LLPS-Mum-1069
Toe1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Target of EGR1 protein 1 |
| Gene Name: | Toe1 |
| Ensembl Gene: | ENSMUSG00000028688.13 |
| Ensembl Protein: | ENSMUSP00000117019.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Cajal body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000145468.1 | ENSMUSP00000117019.1 |
| Ensembl | ENSMUST00000106455.7 | ENSMUSP00000102063.1 |
| Ensembl | ENSMUST00000030451.9 | ENSMUSP00000030451.3 |
| UniProt | Q9D2E2, TOE1_MOUSE, Q3UFD8, Q8R5A4, Q9D412 | |
| GeneBank | AK082975, AK148609, AK016889, BC023109, AK019829, AK046576 | BAB30482.1, BAB31871.1, BAC38718.1, BAE28623.1, BAC32792.1, AAH23109.1 |
| RefSeq | NM_026654.2 | NP_080930.1 |
| Entrez | 68276 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAADSDDDVP PVPTPSDGGV NKNTQPAEEF VVRVPVVDVQ SDNFKEIWPS LLLALKTASF 60 61 VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL GLACFRQQPD KGENSYLAQV 120 121 FNLTLLCIEE YVIEPKSVQF LVQHGFNFNR QYAQGIPYHK GNDKGDESQS QSVRTLFLEL 180 181 IRARRPLVLH NGLIDLVFLY QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV 240 241 ASYLEYAFRK CERENGKQRA AGSPHLALEF CSYPSSMSGH IDYRCCMSPG TCRRSRTTGI 300 301 CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRSL QSQPGTQTLA 360 361 EAEDGPPTKQ VCEDSLETEK MEQKVAEGEA GDQPGSREGH TSSLEMAHRR TSAETADVAT 420 421 SELLVNQAST NPVPGDGLHR AGFDAFMTGY VMAYVGLSQG LQLCSSEPWL PECHNKVYLS 480 481 GKTVPLTVTK SQFSRPSKAH NQKMKLAWGS S 511 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGCGG ACAGTGACGA TGATGTGCCT CCAGTTCCAA CGCCCTCTGA CGGTGGTGTC 60 61 AACAAAAACA CACAACCTGC AGAGGAGTTT GTGGTTCGGG TTCCTGTGGT AGACGTGCAG 120 121 AGTGACAACT TCAAGGAGAT ATGGCCATCA CTCTTGCTAG CCTTAAAGAC AGCTAGCTTT 180 181 GTGGCTGTGG ACACGGAGCT GAGTGGGCTC GGGGATAGGA AGAGTTTGCT GAACCAGTGC 240 241 ATTGAGGAAC GTTACAAGGC CGTGTGTCAT GCTGCCAGGA CCCGTTCTGT CCTGTCCCTG 300 301 GGCCTCGCCT GCTTCAGGCA GCAACCAGAT AAGGGTGAAA ATTCTTACTT GGCTCAAGTG 360 361 TTCAATCTCA CCCTGCTATG CATAGAGGAG TACGTTATAG AACCGAAGTC TGTGCAGTTC 420 421 CTGGTACAGC ATGGCTTCAA CTTCAACCGG CAGTACGCCC AGGGTATCCC CTACCATAAG 480 481 GGCAATGACA AGGGAGATGA GAGCCAGAGC CAGTCGGTAC GGACGCTGTT CCTTGAACTG 540 541 ATTCGGGCCC GACGGCCCCT GGTGCTACAT AATGGCCTTA TAGACTTGGT GTTCCTGTAC 600 601 CAGAATTTCT ACGCGCACCT GCCTGAGAAC TTGGGGACCT TCACTGCTGA CCTGTGTGAG 660 661 ATGTTCCCAG CAGGCATCTA TGACACCAAA TATGCCGCCG AGTTCCATGC CCGATTTGTA 720 721 GCTTCCTACT TAGAATACGC TTTCCGGAAA TGTGAGCGGG AGAATGGGAA GCAGCGGGCA 780 781 GCTGGCAGCC CACATCTTGC CCTGGAATTC TGCAGCTATC CATCTAGCAT GAGCGGGCAC 840 841 ATTGACTACC GCTGCTGTAT GTCCCCTGGG ACCTGCCGTC GTTCTCGTAC CACTGGCATC 900 901 TGTGACAAGT TCTCGGCCTA TGGCTGGTGT CCTCTGGGAC CACAGTGTCC TCAGTCACAC 960 961 GATATTGACC TTATAATTGA CACTGATGAG GCTGTGGCAG AAGATAAGCG GCGGAGACGG 1020 1021 CGACGTAAGG ACAAACGGAA GAGGTCTTTA CAGAGCCAAC CAGGGACACA GACCCTTGCG 1080 1081 GAAGCTGAAG ATGGTCCTCC CACAAAACAG GTCTGTGAAG ATAGCCTCGA GACTGAGAAA 1140 1141 ATGGAACAAA AAGTGGCAGA AGGTGAGGCT GGGGATCAGC CTGGCTCCAG GGAAGGTCAC 1200 1201 ACAAGTAGCT TGGAGATGGC ACATAGGAGG ACAAGTGCTG AAACAGCTGA TGTGGCCACC 1260 1261 TCAGAGCTGC TGGTGAACCA AGCCAGCACT AACCCCGTGC CTGGGGACGG ACTGCATCGT 1320 1321 GCTGGTTTTG ACGCCTTTAT GACAGGCTAT GTGATGGCCT ATGTGGGCCT GAGCCAGGGA 1380 1381 CTTCAACTCT GCAGCTCTGA ACCTTGGCTT CCTGAATGTC ACAACAAGGT ATATCTAAGT 1440 1441 GGCAAAACTG TACCCCTCAC AGTGACCAAG AGCCAGTTTT CCCGTCCATC CAAAGCCCAC 1500 1501 AACCAGAAAA TGAAGCTGGC TTGGGGCAGC AGCTGA 1536 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cajal body | |
Cellular Component | Cytoplasm | |
Cellular Component | Nuclear body | |
Cellular Component | Nuclear speck | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Molecular Function | 3'-5'-exoribonuclease activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Poly(A)-specific ribonuclease activity | |
Molecular Function | SnRNA binding | |
Biological Process | RNA phosphodiester bond hydrolysis, exonucleolytic | |
Biological Process | SnRNA 3'-end processing |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| ENPD | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2013 | Rattus norvegicus | 92.71 | 0.0 | 896 |
| LLPS-Mea-1846 | Mesocricetus auratus | 89.82 | 0.0 | 882 |
| LLPS-Caf-0154 | Canis familiaris | 83.81 | 0.0 | 815 |
| LLPS-Urm-3087 | Ursus maritimus | 83.44 | 0.0 | 784 |
| LLPS-Orc-0870 | Oryctolagus cuniculus | 82.93 | 0.0 | 808 |
| LLPS-Aim-0507 | Ailuropoda melanoleuca | 82.76 | 0.0 | 801 |
| LLPS-Gog-1469 | Gorilla gorilla | 82.19 | 0.0 | 806 |
| LLPS-Fec-2870 | Felis catus | 82.19 | 0.0 | 811 |
| LLPS-Myl-1685 | Myotis lucifugus | 82.11 | 0.0 | 803 |
| LLPS-Dio-0997 | Dipodomys ordii | 82.0 | 0.0 | 806 |
| LLPS-Pap-2099 | Pan paniscus | 82.0 | 0.0 | 807 |
| LLPS-Rhb-1820 | Rhinopithecus bieti | 82.0 | 0.0 | 807 |
| LLPS-Poa-1272 | Pongo abelii | 82.0 | 0.0 | 801 |
| LLPS-Cas-0987 | Carlito syrichta | 82.0 | 0.0 | 810 |
| LLPS-Tut-0011 | Tursiops truncatus | 81.8 | 0.0 | 808 |
| LLPS-Pat-3465 | Pan troglodytes | 81.8 | 0.0 | 805 |
| LLPS-Nol-2762 | Nomascus leucogenys | 81.8 | 0.0 | 800 |
| LLPS-Mup-0383 | Mustela putorius furo | 81.78 | 0.0 | 803 |
| LLPS-Hos-0581 | Homo sapiens | 81.6 | 0.0 | 802 |
| LLPS-Caj-4527 | Callithrix jacchus | 81.45 | 0.0 | 795 |
| LLPS-Chs-1367 | Chlorocebus sabaeus | 81.41 | 0.0 | 796 |
| LLPS-Maf-1883 | Macaca fascicularis | 81.02 | 0.0 | 781 |
| LLPS-Mal-0851 | Mandrillus leucophaeus | 81.02 | 0.0 | 784 |
| LLPS-Paa-2400 | Papio anubis | 81.02 | 0.0 | 783 |
| LLPS-Man-1737 | Macaca nemestrina | 81.02 | 0.0 | 783 |
| LLPS-Mam-1028 | Macaca mulatta | 81.02 | 0.0 | 783 |
| LLPS-Bot-0599 | Bos taurus | 80.95 | 0.0 | 809 |
| LLPS-Cea-2002 | Cercocebus atys | 80.82 | 0.0 | 782 |
| LLPS-Fud-0698 | Fukomys damarensis | 80.82 | 0.0 | 786 |
| LLPS-Eqc-0965 | Equus caballus | 80.82 | 0.0 | 795 |
| LLPS-Ict-1333 | Ictidomys tridecemlineatus | 80.63 | 0.0 | 801 |
| LLPS-Aon-0775 | Aotus nancymaae | 80.47 | 0.0 | 770 |
| LLPS-Loa-1616 | Loxodonta africana | 80.04 | 0.0 | 786 |
| LLPS-Cap-3597 | Cavia porcellus | 79.26 | 0.0 | 789 |
| LLPS-Lac-2024 | Latimeria chalumnae | 78.87 | 8e-78 | 247 |
| LLPS-Sus-0037 | Sus scrofa | 78.71 | 0.0 | 775 |
| LLPS-Ere-0157 | Erinaceus europaeus | 78.47 | 0.0 | 783 |
| LLPS-Ova-3299 | Ovis aries | 78.29 | 0.0 | 805 |
| LLPS-Pes-1265 | Pelodiscus sinensis | 74.07 | 8e-149 | 435 |
| LLPS-Mod-1554 | Monodelphis domestica | 65.98 | 0.0 | 600 |
| LLPS-Anp-1178 | Anas platyrhynchos | 65.95 | 3e-101 | 311 |
| LLPS-Sah-1552 | Sarcophilus harrisii | 64.32 | 0.0 | 597 |
| LLPS-Otg-2838 | Otolemur garnettii | 59.04 | 3e-175 | 509 |
| LLPS-Meg-1186 | Meleagris gallopavo | 56.95 | 1e-172 | 501 |
| LLPS-Anc-3051 | Anolis carolinensis | 55.3 | 0.0 | 551 |
| LLPS-Icp-1552 | Ictalurus punctatus | 54.7 | 6e-162 | 477 |
| LLPS-Scf-1263 | Scleropages formosus | 54.26 | 1e-168 | 493 |
| LLPS-Gaga-2495 | Gallus gallus | 54.02 | 0.0 | 546 |
| LLPS-Dar-0675 | Danio rerio | 53.24 | 4e-166 | 486 |
| LLPS-Tag-3015 | Taeniopygia guttata | 52.97 | 2e-170 | 498 |
| LLPS-Xet-1552 | Xenopus tropicalis | 52.57 | 1e-178 | 520 |
| LLPS-Leo-2481 | Lepisosteus oculatus | 52.29 | 8e-172 | 502 |
| LLPS-Fia-1371 | Ficedula albicollis | 52.23 | 7e-170 | 497 |
| LLPS-Ora-0475 | Ornithorhynchus anatinus | 52.16 | 2e-141 | 422 |
| LLPS-Ten-3114 | Tetraodon nigroviridis | 51.8 | 1e-166 | 486 |
| LLPS-Gaa-1586 | Gasterosteus aculeatus | 51.46 | 1e-159 | 470 |
| LLPS-Asm-1064 | Astyanax mexicanus | 51.43 | 1e-160 | 473 |
| LLPS-Tar-0552 | Takifugu rubripes | 51.24 | 6e-161 | 473 |
| LLPS-Xim-0216 | Xiphophorus maculatus | 50.1 | 2e-158 | 468 |
| LLPS-Php-0429 | Physcomitrella patens | 50.0 | 7e-09 | 62.4 |
| LLPS-Pof-0871 | Poecilia formosa | 50.0 | 2e-158 | 468 |
| LLPS-Orn-2013 | Oreochromis niloticus | 48.29 | 7e-156 | 462 |
| LLPS-Orl-1880 | Oryzias latipes | 47.83 | 6e-152 | 452 |
| LLPS-Cis-0780 | Ciona savignyi | 45.52 | 9e-84 | 273 |
| LLPS-Scm-3130 | Scophthalmus maximus | 45.13 | 3e-110 | 345 |
| LLPS-Tum-0789 | Tuber melanosporum | 37.69 | 5e-13 | 75.1 |
| LLPS-Cii-0353 | Ciona intestinalis | 35.2 | 5e-91 | 292 |
| LLPS-Cae-1398 | Caenorhabditis elegans | 35.2 | 3e-47 | 176 |
| LLPS-Abg-1498 | Absidia glauca | 35.08 | 4e-49 | 180 |
| LLPS-Sem-1656 | Selaginella moellendorffii | 31.52 | 8e-09 | 62.4 |
| LLPS-Scj-0671 | Schizosaccharomyces japonicus | 31.01 | 8e-10 | 65.1 |
| LLPS-Gas-1168 | Galdieria sulphuraria | 30.12 | 2e-25 | 112 |
| LLPS-Brn-1667 | Brassica napus | 29.41 | 2e-06 | 54.7 |
| LLPS-Scp-0307 | Schizosaccharomyces pombe | 29.27 | 1e-07 | 58.2 |
| LLPS-Chr-0763 | Chlamydomonas reinhardtii | 28.89 | 7e-07 | 56.2 |
| LLPS-Lem-1465 | Leptosphaeria maculans | 28.03 | 2e-06 | 54.7 |
| LLPS-Chc-0996 | Chondrus crispus | 26.77 | 9e-33 | 134 |
| LLPS-Zyt-0229 | Zymoseptoria tritici | 26.61 | 3e-06 | 53.9 |
| LLPS-Cym-0953 | Cyanidioschyzon merolae | 26.06 | 3e-23 | 107 |