LLPS-Mum-0945
Nedd8

▼ OVERVIEW


Status: Reviewed
Protein Name: NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8
Gene Name: Nedd8, Nedd-8
Ensembl Gene: ENSMUSG00000010376.15
Ensembl Protein: ENSMUSP00000130492.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granulePredicted from orthologsN/A(View)

▼ FUNCTION


Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MLIKVKTLTG  KEIEIDIEPT  DKVERIKERV  EEKEGIPPQQ  QRLIYSGKQM  NDEKTAADYK  60
61    ILGGSVLHLV  LALRGGGGLG  Q  81
Nucleotide CDS Sequence (FASTA)
1     ATGCTAATTA  AAGTGAAGAC  GCTGACTGGG  AAGGAGATTG  AGATAGACAT  CGAACCCACA  60
61    GACAAGGTGG  AGCGAATCAA  GGAGCGTGTG  GAAGAAAAAG  AAGGGATTCC  CCCCCAGCAG  120
121   CAGCGGCTCA  TCTACAGTGG  CAAGCAAATG  AATGATGAGA  AGACAGCAGC  TGATTACAAG  180
181   ATTCTAGGTG  GTTCCGTCCT  CCACCTGGTG  TTGGCTCTTA  GAGGAGGAGG  TGGTCTTGGG  240
241   CAGTGA  246

▼ KEYWORD


ID
Family
Acetylation
Complete proteome
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation pathway

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Molecular Function
Protein tag
Molecular Function
Ubiquitin protein ligase binding
Biological Process
Modification-dependent protein catabolic process
Biological Process
Protein localization
Biological Process
Protein neddylation
Biological Process
Regulation of proteolysis
Biological Process
Regulation of transcription by RNA polymerase II
Biological Process
Response to organic cyclic compound

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Eqc-0187Equus caballus100.06e-2184.7
LLPS-Cas-1646Carlito syrichta100.02e-28 103
LLPS-Nol-0349Nomascus leucogenys100.02e-28 103
LLPS-Ict-3265Ictidomys tridecemlineatus100.01e-28 103
LLPS-Fec-0097Felis catus100.02e-28 103
LLPS-Hos-0460Homo sapiens100.02e-28 103
LLPS-Pap-1926Pan paniscus100.02e-28 103
LLPS-Man-1000Macaca nemestrina100.02e-28 103
LLPS-Rhb-3756Rhinopithecus bieti100.02e-28 103
LLPS-Orc-2625Oryctolagus cuniculus100.02e-28 103
LLPS-Bot-3469Bos taurus100.02e-28 103
LLPS-Dio-3331Dipodomys ordii100.02e-28 103
LLPS-Ere-0211Erinaceus europaeus100.02e-28 103
LLPS-Ran-1231Rattus norvegicus100.01e-28 103
LLPS-Mal-1473Mandrillus leucophaeus100.02e-28 103
LLPS-Paa-3245Papio anubis100.02e-28 103
LLPS-Maf-1344Macaca fascicularis100.02e-28 103
LLPS-Mea-0636Mesocricetus auratus100.01e-28 103
LLPS-Sus-3636Sus scrofa100.02e-2185.5
LLPS-Aon-1952Aotus nancymaae100.02e-28 103
LLPS-Cea-2667Cercocebus atys100.03e-2493.2
LLPS-Gog-4316Gorilla gorilla100.02e-2493.2
LLPS-Ten-2916Tetraodon nigroviridis98.482e-27 100
LLPS-Poa-1354Pongo abelii98.482e-27 101
LLPS-Xet-2345Xenopus tropicalis98.482e-27 101
LLPS-Gaga-2631Gallus gallus98.483e-27 100
LLPS-Scm-3562Scophthalmus maximus98.483e-27 100
LLPS-Lac-2779Latimeria chalumnae98.481e-27 101
LLPS-Dar-3409Danio rerio98.481e-27 101
LLPS-Pof-2683Poecilia formosa98.481e-27 101
LLPS-Tar-3287Takifugu rubripes98.481e-27 102
LLPS-Xim-0031Xiphophorus maculatus98.482e-27 100
LLPS-Scf-2667Scleropages formosus98.487e-27 101
LLPS-Gaa-0491Gasterosteus aculeatus98.481e-27 101
LLPS-Icp-2570Ictalurus punctatus98.482e-27 101
LLPS-Fud-1954Fukomys damarensis98.487e-28 102
LLPS-Asm-1012Astyanax mexicanus98.481e-27 102
LLPS-Caf-0202Canis familiaris98.362e-2493.2
LLPS-Aim-1413Ailuropoda melanoleuca98.362e-2493.2
LLPS-Urm-1842Ursus maritimus96.881e-2596.7
LLPS-Pat-2161Pan troglodytes96.772e-2493.6
LLPS-Ova-1662Ovis aries96.772e-2493.6
LLPS-Mup-0093Mustela putorius furo96.772e-2493.6
LLPS-Loa-2467Loxodonta africana95.457e-2697.1
LLPS-Mod-0882Monodelphis domestica95.161e-2390.9
LLPS-Cap-2611Cavia porcellus94.123e-2595.5
LLPS-Chs-2712Chlorocebus sabaeus93.941e-2699.0
LLPS-Orl-0688Oryzias latipes93.941e-2391.7
LLPS-Tut-1606Tursiops truncatus92.423e-2390.1
LLPS-Drm-1346Drosophila melanogaster92.425e-2697.4
LLPS-Fia-1910Ficedula albicollis90.915e-2492.0
LLPS-Sah-3702Sarcophilus harrisii90.913e-2492.8
LLPS-Caj-0638Callithrix jacchus90.919e-2696.7
LLPS-Cii-0986Ciona intestinalis89.391e-2391.3
LLPS-Cae-0696Caenorhabditis elegans86.368e-2594.4
LLPS-Osl-0944Ostreococcus lucimarinus86.151e-2185.9
LLPS-Php-0629Physcomitrella patens83.082e-2084.7
LLPS-Amt-0908Amborella trichopoda81.825e-2287.4
LLPS-Gas-0026Galdieria sulphuraria81.824e-1883.2
LLPS-Chr-0965Chlamydomonas reinhardtii81.826e-2186.3
LLPS-Orr-1672Oryza rufipogon81.544e-2084.0
LLPS-Bro-0227Brassica oleracea81.545e-2084.0
LLPS-Tru-1008Triticum urartu81.545e-2084.0
LLPS-Org-1705Oryza glaberrima81.545e-2084.0
LLPS-Ors-0846Oryza sativa81.545e-2084.0
LLPS-Art-0087Arabidopsis thaliana81.545e-2084.0
LLPS-Gor-0256Gossypium raimondii81.544e-2084.0
LLPS-Viv-1970Vitis vinifera81.544e-2084.0
LLPS-Sob-1893Sorghum bicolor81.545e-2084.0
LLPS-Orbr-1085Oryza brachyantha81.544e-2084.0
LLPS-Nia-2595Nicotiana attenuata81.544e-2084.0
LLPS-Mae-1560Manihot esculenta81.544e-2084.0
LLPS-Sot-1346Solanum tuberosum81.544e-2084.0
LLPS-Tra-1216Triticum aestivum81.545e-2084.0
LLPS-Brd-0283Brachypodium distachyon81.545e-2084.0
LLPS-Hov-1414Hordeum vulgare81.548e-2084.0
LLPS-Sei-0006Setaria italica81.545e-2084.0
LLPS-Arl-1417Arabidopsis lyrata81.545e-2083.6
LLPS-Sol-0799Solanum lycopersicum81.541e-2083.6
LLPS-Ori-1969Oryza indica81.545e-2084.0
LLPS-Brn-3059Brassica napus81.545e-2084.0
LLPS-Hea-2440Helianthus annuus81.545e-2084.0
LLPS-Thc-2518Theobroma cacao81.544e-2084.0
LLPS-Usm-1101Ustilago maydis80.32e-2083.2
LLPS-Spr-0987Sporisorium reilianum80.31e-2083.6
LLPS-Abg-0560Absidia glauca80.33e-2082.4
LLPS-Mua-0405Musa acuminata80.33e-2084.3
LLPS-Coc-0913Corchorus capsularis80.02e-1982.4
LLPS-Prp-1661Prunus persica80.02e-1982.4
LLPS-Zem-0849Zea mays80.03e-1981.6
LLPS-Pot-2702Populus trichocarpa80.03e-2084.3
LLPS-Phv-1050Phaseolus vulgaris80.02e-1982.0
LLPS-Met-0627Medicago truncatula80.02e-1982.4
LLPS-Glm-2832Glycine max80.02e-1982.0
LLPS-Scp-0936Schizosaccharomyces pombe78.791e-1980.9
LLPS-Scj-1328Schizosaccharomyces japonicus78.793e-2082.4
LLPS-Scc-1042Schizosaccharomyces cryophilus78.792e-1980.1
LLPS-Phn-0903Phaeosphaeria nodorum78.463e-1877.0
LLPS-Zyt-0907Zymoseptoria tritici77.783e-1877.4
LLPS-Pyt-0010Pyrenophora teres76.928e-1876.3
LLPS-Lem-1463Leptosphaeria maculans76.923e-1774.7
LLPS-Asc-0314Aspergillus clavatus76.928e-1876.3
LLPS-Asn-1532Aspergillus nidulans76.921e-1775.5
LLPS-Pytr-1174Pyrenophora triticirepentis75.385e-1774.3
LLPS-Dos-0881Dothistroma septosporum75.383e-1774.3
LLPS-Asni-0670Aspergillus niger75.383e-1774.7
LLPS-Mao-0897Magnaporthe oryzae75.382e-1775.5
LLPS-Beb-0986Beauveria bassiana75.07e-1876.3
LLPS-Mam-1928Macaca mulatta74.192e-2185.5
LLPS-Tum-0907Tuber melanosporum73.856e-1773.9
LLPS-Map-0759Magnaporthe poae73.854e-1774.3
LLPS-Nec-0905Neurospora crassa72.316e-1773.9
LLPS-Gag-0799Gaeumannomyces graminis72.311e-1672.8
LLPS-Fuo-1064Fusarium oxysporum71.881e-1570.9
LLPS-Trv-0774Trichoderma virens71.883e-1672.0
LLPS-Trr-0394Trichoderma reesei71.881e-1570.9
LLPS-Fus-0504Fusarium solani71.886e-1671.2
LLPS-Fuv-0134Fusarium verticillioides71.881e-1570.9
LLPS-Cym-0976Cyanidioschyzon merolae71.216e-1979.7
LLPS-Asfu-0537Aspergillus fumigatus70.771e-1570.5
LLPS-Nef-0869Neosartorya fischeri70.771e-1570.5
LLPS-Mel-1514Melampsora laricipopulina69.72e-1570.1
LLPS-Cogr-0194Colletotrichum graminicola69.239e-1568.2
LLPS-Miv-0211Microbotryum violaceum69.235e-1671.6
LLPS-Cog-0740Colletotrichum gloeosporioides69.239e-1568.2
LLPS-Blg-1134Blumeria graminis69.238e-1670.9
LLPS-Coo-0866Colletotrichum orbiculare69.237e-1568.6
LLPS-Ved-0561Verticillium dahliae67.692e-1467.4
LLPS-Pug-1054Puccinia graminis67.692e-1569.7
LLPS-Sem-0197Selaginella moellendorffii67.53e-1775.5
LLPS-Chc-0308Chondrus crispus63.643e-1569.3
LLPS-Asg-1222Ashbya gossypii62.52e-1364.7
LLPS-Crn-1017Cryptococcus neoformans61.547e-1568.6
LLPS-Yal-1223Yarrowia lipolytica60.01e-1570.5
LLPS-Tag-1666Taeniopygia guttata55.744e-1262.4
LLPS-Anc-0583Anolis carolinensis55.744e-1262.4
LLPS-Meg-1150Meleagris gallopavo55.745e-1262.4
LLPS-Pes-3306Pelodiscus sinensis55.744e-1262.0
LLPS-Otg-4396Otolemur garnettii55.745e-1262.4
LLPS-Orn-1770Oreochromis niloticus55.744e-1262.8
LLPS-Myl-3697Myotis lucifugus55.745e-1262.4
LLPS-Ora-2070Ornithorhynchus anatinus55.744e-1262.0
LLPS-Leo-2210Lepisosteus oculatus55.744e-1262.4