LLPS-Mum-0884
Psmb1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Proteasome subunit beta type-1; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain |
| Gene Name: | Psmb1 |
| Ensembl Gene: | ENSMUSG00000014769.10 |
| Ensembl Protein: | ENSMUSP00000156355.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|
▼ FUNCTION
| Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000231341.1 | ENSMUSP00000156355.1 |
| Ensembl | ENSMUST00000232500.1 | ENSMUSP00000156359.1 |
| Ensembl | ENSMUST00000014913.10 | ENSMUSP00000014913.8 |
| UniProt | O09061, PSB1_MOUSE, Q62038, Q62039 | |
| GeneBank | U60824, X80686, AK077520, BC018351 | BAC36841.1, CAA56701.1, AAH18351.1, AAB37251.1, CAA56702.1 |
| RefSeq | NM_011185.3 | NP_035315.1 |
| Entrez | 19170 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLSTAAYRDV ERELGMGPHG SAGPVQLRFS PYAFNGGTVL AIAGEDFSIV ASDTRLSEGF 60 61 SIHTRDSPKC YKLTDKTVIG CSGFHGDCLT LTKIIEARLK MYKHSNNKAM TTGAIAAMLS 120 121 TILYSRRFFP YYVYNIIGGL DEEGKGAVYS FDPVGSYQRD SFKAGGSASA MLQPLLDNQV 180 181 GFKNMQNVEH VPLTLDRAMR LVKDVFISAA ERDVYTGDAL RICIVTKEGI REETVPLRKD 240 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTTTCCA CTGCTGCTTA CCGAGACGTG GAACGAGAGC TGGGAATGGG GCCTCACGGC 60 61 TCCGCCGGCC CTGTGCAGCT GCGGTTTTCG CCTTATGCCT TCAACGGAGG TACTGTATTG 120 121 GCAATTGCTG GAGAAGATTT TTCCATCGTC GCTTCAGACA CTCGATTGAG TGAAGGATTT 180 181 TCAATTCATA CCCGAGATAG CCCCAAATGC TACAAACTGA CAGACAAGAC AGTAATTGGC 240 241 TGCAGTGGTT TCCATGGAGA TTGTCTCACT TTGACAAAGA TTATTGAAGC AAGATTAAAG 300 301 ATGTACAAGC ATTCCAATAA CAAGGCCATG ACAACGGGGG CGATTGCTGC AATGCTGTCT 360 361 ACCATCCTGT ACTCACGGCG CTTCTTCCCT TACTATGTTT ACAACATCAT TGGAGGACTT 420 421 GATGAAGAAG GAAAGGGAGC TGTGTACAGC TTTGACCCAG TGGGCTCTTA CCAGAGAGAC 480 481 TCTTTCAAGG CGGGAGGCTC AGCAAGTGCC ATGCTGCAGC CTCTGCTCGA CAACCAGGTT 540 541 GGCTTCAAAA ATATGCAGAA TGTAGAGCAC GTCCCCCTGA CGCTGGACAG AGCCATGAGG 600 601 CTGGTGAAAG ATGTCTTCAT TTCTGCAGCC GAGAGGGATG TGTATACTGG AGATGCTCTC 660 661 AGGATCTGCA TCGTGACCAA AGAGGGCATC AGGGAGGAAA CTGTTCCCCT GCGGAAAGAC 720 721 TGA 723 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Proteasome complex | |
Cellular Component | Proteasome core complex | |
Cellular Component | Proteasome core complex, beta-subunit complex | |
Molecular Function | Endopeptidase activity | |
Molecular Function | Threonine-type endopeptidase activity | |
Biological Process | Proteasomal protein catabolic process | |
Biological Process | Proteasomal ubiquitin-independent protein catabolic process | |
Biological Process | Proteasome-mediated ubiquitin-dependent protein catabolic process |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-0340 | Macaca mulatta | 99.01 | 8e-148 | 418 |
| LLPS-Ict-2312 | Ictidomys tridecemlineatus | 98.19 | 1e-160 | 452 |
| LLPS-Mup-0331 | Mustela putorius furo | 98.03 | 1e-146 | 415 |
| LLPS-Ran-2372 | Rattus norvegicus | 97.92 | 4e-174 | 486 |
| LLPS-Mea-2232 | Mesocricetus auratus | 97.5 | 1e-173 | 485 |
| LLPS-Cas-2428 | Carlito syrichta | 96.51 | 2e-164 | 462 |
| LLPS-Caj-0983 | Callithrix jacchus | 95.8 | 4e-168 | 471 |
| LLPS-Aon-0447 | Aotus nancymaae | 94.96 | 3e-167 | 469 |
| LLPS-Maf-3196 | Macaca fascicularis | 94.61 | 1e-167 | 470 |
| LLPS-Man-0939 | Macaca nemestrina | 94.61 | 1e-167 | 470 |
| LLPS-Sus-0831 | Sus scrofa | 94.54 | 2e-166 | 466 |
| LLPS-Cea-0015 | Cercocebus atys | 94.54 | 4e-167 | 469 |
| LLPS-Chs-2229 | Chlorocebus sabaeus | 94.54 | 3e-166 | 466 |
| LLPS-Mal-0728 | Mandrillus leucophaeus | 94.54 | 4e-167 | 469 |
| LLPS-Poa-1810 | Pongo abelii | 94.54 | 2e-166 | 466 |
| LLPS-Fud-0270 | Fukomys damarensis | 94.17 | 7e-167 | 468 |
| LLPS-Bot-1070 | Bos taurus | 94.12 | 5e-167 | 468 |
| LLPS-Paa-0622 | Papio anubis | 94.12 | 5e-166 | 466 |
| LLPS-Ova-2335 | Ovis aries | 94.12 | 7e-167 | 468 |
| LLPS-Rhb-0287 | Rhinopithecus bieti | 94.12 | 6e-166 | 466 |
| LLPS-Nol-2464 | Nomascus leucogenys | 94.12 | 4e-166 | 466 |
| LLPS-Mod-2079 | Monodelphis domestica | 93.94 | 3e-160 | 451 |
| LLPS-Sah-0396 | Sarcophilus harrisii | 93.91 | 1e-159 | 450 |
| LLPS-Otg-0387 | Otolemur garnettii | 93.91 | 8e-162 | 455 |
| LLPS-Loa-0683 | Loxodonta africana | 93.78 | 1e-146 | 415 |
| LLPS-Orc-1108 | Oryctolagus cuniculus | 93.78 | 3e-164 | 461 |
| LLPS-Hos-3146 | Homo sapiens | 93.7 | 5e-165 | 463 |
| LLPS-Pap-0695 | Pan paniscus | 93.7 | 5e-165 | 463 |
| LLPS-Pat-1290 | Pan troglodytes | 93.7 | 5e-165 | 463 |
| LLPS-Dio-0745 | Dipodomys ordii | 93.36 | 1e-163 | 460 |
| LLPS-Myl-3101 | Myotis lucifugus | 93.0 | 6e-162 | 455 |
| LLPS-Aim-3861 | Ailuropoda melanoleuca | 92.95 | 9e-164 | 460 |
| LLPS-Urm-0245 | Ursus maritimus | 92.95 | 1e-162 | 457 |
| LLPS-Eqc-1171 | Equus caballus | 92.95 | 1e-160 | 459 |
| LLPS-Caf-0994 | Canis familiaris | 92.82 | 5e-117 | 339 |
| LLPS-Cap-1553 | Cavia porcellus | 92.53 | 8e-164 | 460 |
| LLPS-Fec-1291 | Felis catus | 91.7 | 4e-162 | 456 |
| LLPS-Gog-1518 | Gorilla gorilla | 90.85 | 2e-90 | 271 |
| LLPS-Anp-1443 | Anas platyrhynchos | 90.64 | 1e-138 | 395 |
| LLPS-Tag-2850 | Taeniopygia guttata | 90.15 | 9e-138 | 392 |
| LLPS-Lac-0567 | Latimeria chalumnae | 88.67 | 1e-135 | 387 |
| LLPS-Pes-0174 | Pelodiscus sinensis | 87.77 | 5e-145 | 412 |
| LLPS-Fia-0253 | Ficedula albicollis | 85.89 | 2e-150 | 426 |
| LLPS-Meg-0938 | Meleagris gallopavo | 85.83 | 4e-152 | 431 |
| LLPS-Orl-0032 | Oryzias latipes | 85.78 | 2e-146 | 416 |
| LLPS-Asm-3115 | Astyanax mexicanus | 85.52 | 1e-144 | 411 |
| LLPS-Gaga-2707 | Gallus gallus | 85.0 | 3e-151 | 428 |
| LLPS-Xim-0761 | Xiphophorus maculatus | 84.44 | 2e-144 | 410 |
| LLPS-Leo-1577 | Lepisosteus oculatus | 84.17 | 5e-150 | 425 |
| LLPS-Pof-2625 | Poecilia formosa | 84.0 | 6e-144 | 409 |
| LLPS-Ora-0187 | Ornithorhynchus anatinus | 83.67 | 5e-86 | 262 |
| LLPS-Orn-2832 | Oreochromis niloticus | 82.5 | 4e-147 | 418 |
| LLPS-Anc-1404 | Anolis carolinensis | 82.16 | 3e-145 | 413 |
| LLPS-Gaa-1672 | Gasterosteus aculeatus | 82.08 | 3e-146 | 415 |
| LLPS-Scf-2918 | Scleropages formosus | 82.08 | 4e-147 | 418 |
| LLPS-Dar-3168 | Danio rerio | 81.67 | 4e-147 | 417 |
| LLPS-Scm-0080 | Scophthalmus maximus | 81.25 | 1e-145 | 414 |
| LLPS-Icp-1416 | Ictalurus punctatus | 80.83 | 3e-146 | 415 |
| LLPS-Tar-1174 | Takifugu rubripes | 80.83 | 2e-145 | 414 |
| LLPS-Ten-2333 | Tetraodon nigroviridis | 79.17 | 2e-140 | 401 |
| LLPS-Xet-1314 | Xenopus tropicalis | 73.55 | 9e-128 | 369 |
| LLPS-Cii-1500 | Ciona intestinalis | 58.56 | 3e-93 | 281 |
| LLPS-Abg-0495 | Absidia glauca | 53.33 | 3e-86 | 263 |
| LLPS-Crn-1007 | Cryptococcus neoformans | 52.31 | 1e-72 | 229 |
| LLPS-Drm-0396 | Drosophila melanogaster | 51.87 | 9e-81 | 249 |
| LLPS-Hov-0413 | Hordeum vulgare | 50.7 | 9e-68 | 216 |
| LLPS-Tra-0180 | Triticum aestivum | 50.7 | 4e-68 | 216 |
| LLPS-Tru-1330 | Triticum urartu | 50.24 | 2e-65 | 208 |
| LLPS-Brd-1475 | Brachypodium distachyon | 50.23 | 9e-68 | 215 |
| LLPS-Mua-1288 | Musa acuminata | 49.77 | 5e-67 | 213 |
| LLPS-Pot-2522 | Populus trichocarpa | 49.77 | 4e-70 | 221 |
| LLPS-Spr-1137 | Sporisorium reilianum | 49.51 | 5e-68 | 218 |
| LLPS-Kop-0542 | Komagataella pastoris | 49.33 | 1e-71 | 226 |
| LLPS-Orgl-1048 | Oryza glumaepatula | 49.3 | 1e-65 | 211 |
| LLPS-Sei-1570 | Setaria italica | 49.3 | 1e-66 | 212 |
| LLPS-Zem-0790 | Zea mays | 49.3 | 4e-66 | 211 |
| LLPS-Sem-0554 | Selaginella moellendorffii | 49.08 | 4e-68 | 216 |
| LLPS-Php-0181 | Physcomitrella patens | 49.07 | 9e-74 | 231 |
| LLPS-Nec-0364 | Neurospora crassa | 48.95 | 4e-71 | 225 |
| LLPS-Dac-0010 | Daucus carota | 48.86 | 1e-68 | 217 |
| LLPS-Orb-1950 | Oryza barthii | 48.83 | 2e-65 | 211 |
| LLPS-Orni-0375 | Oryza nivara | 48.83 | 1e-65 | 211 |
| LLPS-Lep-1892 | Leersia perrieri | 48.83 | 4e-66 | 211 |
| LLPS-Ors-1181 | Oryza sativa | 48.83 | 5e-66 | 211 |
| LLPS-Orm-0421 | Oryza meridionalis | 48.83 | 5e-66 | 211 |
| LLPS-Org-0416 | Oryza glaberrima | 48.83 | 5e-66 | 211 |
| LLPS-Mae-0520 | Manihot esculenta | 48.64 | 1e-67 | 215 |
| LLPS-Brn-0187 | Brassica napus | 48.39 | 7e-69 | 218 |
| LLPS-Orp-1805 | Oryza punctata | 48.39 | 9e-69 | 218 |
| LLPS-Brr-0590 | Brassica rapa | 48.39 | 5e-69 | 218 |
| LLPS-Bro-2140 | Brassica oleracea | 48.39 | 5e-69 | 218 |
| LLPS-Orbr-1910 | Oryza brachyantha | 48.36 | 6e-66 | 210 |
| LLPS-Ved-0090 | Verticillium dahliae | 48.28 | 8e-68 | 216 |
| LLPS-Arl-0421 | Arabidopsis lyrata | 48.15 | 8e-69 | 218 |
| LLPS-Asg-0632 | Ashbya gossypii | 48.0 | 2e-72 | 228 |
| LLPS-Viv-0038 | Vitis vinifera | 47.95 | 3e-66 | 211 |
| LLPS-Sob-1148 | Sorghum bicolor | 47.93 | 4e-68 | 216 |
| LLPS-Hea-0328 | Helianthus annuus | 47.69 | 2e-65 | 209 |
| LLPS-Map-0017 | Magnaporthe poae | 47.68 | 3e-69 | 220 |
| LLPS-Gas-0225 | Galdieria sulphuraria | 47.66 | 2e-64 | 206 |
| LLPS-Amt-0211 | Amborella trichopoda | 47.6 | 6e-70 | 221 |
| LLPS-Cus-0128 | Cucumis sativus | 47.49 | 3e-67 | 214 |
| LLPS-Gor-1659 | Gossypium raimondii | 47.49 | 6e-66 | 210 |
| LLPS-Ori-0117 | Oryza indica | 47.47 | 1e-66 | 212 |
| LLPS-Prp-1052 | Prunus persica | 47.47 | 7e-65 | 207 |
| LLPS-Orr-0343 | Oryza rufipogon | 47.47 | 1e-66 | 212 |
| LLPS-Gag-1358 | Gaeumannomyces graminis | 47.3 | 1e-69 | 221 |
| LLPS-Thc-2319 | Theobroma cacao | 47.27 | 3e-65 | 208 |
| LLPS-Coc-1598 | Corchorus capsularis | 47.25 | 2e-66 | 211 |
| LLPS-Art-0325 | Arabidopsis thaliana | 47.22 | 7e-67 | 213 |
| LLPS-Sol-0022 | Solanum lycopersicum | 47.03 | 3e-67 | 214 |
| LLPS-Sot-0487 | Solanum tuberosum | 47.03 | 2e-67 | 214 |
| LLPS-Vir-0518 | Vigna radiata | 46.76 | 8e-65 | 207 |
| LLPS-Glm-0031 | Glycine max | 46.58 | 7e-66 | 210 |
| LLPS-Coo-0700 | Colletotrichum orbiculare | 46.58 | 8e-65 | 209 |
| LLPS-Nia-0927 | Nicotiana attenuata | 46.58 | 3e-66 | 211 |
| LLPS-Cogr-0670 | Colletotrichum graminicola | 46.58 | 8e-66 | 211 |
| LLPS-Scj-0888 | Schizosaccharomyces japonicus | 46.56 | 4e-57 | 187 |
| LLPS-Chr-0045 | Chlamydomonas reinhardtii | 46.54 | 6e-66 | 211 |
| LLPS-Usm-0557 | Ustilago maydis | 46.49 | 2e-67 | 217 |
| LLPS-Trv-0041 | Trichoderma virens | 46.47 | 2e-67 | 216 |
| LLPS-Mao-0812 | Magnaporthe oryzae | 46.41 | 2e-66 | 213 |
| LLPS-Met-0841 | Medicago truncatula | 46.33 | 2e-63 | 204 |
| LLPS-Osl-0538 | Ostreococcus lucimarinus | 46.29 | 3e-67 | 214 |
| LLPS-Trr-1020 | Trichoderma reesei | 46.06 | 6e-67 | 214 |
| LLPS-Miv-1333 | Microbotryum violaceum | 46.05 | 4e-61 | 199 |
| LLPS-Cym-0503 | Cyanidioschyzon merolae | 45.91 | 1e-61 | 200 |
| LLPS-Beb-0394 | Beauveria bassiana | 45.87 | 8e-67 | 214 |
| LLPS-Yal-0607 | Yarrowia lipolytica | 45.8 | 1e-75 | 236 |
| LLPS-Lem-0579 | Leptosphaeria maculans | 45.8 | 2e-65 | 210 |
| LLPS-Scp-1411 | Schizosaccharomyces pombe | 45.74 | 7e-68 | 215 |
| LLPS-Fuv-0401 | Fusarium verticillioides | 45.69 | 1e-64 | 208 |
| LLPS-Cog-0296 | Colletotrichum gloeosporioides | 45.69 | 3e-64 | 207 |
| LLPS-Fuo-0246 | Fusarium oxysporum | 45.69 | 1e-64 | 208 |
| LLPS-Scc-0158 | Schizosaccharomyces cryophilus | 45.45 | 1e-68 | 217 |
| LLPS-Blg-0110 | Blumeria graminis | 45.45 | 5e-66 | 212 |
| LLPS-Fus-0839 | Fusarium solani | 45.3 | 3e-65 | 210 |
| LLPS-Dos-0632 | Dothistroma septosporum | 45.04 | 2e-65 | 211 |
| LLPS-Ast-0298 | Aspergillus terreus | 45.02 | 4e-62 | 202 |
| LLPS-Pyt-0267 | Pyrenophora teres | 44.96 | 2e-65 | 210 |
| LLPS-Aso-0297 | Aspergillus oryzae | 44.59 | 3e-62 | 202 |
| LLPS-Asf-0669 | Aspergillus flavus | 44.59 | 3e-62 | 202 |
| LLPS-Pytr-0176 | Pyrenophora triticirepentis | 44.54 | 9e-65 | 209 |
| LLPS-Phn-0420 | Phaeosphaeria nodorum | 44.54 | 6e-64 | 207 |
| LLPS-Chc-0378 | Chondrus crispus | 44.4 | 2e-65 | 211 |
| LLPS-Sac-0976 | Saccharomyces cerevisiae | 44.21 | 2e-64 | 207 |
| LLPS-Asni-0672 | Aspergillus niger | 44.16 | 2e-61 | 200 |
| LLPS-Asc-0345 | Aspergillus clavatus | 43.72 | 2e-61 | 200 |
| LLPS-Asfu-0805 | Aspergillus fumigatus | 43.72 | 2e-60 | 197 |
| LLPS-Mel-1070 | Melampsora laricipopulina | 43.7 | 4e-63 | 204 |
| LLPS-Zyt-0273 | Zymoseptoria tritici | 43.7 | 3e-61 | 199 |
| LLPS-Pug-1148 | Puccinia graminis | 43.61 | 2e-59 | 194 |
| LLPS-Nef-0348 | Neosartorya fischeri | 43.51 | 6e-61 | 199 |
| LLPS-Phv-0497 | Phaseolus vulgaris | 43.22 | 5e-47 | 160 |
| LLPS-Put-0333 | Puccinia triticina | 43.16 | 5e-61 | 200 |
| LLPS-Asn-0512 | Aspergillus nidulans | 42.68 | 1e-61 | 200 |
| LLPS-Tum-0368 | Tuber melanosporum | 41.63 | 7e-47 | 162 |
| LLPS-Cae-0145 | Caenorhabditis elegans | 40.66 | 2e-55 | 184 |
| LLPS-Via-0845 | Vigna angularis | 39.35 | 1e-43 | 152 |
| LLPS-Ere-0721 | Erinaceus europaeus | 28.04 | 9e-20 | 89.0 |