DrLLPS - Data resource of LLPS

LLPS-Mum-1044
Exosc1

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Exosome complex component CSL4; Exosome component 1
Gene Name:	Exosc1, Csl4
Ensembl Gene:	ENSMUSG00000034321.13
Ensembl Protein:	ENSMUSP00000107751.2
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs

▼ FUNCTION

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000112123.2	ENSMUSP00000107751.2
Ensembl	ENSMUST00000075280.10	ENSMUSP00000074756.4
UniProt		Q9DAA6, EXOS1_MOUSE, Q9DCB9
GeneBank	AK006018, AK002930, BC024423	BAB24368.1, BAB22465.1, AAH24423.1
RefSeq	NM_001164561.1, NM_001320231.1, NM_001320232.1, NM_001320233.1, NM_025644.4	NP_001158033.1, NP_001307160.1, NP_001307161.1, NP_001307162.1, NP_079920.1
Entrez	66583

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAPPVRYCIP GERLCNLEEG SPGSGTYTRH GYIFSSLAGC LMKTSENGAV PVVSVMRETE 60 61 SQLLPDVGAV VTCKVSSINS RFAKVHILYV GSTPLKNAFR GTIRKEDIRA TEKDKVEIYK 120 121 SFRPGDIVLA KVISLGDAQS NYLLTTAENE LGVVVAHSES GVQMVPISWC EMQCPKTHTK 180 181 EFRKVARVQP EFLQT 195
Nucleotide CDS Sequence (FASTA)
1 ATGGCACCAC CGGTGAGGTA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAAGGC 60 61 AGCCCCGGCA GCGGCACCTA CACCCGGCAT GGCTACATCT TTTCGTCGCT GGCTGGCTGC 120 121 CTGATGAAGA CCAGCGAGAA TGGCGCGGTT CCCGTGGTGT CAGTGATGAG AGAAACAGAG 180 181 TCCCAGTTGC TTCCAGATGT GGGAGCTGTC GTCACCTGTA AGGTCTCTAG CATCAACTCA 240 241 CGGTTTGCCA AAGTACACAT CCTGTATGTG GGATCCACAC CACTCAAAAA TGCTTTTCGA 300 301 GGAACTATCC GCAAAGAAGA TATCCGAGCA ACTGAAAAAG ACAAGGTAGA AATTTACAAG 360 361 AGTTTTCGGC CAGGTGACAT AGTTTTGGCC AAAGTTATCT CCCTAGGCGA TGCACAGTCC 420 421 AATTACCTGC TGACTACTGC TGAAAACGAG CTGGGCGTTG TGGTGGCCCA CAGTGAGTCA 480 481 GGTGTTCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCCAAGAC CCACACTAAA 540 541 GAATTCCGAA AAGTGGCCCG AGTACAGCCC GAGTTCCTAC AGACCTAA 588

▼ KEYWORD

ID	Family
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0271	Exosome
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0694	RNA-binding
KW-0698	rRNA processing

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0000178	Cellular Component	Exosome (RNase complex)
GO:0000176	Cellular Component	Nuclear exosome (RNase complex)
GO:0005730	Cellular Component	Nucleolus
GO:0003723	Molecular Function	RNA binding
GO:0006396	Biological Process	RNA processing
GO:0006364	Biological Process	RRNA processing

▼ KEGG

mmu:66583

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	Gene3D

PTM
EPSD	PhosphoSitePlus	dbPTM	PTMcode

Mutation
CGAP

Interaction
HINT	RISE	RAIN	Mentha	PINA
IID	iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF

Localization
COMPARTMENTS

Expression
ArrayExpress	GXD	TISSUES

Element
miRTarBase	miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-0694	Rattus norvegicus	98.97	4e-142	401
LLPS-Caj-1714	Callithrix jacchus	97.95	6e-142	401
LLPS-Aon-2222	Aotus nancymaae	97.44	1e-141	400
LLPS-Bot-0050	Bos taurus	96.92	5e-141	399
LLPS-Loa-0834	Loxodonta africana	96.41	2e-139	395
LLPS-Otg-0625	Otolemur garnettii	96.41	1e-139	395
LLPS-Cap-1386	Cavia porcellus	96.41	2e-139	395
LLPS-Ict-0036	Ictidomys tridecemlineatus	96.41	4e-140	396
LLPS-Fud-0564	Fukomys damarensis	96.41	2e-140	397
LLPS-Dio-1270	Dipodomys ordii	96.41	9e-140	395
LLPS-Mup-0223	Mustela putorius furo	96.41	1e-140	397
LLPS-Aim-0845	Ailuropoda melanoleuca	96.41	1e-140	397
LLPS-Ova-0394	Ovis aries	96.41	1e-139	395
LLPS-Tut-0957	Tursiops truncatus	96.2	2e-131	374
LLPS-Orc-0330	Oryctolagus cuniculus	95.92	3e-138	391
LLPS-Pat-0385	Pan troglodytes	95.9	6e-140	395
LLPS-Hos-0013	Homo sapiens	95.9	6e-140	395
LLPS-Man-1104	Macaca nemestrina	95.9	6e-140	395
LLPS-Rhb-1989	Rhinopithecus bieti	95.9	6e-140	395
LLPS-Caf-1618	Canis familiaris	95.9	2e-139	395
LLPS-Mam-3158	Macaca mulatta	95.9	2e-139	395
LLPS-Maf-2323	Macaca fascicularis	95.9	6e-140	395
LLPS-Cea-0050	Cercocebus atys	95.9	6e-140	395
LLPS-Myl-0149	Myotis lucifugus	95.9	2e-139	394
LLPS-Paa-1983	Papio anubis	95.9	6e-140	395
LLPS-Poa-3143	Pongo abelii	95.38	3e-139	394
LLPS-Nol-0315	Nomascus leucogenys	95.38	2e-138	392
LLPS-Chs-1135	Chlorocebus sabaeus	95.38	5e-139	394
LLPS-Sus-0641	Sus scrofa	95.38	3e-139	395
LLPS-Ere-0109	Erinaceus europaeus	95.38	2e-138	392
LLPS-Sah-0537	Sarcophilus harrisii	93.88	2e-97	286
LLPS-Cas-0215	Carlito syrichta	92.93	4e-132	376
LLPS-Ora-0364	Ornithorhynchus anatinus	92.17	3e-75	229
LLPS-Mod-0864	Monodelphis domestica	91.33	2e-133	379
LLPS-Mal-0219	Mandrillus leucophaeus	90.77	6e-128	365
LLPS-Pap-2265	Pan paniscus	90.4	2e-128	367
LLPS-Anp-1722	Anas platyrhynchos	89.83	2e-27	104
LLPS-Fec-2389	Felis catus	89.71	7e-111	323
LLPS-Mea-0477	Mesocricetus auratus	86.67	2e-118	340
LLPS-Anc-0578	Anolis carolinensis	85.49	2e-122	351
LLPS-Fia-1419	Ficedula albicollis	84.1	5e-123	353
LLPS-Gog-1481	Gorilla gorilla	84.1	4e-116	334
LLPS-Tag-0459	Taeniopygia guttata	82.29	3e-117	338
LLPS-Scf-0977	Scleropages formosus	81.82	2e-112	327
LLPS-Pes-1387	Pelodiscus sinensis	80.82	2e-81	247
LLPS-Urm-2107	Ursus maritimus	80.51	1e-107	313
LLPS-Asm-0091	Astyanax mexicanus	80.1	2e-114	331
LLPS-Xet-0025	Xenopus tropicalis	79.69	5e-114	330
LLPS-Scm-0857	Scophthalmus maximus	79.06	4e-113	328
LLPS-Dar-0345	Danio rerio	79.06	3e-114	330
LLPS-Icp-0560	Ictalurus punctatus	79.06	6e-114	330
LLPS-Orn-1940	Oreochromis niloticus	78.53	3e-112	325
LLPS-Gaa-0832	Gasterosteus aculeatus	78.53	7e-112	325
LLPS-Orl-0416	Oryzias latipes	77.08	2e-109	318
LLPS-Eqc-0710	Equus caballus	76.47	2e-56	182
LLPS-Pof-0279	Poecilia formosa	74.87	3e-106	311
LLPS-Gaga-0010	Gallus gallus	73.33	1e-100	295
LLPS-Tar-0325	Takifugu rubripes	72.49	1e-96	286
LLPS-Ten-0076	Tetraodon nigroviridis	72.4	4e-96	285
LLPS-Xim-0540	Xiphophorus maculatus	65.45	6e-87	261
LLPS-Leo-0536	Lepisosteus oculatus	59.39	1e-72	223
LLPS-Amt-0041	Amborella trichopoda	57.27	5e-37	130
LLPS-Dac-0998	Daucus carota	56.88	3e-35	126
LLPS-Cis-0745	Ciona savignyi	55.61	3e-67	211
LLPS-Cii-1169	Ciona intestinalis	55.08	3e-66	209
LLPS-Thc-0206	Theobroma cacao	53.12	7e-25	99.0
LLPS-Ors-0558	Oryza sativa	52.38	3e-36	131
LLPS-Ori-1041	Oryza indica	52.38	4e-36	130
LLPS-Tra-0701	Triticum aestivum	52.38	5e-36	130
LLPS-Orgl-0221	Oryza glumaepatula	51.61	2e-33	124
LLPS-Orr-0623	Oryza rufipogon	51.59	2e-34	126
LLPS-Org-0440	Oryza glaberrima	51.59	8e-36	130
LLPS-Hov-0488	Hordeum vulgare	51.59	2e-35	130
LLPS-Orb-0080	Oryza barthii	50.79	6e-34	125
LLPS-Abg-0483	Absidia glauca	50.27	7e-57	184
LLPS-Php-1214	Physcomitrella patens	50.0	3e-53	175
LLPS-Osl-0259	Ostreococcus lucimarinus	48.44	5e-27	105
LLPS-Zem-1331	Zea mays	48.44	5e-13	68.6
LLPS-Kop-0262	Komagataella pastoris	48.35	5e-19	87.0
LLPS-Drm-0614	Drosophila melanogaster	48.15	1e-51	171
LLPS-Orni-0421	Oryza nivara	47.22	5e-15	73.6
LLPS-Brn-0032	Brassica napus	47.03	1e-45	155
LLPS-Sac-0296	Saccharomyces cerevisiae	46.94	3e-20	90.5
LLPS-Zyt-0110	Zymoseptoria tritici	46.77	4e-42	146
LLPS-Bro-0140	Brassica oleracea	46.49	1e-44	152
LLPS-Pot-0667	Populus trichocarpa	45.5	1e-41	145
LLPS-Dos-0460	Dothistroma septosporum	45.41	1e-39	140
LLPS-Arl-0332	Arabidopsis lyrata	45.41	1e-41	145
LLPS-Fus-0996	Fusarium solani	44.88	1e-42	148
LLPS-Sem-0622	Selaginella moellendorffii	44.81	7e-47	159
LLPS-Fuv-0960	Fusarium verticillioides	44.5	2e-40	142
LLPS-Fuo-1164	Fusarium oxysporum	44.44	4e-41	144
LLPS-Viv-0766	Vitis vinifera	44.32	7e-42	146
LLPS-Hea-0866	Helianthus annuus	44.32	3e-40	142
LLPS-Sol-1721	Solanum lycopersicum	44.09	1e-38	137
LLPS-Mua-0347	Musa acuminata	44.09	1e-37	135
LLPS-Scp-0610	Schizosaccharomyces pombe	43.96	5e-36	130
LLPS-Chr-0666	Chlamydomonas reinhardtii	43.96	1e-42	148
LLPS-Mae-0139	Manihot esculenta	43.92	6e-41	144
LLPS-Chc-0481	Chondrus crispus	43.92	7e-50	166
LLPS-Orbr-0229	Oryza brachyantha	43.85	1e-37	135
LLPS-Scs-0311	Sclerotinia sclerotiorum	43.78	8e-45	154
LLPS-Art-1119	Arabidopsis thaliana	43.72	4e-41	144
LLPS-Cus-0440	Cucumis sativus	43.55	8e-43	148
LLPS-Crn-0005	Cryptococcus neoformans	43.45	2e-29	113
LLPS-Trr-0215	Trichoderma reesei	43.37	1e-38	144
LLPS-Scc-0095	Schizosaccharomyces cryophilus	43.37	8e-31	117
LLPS-Nec-0098	Neurospora crassa	43.35	2e-43	150
LLPS-Via-0569	Vigna angularis	43.24	4e-37	133
LLPS-Vir-1111	Vigna radiata	43.24	4e-37	134
LLPS-Nia-0388	Nicotiana attenuata	43.16	4e-38	139
LLPS-Cog-0077	Colletotrichum gloeosporioides	43.13	7e-44	152
LLPS-Coc-0044	Corchorus capsularis	43.12	3e-24	103
LLPS-Sot-0055	Solanum tuberosum	43.01	4e-38	136
LLPS-Sob-0434	Sorghum bicolor	42.93	6e-38	135
LLPS-Phv-0332	Phaseolus vulgaris	42.93	4e-37	133
LLPS-Gag-0125	Gaeumannomyces graminis	42.86	4e-41	144
LLPS-Cogr-0098	Colletotrichum graminicola	42.79	2e-42	147
LLPS-Lep-0002	Leersia perrieri	42.7	4e-34	127
LLPS-Trv-0628	Trichoderma virens	42.55	1e-34	132
LLPS-Coo-0295	Colletotrichum orbiculare	42.51	3e-42	147
LLPS-Glm-1115	Glycine max	42.39	1e-37	135
LLPS-Sei-0706	Setaria italica	42.39	1e-36	132
LLPS-Miv-0799	Microbotryum violaceum	42.33	5e-37	133
LLPS-Scj-1116	Schizosaccharomyces japonicus	42.31	1e-30	116
LLPS-Mel-0821	Melampsora laricipopulina	42.11	3e-30	115
LLPS-Asni-0266	Aspergillus niger	42.05	4e-38	136
LLPS-Met-1858	Medicago truncatula	41.94	2e-38	139
LLPS-Brd-0078	Brachypodium distachyon	41.8	3e-36	131
LLPS-Beb-0428	Beauveria bassiana	41.41	1e-40	143
LLPS-Ved-0567	Verticillium dahliae	41.18	2e-35	132
LLPS-Prp-1120	Prunus persica	40.96	7e-39	138
LLPS-Mao-0450	Magnaporthe oryzae	40.95	3e-40	142
LLPS-Blg-0099	Blumeria graminis	40.95	5e-43	149
LLPS-Brr-2262	Brassica rapa	40.91	1e-22	94.4
LLPS-Yal-0342	Yarrowia lipolytica	40.24	2e-23	99.4
LLPS-Map-0192	Magnaporthe poae	40.19	3e-39	140
LLPS-Orp-0605	Oryza punctata	39.88	4e-23	97.1
LLPS-Tum-0371	Tuber melanosporum	39.5	1e-35	130
LLPS-Asg-0103	Ashbya gossypii	38.61	7e-23	97.8
LLPS-Pug-0066	Puccinia graminis	38.5	9e-31	117
LLPS-Phn-0067	Phaeosphaeria nodorum	38.35	5e-39	139
LLPS-Gor-0177	Gossypium raimondii	38.21	5e-33	124
LLPS-Lem-0495	Leptosphaeria maculans	38.05	1e-37	135
LLPS-Tru-0030	Triticum urartu	38.03	7e-19	85.1
LLPS-Put-0286	Puccinia triticina	37.43	4e-25	101
LLPS-Pytr-0113	Pyrenophora triticirepentis	37.25	2e-35	130
LLPS-Pyt-0417	Pyrenophora teres	36.76	4e-33	124
LLPS-Asn-0233	Aspergillus nidulans	36.29	3e-31	119
LLPS-Nef-0445	Neosartorya fischeri	36.25	9e-32	121
LLPS-Asfu-0591	Aspergillus fumigatus	35.83	3e-31	119
LLPS-Ast-0278	Aspergillus terreus	35.56	2e-29	115
LLPS-Aso-0488	Aspergillus oryzae	34.27	4e-28	111
LLPS-Asc-0161	Aspergillus clavatus	34.15	1e-30	118
LLPS-Asf-0165	Aspergillus flavus	33.87	3e-28	112
LLPS-Gas-0212	Galdieria sulphuraria	33.54	7e-19	84.7
LLPS-Usm-0333	Ustilago maydis	33.06	7e-23	97.4
LLPS-Cae-0432	Caenorhabditis elegans	32.98	1e-23	98.6
LLPS-Spr-1004	Sporisorium reilianum	31.88	6e-21	92.0
LLPS-Cym-0574	Cyanidioschyzon merolae	29.61	2e-12	67.4

LLPS-Mum-1044Exosc1

Protein Sequence

Nucleotide Sequence

LLPS-Mum-1044
Exosc1