LLPS-Mum-0973
Ubqln1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Ubiquilin-1; Protein linking IAP with cytoskeleton 1; PLIC-1 |
| Gene Name: | Ubqln1, Plic1 |
| Ensembl Gene: | ENSMUSG00000005312.15 |
| Ensembl Protein: | ENSMUSP00000075782.6 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|
▼ FUNCTION
| Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway. Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis. Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization. Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Links CD47 to the cytoskeleton (PubMed:10549293). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000076454.7 | ENSMUSP00000075782.6 |
| Ensembl | ENSMUST00000225645.1 | ENSMUSP00000153666.1 |
| Ensembl | ENSMUST00000058735.11 | ENSMUSP00000050191.5 |
| UniProt | Q8R317, UBQL1_MOUSE, Q80V10, Q8C7T4, Q8C835, Q8K141, Q91VI8, Q9D0Z0, Q9QZM1 | |
| GeneBank | AK004183, BC027375, AK048534, BC051098, BC010213, BC026847, BC028857, AF177345, AK049298 | AAH27375.1, BAB23211.1, AAF01365.1, AAH26847.1, BAC33365.1, BAC33666.1, AAH51098.1, AAH28857.1, AAH10213.1 |
| RefSeq | NM_026842.4, NM_152234.2 | NP_081118.4, NP_689420.1 |
| Entrez | 56085 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGAGA GCGCAGAGAG CGGCGGCCCA CCGGGCGCGC AGGACAGTGC GGCCGACGGC 60 61 GGCCCCGCAG AGCCCAAGAT CATGAAGGTC ACGGTGAAGA CGCCTAAAGA GAAGGAGGAG 120 121 TTTGCCGTGC CCGAGAACAG CTCGGTCCAG CAGTTCAAAG AGGAAATCTC TAAACGTTTC 180 181 AAATCTCATA TTGACCAACT TGTGTTGATA TTTGCTGGAA AAATTTTAAA AGATCAAGAT 240 241 ACTCTGAGTC AGCATGGGAT TCATGATGGA CTTACGGTTC ACCTTGTCAT CAAAACACAG 300 301 AACAGGCCGC AAGATAATTC AGCTCAGCAA ACAAATGCCC CTGGAAGCAC TGTGACCAGC 360 361 TCACCAGCTC CCGATAGCAA CCCCACGTCT GGTTCTGCTG CTAACAGCTC CTTTGGCGTA 420 421 GGCGGACTTG GAGGACTTGC AGGTCTTAGC AGCTTGGGTT TAAACACCAC CAACTTCTCT 480 481 GAACTCCAGA GCCAAATGCA GCGGCAACTT TTGTCTAACC CTGAAATGAT GGTCCAGATC 540 541 ATGGAAAATC CCTTTGTCCA GAGCATGCTC TCAAATCCTG ACCTGATGCG GCAATTGATT 600 601 ATGGCCAATC CACAGATGCA ACAGTTGATA CAGAGAAATC CAGAGATTAG TCATATGCTT 660 661 AATAATCCAG ATATAATGAG ACAAACACTG GAACTTGCGA GAAATCCAGC GATGATGCAG 720 721 GAAATGATGA GAAACCAGGA CCGAGCCTTG AGCAACCTAG AAAGTATTCC TGGGGGCTAT 780 781 AATGCCTTAC GGCGCATGTA CACCGATATC CAGGAGCCTA TGCTGAATGC TGCTCAAGAA 840 841 CAGTTTGGTG GTAATCCATT TGCGTCCTTA GTGAGCAGTT CGTCCTCAGC AGAAGGGACT 900 901 CAGCCTTCTC GAACAGAAAA TAGGGATCCG CTCCCCAACC CGTGGGCTCC GCAGACTTCC 960 961 CAGAGCTCAC CAGCCTCCGG TACCACTGGC AGCACCACTA ACACCATGAG CACCTCTGGT 1020 1021 GGCACTGCCA CCAGTACCCC TGCTGGACAG AGCACCTCGG GCCCAAGCTT GGTGCCTGGC 1080 1081 GCAGGAGCTA GTATGTTCAA CACCCCCGGA ATGCAGAGCC TGCTGCAGCA GATAACTGAG 1140 1141 AACCCACAGC TCATGCAGAA CATGCTGTCC GCCCCATACA TGAGGAGCAT GCTGCAGTCC 1200 1201 CTGAGCCAGA ACCCCGACCT TGCTGCGCAG ATGATGCTGA ATAATCCCCT ATTTGCTGGA 1260 1261 AATCCTCAGC TTCAAGAACA AATGAGACAA CAGCTCCCAA CTTTCCTCCA ACAAATGCAG 1320 1321 AACCCCGACA CGCTCTCAGC GATGTCGAAT CCTAGAGCCA TGCAGGCGCT GCTGCAGATC 1380 1381 CAGCAGGGCT TGCAGACGCT GGCCACAGAA GCTCCTGGCC TCATCCCAGG GTTTACTCCT 1440 1441 GGCTTGGCAG CAGGCAATTC TGGAGGCTCT TCCGGAACCA ATGCACCTAG CACTGCACCT 1500 1501 AGTGAAGATA CGAACCCCCA AGGGGGCACT GCTGAGCCAG GCCACCAGCA GTTTATCCAG 1560 1561 CAGATGCTGC AGGCCCTTGC GGGGGTGAAT CCTCAGCTGC AGAGTCCAGA AGTCAGATTT 1620 1621 CAGCAACAAC TGGAACAACT CAGTGCCATG GGATTCTTGA ACCGTGAAGC AAACCTGCAA 1680 1681 GCTCTGATAG CCACAGGGGG CGACATCAAT GCAGCAATCG AAAGGTTGCT GGGCTCCCAG 1740 1741 CCGTCATAG 1749 |
▼ KEYWORD
ID | Family |
Acetylation | |
Alternative splicing | |
Autophagy | |
Cell membrane | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Direct protein sequencing | |
Endoplasmic reticulum | |
Membrane | |
Nucleus | |
Proteasome | |
Reference proteome | |
Ubl conjugation
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Aggresome | |
Cellular Component | Autophagosome | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Nucleoplasm | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Plasma membrane | |
Cellular Component | Proteasome complex | |
Cellular Component | Protein-containing complex | |
Molecular Function | Identical protein binding | |
Molecular Function | Intermediate filament binding | |
Molecular Function | Kinase binding | |
Molecular Function | Polyubiquitin modification-dependent protein binding | |
Molecular Function | Protein domain specific binding | |
Molecular Function | Signaling receptor binding | |
Molecular Function | Aggrephagy | |
Molecular Function | Autophagosome assembly | |
Molecular Function | Autophagosome maturation | |
Molecular Function | Cellular response to hypoxia | |
Molecular Function | Macroautophagy | |
Molecular Function | Negative regulation of store-operated calcium channel activity | |
Molecular Function | Negative regulation of toll-like receptor 3 signaling pathway | |
Molecular Function | Positive regulation of ER-associated ubiquitin-dependent protein catabolic process | |
Molecular Function | Positive regulation of protein ubiquitination | |
Molecular Function | Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | |
Molecular Function | Regulation of protein ubiquitination | |
Molecular Function | Response to endoplasmic reticulum stress | |
Molecular Function | Ubiquitin-dependent ERAD pathway |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0240 | Rattus norvegicus | 96.39 | 0.0 | 922 |
| LLPS-Ere-0023 | Erinaceus europaeus | 90.0 | 7e-60 | 216 |
| LLPS-Paa-2606 | Papio anubis | 90.0 | 3e-59 | 214 |
| LLPS-Mal-2870 | Mandrillus leucophaeus | 90.0 | 6e-59 | 213 |
| LLPS-Chs-0029 | Chlorocebus sabaeus | 90.0 | 4e-59 | 213 |
| LLPS-Cea-3174 | Cercocebus atys | 90.0 | 5e-59 | 213 |
| LLPS-Aon-1265 | Aotus nancymaae | 90.0 | 4e-59 | 214 |
| LLPS-Gog-3102 | Gorilla gorilla | 90.0 | 4e-59 | 213 |
| LLPS-Caj-1672 | Callithrix jacchus | 90.0 | 4e-59 | 214 |
| LLPS-Cap-1834 | Cavia porcellus | 90.0 | 3e-59 | 214 |
| LLPS-Poa-4376 | Pongo abelii | 90.0 | 3e-59 | 214 |
| LLPS-Cas-3173 | Carlito syrichta | 90.0 | 5e-59 | 213 |
| LLPS-Nol-0982 | Nomascus leucogenys | 90.0 | 4e-59 | 213 |
| LLPS-Hos-0803 | Homo sapiens | 90.0 | 4e-59 | 214 |
| LLPS-Pap-3255 | Pan paniscus | 90.0 | 4e-59 | 213 |
| LLPS-Man-2867 | Macaca nemestrina | 90.0 | 5e-59 | 213 |
| LLPS-Rhb-2776 | Rhinopithecus bieti | 90.0 | 4e-59 | 213 |
| LLPS-Mea-4338 | Mesocricetus auratus | 89.54 | 0.0 | 862 |
| LLPS-Ict-1384 | Ictidomys tridecemlineatus | 89.46 | 0.0 | 805 |
| LLPS-Ova-2093 | Ovis aries | 89.17 | 1e-58 | 212 |
| LLPS-Sus-4069 | Sus scrofa | 89.17 | 6e-59 | 213 |
| LLPS-Caf-1183 | Canis familiaris | 89.17 | 1e-58 | 212 |
| LLPS-Fec-4285 | Felis catus | 89.17 | 9e-59 | 213 |
| LLPS-Urm-4036 | Ursus maritimus | 89.17 | 6e-59 | 213 |
| LLPS-Fud-2552 | Fukomys damarensis | 88.72 | 0.0 | 805 |
| LLPS-Mup-3929 | Mustela putorius furo | 88.41 | 6e-26 | 116 |
| LLPS-Dio-2141 | Dipodomys ordii | 88.33 | 6e-58 | 210 |
| LLPS-Eqc-1584 | Equus caballus | 88.18 | 0.0 | 820 |
| LLPS-Mam-4138 | Macaca mulatta | 86.82 | 0.0 | 840 |
| LLPS-Maf-2710 | Macaca fascicularis | 86.46 | 0.0 | 832 |
| LLPS-Loa-3611 | Loxodonta africana | 86.15 | 0.0 | 824 |
| LLPS-Otg-1490 | Otolemur garnettii | 86.15 | 0.0 | 823 |
| LLPS-Pat-4191 | Pan troglodytes | 85.79 | 0.0 | 827 |
| LLPS-Bot-1917 | Bos taurus | 85.14 | 0.0 | 822 |
| LLPS-Mod-0642 | Monodelphis domestica | 83.96 | 0.0 | 806 |
| LLPS-Myl-0209 | Myotis lucifugus | 83.45 | 0.0 | 834 |
| LLPS-Orc-0800 | Oryctolagus cuniculus | 82.64 | 2e-120 | 375 |
| LLPS-Pes-3755 | Pelodiscus sinensis | 82.4 | 0.0 | 725 |
| LLPS-Anp-2544 | Anas platyrhynchos | 81.9 | 0.0 | 734 |
| LLPS-Sah-3914 | Sarcophilus harrisii | 80.04 | 0.0 | 711 |
| LLPS-Fia-1128 | Ficedula albicollis | 79.76 | 0.0 | 763 |
| LLPS-Anc-2639 | Anolis carolinensis | 78.81 | 0.0 | 719 |
| LLPS-Gaga-2916 | Gallus gallus | 78.65 | 0.0 | 724 |
| LLPS-Lac-0414 | Latimeria chalumnae | 78.34 | 0.0 | 608 |
| LLPS-Ora-2727 | Ornithorhynchus anatinus | 77.27 | 0.0 | 736 |
| LLPS-Xet-1243 | Xenopus tropicalis | 76.65 | 0.0 | 673 |
| LLPS-Tag-3326 | Taeniopygia guttata | 75.76 | 0.0 | 691 |
| LLPS-Aim-1331 | Ailuropoda melanoleuca | 75.55 | 0.0 | 665 |
| LLPS-Leo-3072 | Lepisosteus oculatus | 73.55 | 0.0 | 682 |
| LLPS-Scf-3197 | Scleropages formosus | 67.22 | 0.0 | 649 |
| LLPS-Cis-1343 | Ciona savignyi | 57.81 | 4e-12 | 73.2 |
| LLPS-Chr-1627 | Chlamydomonas reinhardtii | 56.25 | 2e-07 | 58.5 |
| LLPS-Orm-1683 | Oryza meridionalis | 54.55 | 3e-06 | 54.3 |
| LLPS-Orp-1197 | Oryza punctata | 54.55 | 3e-06 | 54.3 |
| LLPS-Lep-0674 | Leersia perrieri | 52.27 | 3e-06 | 54.3 |
| LLPS-Thc-1187 | Theobroma cacao | 50.29 | 5e-43 | 167 |
| LLPS-Cii-0394 | Ciona intestinalis | 49.36 | 1e-137 | 418 |
| LLPS-Met-0551 | Medicago truncatula | 48.5 | 2e-39 | 155 |
| LLPS-Cym-0692 | Cyanidioschyzon merolae | 47.59 | 3e-35 | 143 |
| LLPS-Drm-1168 | Drosophila melanogaster | 45.31 | 1e-142 | 431 |
| LLPS-Ori-1143 | Oryza indica | 41.03 | 8e-46 | 175 |
| LLPS-Orb-1258 | Oryza barthii | 41.03 | 4e-46 | 176 |
| LLPS-Orni-2103 | Oryza nivara | 41.03 | 8e-46 | 175 |
| LLPS-Org-2035 | Oryza glaberrima | 41.03 | 4e-46 | 176 |
| LLPS-Ors-2003 | Oryza sativa | 41.03 | 8e-46 | 175 |
| LLPS-Tru-0586 | Triticum urartu | 39.66 | 2e-47 | 179 |
| LLPS-Orbr-2211 | Oryza brachyantha | 38.68 | 4e-46 | 176 |
| LLPS-Sem-1316 | Selaginella moellendorffii | 38.61 | 1e-40 | 159 |
| LLPS-Sob-1070 | Sorghum bicolor | 38.41 | 2e-46 | 177 |
| LLPS-Zem-2304 | Zea mays | 37.37 | 8e-46 | 175 |
| LLPS-Chc-0129 | Chondrus crispus | 36.84 | 2e-39 | 155 |
| LLPS-Dac-0586 | Daucus carota | 36.5 | 5e-44 | 169 |
| LLPS-Via-1447 | Vigna angularis | 36.13 | 8e-40 | 155 |
| LLPS-Arl-2142 | Arabidopsis lyrata | 36.05 | 6e-47 | 178 |
| LLPS-Sei-0852 | Setaria italica | 35.63 | 1e-52 | 194 |
| LLPS-Cae-1055 | Caenorhabditis elegans | 35.6 | 2e-89 | 291 |
| LLPS-Nia-2136 | Nicotiana attenuata | 35.6 | 1e-53 | 197 |
| LLPS-Amt-1854 | Amborella trichopoda | 35.21 | 1e-49 | 186 |
| LLPS-Prp-1663 | Prunus persica | 35.19 | 6e-56 | 203 |
| LLPS-Orgl-1656 | Oryza glumaepatula | 34.9 | 2e-48 | 182 |
| LLPS-Viv-0114 | Vitis vinifera | 34.86 | 3e-52 | 193 |
| LLPS-Orr-1979 | Oryza rufipogon | 34.81 | 9e-49 | 183 |
| LLPS-Bro-2488 | Brassica oleracea | 34.04 | 3e-49 | 184 |
| LLPS-Sot-1278 | Solanum tuberosum | 33.87 | 1e-62 | 221 |
| LLPS-Php-1090 | Physcomitrella patens | 33.8 | 2e-56 | 204 |
| LLPS-Coc-2306 | Corchorus capsularis | 33.69 | 1e-62 | 221 |
| LLPS-Hov-0979 | Hordeum vulgare | 33.45 | 3e-56 | 204 |
| LLPS-Hea-1192 | Helianthus annuus | 32.98 | 3e-63 | 223 |
| LLPS-Brr-1913 | Brassica rapa | 32.92 | 2e-46 | 176 |
| LLPS-Mua-0027 | Musa acuminata | 32.89 | 2e-62 | 221 |
| LLPS-Sac-0966 | Saccharomyces cerevisiae | 32.84 | 4e-13 | 75.1 |
| LLPS-Mae-2003 | Manihot esculenta | 32.72 | 2e-60 | 216 |
| LLPS-Brn-2028 | Brassica napus | 32.71 | 5e-46 | 174 |
| LLPS-Vir-2081 | Vigna radiata | 32.66 | 3e-47 | 179 |
| LLPS-Pot-2695 | Populus trichocarpa | 32.58 | 3e-60 | 216 |
| LLPS-Glm-0556 | Glycine max | 32.51 | 2e-50 | 188 |
| LLPS-Phv-2460 | Phaseolus vulgaris | 32.51 | 2e-56 | 204 |
| LLPS-Tra-0865 | Triticum aestivum | 32.28 | 1e-58 | 211 |
| LLPS-Gor-2695 | Gossypium raimondii | 32.22 | 2e-62 | 221 |
| LLPS-Gas-1056 | Galdieria sulphuraria | 32.21 | 9e-56 | 202 |
| LLPS-Art-2800 | Arabidopsis thaliana | 32.15 | 1e-49 | 186 |
| LLPS-Sol-0358 | Solanum lycopersicum | 32.05 | 1e-64 | 227 |
| LLPS-Phn-0097 | Phaeosphaeria nodorum | 31.25 | 3e-06 | 53.5 |
| LLPS-Brd-1788 | Brachypodium distachyon | 31.14 | 7e-59 | 211 |
| LLPS-Lem-1600 | Leptosphaeria maculans | 30.9 | 3e-13 | 76.3 |
| LLPS-Osl-0977 | Ostreococcus lucimarinus | 30.69 | 1e-26 | 117 |
| LLPS-Cus-1072 | Cucumis sativus | 30.52 | 7e-61 | 217 |
| LLPS-Dos-1037 | Dothistroma septosporum | 28.88 | 2e-10 | 67.4 |
| LLPS-Asni-0840 | Aspergillus niger | 27.31 | 2e-06 | 54.3 |
| LLPS-Crn-0324 | Cryptococcus neoformans | 26.98 | 3e-08 | 60.1 |
| LLPS-Asg-0861 | Ashbya gossypii | 26.47 | 3e-07 | 57.0 |