LLPS-Mum-0701
Eif2s3x

▼ OVERVIEW

Status: Reviewed
Protein Name: Eukaryotic translation initiation factor 2 subunit 3, X-linked; Eukaryotic translation initiation factor 2 subunit gamma, X-linked; eIF-2-gamma X
Gene Name: Eif2s3x
Ensembl Gene: ENSMUSG00000035150.15
Ensembl Protein: ENSMUSP00000109555.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granulePredicted from orthologsN/A(View)

▼ FUNCTION

As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (PubMed:26823431).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGGEGGVTL  GQPHLSRQDL  ATLDVTKLTP  LSHEVISRQA  TINIGTIGHV  AHGKSTVVKA  60
61    ISGVHTVRFK  NELERNITIK  LGYANAKIYK  LDDPSCPRPE  CYRSCGSSTP  DEFPTDIPGT  120
121   KGNFKLVRHV  SFVDCPGHDI  LMATMLNGAA  VMDAALLLIA  GNESCPQPQT  SEHLAAIEIM  180
181   KLKHILILQN  KIDLVKESQA  KEQYEQILAF  VQGTVAEGAP  IIPISAQLKY  NIEVVCEYIV  240
241   KKIPVPPRDF  TSEPRLIVIR  SFDVNKPGCE  VDDLKGGVAG  GSILKGVLKV  GQEIEVRPGI  300
301   VSKDSEGKLM  CKPIFSKIVS  LFAEHNDLQY  AAPGGLIGVG  TKIDPTLCRA  DRMVGQVLGA  360
361   VGALPEIFTE  LEISYFLLRR  LLGVRTEGDK  KAAKVQKLSK  NEVLMVNIGS  LSTGGRVSAV  420
421   KADLGKIVLT  NPVCTEVGEK  IALSRRVEKH  WRLIGWGQIR  RGVTIKPTVD  DD  472
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGGGG  GTGAGGGTGG  AGTGACTCTC  GGTCAGCCCC  ATCTTTCCCG  ACAGGATCTC  60
61    GCCACATTGG  ATGTTACCAA  GTTGACACCA  CTTTCACATG  AAGTTATCAG  CAGACAAGCT  120
121   ACAATTAATA  TTGGTACAAT  TGGTCACGTA  GCTCATGGGA  AGTCCACTGT  GGTGAAGGCT  180
181   ATTTCTGGAG  TTCACACTGT  CAGATTCAAA  AATGAACTCG  AAAGGAACAT  TACCATCAAG  240
241   CTTGGATATG  CTAATGCTAA  GATTTATAAA  CTTGATGACC  CAAGTTGTCC  TAGACCAGAA  300
301   TGTTACAGAT  CGTGTGGAAG  CAGCACACCA  GATGAGTTTC  CTACAGACAT  TCCGGGGACC  360
361   AAAGGGAACT  TCAAGTTAGT  CAGGCATGTT  TCCTTTGTTG  ACTGTCCTGG  CCATGATATT  420
421   TTGATGGCTA  CGATGCTGAA  CGGTGCAGCA  GTGATGGATG  CGGCCCTTCT  GTTGATAGCT  480
481   GGTAACGAAT  CATGCCCTCA  GCCCCAGACT  TCCGAACACC  TGGCTGCCAT  AGAAATCATG  540
541   AAACTCAAGC  ATATTTTGAT  CTTACAGAAT  AAAATTGATC  TGGTAAAAGA  AAGTCAGGCT  600
601   AAGGAACAAT  ATGAGCAAAT  CCTCGCATTT  GTGCAAGGAA  CCGTAGCAGA  AGGGGCACCA  660
661   ATTATTCCAA  TTTCTGCTCA  ACTGAAGTAC  AATATTGAAG  TTGTCTGTGA  GTATATAGTG  720
721   AAGAAAATAC  CAGTGCCCCC  AAGAGACTTT  ACTTCAGAGC  CCCGTCTCAT  TGTCATCAGG  780
781   TCATTTGATG  TCAACAAACC  TGGCTGTGAA  GTCGATGACC  TTAAGGGAGG  TGTAGCTGGT  840
841   GGTAGTATCC  TAAAAGGAGT  GTTAAAGGTA  GGCCAGGAGA  TAGAAGTGAG  ACCCGGTATT  900
901   GTCTCCAAAG  ACAGTGAAGG  AAAACTCATG  TGTAAACCAA  TCTTTTCCAA  AATTGTGTCA  960
961   CTTTTTGCGG  AACATAATGA  TCTTCAATAT  GCTGCCCCGG  GTGGTCTCAT  TGGAGTTGGA  1020
1021  ACAAAGATCG  ACCCCACCTT  GTGCCGAGCT  GACAGAATGG  TGGGACAAGT  GCTCGGTGCA  1080
1081  GTTGGAGCTT  TACCTGAAAT  ATTCACCGAA  CTGGAGATTT  CCTATTTCCT  GCTTAGACGT  1140
1141  CTTCTGGGTG  TACGTACTGA  AGGAGACAAG  AAAGCAGCAA  AGGTCCAAAA  GCTGTCTAAG  1200
1201  AATGAAGTGC  TTATGGTCAA  CATAGGCTCC  CTGTCGACAG  GAGGAAGAGT  TAGTGCAGTC  1260
1261  AAGGCTGATT  TGGGCAAAAT  TGTTTTGACC  AATCCCGTGT  GCACAGAAGT  AGGAGAAAAA  1320
1321  ATTGCCCTTA  GCAGAAGAGT  TGAGAAACAC  TGGCGTTTAA  TTGGTTGGGG  TCAGATAAGA  1380
1381  AGAGGAGTGA  CCATTAAGCC  AACTGTAGAT  GATGACTGA  1419

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
GTP-binding
Initiation factor
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Eukaryotic translation initiation factor 2 complex
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Translation factor activity, RNA binding
Molecular Function
Translation initiation factor activity
Biological Process
Formation of translation preinitiation complex
Biological Process
Translational initiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-1610Nomascus leucogenys100.03e-42 160
LLPS-Caf-0647Canis familiaris99.790.0 959
LLPS-Mup-1054Mustela putorius furo99.790.0 959
LLPS-Aim-2174Ailuropoda melanoleuca99.790.0 959
LLPS-Myl-0619Myotis lucifugus99.790.0 959
LLPS-Ran-0092Rattus norvegicus99.790.0 959
LLPS-Mea-0372Mesocricetus auratus99.70.0 688
LLPS-Fec-0278Felis catus99.580.0 957
LLPS-Hos-1067Homo sapiens99.580.0 957
LLPS-Urm-1517Ursus maritimus99.580.0 958
LLPS-Pap-0619Pan paniscus99.580.0 957
LLPS-Ict-0254Ictidomys tridecemlineatus99.580.0 956
LLPS-Cas-0068Carlito syrichta99.580.0 957
LLPS-Eqc-1416Equus caballus99.580.0 958
LLPS-Poa-1483Pongo abelii99.580.0 957
LLPS-Caj-1356Callithrix jacchus99.580.0 957
LLPS-Sus-2518Sus scrofa99.580.0 957
LLPS-Aon-1024Aotus nancymaae99.580.0 957
LLPS-Ova-2130Ovis aries99.580.0 957
LLPS-Bot-0881Bos taurus99.580.0 957
LLPS-Tut-0004Tursiops truncatus99.580.0 957
LLPS-Mam-0159Macaca mulatta99.360.0 955
LLPS-Cap-2238Cavia porcellus99.360.0 956
LLPS-Fud-0123Fukomys damarensis99.360.0 956
LLPS-Cea-3248Cercocebus atys99.360.0 955
LLPS-Maf-0717Macaca fascicularis99.360.0 955
LLPS-Paa-2545Papio anubis99.360.0 955
LLPS-Dio-0744Dipodomys ordii99.360.0 955
LLPS-Fia-1124Ficedula albicollis99.330.0 903
LLPS-Meg-1265Meleagris gallopavo99.110.0 897
LLPS-Gaga-1098Gallus gallus98.940.0 946
LLPS-Loa-1704Loxodonta africana98.730.0 949
LLPS-Sah-1141Sarcophilus harrisii98.730.0 949
LLPS-Mod-3336Monodelphis domestica98.520.0 948
LLPS-Man-0891Macaca nemestrina98.320.0 947
LLPS-Ora-1192Ornithorhynchus anatinus98.20.0 782
LLPS-Tag-2121Taeniopygia guttata98.10.0 937
LLPS-Pes-0471Pelodiscus sinensis98.00.0 892
LLPS-Lac-2330Latimeria chalumnae97.880.0 938
LLPS-Gog-2612Gorilla gorilla97.480.0 870
LLPS-Anc-1377Anolis carolinensis97.460.0 936
LLPS-Scf-1017Scleropages formosus97.460.0 939
LLPS-Xet-2469Xenopus tropicalis97.050.0 928
LLPS-Orn-1598Oreochromis niloticus96.820.0 933
LLPS-Icp-1234Ictalurus punctatus96.820.0 935
LLPS-Leo-0739Lepisosteus oculatus96.820.0 929
LLPS-Dar-1945Danio rerio96.610.0 932
LLPS-Pof-1629Poecilia formosa96.610.0 931
LLPS-Anp-1338Anas platyrhynchos96.580.0 909
LLPS-Ten-0503Tetraodon nigroviridis96.40.0 929
LLPS-Tar-0519Takifugu rubripes96.40.0 927
LLPS-Xim-2128Xiphophorus maculatus96.40.0 931
LLPS-Asm-1782Astyanax mexicanus96.190.0 926
LLPS-Orl-1280Oryzias latipes95.970.0 923
LLPS-Gaa-2302Gasterosteus aculeatus95.970.0 925
LLPS-Scm-0579Scophthalmus maximus95.760.0 925
LLPS-Pat-0358Pan troglodytes94.70.0 894
LLPS-Otg-0882Otolemur garnettii93.870.0 882
LLPS-Chs-2960Chlorocebus sabaeus93.010.0 865
LLPS-Orc-3003Oryctolagus cuniculus91.820.0 874
LLPS-Rhb-0049Rhinopithecus bieti91.520.0 850
LLPS-Mal-1884Mandrillus leucophaeus90.250.0 862
LLPS-Cis-0400Ciona savignyi85.10.0 813
LLPS-Cii-0698Ciona intestinalis83.40.0 809
LLPS-Drm-0618Drosophila melanogaster81.060.0 778
LLPS-Scj-0952Schizosaccharomyces japonicus76.580.0 708
LLPS-Usm-0609Ustilago maydis76.170.0 714
LLPS-Abg-1211Absidia glauca76.130.0 702
LLPS-Spr-0960Sporisorium reilianum76.010.0 709
LLPS-Chc-0360Chondrus crispus75.880.0 709
LLPS-Scp-1322Schizosaccharomyces pombe75.510.0 703
LLPS-Scc-0479Schizosaccharomyces cryophilus75.280.0 697
LLPS-Brd-1962Brachypodium distachyon75.193e-64 217
LLPS-Pug-0309Puccinia graminis75.170.0 707
LLPS-Osl-0113Ostreococcus lucimarinus75.00.0 709
LLPS-Cae-0475Caenorhabditis elegans75.00.0 722
LLPS-Mua-1834Musa acuminata74.890.0 700
LLPS-Gas-0314Galdieria sulphuraria74.720.0 703
LLPS-Sem-2046Selaginella moellendorffii74.610.0 702
LLPS-Gor-0921Gossypium raimondii74.390.0 697
LLPS-Phv-1683Phaseolus vulgaris74.340.0 696
LLPS-Sob-0632Sorghum bicolor74.340.0 701
LLPS-Glm-0799Glycine max74.340.0 699
LLPS-Orbr-0249Oryza brachyantha74.170.0 702
LLPS-Orp-0449Oryza punctata74.170.0 702
LLPS-Ors-0895Oryza sativa74.170.0 702
LLPS-Zem-2496Zea mays74.170.0 702
LLPS-Orm-1650Oryza meridionalis74.170.0 703
LLPS-Orni-0592Oryza nivara74.170.0 702
LLPS-Orb-1088Oryza barthii74.170.0 702
LLPS-Sei-0431Setaria italica74.170.0 701
LLPS-Orgl-0653Oryza glumaepatula74.170.0 702
LLPS-Php-0865Physcomitrella patens74.120.0 696
LLPS-Via-1072Vigna angularis74.120.0 695
LLPS-Asg-0605Ashbya gossypii74.10.0 694
LLPS-Put-1101Puccinia triticina74.060.0 687
LLPS-Ori-0084Oryza indica73.950.0 702
LLPS-Nia-2377Nicotiana attenuata73.890.0 689
LLPS-Dac-1118Daucus carota73.890.0 698
LLPS-Sac-1050Saccharomyces cerevisiae73.870.0 689
LLPS-Kop-1401Komagataella pastoris73.870.0 689
LLPS-Coc-1178Corchorus capsularis73.760.0 653
LLPS-Tru-1207Triticum urartu73.730.0 701
LLPS-Org-1131Oryza glaberrima73.730.0 700
LLPS-Tra-1892Triticum aestivum73.730.0 700
LLPS-Hov-1553Hordeum vulgare73.730.0 701
LLPS-Mae-1101Manihot esculenta73.670.0 690
LLPS-Viv-1194Vitis vinifera73.670.0 693
LLPS-Sol-2242Solanum lycopersicum73.670.0 690
LLPS-Cus-0317Cucumis sativus73.670.0 688
LLPS-Mel-0218Melampsora laricipopulina73.480.0 703
LLPS-Lep-1865Leersia perrieri73.450.0 696
LLPS-Orr-1468Oryza rufipogon73.360.0 696
LLPS-Hea-0386Helianthus annuus73.290.0 694
LLPS-Miv-0730Microbotryum violaceum73.250.0 684
LLPS-Chr-0217Chlamydomonas reinhardtii73.130.0 694
LLPS-Prp-0466Prunus persica73.010.0 684
LLPS-Pot-1487Populus trichocarpa72.850.0 687
LLPS-Brr-1346Brassica rapa72.850.0 686
LLPS-Bro-2119Brassica oleracea72.850.0 685
LLPS-Brn-0980Brassica napus72.850.0 685
LLPS-Amt-1272Amborella trichopoda72.790.0 687
LLPS-Sot-1020Solanum tuberosum72.790.0 688
LLPS-Met-0686Medicago truncatula72.770.0 694
LLPS-Arl-0228Arabidopsis lyrata72.410.0 685
LLPS-Art-0104Arabidopsis thaliana72.190.0 682
LLPS-Lem-0244Leptosphaeria maculans71.960.0 688
LLPS-Phn-1239Phaeosphaeria nodorum71.740.0 687
LLPS-Tum-0278Tuber melanosporum71.490.0 672
LLPS-Cym-0020Cyanidioschyzon merolae71.40.0 679
LLPS-Ast-0511Aspergillus terreus71.30.0 682
LLPS-Asn-0748Aspergillus nidulans71.30.0 679
LLPS-Pyt-0506Pyrenophora teres71.220.0 688
LLPS-Zyt-1107Zymoseptoria tritici71.120.0 673
LLPS-Asc-1364Aspergillus clavatus71.090.0 681
LLPS-Asf-1146Aspergillus flavus71.090.0 682
LLPS-Aso-1272Aspergillus oryzae71.090.0 682
LLPS-Pytr-0272Pyrenophora triticirepentis71.00.0 687
LLPS-Asfu-0352Aspergillus fumigatus70.870.0 679
LLPS-Nec-0331Neurospora crassa70.740.0 672
LLPS-Nef-1097Neosartorya fischeri70.650.0 677
LLPS-Dos-1450Dothistroma septosporum70.560.0 674
LLPS-Fuo-0600Fusarium oxysporum70.520.0 665
LLPS-Fuv-0691Fusarium verticillioides70.520.0 666
LLPS-Blg-1430Blumeria graminis70.470.0 653
LLPS-Asni-0791Aspergillus niger70.430.0 672
LLPS-Fus-0178Fusarium solani70.310.0 665
LLPS-Yal-0403Yarrowia lipolytica70.110.0 642
LLPS-Trv-0351Trichoderma virens69.870.0 664
LLPS-Thc-0970Theobroma cacao69.870.0 679
LLPS-Gag-0156Gaeumannomyces graminis69.870.0 670
LLPS-Cog-0901Colletotrichum gloeosporioides69.850.0 663
LLPS-Coo-0613Colletotrichum orbiculare69.850.0 667
LLPS-Trr-0980Trichoderma reesei69.650.0 663
LLPS-Map-0246Magnaporthe poae69.650.0 669
LLPS-Mao-1263Magnaporthe oryzae69.210.0 664
LLPS-Ved-0956Verticillium dahliae68.340.0 650
LLPS-Beb-1014Beauveria bassiana68.110.0 659
LLPS-Cogr-0313Colletotrichum graminicola67.970.0 635
LLPS-Crn-0199Cryptococcus neoformans64.380.0 583
LLPS-Ere-0933Erinaceus europaeus28.846e-1786.7
LLPS-Scs-1106Sclerotinia sclerotiorum28.532e-1891.7