LLPS-Mum-0651
Ino80b
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | INO80 complex subunit B; High mobility group AT-hook 1-like 4; PAP-1-associated protein 1; PAPA-1; Zinc finger HIT domain-containing protein 4 |
| Gene Name: | Ino80b, Hmga1l4, Papa1, Znhit4 |
| Ensembl Gene: | ENSMUSG00000030034.11 |
| Ensembl Protein: | ENSMUSP00000109568.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|
▼ FUNCTION
| Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000113935.7 | ENSMUSP00000109568.1 |
| Ensembl | ENSMUST00000143814.1 | ENSMUSP00000117556.1 |
| Ensembl | ENSMUST00000032109.4 | ENSMUSP00000032109.4 |
| UniProt | Q99PT3, IN80B_MOUSE, Q9CY38 | |
| GeneBank | BC019383, AK010946, AB054537, BC058788 | AAH58788.1, AAH19383.1, BAB27284.1, BAB21110.1 |
| RefSeq | NM_023547.1 | NP_076036.1 |
| Entrez | 70020 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSACVPTVSS PLPLQDPMSK LWRRGSTSGA MEAPEPGETL ELSLAGAHGH GVHKKKHKKH 60 61 KKKHKKKHHQ EEEAGPTLQT PAKPQLKLKI KLGGQVLGTK SVPTFTVIPE GPRSPSPLMV 120 121 VDNEEEPMEG VPLEQYRAWL DEDSNLSPSP LRDLPGDLEG QEEEEEQRWL DALEKGELDD 180 181 NGDLKKEINE RLLTARQRAL LQKARSQPSP TLPLPVGGGC PAPALTEEML LKREERARKR 240 241 RLQAARRAEE HKNQTIERLT KTAAPSGRGG RGAARGERRG GRAAAPAPAP MVRYCSGAQG 300 301 STLSFPPGVP TPTAVAQRPA PSGPAPRCSV PGCPHPRRYA CSRTGQALCS LQCYRINLQL 360 361 RLGGPEGPGS PLLAT 375 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCCC CCGAGCCAGG GGAAACGCTG GAGCTGAGCC TGGCAGGTGC CCACGGCCAC 60 61 GGAGTACACA AGAAAAAACA CAAGAAACAT AAAAAGAAAC ACAAGAAAAA GCATCATCAG 120 121 GAAGAGGAGG CCGGACCGAC GCTGCAGACT CCTGCCAAGC CCCAACTTAA ACTTAAAATC 180 181 AAGCTGGGTG GACAGGTCCT GGGCACCAAG AGTGTCCCCA CTTTCACTGT GATTCCTGAG 240 241 GGGCCTCGCT CACCGTCTCC CCTGATGGTG GTGGATAATG AAGAGGAACC TATGGAAGGC 300 301 GTACCTCTGG AGCAGTACCG CGCCTGGCTG GATGAAGACA GTAATCTGTC CCCCTCCCCA 360 361 CTTCGGGACC TGCCAGGGGA TCTGGAGGGC CAGGAGGAAG AGGAGGAACA GAGATGGTTA 420 421 GACGCCCTGG AGAAGGGAGA GCTGGATGAC AACGGAGACC TCAAGAAGGA GATCAATGAG 480 481 CGGCTGCTTA CAGCGAGACA GCGAGCCCTC CTCCAGAAGG CGCGGAGCCA GCCGTCCCCG 540 541 ACTCTGCCTC TGCCAGTGGG TGGGGGCTGC CCTGCCCCTG CCCTCACCGA AGAGATGCTG 600 601 CTGAAGCGTG AGGAGCGTGC ACGGAAGCGG CGGCTGCAGG CGGCGAGGAG GGCCGAGGAG 660 661 CACAAAAATC AGACAATTGA GCGCCTCACC AAGACGGCCG CTCCTAGCGG GCGTGGAGGG 720 721 CGCGGGGCGG CGCGGGGCGA GCGGCGCGGA GGACGGGCTG CTGCCCCGGC CCCTGCACCC 780 781 ATGGTGCGCT ACTGCAGCGG GGCACAGGGC TCCACCTTGT CTTTTCCTCC CGGCGTTCCC 840 841 ACACCCACGG CGGTGGCACA GCGGCCTGCC CCATCGGGCC CCGCTCCACG ATGCTCTGTC 900 901 CCCGGCTGCC CCCACCCGCG TCGTTATGCC TGCTCCCGCA CCGGCCAGGC CCTTTGCAGC 960 961 CTACAGTGCT ACCGCATCAA CCTGCAGCTA CGGCTGGGAG GGCCCGAGGG CCCGGGGTCC 1020 1021 CCACTCCTGG CCACCTAA 1038 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Ino80 complex | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Molecular Function | Metal ion binding | |
Biological Process | Chromatin remodeling | |
Biological Process | DNA recombination | |
Biological Process | DNA repair |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-4061 | Rattus norvegicus | 98.54 | 1e-157 | 454 |
| LLPS-Mea-1335 | Mesocricetus auratus | 95.26 | 5e-161 | 464 |
| LLPS-Caj-2286 | Callithrix jacchus | 95.03 | 1e-136 | 401 |
| LLPS-Paa-3363 | Papio anubis | 94.74 | 5e-147 | 427 |
| LLPS-Mal-0042 | Mandrillus leucophaeus | 94.74 | 5e-147 | 427 |
| LLPS-Aon-2156 | Aotus nancymaae | 94.74 | 1e-135 | 399 |
| LLPS-Maf-1255 | Macaca fascicularis | 94.74 | 5e-147 | 427 |
| LLPS-Man-0440 | Macaca nemestrina | 94.44 | 3e-146 | 426 |
| LLPS-Fec-0753 | Felis catus | 94.44 | 4e-132 | 390 |
| LLPS-Nol-2766 | Nomascus leucogenys | 94.15 | 3e-145 | 423 |
| LLPS-Mam-0958 | Macaca mulatta | 94.15 | 3e-157 | 454 |
| LLPS-Eqc-0617 | Equus caballus | 94.15 | 7e-150 | 436 |
| LLPS-Rhb-0613 | Rhinopithecus bieti | 94.15 | 4e-150 | 436 |
| LLPS-Hos-1029 | Homo sapiens | 94.15 | 1e-138 | 406 |
| LLPS-Pap-3742 | Pan paniscus | 94.15 | 1e-138 | 406 |
| LLPS-Mup-1224 | Mustela putorius furo | 94.15 | 2e-136 | 400 |
| LLPS-Cea-2464 | Cercocebus atys | 93.87 | 2e-156 | 452 |
| LLPS-Pat-2988 | Pan troglodytes | 93.86 | 4e-138 | 405 |
| LLPS-Sus-2129 | Sus scrofa | 93.86 | 2e-133 | 393 |
| LLPS-Myl-1800 | Myotis lucifugus | 93.62 | 3e-144 | 421 |
| LLPS-Orc-0037 | Oryctolagus cuniculus | 93.59 | 5e-155 | 449 |
| LLPS-Aim-0193 | Ailuropoda melanoleuca | 93.59 | 9e-142 | 415 |
| LLPS-Chs-0406 | Chlorocebus sabaeus | 93.59 | 1e-155 | 450 |
| LLPS-Poa-0685 | Pongo abelii | 93.57 | 1e-137 | 404 |
| LLPS-Ict-3654 | Ictidomys tridecemlineatus | 93.31 | 8e-156 | 451 |
| LLPS-Loa-0388 | Loxodonta africana | 93.04 | 3e-145 | 424 |
| LLPS-Otg-2372 | Otolemur garnettii | 92.69 | 4e-132 | 389 |
| LLPS-Caf-0117 | Canis familiaris | 92.35 | 3e-122 | 365 |
| LLPS-Ova-2986 | Ovis aries | 91.92 | 2e-137 | 404 |
| LLPS-Bot-3262 | Bos taurus | 91.64 | 1e-144 | 422 |
| LLPS-Cap-1559 | Cavia porcellus | 91.09 | 2e-154 | 447 |
| LLPS-Dio-3924 | Dipodomys ordii | 91.06 | 1e-145 | 425 |
| LLPS-Anp-0021 | Anas platyrhynchos | 86.96 | 1e-06 | 50.1 |
| LLPS-Mod-0437 | Monodelphis domestica | 82.49 | 3e-88 | 276 |
| LLPS-Ora-2021 | Ornithorhynchus anatinus | 81.08 | 8e-38 | 140 |
| LLPS-Xet-0181 | Xenopus tropicalis | 78.57 | 2e-24 | 106 |
| LLPS-Scf-1817 | Scleropages formosus | 61.35 | 2e-66 | 220 |
| LLPS-Gaga-2300 | Gallus gallus | 60.5 | 9e-55 | 190 |
| LLPS-Anc-0898 | Anolis carolinensis | 60.42 | 3e-64 | 214 |
| LLPS-Leo-1540 | Lepisosteus oculatus | 58.92 | 8e-73 | 236 |
| LLPS-Lac-3629 | Latimeria chalumnae | 58.36 | 1e-61 | 207 |
| LLPS-Pof-2611 | Poecilia formosa | 56.88 | 2e-50 | 178 |
| LLPS-Icp-3512 | Ictalurus punctatus | 56.31 | 5e-58 | 198 |
| LLPS-Orn-2006 | Oreochromis niloticus | 55.75 | 2e-51 | 180 |
| LLPS-Xim-2175 | Xiphophorus maculatus | 55.63 | 3e-51 | 180 |
| LLPS-Ten-1412 | Tetraodon nigroviridis | 55.4 | 1e-50 | 178 |
| LLPS-Dar-1270 | Danio rerio | 54.64 | 2e-53 | 186 |
| LLPS-Asm-1399 | Astyanax mexicanus | 54.58 | 8e-52 | 182 |
| LLPS-Gaa-1581 | Gasterosteus aculeatus | 53.99 | 2e-45 | 164 |
| LLPS-Pes-1383 | Pelodiscus sinensis | 53.42 | 1e-24 | 104 |
| LLPS-Orl-0476 | Oryzias latipes | 53.29 | 2e-51 | 181 |
| LLPS-Tar-0349 | Takifugu rubripes | 52.26 | 4e-46 | 166 |
| LLPS-Scm-1634 | Scophthalmus maximus | 50.35 | 1e-39 | 149 |
| LLPS-Drm-0947 | Drosophila melanogaster | 40.3 | 4e-06 | 52.0 |