LLPS-Mum-0945
Nedd8
▼ OVERVIEW
Status: | Reviewed |
Protein Name: | NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8 |
Gene Name: | Nedd8, Nedd-8 |
Ensembl Gene: | ENSMUSG00000010376.15 |
Ensembl Protein: | ENSMUSP00000130492.1 |
Organism: | Mus musculus |
Taxa ID: | 10090 |
LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
Condensate | Description | Tissue/Cell | PMIDs |
---|---|---|---|
Stress granule | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSMUST00000163750.7 | ENSMUSP00000130492.1 |
Ensembl | ENSMUST00000227250.1 | ENSMUSP00000154561.1 |
Ensembl | ENSMUST00000010520.9 | ENSMUSP00000010520.8 |
UniProt | P29595, NEDD8_MOUSE | |
GeneBank | D10918, BC004625 | BAA01719.1, AAH04625.1 |
RefSeq | NM_008683.3 | NP_032709.1 |
Entrez | 18002 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK 60 61 ILGGSVLHLV LALRGGGGLG Q 81 |
Nucleotide CDS Sequence (FASTA) |
1 ATGCTAATTA AAGTGAAGAC GCTGACTGGG AAGGAGATTG AGATAGACAT CGAACCCACA 60 61 GACAAGGTGG AGCGAATCAA GGAGCGTGTG GAAGAAAAAG AAGGGATTCC CCCCCAGCAG 120 121 CAGCGGCTCA TCTACAGTGG CAAGCAAATG AATGATGAGA AGACAGCAGC TGATTACAAG 180 181 ATTCTAGGTG GTTCCGTCCT CCACCTGGTG TTGGCTCTTA GAGGAGGAGG TGGTCTTGGG 240 241 CAGTGA 246 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Protein tag | |
Molecular Function | Ubiquitin protein ligase binding | |
Biological Process | Modification-dependent protein catabolic process | |
Biological Process | Protein localization | |
Biological Process | Protein neddylation | |
Biological Process | Regulation of proteolysis | |
Biological Process | Regulation of transcription by RNA polymerase II | |
Biological Process | Response to organic cyclic compound |
▼ ANNOTATION
Disorder | ||||
IUPred2A |
Mutation | ||||
CGAP |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Localization | ||||
COMPARTMENTS | NLSdb |
Expression | ||||
ArrayExpress | GXD | TISSUES |
Element | ||||
miRWalk | RAID | microRNA.org |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Eqc-0187 | Equus caballus | 100.0 | 6e-21 | 84.7 |
LLPS-Cas-1646 | Carlito syrichta | 100.0 | 2e-28 | 103 |
LLPS-Nol-0349 | Nomascus leucogenys | 100.0 | 2e-28 | 103 |
LLPS-Ict-3265 | Ictidomys tridecemlineatus | 100.0 | 1e-28 | 103 |
LLPS-Fec-0097 | Felis catus | 100.0 | 2e-28 | 103 |
LLPS-Hos-0460 | Homo sapiens | 100.0 | 2e-28 | 103 |
LLPS-Pap-1926 | Pan paniscus | 100.0 | 2e-28 | 103 |
LLPS-Man-1000 | Macaca nemestrina | 100.0 | 2e-28 | 103 |
LLPS-Rhb-3756 | Rhinopithecus bieti | 100.0 | 2e-28 | 103 |
LLPS-Orc-2625 | Oryctolagus cuniculus | 100.0 | 2e-28 | 103 |
LLPS-Bot-3469 | Bos taurus | 100.0 | 2e-28 | 103 |
LLPS-Dio-3331 | Dipodomys ordii | 100.0 | 2e-28 | 103 |
LLPS-Ere-0211 | Erinaceus europaeus | 100.0 | 2e-28 | 103 |
LLPS-Ran-1231 | Rattus norvegicus | 100.0 | 1e-28 | 103 |
LLPS-Mal-1473 | Mandrillus leucophaeus | 100.0 | 2e-28 | 103 |
LLPS-Paa-3245 | Papio anubis | 100.0 | 2e-28 | 103 |
LLPS-Maf-1344 | Macaca fascicularis | 100.0 | 2e-28 | 103 |
LLPS-Mea-0636 | Mesocricetus auratus | 100.0 | 1e-28 | 103 |
LLPS-Sus-3636 | Sus scrofa | 100.0 | 2e-21 | 85.5 |
LLPS-Aon-1952 | Aotus nancymaae | 100.0 | 2e-28 | 103 |
LLPS-Cea-2667 | Cercocebus atys | 100.0 | 3e-24 | 93.2 |
LLPS-Gog-4316 | Gorilla gorilla | 100.0 | 2e-24 | 93.2 |
LLPS-Ten-2916 | Tetraodon nigroviridis | 98.48 | 2e-27 | 100 |
LLPS-Poa-1354 | Pongo abelii | 98.48 | 2e-27 | 101 |
LLPS-Xet-2345 | Xenopus tropicalis | 98.48 | 2e-27 | 101 |
LLPS-Gaga-2631 | Gallus gallus | 98.48 | 3e-27 | 100 |
LLPS-Scm-3562 | Scophthalmus maximus | 98.48 | 3e-27 | 100 |
LLPS-Lac-2779 | Latimeria chalumnae | 98.48 | 1e-27 | 101 |
LLPS-Dar-3409 | Danio rerio | 98.48 | 1e-27 | 101 |
LLPS-Pof-2683 | Poecilia formosa | 98.48 | 1e-27 | 101 |
LLPS-Tar-3287 | Takifugu rubripes | 98.48 | 1e-27 | 102 |
LLPS-Xim-0031 | Xiphophorus maculatus | 98.48 | 2e-27 | 100 |
LLPS-Scf-2667 | Scleropages formosus | 98.48 | 7e-27 | 101 |
LLPS-Gaa-0491 | Gasterosteus aculeatus | 98.48 | 1e-27 | 101 |
LLPS-Icp-2570 | Ictalurus punctatus | 98.48 | 2e-27 | 101 |
LLPS-Fud-1954 | Fukomys damarensis | 98.48 | 7e-28 | 102 |
LLPS-Asm-1012 | Astyanax mexicanus | 98.48 | 1e-27 | 102 |
LLPS-Caf-0202 | Canis familiaris | 98.36 | 2e-24 | 93.2 |
LLPS-Aim-1413 | Ailuropoda melanoleuca | 98.36 | 2e-24 | 93.2 |
LLPS-Urm-1842 | Ursus maritimus | 96.88 | 1e-25 | 96.7 |
LLPS-Pat-2161 | Pan troglodytes | 96.77 | 2e-24 | 93.6 |
LLPS-Ova-1662 | Ovis aries | 96.77 | 2e-24 | 93.6 |
LLPS-Mup-0093 | Mustela putorius furo | 96.77 | 2e-24 | 93.6 |
LLPS-Loa-2467 | Loxodonta africana | 95.45 | 7e-26 | 97.1 |
LLPS-Mod-0882 | Monodelphis domestica | 95.16 | 1e-23 | 90.9 |
LLPS-Cap-2611 | Cavia porcellus | 94.12 | 3e-25 | 95.5 |
LLPS-Chs-2712 | Chlorocebus sabaeus | 93.94 | 1e-26 | 99.0 |
LLPS-Orl-0688 | Oryzias latipes | 93.94 | 1e-23 | 91.7 |
LLPS-Tut-1606 | Tursiops truncatus | 92.42 | 3e-23 | 90.1 |
LLPS-Drm-1346 | Drosophila melanogaster | 92.42 | 5e-26 | 97.4 |
LLPS-Fia-1910 | Ficedula albicollis | 90.91 | 5e-24 | 92.0 |
LLPS-Sah-3702 | Sarcophilus harrisii | 90.91 | 3e-24 | 92.8 |
LLPS-Caj-0638 | Callithrix jacchus | 90.91 | 9e-26 | 96.7 |
LLPS-Cii-0986 | Ciona intestinalis | 89.39 | 1e-23 | 91.3 |
LLPS-Cae-0696 | Caenorhabditis elegans | 86.36 | 8e-25 | 94.4 |
LLPS-Osl-0944 | Ostreococcus lucimarinus | 86.15 | 1e-21 | 85.9 |
LLPS-Php-0629 | Physcomitrella patens | 83.08 | 2e-20 | 84.7 |
LLPS-Amt-0908 | Amborella trichopoda | 81.82 | 5e-22 | 87.4 |
LLPS-Gas-0026 | Galdieria sulphuraria | 81.82 | 4e-18 | 83.2 |
LLPS-Chr-0965 | Chlamydomonas reinhardtii | 81.82 | 6e-21 | 86.3 |
LLPS-Orr-1672 | Oryza rufipogon | 81.54 | 4e-20 | 84.0 |
LLPS-Bro-0227 | Brassica oleracea | 81.54 | 5e-20 | 84.0 |
LLPS-Tru-1008 | Triticum urartu | 81.54 | 5e-20 | 84.0 |
LLPS-Org-1705 | Oryza glaberrima | 81.54 | 5e-20 | 84.0 |
LLPS-Ors-0846 | Oryza sativa | 81.54 | 5e-20 | 84.0 |
LLPS-Art-0087 | Arabidopsis thaliana | 81.54 | 5e-20 | 84.0 |
LLPS-Gor-0256 | Gossypium raimondii | 81.54 | 4e-20 | 84.0 |
LLPS-Viv-1970 | Vitis vinifera | 81.54 | 4e-20 | 84.0 |
LLPS-Sob-1893 | Sorghum bicolor | 81.54 | 5e-20 | 84.0 |
LLPS-Orbr-1085 | Oryza brachyantha | 81.54 | 4e-20 | 84.0 |
LLPS-Nia-2595 | Nicotiana attenuata | 81.54 | 4e-20 | 84.0 |
LLPS-Mae-1560 | Manihot esculenta | 81.54 | 4e-20 | 84.0 |
LLPS-Sot-1346 | Solanum tuberosum | 81.54 | 4e-20 | 84.0 |
LLPS-Tra-1216 | Triticum aestivum | 81.54 | 5e-20 | 84.0 |
LLPS-Brd-0283 | Brachypodium distachyon | 81.54 | 5e-20 | 84.0 |
LLPS-Hov-1414 | Hordeum vulgare | 81.54 | 8e-20 | 84.0 |
LLPS-Sei-0006 | Setaria italica | 81.54 | 5e-20 | 84.0 |
LLPS-Arl-1417 | Arabidopsis lyrata | 81.54 | 5e-20 | 83.6 |
LLPS-Sol-0799 | Solanum lycopersicum | 81.54 | 1e-20 | 83.6 |
LLPS-Ori-1969 | Oryza indica | 81.54 | 5e-20 | 84.0 |
LLPS-Brn-3059 | Brassica napus | 81.54 | 5e-20 | 84.0 |
LLPS-Hea-2440 | Helianthus annuus | 81.54 | 5e-20 | 84.0 |
LLPS-Thc-2518 | Theobroma cacao | 81.54 | 4e-20 | 84.0 |
LLPS-Usm-1101 | Ustilago maydis | 80.3 | 2e-20 | 83.2 |
LLPS-Spr-0987 | Sporisorium reilianum | 80.3 | 1e-20 | 83.6 |
LLPS-Abg-0560 | Absidia glauca | 80.3 | 3e-20 | 82.4 |
LLPS-Mua-0405 | Musa acuminata | 80.3 | 3e-20 | 84.3 |
LLPS-Coc-0913 | Corchorus capsularis | 80.0 | 2e-19 | 82.4 |
LLPS-Prp-1661 | Prunus persica | 80.0 | 2e-19 | 82.4 |
LLPS-Zem-0849 | Zea mays | 80.0 | 3e-19 | 81.6 |
LLPS-Pot-2702 | Populus trichocarpa | 80.0 | 3e-20 | 84.3 |
LLPS-Phv-1050 | Phaseolus vulgaris | 80.0 | 2e-19 | 82.0 |
LLPS-Met-0627 | Medicago truncatula | 80.0 | 2e-19 | 82.4 |
LLPS-Glm-2832 | Glycine max | 80.0 | 2e-19 | 82.0 |
LLPS-Scp-0936 | Schizosaccharomyces pombe | 78.79 | 1e-19 | 80.9 |
LLPS-Scj-1328 | Schizosaccharomyces japonicus | 78.79 | 3e-20 | 82.4 |
LLPS-Scc-1042 | Schizosaccharomyces cryophilus | 78.79 | 2e-19 | 80.1 |
LLPS-Phn-0903 | Phaeosphaeria nodorum | 78.46 | 3e-18 | 77.0 |
LLPS-Zyt-0907 | Zymoseptoria tritici | 77.78 | 3e-18 | 77.4 |
LLPS-Pyt-0010 | Pyrenophora teres | 76.92 | 8e-18 | 76.3 |
LLPS-Lem-1463 | Leptosphaeria maculans | 76.92 | 3e-17 | 74.7 |
LLPS-Asc-0314 | Aspergillus clavatus | 76.92 | 8e-18 | 76.3 |
LLPS-Asn-1532 | Aspergillus nidulans | 76.92 | 1e-17 | 75.5 |
LLPS-Pytr-1174 | Pyrenophora triticirepentis | 75.38 | 5e-17 | 74.3 |
LLPS-Dos-0881 | Dothistroma septosporum | 75.38 | 3e-17 | 74.3 |
LLPS-Asni-0670 | Aspergillus niger | 75.38 | 3e-17 | 74.7 |
LLPS-Mao-0897 | Magnaporthe oryzae | 75.38 | 2e-17 | 75.5 |
LLPS-Beb-0986 | Beauveria bassiana | 75.0 | 7e-18 | 76.3 |
LLPS-Mam-1928 | Macaca mulatta | 74.19 | 2e-21 | 85.5 |
LLPS-Tum-0907 | Tuber melanosporum | 73.85 | 6e-17 | 73.9 |
LLPS-Map-0759 | Magnaporthe poae | 73.85 | 4e-17 | 74.3 |
LLPS-Nec-0905 | Neurospora crassa | 72.31 | 6e-17 | 73.9 |
LLPS-Gag-0799 | Gaeumannomyces graminis | 72.31 | 1e-16 | 72.8 |
LLPS-Fuo-1064 | Fusarium oxysporum | 71.88 | 1e-15 | 70.9 |
LLPS-Trv-0774 | Trichoderma virens | 71.88 | 3e-16 | 72.0 |
LLPS-Trr-0394 | Trichoderma reesei | 71.88 | 1e-15 | 70.9 |
LLPS-Fus-0504 | Fusarium solani | 71.88 | 6e-16 | 71.2 |
LLPS-Fuv-0134 | Fusarium verticillioides | 71.88 | 1e-15 | 70.9 |
LLPS-Cym-0976 | Cyanidioschyzon merolae | 71.21 | 6e-19 | 79.7 |
LLPS-Asfu-0537 | Aspergillus fumigatus | 70.77 | 1e-15 | 70.5 |
LLPS-Nef-0869 | Neosartorya fischeri | 70.77 | 1e-15 | 70.5 |
LLPS-Mel-1514 | Melampsora laricipopulina | 69.7 | 2e-15 | 70.1 |
LLPS-Cogr-0194 | Colletotrichum graminicola | 69.23 | 9e-15 | 68.2 |
LLPS-Miv-0211 | Microbotryum violaceum | 69.23 | 5e-16 | 71.6 |
LLPS-Cog-0740 | Colletotrichum gloeosporioides | 69.23 | 9e-15 | 68.2 |
LLPS-Blg-1134 | Blumeria graminis | 69.23 | 8e-16 | 70.9 |
LLPS-Coo-0866 | Colletotrichum orbiculare | 69.23 | 7e-15 | 68.6 |
LLPS-Ved-0561 | Verticillium dahliae | 67.69 | 2e-14 | 67.4 |
LLPS-Pug-1054 | Puccinia graminis | 67.69 | 2e-15 | 69.7 |
LLPS-Sem-0197 | Selaginella moellendorffii | 67.5 | 3e-17 | 75.5 |
LLPS-Chc-0308 | Chondrus crispus | 63.64 | 3e-15 | 69.3 |
LLPS-Asg-1222 | Ashbya gossypii | 62.5 | 2e-13 | 64.7 |
LLPS-Crn-1017 | Cryptococcus neoformans | 61.54 | 7e-15 | 68.6 |
LLPS-Yal-1223 | Yarrowia lipolytica | 60.0 | 1e-15 | 70.5 |
LLPS-Tag-1666 | Taeniopygia guttata | 55.74 | 4e-12 | 62.4 |
LLPS-Anc-0583 | Anolis carolinensis | 55.74 | 4e-12 | 62.4 |
LLPS-Meg-1150 | Meleagris gallopavo | 55.74 | 5e-12 | 62.4 |
LLPS-Pes-3306 | Pelodiscus sinensis | 55.74 | 4e-12 | 62.0 |
LLPS-Otg-4396 | Otolemur garnettii | 55.74 | 5e-12 | 62.4 |
LLPS-Orn-1770 | Oreochromis niloticus | 55.74 | 4e-12 | 62.8 |
LLPS-Myl-3697 | Myotis lucifugus | 55.74 | 5e-12 | 62.4 |
LLPS-Ora-2070 | Ornithorhynchus anatinus | 55.74 | 4e-12 | 62.0 |
LLPS-Leo-2210 | Lepisosteus oculatus | 55.74 | 4e-12 | 62.4 |