGGTCAC  TCTGGAGCAG  CAGAAGAAGG  AGCGGATAGA  GAGACTGGGC  1620
1621  TATGATCCAG  ACGCCAAGGC  TGCCTTTCAG  CCCAAGGCCA  AGCAGAAGGG  CCGAAGCTCT  1680
1681  ACGGCGAGCC  TAGTGAAGAG  GAAGAAGAAG  GTCATGGACC  AGGAGCACAG  GGACAAAGTC  1740
1741  CGGCAGAGCC  TTGAGCAGCA  GCAGCAGAAG  AAAAAGCAGG  ATATGGCCAT  GCCTCCTGGA  1800
1801  GCCCGTCCCT  CTGCACTGGA  TAGATTTGTA  CGACGAGCCA  GAGAAGGCGG  TCTCCAAGTT  1860
1861  GACCCTTAG  1869

▼ KEYWORD

ID
Family
Complete proteome
Nucleus
Phosphoprotein
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Cellular Component
Small-subunit processome
Biological Process
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0458Rattus norvegicus93.620.01035
LLPS-Mea-1350Mesocricetus auratus90.690.0 988
LLPS-Dio-0917Dipodomys ordii87.250.0 968
LLPS-Eqc-0704Equus caballus86.130.0 954
LLPS-Man-1069Macaca nemestrina85.20.0 947
LLPS-Aon-2480Aotus nancymaae85.040.0 940
LLPS-Hos-3361Homo sapiens84.990.0 952
LLPS-Pat-0196Pan troglodytes84.990.0 952
LLPS-Mam-0570Macaca mulatta84.880.0 943
LLPS-Paa-4100Papio anubis84.880.0 942
LLPS-Cea-1401Cercocebus atys84.880.0 940
LLPS-Loa-1339Loxodonta africana84.850.0 924
LLPS-Maf-0520Macaca fascicularis84.850.0 944
LLPS-Pap-1610Pan paniscus84.830.0 949
LLPS-Gog-0767Gorilla gorilla84.830.0 952
LLPS-Mup-1637Mustela putorius furo84.80.0 905
LLPS-Mal-1478Mandrillus leucophaeus84.720.0 936
LLPS-Poa-3052Pongo abelii84.690.0 952
LLPS-Myl-1461Myotis lucifugus84.670.0 928
LLPS-Caj-1350Callithrix jacchus84.550.0 917
LLPS-Chs-0557Chlorocebus sabaeus84.360.0 936
LLPS-Ict-0759Ictidomys tridecemlineatus84.170.0 939
LLPS-Otg-1661Otolemur garnettii83.990.0 907
LLPS-Aim-0909Ailuropoda melanoleuca83.850.0 941
LLPS-Tut-0185Tursiops truncatus83.850.0 918
LLPS-Cas-0290Carlito syrichta83.690.0 928
LLPS-Bot-0196Bos taurus83.630.0 934
LLPS-Fec-2340Felis catus83.520.0 938
LLPS-Sus-0269Sus scrofa83.390.0 918
LLPS-Urm-1730Ursus maritimus82.710.0 922
LLPS-Orc-1192Oryctolagus cuniculus82.680.0 924
LLPS-Rhb-1864Rhinopithecus bieti82.380.0 892
LLPS-Fud-1696Fukomys damarensis81.720.0 897
LLPS-Nol-1853Nomascus leucogenys81.180.0 540
LLPS-Cap-0476Cavia porcellus80.640.0 927
LLPS-Caf-3299Canis familiaris79.970.0 878
LLPS-Ova-1256Ovis aries79.870.0 864
LLPS-Anp-0478Anas platyrhynchos73.213e-1164.7
LLPS-Mod-1021Monodelphis domestica69.420.0 744
LLPS-Sah-0132Sarcophilus harrisii68.40.0 728
LLPS-Pof-0367Poecilia formosa59.614e-172 512
LLPS-Gaa-0296Gasterosteus aculeatus55.773e-176 519
LLPS-Tar-1927Takifugu rubripes55.360.0 549
LLPS-Icp-2836Ictalurus punctatus54.420.0 544
LLPS-Dar-0294Danio rerio54.00.0 562
LLPS-Xet-1222Xenopus tropicalis53.910.0 555
LLPS-Scf-0989Scleropages formosus53.860.0 541
LLPS-Ten-0497Tetraodon nigroviridis53.70.0 544
LLPS-Asm-2415Astyanax mexicanus53.666e-159 473
LLPS-Orl-0122Oryzias latipes53.66e-177 523
LLPS-Orn-0995Oreochromis niloticus53.230.0 540
LLPS-Xim-1008Xiphophorus maculatus52.930.0 535
LLPS-Scm-0653Scophthalmus maximus52.271e-177 524
LLPS-Lac-1961Latimeria chalumnae52.220.0 563
LLPS-Cae-0481Caenorhabditis elegans51.792e-118 372
LLPS-Cii-0534Ciona intestinalis50.738e-93 297
LLPS-Sem-0137Selaginella moellendorffii47.573e-109 345
LLPS-Trr-0723Trichoderma reesei47.273e-106 338
LLPS-Mel-0462Melampsora laricipopulina47.252e-99 318
LLPS-Nec-0047Neurospora crassa47.146e-108 343
LLPS-Tum-0403Tuber melanosporum47.122e-111 352
LLPS-Trv-0511Trichoderma virens46.492e-107 342
LLPS-Map-0416Magnaporthe poae46.355e-107 341
LLPS-Cis-0655Ciona savignyi46.251e-118 370
LLPS-Scp-0217Schizosaccharomyces pombe46.223e-101 325
LLPS-Mao-0141Magnaporthe oryzae46.098e-105 335
LLPS-Php-0815Physcomitrella patens46.031e-103 331
LLPS-Scj-1436Schizosaccharomyces japonicus45.958e-108 342
LLPS-Abg-1139Absidia glauca45.933e-106 338
LLPS-Asg-0222Ashbya gossypii45.671e-105 337
LLPS-Usm-0123Ustilago maydis45.66e-92 304
LLPS-Zyt-0781Zymoseptoria tritici45.65e-107 341
LLPS-Lep-1202Leersia perrieri45.52e-79 282
LLPS-Yal-1273Yarrowia lipolytica45.451e-102 328
LLPS-Ast-1006Aspergillus terreus45.316e-104 332
LLPS-Gag-0417Gaeumannomyces graminis45.311e-105 337
LLPS-Scc-0490Schizosaccharomyces cryophilus45.143e-102 327
LLPS-Ved-0864Verticillium dahliae45.051e-104 334
LLPS-Cogr-0196Colletotrichum graminicola45.055e-104 333
LLPS-Fuo-0742Fusarium oxysporum45.059e-105 335
LLPS-Cog-0002Colletotrichum gloeosporioides45.057e-105 335
LLPS-Asf-0155Aspergillus flavus45.055e-104 332
LLPS-Aso-0563Aspergillus oryzae45.054e-104 332
LLPS-Coo-0165Colletotrichum orbiculare45.058e-104 332
LLPS-Fuv-0677Fusarium verticillioides45.056e-105 335
LLPS-Sob-0068Sorghum bicolor44.991e-88 292
LLPS-Spr-0208Sporisorium reilianum44.89e-90 298
LLPS-Beb-0862Beauveria bassiana44.792e-103 331
LLPS-Blg-0401Blumeria graminis44.791e-104 335
LLPS-Asni-0789Aspergillus niger44.791e-103 332
LLPS-Sac-0021Saccharomyces cerevisiae44.761e-102 329
LLPS-Drm-0426Drosophila melanogaster44.732e-119 374
LLPS-Vir-0088Vigna radiata44.722e-90 300
LLPS-Kop-0359Komagataella pastoris44.622e-96 312
LLPS-Fus-0107Fusarium solani44.532e-103 331
LLPS-Asc-0904Aspergillus clavatus44.536e-100 322
LLPS-Zem-0557Zea mays44.511e-87 288
LLPS-Orbr-1240Oryza brachyantha44.51e-87 289
LLPS-Pot-2255Populus trichocarpa44.446e-89 293
LLPS-Miv-0234Microbotryum violaceum44.422e-90 299
LLPS-Crn-1204Cryptococcus neoformans44.272e-81 275
LLPS-Phv-0880Phaseolus vulgaris44.171e-90 297
LLPS-Chr-0054Chlamydomonas reinhardtii44.172e-95 310
LLPS-Mua-0073Musa acuminata44.173e-86 285
LLPS-Prp-0074Prunus persica44.056e-86 285
LLPS-Mae-1699Manihot esculenta44.059e-84 279
LLPS-Org-1335Oryza glaberrima44.024e-85 283
LLPS-Orr-0816Oryza rufipogon44.025e-85 282
LLPS-Ors-0648Oryza sativa44.024e-85 282
LLPS-Orni-0918Oryza nivara44.025e-85 282
LLPS-Orb-0001Oryza barthii44.024e-85 283
LLPS-Ori-0284Oryza indica44.025e-85 282
LLPS-Asfu-0151Aspergillus fumigatus44.011e-97 316
LLPS-Nef-0186Neosartorya fischeri44.019e-99 318
LLPS-Met-0121Medicago truncatula43.881e-92 302
LLPS-Tra-0425Triticum aestivum43.823e-85 283
LLPS-Scs-0070Sclerotinia sclerotiorum43.784e-96 311
LLPS-Orgl-0691Oryza glumaepatula43.755e-84 280
LLPS-Asn-0222Aspergillus nidulans43.753e-100 322
LLPS-Osl-0426Ostreococcus lucimarinus43.725e-105 335
LLPS-Orp-0211Oryza punctata43.69e-86 284
LLPS-Cus-0479Cucumis sativus43.554e-84 280
LLPS-Amt-0424Amborella trichopoda43.371e-83 278
LLPS-Brr-0897Brassica rapa43.368e-87 287
LLPS-Brd-0690Brachypodium distachyon43.365e-87 287
LLPS-Bro-0172Brassica oleracea43.283e-85 283
LLPS-Tru-2097Triticum urartu43.282e-80 270
LLPS-Gas-0624Galdieria sulphuraria43.266e-101 325
LLPS-Sei-0113Setaria italica43.249e-86 284
LLPS-Arl-0424Arabidopsis lyrata43.017e-89 293
LLPS-Art-0011Arabidopsis thaliana42.746e-88 290
LLPS-Brn-2052Brassica napus42.741e-86 286
LLPS-Viv-0405Vitis vinifera42.556e-84 280
LLPS-Dac-0325Daucus carota42.552e-85 283
LLPS-Hov-0134Hordeum vulgare42.477e-85 282
LLPS-Put-0319Puccinia triticina41.898e-84 282
LLPS-Hea-0825Helianthus annuus41.731e-86 286
LLPS-Cym-0127Cyanidioschyzon merolae41.04e-63 226
LLPS-Dos-0071Dothistroma septosporum40.926e-99 320
LLPS-Via-0728Vigna angularis40.314e-93 303
LLPS-Glm-0383Glycine max39.871e-91 300
LLPS-Thc-0078Theobroma cacao39.77e-86 286
LLPS-Nia-0422Nicotiana attenuata39.612e-91 299
LLPS-Sol-0085Solanum lycopersicum38.976e-91 298
LLPS-Pug-0213Puccinia graminis38.956e-73 248
LLPS-Gor-0908Gossypium raimondii38.913e-93 304
LLPS-Phn-0435Phaeosphaeria nodorum38.669e-88 290
LLPS-Pytr-0715Pyrenophora triticirepentis38.662e-87 289
LLPS-Pyt-1027Pyrenophora teres38.661e-87 290
LLPS-Lem-0111Leptosphaeria maculans38.562e-87 291
LLPS-Sot-1239Solanum tuberosum38.481e-90 296
LLPS-Chc-0722Chondrus crispus36.095e-65 229