LLPS-Mum-1333
Bicd1

▼ OVERVIEW

Status: Reviewed
Protein Name: Protein bicaudal D homolog 1
Gene Name: Bicd1
Ensembl Gene: ENSMUSG00000003452.15
Ensembl Protein: ENSMUSP00000107138.2
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator
PDB: 4YTD (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Here, we show that impairment of retrograde transport by knockdown of mammalian dynein heavy chain 1 or bicaudal D1 inhibits SG formation and PB growth upon stress, without affecting protein-synthesis blockage. Conversely, impairment of anterograde transport by knockdown of kinesin-1 heavy chain or kinesin light chain 1 delayed SG dissolution."
NIH3T3 cells20169188
Stress granule
"...Here, we show that impairment of retrograde transport by knockdown of mammalian dynein heavy chain 1 or bicaudal D1 inhibits SG formation and PB growth upon stress, without affecting protein-synthesis blockage. Conversely, impairment of anterograde transport by knockdown of kinesin-1 heavy chain or kinesin light chain 1 delayed SG dissolution."
NIH3T3 cells20169188

▼ FUNCTION

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAEEALKTV  DQYKTEIERL  TKELTETTHE  KIQAAEYGLV  VLEEKLTLKQ  QYDELEAEYD  60
61    GLKQELEQLR  EAFGQSFSIH  RKVAEDGETR  EETLLQESAS  KEAYYLNKIL  EMQNELKQSR  120
121   AVVTNVQAEN  ERLSAVVQEL  KENNEMVELQ  RIRMKDEIRE  YKFREARLLQ  DYTELEEENI  180
181   TLQKLVSTLK  QNQVEYEGLK  HEIKRFEEET  VLLNSQLEDA  IRLKEIAEHQ  LEEALETLKN  240
241   EREQKNNLRK  ELSQYINLSD  SHISISVDGL  KFAEDGSEPN  NDDKMNGHIH  GPLGKLNGDY  300
301   RTPTTRKGES  LHPVSDLFSE  LNISEIQKLK  QQLIQVEREK  AILLANLQES  QTQLEHTKGA  360
361   LTEQHERVHR  LTEHVNAMRG  LQNSKEIKAE  LDCEKGRNSA  EEAHDYEVDI  NGLEILECKY  420
421   RVAVTEVIDL  KAEIKALKEK  YNKSVENYTE  EKTKYESKIQ  MYDEQVTNLE  KTSKESGEKM  480
481   AHMEKELQKM  TGIANENHNT  LNTAQDELVT  FSEELAQLYH  HVCLCNNETP  NRVMLDYYRQ  540
541   SRVTRSGSLK  GPDDPRGLLS  PRLSRRGVSS  PVESRTSSEP  VSKENTETSK  EPSPTKTPTI  600
601   SPVITAPPSS  PVLDTSDIRK  EPMNIYNLNA  IIRDQIKHLQ  KAVDRSLQLS  RQRAAARELA  660
661   PMIDKDKEAL  MEEILKLKSL  LSTKREQIAT  LRAVLKANKQ  TAEVALANLK  NKYENEKAMV  720
721   TETMTKLRNE  LKALKEDAAT  FSSLRAMFAT  RCDEYVTQLD  EMQRQLAAAE  DEKKTLNTLL  780
781   RMAIQQKLAL  TQRLEDLEFD  HEQSRRSKGK  LGKSKIGSPK  VSGEAPDTVP  TIDTYLLHSQ  840
841   GPQIPTIRVS  SGTQRKRQFS  PSLCDQSRPR  TSGASYLQNL  LRVPPDPTST  ESFLLKGSPS  900
901   MSELIQGHRL  SKEKRLTVAP  PDCQQPAASV  PPQCSQLAGR  QDYPTVSPDI  ALSKEQPHSS  960
961   SQCAPLHCLT  KPPYP  975
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGCAG  AGGAGGCGCT  GAAGACGGTA  GACCAATATA  AGACTGAAAT  AGAGAGACTG  60
61    ACCAAGGAGC  TCACAGAAAC  GACCCATGAG  AAGATCCAGG  CTGCAGAGTA  TGGGCTGGTG  120
121   GTGCTGGAGG  AGAAACTGAC  TCTCAAGCAA  CAGTATGACG  AGCTGGAGGC  CGAGTATGAC  180
181   GGCCTCAAAC  AAGAGCTGGA  GCAGCTCAGA  GAGGCATTTG  GGCAGTCCTT  CTCTATCCAC  240
241   CGTAAAGTAG  CTGAGGATGG  AGAGACTCGG  GAGGAAACAC  TTCTTCAGGA  GTCTGCATCC  300
301   AAAGAAGCTT  ACTATCTAAA  CAAGATCTTG  GAGATGCAGA  ATGAGCTGAA  GCAGAGCCGG  360
361   GCTGTGGTTA  CAAATGTCCA  GGCAGAAAAT  GAGAGGCTCT  CGGCCGTTGT  ACAGGAACTG  420
421   AAAGAGAACA  ACGAGATGGT  GGAGCTACAG  AGAATACGAA  TGAAAGATGA  AATCCGAGAA  480
481   TATAAATTCC  GGGAGGCCCG  ACTCCTTCAG  GACTACACAG  AATTGGAAGA  AGAAAATATC  540
541   ACATTGCAGA  AACTAGTGTC  CACATTGAAG  CAGAACCAGG  TTGAATACGA  AGGCTTAAAG  600
601   CATGAAATTA  AGCGATTTGA  AGAAGAAACA  GTATTACTGA  ATAGCCAACT  AGAAGATGCC  660
661   ATTCGACTGA  AAGAGATTGC  AGAGCATCAG  TTGGAAGAAG  CCCTTGAGAC  ACTGAAGAAT  720
721   GAAAGAGAGC  AAAAGAACAA  CCTGAGGAAG  GAGCTGTCCC  AGTACATCAA  CCTCAGTGAT  780
781   AGCCACATCA  GCATCTCAGT  AGATGGGCTC  AAGTTTGCTG  AGGATGGAAG  TGAGCCAAAT  840
841   AACGATGACA  AGATGAATGG  ACATATCCAT  GGGCCTCTTG  GGAAACTGAA  TGGAGACTAT  900
901   CGTACTCCCA  CTACCAGGAA  AGGAGAGTCC  CTACACCCTG  TGTCTGACTT  ATTCAGTGAG  960
961   TTGAACATTT  CAGAAATACA  GAAATTGAAG  CAGCAGCTTA  TTCAGGTAGA  GAGGGAAAAA  1020
1021  GCTATTCTTC  TGGCCAACCT  CCAGGAGTCA  CAAACCCAGC  TAGAACATAC  CAAGGGGGCA  1080
1081  CTGACAGAGC  AGCATGAGCG  AGTGCACCGG  CTCACAGAGC  ATGTCAATGC  TATGAGGGGC  1140
1141  TTGCAAAACA  GCAAAGAGAT  CAAGGCTGAG  CTAGATTGTG  AGAAGGGCCG  GAACTCAGCG  1200
1201  GAGGAAGCTC  ATGACTATGA  GGTGGACATC  AATGGCTTAG  AGATCCTTGA  GTGCAAATAT  1260
1261  AGAGTGGCCG  TCACAGAAGT  CATTGATTTG  AAAGCAGAAA  TTAAGGCCTT  AAAGGAAAAA  1320
1321  TATAATAAAT  CTGTAGAAAA  TTATACAGAA  GAAAAGACCA  AATATGAGAG  TAAGATCCAA  1380
1381  ATGTATGATG  AACAAGTGAC  AAACCTTGAG  AAGACATCTA  AGGAGAGTGG  TGAGAAGATG  1440
1441  GCCCACATGG  AGAAGGAGTT  GCAAAAGATG  ACTGGCATAG  CCAACGAAAA  TCACAACACC  1500
1501  CTCAATACAG  CCCAGGATGA  GTTGGTGACA  TTTAGTGAGG  AACTAGCCCA  GCTTTACCAC  1560
1561  CATGTGTGTC  TATGTAATAA  TGAAACTCCC  AATAGAGTCA  TGTTGGACTA  CTATAGACAA  1620
1621  AGCAGAGTTA  CTCGAAGTGG  CAGCCTCAAG  GGGCCTGATG  ATCCCAGAGG  GCTTTTGTCG  1680
1681  CCAAGATTAT  CCAGGAGGGG  TGTGTCATCC  CCTGTAGAAT  CAAGGACATC  ATCTGAACCA  1740
1741  GTTTCAAAGG  AAAATACAGA  GACTAGTAAA  GAGCCAAGTC  CAACTAAGAC  TCCCACAATC  1800
1801  TCTCCTGTTA  TTACTGCCCC  ACCATCATCT  CCAGTTTTGG  ATACCAGTGA  TATTCGCAAA  1860
1861  GAGCCAATGA  ATATCTACAA  CCTCAATGCC  ATAATCCGGG  ACCAAATCAA  GCATCTGCAG  1920
1921  AAGGCAGTGG  ACAGGTCCTT  ACAGCTGTCT  CGTCAAAGAG  CAGCAGCCCG  AGAGTTGGCC  1980
1981  CCCATGATTG  ATAAGGACAA  GGAAGCCTTA  ATGGAAGAGA  TTCTCAAACT  GAAGTCCTTG  2040
2041  CTGAGCACCA  AACGGGAGCA  GATTGCGACA  CTGAGGGCAG  TGTTGAAAGC  CAATAAGCAG  2100
2101  ACAGCTGAAG  TGGCTTTAGC  TAACCTGAAG  AACAAATATG  AAAATGAAAA  GGCAATGGTT  2160
2161  ACTGAAACAA  TGACAAAACT  GAGGAATGAA  CTAAAGGCTT  TGAAGGAAGA  TGCTGCAACC  2220
2221  TTCTCATCCC  TGAGAGCAAT  GTTTGCAACA  AGATGCGATG  AATATGTCAC  ACAGTTGGAT  2280
2281  GAGATGCAGA  GACAGTTAGC  AGCTGCAGAA  GATGAGAAGA  AGACTCTAAA  CACTTTATTG  2340
2341  CGAATGGCTA  TCCAGCAAAA  ACTCGCCCTG  ACACAGAGGC  TGGAGGACTT  AGAGTTTGAC  2400
2401  CATGAGCAGT  CCCGACGCAG  CAAAGGCAAA  CTTGGAAAGA  GCAAGATCGG  CAGCCCTAAA  2460
2461  GTAAGTGGGG  AGGCGCCAGA  CACCGTGCCT  ACCATAGACA  CTTACCTCCT  GCATAGTCAG  2520
2521  GGCCCACAGA  TCCCTACCAT  TCGGGTCAGC  AGTGGCACTC  AGAGGAAAAG  ACAATTTTCA  2580
2581  CCTTCCCTTT  GTGATCAGAG  TCGTCCCAGG  ACTTCAGGGG  CTTCCTACCT  ACAGAATTTA  2640
2641  TTAAGAGTTC  CCCCTGATCC  CACCTCCACA  GAATCATTTC  TTCTGAAGGG  TTCCCCTTCC  2700
2701  ATGAGTGAAC  TCATCCAAGG  GCATCGGCTC  AGCAAGGAAA  AAAGGTTAAC  CGTGGCTCCA  2760
2761  CCAGATTGTC  AGCAGCCTGC  TGCCTCCGTA  CCGCCACAGT  GCTCACAACT  AGCTGGGAGG  2820
2821  CAAGACTACC  CAACGGTCAG  TCCGGACATT  GCCCTCAGTA  AGGAACAGCC  ACATTCCAGC  2880
2881  TCACAGTGTG  CACCTCTTCA  TTGTCTCACC  AAGCCTCCTT  ACCCCTAG  2928

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Golgi apparatus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytoplasmic microtubule
Cellular Component
Cytoplasmic vesicle
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Host cell viral assembly compartment
Cellular Component
Membrane
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Trans-Golgi network
Molecular Function
Cytoskeletal adaptor activity
Molecular Function
Dynactin binding
Molecular Function
Dynein complex binding
Molecular Function
Dynein intermediate chain binding
Molecular Function
Protein kinase binding
Molecular Function
Proteinase activated receptor binding
Molecular Function
Rab GTPase binding
Biological Process
Microtubule anchoring at microtubule organizing center
Biological Process
Minus-end-directed organelle transport along microtubule
Biological Process
Negative regulation of phospholipase C activity
Biological Process
Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process
Positive regulation of protein localization to centrosome
Biological Process
Positive regulation of receptor-mediated endocytosis
Biological Process
Protein localization to organelle
Biological Process
Regulation of microtubule cytoskeleton organization
Biological Process
Regulation of proteinase activated receptor activity
Biological Process
Stress granule assembly
Biological Process
Viral process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0245Rattus norvegicus98.880.01469
LLPS-Eqc-0070Equus caballus96.40.01427
LLPS-Urm-1834Ursus maritimus96.40.01428
LLPS-Chs-4112Chlorocebus sabaeus96.280.01431
LLPS-Sus-2330Sus scrofa96.030.01420
LLPS-Bot-3237Bos taurus95.780.01414
LLPS-Paa-4713Papio anubis95.690.01738
LLPS-Maf-1819Macaca fascicularis95.690.01738
LLPS-Cea-2478Cercocebus atys95.690.01738
LLPS-Caj-2014Callithrix jacchus95.690.01739
LLPS-Mam-4493Macaca mulatta95.690.01738
LLPS-Fec-0076Felis catus95.690.01736
LLPS-Man-3474Macaca nemestrina95.690.01738
LLPS-Rhb-4607Rhinopithecus bieti95.690.01738
LLPS-Cas-0904Carlito syrichta95.590.01738
LLPS-Hos-4406Homo sapiens95.590.01735
LLPS-Mal-3988Mandrillus leucophaeus95.490.01733
LLPS-Aon-2181Aotus nancymaae95.490.01738
LLPS-Pap-1214Pan paniscus95.490.01732
LLPS-Pat-3278Pan troglodytes95.490.01732
LLPS-Ova-0186Ovis aries95.440.01611
LLPS-Poa-3698Pongo abelii95.380.01730
LLPS-Caf-4650Canis familiaris95.360.01643
LLPS-Ict-3896Ictidomys tridecemlineatus95.280.01734
LLPS-Myl-4269Myotis lucifugus95.250.01640
LLPS-Aim-3946Ailuropoda melanoleuca95.080.01723
LLPS-Loa-1506Loxodonta africana94.970.01720
LLPS-Tut-1870Tursiops truncatus94.870.01713
LLPS-Otg-0507Otolemur garnettii94.70.01622
LLPS-Dio-2609Dipodomys ordii93.420.01405
LLPS-Cap-3639Cavia porcellus92.820.01680
LLPS-Mod-2754Monodelphis domestica92.540.01370
LLPS-Mea-2215Mesocricetus auratus91.810.01329
LLPS-Fud-3037Fukomys damarensis91.380.01652
LLPS-Anp-1506Anas platyrhynchos90.460.01545
LLPS-Meg-1083Meleagris gallopavo90.210.01511
LLPS-Mup-3977Mustela putorius furo90.160.01624
LLPS-Nol-4206Nomascus leucogenys89.850.01583
LLPS-Fia-1654Ficedula albicollis89.80.01622
LLPS-Gog-0819Gorilla gorilla89.740.01592
LLPS-Pes-3307Pelodiscus sinensis88.960.01526
LLPS-Anc-2917Anolis carolinensis88.950.01593
LLPS-Lac-4075Latimeria chalumnae85.570.01300
LLPS-Gaga-1965Gallus gallus84.730.01415
LLPS-Xet-2947Xenopus tropicalis82.280.01065
LLPS-Leo-0812Lepisosteus oculatus80.470.01213
LLPS-Ora-2163Ornithorhynchus anatinus80.050.0 643
LLPS-Asm-4132Astyanax mexicanus71.220.01050
LLPS-Dar-0761Danio rerio69.20.01008
LLPS-Tar-2273Takifugu rubripes69.190.0 978
LLPS-Scf-0088Scleropages formosus69.060.0 968
LLPS-Icp-2155Ictalurus punctatus68.230.0 978
LLPS-Xim-1311Xiphophorus maculatus67.580.0 956
LLPS-Scm-1663Scophthalmus maximus66.750.0 932
LLPS-Orn-3513Oreochromis niloticus66.470.01004
LLPS-Gaa-3974Gasterosteus aculeatus65.950.0 964
LLPS-Orl-3420Oryzias latipes65.560.0 974
LLPS-Pof-1773Poecilia formosa65.250.0 968
LLPS-Ten-3456Tetraodon nigroviridis64.210.0 914
LLPS-Cae-0557Caenorhabditis elegans60.478e-36 150