LLPS-Mum-1822
Gnl3l
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Guanine nucleotide-binding protein-like 3-like protein |
| Gene Name: | Gnl3l |
| Ensembl Gene: | ENSMUSG00000025266.11 |
| Ensembl Protein: | ENSMUSP00000026297.5 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000026297.11 | ENSMUSP00000026297.5 |
| Ensembl | ENSMUST00000156233.1 | ENSMUSP00000117281.1 |
| Ensembl | ENSMUST00000112691.8 | ENSMUSP00000108311.2 |
| Ensembl | ENSMUST00000124022.7 | ENSMUSP00000138542.1 |
| Ensembl | ENSMUST00000154393.7 | ENSMUSP00000138737.1 |
| UniProt | Q6PGG6, GNL3L_MOUSE | |
| GeneBank | BC057033, BC079653, AL805937 | , AAH79653.1, AAH57033.1 |
| RefSeq | NM_001168600.1, NM_198110.2, XM_006528805.3 | NP_001162071.1, NP_932778.1, XP_006528868.1 |
| Entrez | 237107 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MMKIRHKNKK PGKGSKGCKK PARQNGKKVT SRPSSAPQIV HGNDHASREA ELKKKRVEEM 60 61 REKQQVAREQ ERQRHRTMES YCQDVLKRQQ EFEQKEEVLQ ELNMFPQLDD EATRKAYYKE 120 121 FRKVVEYSDV ILEVLDARDP LGCRCFQMEE TVLRAEGNKK LVLVLNKIDL VPKEIVEKWL 180 181 EYLLNELPTV AFKASTQHHQ VKNLTRCKVP VDQASESLLK SRACFGAENL MRVLGNYCRL 240 241 GEVRGHIRVG VVGLPNVGKS SLINSLKRSR ACSVGAVPGV TKFMQEVYLD KFIRLLDAPG 300 301 IVPGPNSEVG TILRNCIHVQ KLADPVTPVE TILQRCNLEE ISSYYGVSGF QTTEHFLTAV 360 361 AHRLGKKKKG GVYSQEQAAK AVLADWVSGK ISFYTLPPPT HTLPTHLSAE IVKEMTEVFD 420 421 IEDTEHANED TMECLAVGES DELLGDMDPQ EMEVRWLHSP LVKIADAIEN RSTVYKIGNL 480 481 TGYCTKPNRN QMGWPKRNVD HHCPQNNRVV EVSSVDRRPM LQRILETDPL QQGQALASAL 540 541 KNKKKLQKRS DKIATKLSDS MMSMLDLSGN SDDCAGD 577 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATGAAGA TTAGACACAA AAACAAAAAA CCAGGTAAAG GTTCCAAAGG CTGTAAGAAG 60 61 CCTGCAAGGC AAAATGGGAA GAAAGTAACC TCCAGACCAT CATCTGCTCC CCAGATTGTT 120 121 CATGGCAATG ACCATGCCAG TCGCGAGGCC GAATTAAAGA AGAAAAGGGT CGAGGAGATG 180 181 AGGGAGAAGC AGCAAGTTGC CCGGGAGCAA GAGAGACAGA GACACAGGAC CATGGAGAGC 240 241 TATTGTCAGG ATGTCCTGAA ACGTCAGCAG GAATTTGAAC AAAAGGAGGA AGTTTTGCAG 300 301 GAATTAAACA TGTTTCCTCA GTTGGATGAT GAGGCCACAA GGAAGGCCTA TTACAAGGAA 360 361 TTCCGGAAGG TGGTAGAGTA CTCTGATGTG ATTCTGGAAG TCCTAGATGC CAGAGACCCA 420 421 TTGGGCTGCC GCTGTTTCCA GATGGAGGAG ACTGTCCTTC GTGCAGAAGG CAACAAGAAG 480 481 CTGGTCTTGG TCTTAAATAA GATAGATCTC GTTCCCAAGG AGATTGTGGA AAAGTGGCTG 540 541 GAATACCTTC TCAATGAACT GCCAACTGTG GCTTTCAAGG CCAGCACCCA GCATCATCAG 600 601 GTCAAAAACT TGACTCGTTG TAAAGTTCCA GTGGACCAGG CCTCTGAGTC GCTTTTGAAA 660 661 AGCAGAGCCT GCTTTGGAGC CGAAAATCTC ATGAGGGTCC TGGGGAACTA TTGTCGCCTG 720 721 GGGGAAGTGC GTGGCCACAT TCGTGTGGGT GTTGTAGGCC TTCCCAATGT GGGGAAGAGC 780 781 AGTCTGATCA ATAGCCTGAA GCGCAGCCGT GCTTGTAGTG TGGGAGCTGT TCCTGGTGTC 840 841 ACAAAATTCA TGCAGGAGGT CTACCTAGAC AAGTTTATCA GGCTTCTGGA TGCACCAGGC 900 901 ATTGTCCCAG GACCCAATTC AGAGGTGGGC ACCATCCTGC GTAATTGCAT CCATGTGCAG 960 961 AAGCTGGCAG ACCCTGTGAC CCCGGTGGAG ACCATCCTTC AGCGCTGCAA CCTGGAGGAG 1020 1021 ATTTCCAGCT ACTATGGTGT ATCTGGATTC CAGACGACTG AGCACTTTCT GACTGCAGTG 1080 1081 GCCCATCGCT TGGGAAAGAA GAAGAAGGGA GGTGTATATA GTCAGGAACA GGCTGCCAAA 1140 1141 GCTGTGCTGG CTGACTGGGT GAGTGGGAAG ATCAGCTTCT ATACACTACC ACCGCCCACT 1200 1201 CACACTCTGC CCACCCATCT CAGTGCTGAG ATTGTTAAGG AGATGACTGA GGTCTTTGAT 1260 1261 ATAGAAGATA CTGAGCACGC CAATGAAGAC ACCATGGAAT GCTTAGCTGT GGGAGAATCC 1320 1321 GATGAGCTGT TGGGTGACAT GGACCCACAA GAAATGGAGG TCAGGTGGCT CCATTCTCCA 1380 1381 CTGGTGAAAA TAGCAGATGC TATTGAAAAT AGAAGCACCG TGTATAAGAT TGGAAATCTC 1440 1441 ACTGGGTATT GTACCAAACC AAACCGTAAT CAGATGGGGT GGCCTAAACG CAATGTGGAC 1500 1501 CACCATTGCC CCCAAAATAA CCGTGTAGTA GAGGTCAGTT CTGTGGACCG CCGCCCGATG 1560 1561 TTGCAGAGGA TCCTGGAGAC AGACCCACTT CAGCAAGGCC AGGCTCTGGC ATCTGCCTTG 1620 1621 AAGAATAAGA AAAAATTGCA GAAGCGTTCA GATAAAATCG CCACTAAGTT GTCTGACTCC 1680 1681 ATGATGTCCA TGCTTGACCT CTCTGGCAAC TCCGATGACT GTGCAGGTGA CTGA 1734 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Cellular Component | Telomerase holoenzyme complex | |
Molecular Function | GTP binding | |
Biological Process | Negative regulation of protein binding | |
Biological Process | Negative regulation of protein sumoylation | |
Biological Process | Negative regulation of protein ubiquitination | |
Biological Process | Negative regulation of telomere maintenance via telomerase | |
Biological Process | Positive regulation of protein homodimerization activity | |
Biological Process | Positive regulation of protein localization to chromosome, telomeric region | |
Biological Process | Regulation of protein stability | |
Biological Process | Ribosome biogenesis |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2696 | Rattus norvegicus | 97.92 | 0.0 | 1043 |
| LLPS-Mea-1161 | Mesocricetus auratus | 92.28 | 0.0 | 981 |
| LLPS-Chs-0218 | Chlorocebus sabaeus | 90.29 | 0.0 | 801 |
| LLPS-Ict-0105 | Ictidomys tridecemlineatus | 89.6 | 0.0 | 952 |
| LLPS-Sus-2870 | Sus scrofa | 89.57 | 0.0 | 944 |
| LLPS-Orc-0050 | Oryctolagus cuniculus | 89.39 | 0.0 | 943 |
| LLPS-Bot-0099 | Bos taurus | 89.08 | 0.0 | 946 |
| LLPS-Urm-0140 | Ursus maritimus | 88.62 | 0.0 | 941 |
| LLPS-Fec-1186 | Felis catus | 88.56 | 0.0 | 944 |
| LLPS-Caf-0572 | Canis familiaris | 88.31 | 0.0 | 940 |
| LLPS-Nol-0223 | Nomascus leucogenys | 88.25 | 0.0 | 935 |
| LLPS-Hos-0850 | Homo sapiens | 88.25 | 0.0 | 929 |
| LLPS-Mam-1192 | Macaca mulatta | 88.22 | 0.0 | 928 |
| LLPS-Rhb-0036 | Rhinopithecus bieti | 88.22 | 0.0 | 928 |
| LLPS-Mup-0528 | Mustela putorius furo | 88.13 | 0.0 | 941 |
| LLPS-Pap-0639 | Pan paniscus | 88.06 | 0.0 | 926 |
| LLPS-Pat-0355 | Pan troglodytes | 88.06 | 0.0 | 926 |
| LLPS-Maf-0094 | Macaca fascicularis | 88.04 | 0.0 | 927 |
| LLPS-Man-0602 | Macaca nemestrina | 88.04 | 0.0 | 927 |
| LLPS-Ova-0133 | Ovis aries | 87.59 | 0.0 | 713 |
| LLPS-Aim-3485 | Ailuropoda melanoleuca | 87.5 | 0.0 | 930 |
| LLPS-Gog-0546 | Gorilla gorilla | 87.5 | 0.0 | 919 |
| LLPS-Poa-1043 | Pongo abelii | 87.31 | 0.0 | 918 |
| LLPS-Eqc-1430 | Equus caballus | 87.23 | 0.0 | 924 |
| LLPS-Cea-2143 | Cercocebus atys | 86.92 | 0.0 | 912 |
| LLPS-Aon-0995 | Aotus nancymaae | 86.85 | 0.0 | 926 |
| LLPS-Paa-0570 | Papio anubis | 86.73 | 0.0 | 905 |
| LLPS-Caj-1282 | Callithrix jacchus | 86.33 | 0.0 | 927 |
| LLPS-Otg-0641 | Otolemur garnettii | 86.19 | 0.0 | 910 |
| LLPS-Cas-0005 | Carlito syrichta | 85.79 | 0.0 | 912 |
| LLPS-Fud-0125 | Fukomys damarensis | 84.43 | 0.0 | 873 |
| LLPS-Dio-1807 | Dipodomys ordii | 84.19 | 0.0 | 863 |
| LLPS-Loa-1418 | Loxodonta africana | 83.27 | 0.0 | 865 |
| LLPS-Myl-0478 | Myotis lucifugus | 82.76 | 0.0 | 868 |
| LLPS-Cap-1392 | Cavia porcellus | 82.7 | 0.0 | 863 |
| LLPS-Mal-2721 | Mandrillus leucophaeus | 82.43 | 0.0 | 846 |
| LLPS-Mod-0517 | Monodelphis domestica | 61.32 | 2e-154 | 460 |
| LLPS-Ora-0515 | Ornithorhynchus anatinus | 55.31 | 5e-168 | 496 |
| LLPS-Sei-1758 | Setaria italica | 54.58 | 2e-91 | 299 |
| LLPS-Tra-1893 | Triticum aestivum | 53.95 | 3e-90 | 296 |
| LLPS-Tru-0749 | Triticum urartu | 53.26 | 2e-89 | 294 |
| LLPS-Lep-0614 | Leersia perrieri | 52.98 | 5e-91 | 301 |
| LLPS-Cii-0174 | Ciona intestinalis | 51.87 | 1e-119 | 372 |
| LLPS-Sol-0420 | Solanum lycopersicum | 51.56 | 5e-86 | 286 |
| LLPS-Cis-0383 | Ciona savignyi | 51.31 | 7e-127 | 390 |
| LLPS-Anc-0429 | Anolis carolinensis | 50.81 | 2e-154 | 461 |
| LLPS-Php-0189 | Physcomitrella patens | 50.64 | 9e-93 | 303 |
| LLPS-Zem-0566 | Zea mays | 50.61 | 2e-90 | 297 |
| LLPS-Hea-0103 | Helianthus annuus | 50.16 | 5e-91 | 298 |
| LLPS-Bro-1063 | Brassica oleracea | 50.16 | 7e-88 | 290 |
| LLPS-Asm-0141 | Astyanax mexicanus | 50.1 | 4e-144 | 435 |
| LLPS-Scf-0067 | Scleropages formosus | 50.09 | 2e-151 | 454 |
| LLPS-Orl-0192 | Oryzias latipes | 49.9 | 1e-138 | 422 |
| LLPS-Xet-0269 | Xenopus tropicalis | 49.72 | 7e-137 | 417 |
| LLPS-Lac-2571 | Latimeria chalumnae | 49.39 | 1e-71 | 239 |
| LLPS-Pof-2492 | Poecilia formosa | 49.25 | 8e-144 | 435 |
| LLPS-Scm-1065 | Scophthalmus maximus | 49.21 | 3e-145 | 439 |
| LLPS-Sem-0744 | Selaginella moellendorffii | 49.16 | 6e-97 | 309 |
| LLPS-Arl-1470 | Arabidopsis lyrata | 49.04 | 1e-86 | 287 |
| LLPS-Dar-1937 | Danio rerio | 48.98 | 3e-144 | 436 |
| LLPS-Xim-0010 | Xiphophorus maculatus | 48.85 | 7e-145 | 437 |
| LLPS-Gaa-1269 | Gasterosteus aculeatus | 48.82 | 7e-143 | 432 |
| LLPS-Brr-2490 | Brassica rapa | 48.62 | 4e-86 | 286 |
| LLPS-Leo-0023 | Lepisosteus oculatus | 48.17 | 2e-147 | 445 |
| LLPS-Tar-1141 | Takifugu rubripes | 48.1 | 1e-139 | 424 |
| LLPS-Dac-0453 | Daucus carota | 47.84 | 4e-87 | 288 |
| LLPS-Orp-0386 | Oryza punctata | 47.79 | 2e-92 | 302 |
| LLPS-Icp-1834 | Ictalurus punctatus | 47.74 | 5e-138 | 420 |
| LLPS-Ten-1322 | Tetraodon nigroviridis | 47.42 | 8e-135 | 412 |
| LLPS-Orbr-0445 | Oryza brachyantha | 46.72 | 2e-92 | 302 |
| LLPS-Sob-0523 | Sorghum bicolor | 46.45 | 2e-92 | 302 |
| LLPS-Mua-0170 | Musa acuminata | 46.07 | 1e-89 | 295 |
| LLPS-Orni-0701 | Oryza nivara | 45.9 | 2e-92 | 302 |
| LLPS-Ori-0306 | Oryza indica | 45.9 | 2e-92 | 302 |
| LLPS-Orb-0405 | Oryza barthii | 45.9 | 5e-91 | 302 |
| LLPS-Org-0176 | Oryza glaberrima | 45.9 | 1e-92 | 303 |
| LLPS-Orr-1753 | Oryza rufipogon | 45.9 | 4e-91 | 303 |
| LLPS-Orm-0161 | Oryza meridionalis | 45.9 | 2e-92 | 302 |
| LLPS-Ors-0462 | Oryza sativa | 45.9 | 1e-92 | 303 |
| LLPS-Thc-1127 | Theobroma cacao | 45.88 | 1e-88 | 292 |
| LLPS-Brd-0298 | Brachypodium distachyon | 45.76 | 2e-92 | 302 |
| LLPS-Sot-1064 | Solanum tuberosum | 45.36 | 6e-89 | 292 |
| LLPS-Amt-0971 | Amborella trichopoda | 45.34 | 1e-91 | 301 |
| LLPS-Nia-1174 | Nicotiana attenuata | 45.27 | 1e-89 | 295 |
| LLPS-Brn-0657 | Brassica napus | 45.1 | 2e-88 | 291 |
| LLPS-Chc-0107 | Chondrus crispus | 45.04 | 1e-94 | 306 |
| LLPS-Coc-0179 | Corchorus capsularis | 44.99 | 2e-89 | 294 |
| LLPS-Orgl-0147 | Oryza glumaepatula | 44.96 | 5e-92 | 305 |
| LLPS-Gor-1262 | Gossypium raimondii | 44.85 | 7e-88 | 290 |
| LLPS-Cus-1998 | Cucumis sativus | 44.5 | 6e-90 | 295 |
| LLPS-Usm-0922 | Ustilago maydis | 44.3 | 4e-71 | 249 |
| LLPS-Chr-0499 | Chlamydomonas reinhardtii | 44.28 | 4e-79 | 269 |
| LLPS-Viv-0112 | Vitis vinifera | 43.88 | 6e-92 | 301 |
| LLPS-Art-0362 | Arabidopsis thaliana | 43.86 | 1e-88 | 292 |
| LLPS-Prp-0140 | Prunus persica | 43.77 | 3e-88 | 291 |
| LLPS-Pot-0580 | Populus trichocarpa | 43.73 | 5e-87 | 288 |
| LLPS-Spr-0294 | Sporisorium reilianum | 43.04 | 2e-68 | 242 |
| LLPS-Crn-0158 | Cryptococcus neoformans | 42.86 | 2e-66 | 234 |
| LLPS-Cae-0008 | Caenorhabditis elegans | 42.59 | 4e-94 | 306 |
| LLPS-Via-0876 | Vigna angularis | 41.88 | 8e-83 | 277 |
| LLPS-Phv-0577 | Phaseolus vulgaris | 41.73 | 9e-86 | 285 |
| LLPS-Glm-0203 | Glycine max | 41.36 | 1e-83 | 279 |
| LLPS-Drm-0469 | Drosophila melanogaster | 41.26 | 4e-86 | 285 |
| LLPS-Pes-0574 | Pelodiscus sinensis | 41.18 | 4e-93 | 303 |
| LLPS-Mel-0795 | Melampsora laricipopulina | 41.12 | 5e-63 | 221 |
| LLPS-Miv-1054 | Microbotryum violaceum | 41.02 | 7e-64 | 228 |
| LLPS-Anp-1440 | Anas platyrhynchos | 40.86 | 9e-83 | 275 |
| LLPS-Gaga-0548 | Gallus gallus | 40.71 | 3e-85 | 282 |
| LLPS-Pug-0055 | Puccinia graminis | 40.62 | 2e-62 | 221 |
| LLPS-Fia-0753 | Ficedula albicollis | 40.53 | 9e-82 | 273 |
| LLPS-Put-0547 | Puccinia triticina | 40.31 | 1e-62 | 221 |
| LLPS-Tag-0236 | Taeniopygia guttata | 40.29 | 4e-81 | 271 |
| LLPS-Met-0737 | Medicago truncatula | 40.1 | 2e-76 | 259 |
| LLPS-Orn-0692 | Oreochromis niloticus | 40.05 | 3e-76 | 258 |
| LLPS-Osl-1029 | Ostreococcus lucimarinus | 39.2 | 6e-80 | 269 |
| LLPS-Vir-0325 | Vigna radiata | 38.8 | 9e-69 | 238 |
| LLPS-Sah-0362 | Sarcophilus harrisii | 38.24 | 5e-76 | 258 |
| LLPS-Ere-0448 | Erinaceus europaeus | 38.11 | 1e-71 | 246 |
| LLPS-Asn-0657 | Aspergillus nidulans | 37.26 | 2e-48 | 182 |
| LLPS-Scj-1251 | Schizosaccharomyces japonicus | 36.56 | 8e-52 | 191 |
| LLPS-Gas-0629 | Galdieria sulphuraria | 36.49 | 1e-49 | 183 |
| LLPS-Kop-1419 | Komagataella pastoris | 36.17 | 2e-51 | 190 |
| LLPS-Asc-0708 | Aspergillus clavatus | 36.08 | 4e-48 | 181 |
| LLPS-Abg-1947 | Absidia glauca | 36.04 | 2e-48 | 184 |
| LLPS-Phn-0558 | Phaeosphaeria nodorum | 35.54 | 2e-47 | 179 |
| LLPS-Zyt-0139 | Zymoseptoria tritici | 35.21 | 4e-47 | 179 |
| LLPS-Asni-0685 | Aspergillus niger | 35.16 | 1e-48 | 182 |
| LLPS-Hov-1604 | Hordeum vulgare | 34.75 | 3e-47 | 179 |
| LLPS-Trr-1371 | Trichoderma reesei | 34.49 | 2e-47 | 180 |
| LLPS-Yal-0593 | Yarrowia lipolytica | 34.29 | 7e-50 | 185 |
| LLPS-Pytr-0068 | Pyrenophora triticirepentis | 34.29 | 5e-48 | 181 |
| LLPS-Pyt-0560 | Pyrenophora teres | 33.97 | 3e-47 | 179 |
| LLPS-Scc-0315 | Schizosaccharomyces cryophilus | 33.7 | 2e-56 | 204 |
| LLPS-Scp-1435 | Schizosaccharomyces pombe | 33.13 | 2e-53 | 196 |
| LLPS-Asg-0638 | Ashbya gossypii | 31.98 | 2e-49 | 184 |
| LLPS-Sac-0032 | Saccharomyces cerevisiae | 31.59 | 1e-49 | 184 |