DrLLPS - Data resource of LLPS

LLPS-Mum-1777
Rpl21

▼ OVERVIEW


Status:	Reviewed
Protein Name:	60S ribosomal protein L21
Gene Name:	Rpl21
Ensembl Gene:	ENSMUSG00000041453.12
Ensembl Protein:	ENSMUSP00000106213.1
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Mouse cortex	23071613

▼ FUNCTION

Component of the large ribosomal subunit.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000075453.8	ENSMUSP00000106213.1
Ensembl	ENSMUST00000099272.2	ENSMUSP00000106211.1
Ensembl	ENSMUST00000035983.11	ENSMUSP00000041652.5
UniProt		O09167, RL21_MOUSE
GeneBank	U93863	AAB52255.1
Entrez	19933

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK 60 61 TGRVYNVTQH AVGIIVNKQV KGKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK 120 121 EKGTWVQLKR QPAPPREAHF VRTNGKEPEL LEPIPYEFMA 160
Nucleotide CDS Sequence (FASTA)
1 ATGACGAACA CAAAGGGAAA GAGGAGAGGC ACCCGGTACA TGTTCTCTAG GCCTTTTAGG 60 61 AAACATGGCG TTGTTCCTTT GGCCACATAC ATGCGAATCT ACAAGAAGGG TGATATTGTA 120 121 GACATCAAGG GAATGGGCAC TGTTCAAAAA GGAATGCCCC ATAAGTGCTA CCACGGCAAA 180 181 ACCGGAAGAG TCTACAATGT CACCCAGCAT GCCGTGGGCA TCATTGTCAA CAAGCAGGTT 240 241 AAGGGCAAAA TTCTGGCCAA GAGGATCAAT GTGCGGATTG AGCACATCAA GCACTCAAAG 300 301 AGCAGAGACA GCTTCCTGAA GCGGGTGAAG GAGAATGACC AGAAGAAAAA GGAAGCCAAA 360 361 GAGAAGGGCA CCTGGGTGCA GCTGAAGCGC CAGCCTGCGC CACCCAGAGA AGCACACTTT 420 421 GTGAGGACTA ATGGAAAAGA GCCTGAGCTG TTGGAGCCCA TTCCATACGA ATTCATGGCC 480 481 TAA 483

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0256	Endoplasmic reticulum
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0689	Ribosomal protein

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0022625	Cellular Component	Cytosolic large ribosomal subunit
GO:0005783	Cellular Component	Endoplasmic reticulum
GO:0005840	Cellular Component	Ribosome
GO:0003735	Molecular Function	Structural constituent of ribosome
GO:0006412	Biological Process	Translation

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	BioGRID
mUbiSiDa	PTMcode

Mutation
CGAP

Interaction
HINT	RISE	RAIN	Mentha	IID
iRefIndex	MIST	RNAct

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CORUM	CellMarker	RaftProt

Localization
COMPARTMENTS

Expression
ArrayExpress	GXD	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-2879	Rattus norvegicus	100.0	8e-115	329
LLPS-Myl-1137	Myotis lucifugus	100.0	8e-115	329
LLPS-Mea-3578	Mesocricetus auratus	100.0	8e-115	329
LLPS-Paa-4069	Papio anubis	99.38	1e-114	328
LLPS-Mal-3589	Mandrillus leucophaeus	99.38	1e-114	328
LLPS-Mup-3957	Mustela putorius furo	99.38	1e-114	328
LLPS-Dio-3944	Dipodomys ordii	99.38	1e-114	328
LLPS-Bot-2134	Bos taurus	99.38	2e-114	328
LLPS-Gog-2884	Gorilla gorilla	99.38	1e-114	328
LLPS-Fud-2110	Fukomys damarensis	99.38	1e-114	328
LLPS-Maf-0372	Macaca fascicularis	99.38	1e-114	328
LLPS-Chs-3480	Chlorocebus sabaeus	99.38	1e-114	328
LLPS-Aon-2473	Aotus nancymaae	99.38	1e-114	328
LLPS-Cea-3692	Cercocebus atys	99.38	1e-114	328
LLPS-Sus-0790	Sus scrofa	99.38	1e-114	328
LLPS-Cas-3554	Carlito syrichta	99.38	1e-114	328
LLPS-Nol-2200	Nomascus leucogenys	99.38	1e-114	328
LLPS-Poa-0975	Pongo abelii	99.38	1e-114	328
LLPS-Eqc-2546	Equus caballus	99.38	1e-114	328
LLPS-Cap-1899	Cavia porcellus	99.38	1e-114	328
LLPS-Mam-1212	Macaca mulatta	99.38	1e-114	328
LLPS-Orc-2052	Oryctolagus cuniculus	99.38	1e-114	328
LLPS-Rhb-3415	Rhinopithecus bieti	99.38	1e-114	328
LLPS-Pat-1227	Pan troglodytes	99.38	1e-114	328
LLPS-Pap-3066	Pan paniscus	99.38	1e-114	328
LLPS-Hos-1873	Homo sapiens	99.38	1e-114	328
LLPS-Fec-2006	Felis catus	99.38	1e-114	328
LLPS-Man-2489	Macaca nemestrina	99.38	1e-114	328
LLPS-Ova-2882	Ovis aries	98.76	1e-112	324
LLPS-Caf-2289	Canis familiaris	98.75	2e-113	326
LLPS-Otg-2045	Otolemur garnettii	98.75	7e-114	327
LLPS-Urm-3755	Ursus maritimus	98.75	8e-114	327
LLPS-Mod-0384	Monodelphis domestica	98.75	3e-114	328
LLPS-Loa-3514	Loxodonta africana	98.75	1e-113	326
LLPS-Caj-3551	Callithrix jacchus	98.12	1e-113	326
LLPS-Sah-0303	Sarcophilus harrisii	97.52	5e-112	322
LLPS-Ora-1369	Ornithorhynchus anatinus	97.5	4e-112	322
LLPS-Tag-2027	Taeniopygia guttata	96.88	4e-102	297
LLPS-Fia-0858	Ficedula albicollis	96.88	4e-102	297
LLPS-Aim-0362	Ailuropoda melanoleuca	96.25	1e-108	314
LLPS-Pes-0427	Pelodiscus sinensis	95.62	2e-101	295
LLPS-Meg-0530	Meleagris gallopavo	95.62	4e-101	295
LLPS-Gaga-0382	Gallus gallus	95.0	1e-100	293
LLPS-Anp-1767	Anas platyrhynchos	95.0	5e-101	294
LLPS-Anc-1266	Anolis carolinensis	94.38	6e-99	289
LLPS-Lac-2088	Latimeria chalumnae	91.25	1e-104	303
LLPS-Tar-1199	Takifugu rubripes	89.38	5e-103	299
LLPS-Xet-0981	Xenopus tropicalis	89.38	2e-95	280
LLPS-Ten-0584	Tetraodon nigroviridis	89.38	5e-103	299
LLPS-Pof-1675	Poecilia formosa	89.38	1e-103	301
LLPS-Xim-0249	Xiphophorus maculatus	88.75	4e-103	300
LLPS-Orn-0558	Oreochromis niloticus	88.75	5e-103	299
LLPS-Orl-1216	Oryzias latipes	88.12	5e-102	297
LLPS-Scm-1584	Scophthalmus maximus	87.97	2e-83	252
LLPS-Leo-0427	Lepisosteus oculatus	86.88	7e-101	294
LLPS-Gaa-1657	Gasterosteus aculeatus	86.25	2e-100	293
LLPS-Scf-2228	Scleropages formosus	86.25	2e-99	290
LLPS-Asm-2266	Astyanax mexicanus	85.62	1e-99	291
LLPS-Dar-1938	Danio rerio	85.62	2e-92	272
LLPS-Ict-1743	Ictidomys tridecemlineatus	83.65	1e-87	259
LLPS-Icp-3445	Ictalurus punctatus	83.12	1e-97	285
LLPS-Drm-0859	Drosophila melanogaster	73.12	2e-81	244
LLPS-Cii-1211	Ciona intestinalis	71.88	1e-79	239
LLPS-Cis-0314	Ciona savignyi	71.88	5e-79	238
LLPS-Cae-0699	Caenorhabditis elegans	63.98	5e-65	202
LLPS-Fuv-1158	Fusarium verticillioides	61.78	4e-63	198
LLPS-Fuo-0038	Fusarium oxysporum	61.78	4e-63	198
LLPS-Sac-1583	Saccharomyces cerevisiae	60.51	6e-64	200
LLPS-Tum-0456	Tuber melanosporum	60.45	1e-50	165
LLPS-Ors-0587	Oryza sativa	60.0	6e-26	100
LLPS-Map-0923	Magnaporthe poae	59.87	3e-59	188
LLPS-Fus-1006	Fusarium solani	59.87	8e-60	189
LLPS-Beb-0448	Beauveria bassiana	59.87	6e-60	189
LLPS-Scp-1358	Schizosaccharomyces pombe	59.24	9e-61	192
LLPS-Asn-0049	Aspergillus nidulans	59.24	3e-59	188
LLPS-Cog-0278	Colletotrichum gloeosporioides	59.24	1e-57	184
LLPS-Asni-0092	Aspergillus niger	58.6	1e-59	189
LLPS-Coo-1125	Colletotrichum orbiculare	58.6	4e-58	185
LLPS-Asg-0201	Ashbya gossypii	58.6	2e-55	178
LLPS-Gag-1515	Gaeumannomyces graminis	58.6	7e-57	182
LLPS-Scc-0336	Schizosaccharomyces cryophilus	58.6	1e-59	189
LLPS-Nec-1070	Neurospora crassa	57.96	2e-56	181
LLPS-Asfu-0393	Aspergillus fumigatus	57.96	2e-58	186
LLPS-Cogr-0164	Colletotrichum graminicola	57.96	2e-57	183
LLPS-Trv-1199	Trichoderma virens	57.96	8e-51	166
LLPS-Nef-1086	Neosartorya fischeri	57.96	2e-58	186
LLPS-Dos-1475	Dothistroma septosporum	57.46	9e-49	160
LLPS-Asf-0109	Aspergillus flavus	57.32	7e-60	189
LLPS-Aso-0586	Aspergillus oryzae	57.32	7e-60	189
LLPS-Mao-1314	Magnaporthe oryzae	57.32	3e-57	183
LLPS-Scs-0037	Sclerotinia sclerotiorum	57.32	9e-58	184
LLPS-Ved-1002	Verticillium dahliae	57.32	3e-58	185
LLPS-Trr-0562	Trichoderma reesei	57.32	8e-51	166
LLPS-Pug-0541	Puccinia graminis	57.32	2e-49	162
LLPS-Zyt-1205	Zymoseptoria tritici	56.69	2e-57	183
LLPS-Pyt-0790	Pyrenophora teres	56.69	4e-57	182
LLPS-Asc-0399	Aspergillus clavatus	56.69	5e-58	185
LLPS-Pytr-0200	Pyrenophora triticirepentis	56.69	4e-57	182
LLPS-Ast-0190	Aspergillus terreus	56.69	1e-57	184
LLPS-Blg-0387	Blumeria graminis	56.05	1e-55	179
LLPS-Abg-1476	Absidia glauca	55.97	3e-57	183
LLPS-Yal-1380	Yarrowia lipolytica	55.7	3e-56	180
LLPS-Scj-0759	Schizosaccharomyces japonicus	55.41	8e-56	179
LLPS-Mel-1331	Melampsora laricipopulina	55.41	4e-54	175
LLPS-Crn-0953	Cryptococcus neoformans	55.41	8e-46	153
LLPS-Phn-0178	Phaeosphaeria nodorum	54.78	2e-53	173
LLPS-Usm-0161	Ustilago maydis	54.78	1e-53	173
LLPS-Php-0675	Physcomitrella patens	54.72	7e-50	164
LLPS-Nia-2086	Nicotiana attenuata	54.55	2e-49	162
LLPS-Spr-0833	Sporisorium reilianum	54.14	5e-53	172
LLPS-Put-1295	Puccinia triticina	54.14	3e-42	144
LLPS-Miv-0316	Microbotryum violaceum	54.14	8e-47	156
LLPS-Sol-2281	Solanum lycopersicum	53.9	4e-48	160
LLPS-Chr-0787	Chlamydomonas reinhardtii	52.67	7e-35	127
LLPS-Sot-1256	Solanum tuberosum	52.2	6e-48	159
LLPS-Glm-0421	Glycine max	51.95	2e-44	150
LLPS-Mae-1053	Manihot esculenta	51.95	5e-47	157
LLPS-Kop-1132	Komagataella pastoris	51.9	3e-51	168
LLPS-Met-0691	Medicago truncatula	51.57	1e-45	153
LLPS-Thc-1021	Theobroma cacao	51.57	3e-47	157
LLPS-Mua-0238	Musa acuminata	51.57	3e-49	162
LLPS-Gor-0896	Gossypium raimondii	51.57	9e-48	159
LLPS-Vir-1374	Vigna radiata	51.3	4e-44	149
LLPS-Hea-0178	Helianthus annuus	51.3	4e-45	152
LLPS-Phv-0734	Phaseolus vulgaris	51.3	3e-44	149
LLPS-Lem-1202	Leptosphaeria maculans	50.96	6e-48	158
LLPS-Coc-0527	Corchorus capsularis	50.94	3e-46	157
LLPS-Pot-0899	Populus trichocarpa	50.94	9e-49	161
LLPS-Via-1569	Vigna angularis	50.31	2e-44	150
LLPS-Zem-2336	Zea mays	50.31	1e-47	158
LLPS-Hov-0052	Hordeum vulgare	50.0	1e-45	154
LLPS-Cus-0373	Cucumis sativus	49.69	8e-45	151
LLPS-Sei-1097	Setaria italica	49.69	1e-46	160
LLPS-Brd-0586	Brachypodium distachyon	49.69	8e-46	154
LLPS-Tra-0690	Triticum aestivum	49.69	7e-47	156
LLPS-Tru-1715	Triticum urartu	49.69	7e-47	156
LLPS-Sob-1100	Sorghum bicolor	49.69	4e-47	157
LLPS-Dac-0119	Daucus carota	49.35	4e-42	144
LLPS-Gas-0449	Galdieria sulphuraria	49.07	2e-44	150
LLPS-Arl-0171	Arabidopsis lyrata	49.06	6e-46	154
LLPS-Prp-2319	Prunus persica	49.06	7e-45	151
LLPS-Orbr-1021	Oryza brachyantha	49.06	2e-45	152
LLPS-Amt-0342	Amborella trichopoda	49.06	5e-44	149
LLPS-Viv-1947	Vitis vinifera	49.06	1e-45	153
LLPS-Orp-2213	Oryza punctata	49.06	6e-45	151
LLPS-Brn-1025	Brassica napus	48.7	2e-45	153
LLPS-Bro-1451	Brassica oleracea	48.7	2e-45	153
LLPS-Brr-2532	Brassica rapa	48.7	2e-45	152
LLPS-Orgl-0061	Oryza glumaepatula	48.43	2e-44	150
LLPS-Lep-0183	Leersia perrieri	48.43	7e-45	151
LLPS-Orni-1119	Oryza nivara	48.43	8e-45	151
LLPS-Orb-0279	Oryza barthii	48.43	8e-45	151
LLPS-Ori-1635	Oryza indica	48.43	8e-45	151
LLPS-Org-0850	Oryza glaberrima	48.43	8e-45	151
LLPS-Orr-0624	Oryza rufipogon	48.43	8e-45	151
LLPS-Orm-1562	Oryza meridionalis	48.43	8e-45	151
LLPS-Art-2107	Arabidopsis thaliana	47.8	2e-45	152
LLPS-Sem-1830	Selaginella moellendorffii	47.17	7e-43	146
LLPS-Osl-0238	Ostreococcus lucimarinus	45.51	4e-38	134
LLPS-Chc-0258	Chondrus crispus	44.72	5e-41	141
LLPS-Cym-0314	Cyanidioschyzon merolae	42.59	5e-35	126

LLPS-Mum-1777Rpl21

Protein Sequence

Nucleotide Sequence

LLPS-Mum-1777
Rpl21