LLPS-Mum-0398
Pum3

▼ OVERVIEW

Status: Reviewed
Protein Name: Pumilio homolog 3
Gene Name: Pum3, D19Bwg1357e, Kiaa0020
Ensembl Gene: ENSMUSG00000041360.7
Ensembl Protein: ENSMUSP00000075573.4
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
OthersPredicted from orthologsN/A(View)

▼ FUNCTION

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMEVKGKKKF  TGKSPQTSQG  KNKFHKNSES  SSSKTFPRKA  VKEGGPKVTS  KNFEKGATKP  60
61    GKKGVKQFKN  KPQGGKGPKD  KFQKANKFSK  KRKFQPDGES  DESGAKKPKW  DDFKKKKKEL  120
121   KQSRQLSDKT  NYDIVVRAKH  IWESLRRKDC  DKEKRVKLMS  DLQKLIQGKI  KTIAFAHDST  180
181   RVIQCFIQYG  NEEQRKQAFQ  ELQGDLVELS  KAKYSRNIVK  KFLMYGSKPQ  VAEIIRSFKG  240
241   HVRKMLRHSE  ASAIVEYAYN  DKAILEQRNM  LTEELYGNTF  QLYKSADHPT  LDKVLELQPA  300
301   KLELIMDEMK  QILTPMAQKE  AVIKHSLVHK  VFLDFFTYAP  PKPRSELIEA  IREAVVYLAH  360
361   THDGARVAMH  CLWHGTPKDR  KVIVKTMKTY  VEKVANGQYS  HLVLLAAFDC  IDDTKLVKQI  420
421   IISEIISSLP  SIVNDKYGRK  VLLYLMSPRD  PAHTVPELIE  LLQKGDGNAH  SKKDTAIRRR  480
481   ELLESISPAL  LSYLQGHTQE  VVLDKSACVL  VSDMLGSATG  DVQPAMDAIA  SLAAAELHPG  540
541   GKDGELHVAE  HPAGHLVLKW  LLEQDKKMKE  SGKEGCFAKT  LVERVGMKNL  KSWASINRGA  600
601   IILSSLLQSC  DQEVVNKVKG  GLKPLIPTLE  KNKSSSRGIQ  TLLEKLTA  648
Nucleotide CDS Sequence (FASTA)
1     ATGATGGAAG  TCAAAGGGAA  GAAAAAGTTT  ACAGGAAAGA  GTCCACAGAC  ATCACAAGGA  60
61    AAGAATAAAT  TTCATAAGAA  CAGTGAGTCT  AGTTCTTCAA  AGACATTCCC  AAGGAAAGCT  120
121   GTTAAGGAAG  GCGGACCTAA  AGTCACATCT  AAGAACTTTG  AGAAAGGTGC  CACAAAACCT  180
181   GGCAAGAAAG  GTGTGAAGCA  GTTCAAGAAC  AAGCCACAAG  GGGGCAAAGG  ACCGAAGGAC  240
241   AAATTTCAGA  AGGCAAATAA  ATTCAGCAAG  AAGCGGAAAT  TCCAGCCAGA  TGGTGAAAGT  300
301   GATGAATCAG  GAGCCAAGAA  ACCCAAGTGG  GATGACTTCA  AAAAGAAGAA  GAAAGAGCTG  360
361   AAGCAGAGCA  GGCAGCTCAG  TGACAAGACC  AACTATGACA  TCGTGGTTCG  AGCAAAGCAC  420
421   ATTTGGGAGA  GCTTGAGAAG  AAAAGATTGT  GACAAGGAAA  AACGGGTGAA  GCTCATGAGT  480
481   GATTTGCAGA  AGTTGATTCA  AGGGAAAATT  AAAACTATCG  CCTTTGCACA  TGACTCGACG  540
541   CGCGTGATCC  AGTGCTTCAT  TCAGTATGGG  AACGAGGAGC  AGAGGAAGCA  GGCTTTCCAA  600
601   GAGTTGCAAG  GCGACTTGGT  TGAATTAAGT  AAAGCCAAAT  ATTCCAGGAA  TATCGTTAAG  660
661   AAATTTCTCA  TGTATGGAAG  TAAGCCACAA  GTTGCGGAGA  TAATCAGAAG  TTTTAAAGGT  720
721   CATGTGAGGA  AGATGCTGCG  GCATTCGGAG  GCATCGGCCA  TTGTGGAGTA  CGCATACAAC  780
781   GACAAAGCCA  TTTTGGAACA  GAGGAACATG  CTGACAGAGG  AGCTCTATGG  GAACACGTTT  840
841   CAGCTTTACA  AGTCAGCAGA  TCACCCAACG  CTGGACAAGG  TGCTGGAGCT  GCAGCCAGCA  900
901   AAGCTAGAGC  TTATCATGGA  CGAGATGAAG  CAGATTCTGA  CACCGATGGC  CCAAAAGGAA  960
961   GCTGTGATTA  AGCACTCACT  CGTTCATAAA  GTATTCTTGG  ACTTTTTTAC  CTACGCACCC  1020
1021  CCAAAACCTC  GATCAGAACT  AATTGAAGCC  ATCCGGGAAG  CAGTGGTGTA  CCTGGCCCAC  1080
1081  ACACACGATG  GCGCCAGAGT  GGCCATGCAC  TGCCTGTGGC  ACGGCACACC  CAAGGACAGG  1140
1141  AAAGTGATCG  TGAAAACGAT  GAAGACGTAT  GTGGAGAAGG  TTGCCAATGG  CCAGTACTCT  1200
1201  CACTTGGTTC  TCCTGGCAGC  GTTTGACTGT  ATTGATGATA  CTAAGCTTGT  GAAGCAGATA  1260
1261  ATCATATCAG  AAATCATCAG  TTCCTTGCCC  AGCATAGTTA  ATGACAAATA  CGGAAGGAAA  1320
1321  GTCCTCTTGT  ACTTGATGAG  CCCCAGAGAC  CCCGCCCACA  CGGTGCCCGA  GCTCATCGAG  1380
1381  CTTCTGCAGA  AGGGTGATGG  CAACGCGCAC  AGCAAGAAGG  ACACTGCAAT  CCGCCGGCGT  1440
1441  GAGCTCTTGG  AGTCCATCTC  TCCAGCTTTG  CTGAGCTACC  TGCAAGGACA  CACTCAAGAG  1500
1501  GTGGTGCTGG  ATAAGTCTGC  ATGTGTGCTG  GTGTCTGACA  TGCTGGGATC  TGCTACTGGA  1560
1561  GATGTTCAGC  CTGCTATGGA  TGCCATCGCC  AGTTTGGCAG  CAGCAGAACT  GCATCCTGGT  1620
1621  GGCAAGGACG  GAGAGCTTCA  TGTTGCTGAG  CATCCTGCAG  GACATCTGGT  TCTCAAATGG  1680
1681  TTACTAGAGC  AAGATAAAAA  GATGAAAGAA  AGCGGAAAGG  AAGGTTGTTT  TGCAAAAACC  1740
1741  CTTGTAGAGC  GTGTTGGTAT  GAAGAACCTC  AAGTCCTGGG  CCAGCATCAA  CCGAGGTGCC  1800
1801  ATTATTCTTT  CCAGCCTTCT  TCAGAGTTGT  GACCAAGAAG  TTGTAAACAA  AGTCAAAGGT  1860
1861  GGACTGAAAC  CCCTGATTCC  TACCTTGGAA  AAAAACAAAA  GCAGCAGCAG  AGGCATCCAG  1920
1921  ACCCTGCTTG  AGAAGCTGAC  TGCGTAG  1947

▼ KEYWORD

ID
Family
Acetylation
Chromosome
Complete proteome
DNA-binding
Nucleus
Reference proteome
Repeat
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Endoplasmic reticulum
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Molecular Function
DNA binding
Molecular Function
RNA binding
Biological Process
Regulation of protein ADP-ribosylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-0021Mesocricetus auratus93.520.01189
LLPS-Ran-3121Rattus norvegicus92.890.01183
LLPS-Dio-1067Dipodomys ordii92.416e-151 443
LLPS-Maf-2089Macaca fascicularis91.040.01080
LLPS-Ict-1069Ictidomys tridecemlineatus90.90.01149
LLPS-Eqc-1998Equus caballus90.560.01127
LLPS-Mal-0539Mandrillus leucophaeus90.420.01156
LLPS-Rhb-0243Rhinopithecus bieti90.40.01155
LLPS-Paa-0214Papio anubis90.260.01154
LLPS-Mam-0323Macaca mulatta90.250.01151
LLPS-Chs-0685Chlorocebus sabaeus90.110.01152
LLPS-Man-0728Macaca nemestrina90.110.01151
LLPS-Cea-2054Cercocebus atys90.090.01153
LLPS-Aon-1657Aotus nancymaae89.950.01147
LLPS-Pat-1615Pan troglodytes89.810.01139
LLPS-Gog-0658Gorilla gorilla89.80.01143
LLPS-Poa-0349Pongo abelii89.80.01142
LLPS-Pap-2231Pan paniscus89.660.01136
LLPS-Nol-0883Nomascus leucogenys89.640.01146
LLPS-Hos-2191Homo sapiens89.510.01133
LLPS-Caj-3367Callithrix jacchus89.180.01139
LLPS-Aim-1244Ailuropoda melanoleuca89.030.01114
LLPS-Bot-0053Bos taurus88.720.01120
LLPS-Orc-0321Oryctolagus cuniculus88.720.01105
LLPS-Caf-0399Canis familiaris88.580.01101
LLPS-Fud-0380Fukomys damarensis88.430.01127
LLPS-Sus-0368Sus scrofa88.270.01102
LLPS-Cas-0066Carlito syrichta88.10.01127
LLPS-Ova-0202Ovis aries87.980.01110
LLPS-Otg-0801Otolemur garnettii87.50.01112
LLPS-Myl-0483Myotis lucifugus87.150.01111
LLPS-Loa-0598Loxodonta africana86.880.01085
LLPS-Mup-0088Mustela putorius furo86.710.01085
LLPS-Cap-0589Cavia porcellus86.420.01098
LLPS-Urm-0571Ursus maritimus80.250.0 974
LLPS-Sah-0228Sarcophilus harrisii77.020.0 914
LLPS-Pes-2195Pelodiscus sinensis71.870.0 899
LLPS-Fia-1801Ficedula albicollis71.630.0 891
LLPS-Tag-0320Taeniopygia guttata71.560.0 893
LLPS-Gaga-1653Gallus gallus70.050.0 874
LLPS-Anc-1757Anolis carolinensis68.60.0 812
LLPS-Mod-0096Monodelphis domestica68.520.0 936
LLPS-Icp-0956Ictalurus punctatus68.150.0 664
LLPS-Lac-0255Latimeria chalumnae66.310.0 807
LLPS-Leo-0264Lepisosteus oculatus65.610.0 781
LLPS-Scf-0162Scleropages formosus64.80.0 757
LLPS-Dar-0228Danio rerio64.330.0 759
LLPS-Asm-1427Astyanax mexicanus63.890.0 714
LLPS-Meg-0621Meleagris gallopavo63.610.0 772
LLPS-Ten-1225Tetraodon nigroviridis61.980.0 687
LLPS-Tar-0093Takifugu rubripes61.450.0 670
LLPS-Xet-1273Xenopus tropicalis61.260.0 677
LLPS-Scm-0091Scophthalmus maximus60.340.0 664
LLPS-Gaa-0496Gasterosteus aculeatus58.440.0 648
LLPS-Pof-0965Poecilia formosa55.740.0 655
LLPS-Xim-1141Xiphophorus maculatus55.440.0 653
LLPS-Orn-0308Oreochromis niloticus54.060.0 668
LLPS-Orl-0974Oryzias latipes52.290.0 648
LLPS-Cis-0339Ciona savignyi41.632e-134 414
LLPS-Cii-0696Ciona intestinalis41.343e-117 369
LLPS-Abg-0100Absidia glauca35.888e-80 269
LLPS-Amt-0209Amborella trichopoda34.533e-51 192
LLPS-Prp-1621Prunus persica34.025e-54 201
LLPS-Asfu-0360Aspergillus fumigatus32.563e-59 216
LLPS-Thc-0308Theobroma cacao32.516e-53 198
LLPS-Tum-0230Tuber melanosporum32.278e-73 253
LLPS-Vir-0006Vigna radiata32.174e-44 172
LLPS-Nef-0289Neosartorya fischeri32.063e-57 211
LLPS-Cae-0540Caenorhabditis elegans31.994e-73 256
LLPS-Gor-0542Gossypium raimondii31.937e-49 186
LLPS-Ast-0462Aspergillus terreus31.916e-55 204
LLPS-Cogr-0235Colletotrichum graminicola31.863e-54 202
LLPS-Chr-0181Chlamydomonas reinhardtii31.622e-50 192
LLPS-Blg-0313Blumeria graminis31.622e-54 203
LLPS-Php-0298Physcomitrella patens31.414e-46 177
LLPS-Nec-0423Neurospora crassa31.42e-50 191
LLPS-Aso-0938Aspergillus oryzae31.41e-54 203
LLPS-Asc-0646Aspergillus clavatus31.332e-55 206
LLPS-Scc-0411Schizosaccharomyces cryophilus31.241e-66 236
LLPS-Coo-0010Colletotrichum orbiculare31.212e-58 214
LLPS-Cog-0615Colletotrichum gloeosporioides31.211e-53 200
LLPS-Asf-0079Aspergillus flavus31.092e-51 193
LLPS-Fus-0450Fusarium solani31.04e-56 207
LLPS-Trv-0730Trichoderma virens30.931e-56 208
LLPS-Pytr-0297Pyrenophora triticirepentis30.934e-47 181
LLPS-Trr-0321Trichoderma reesei30.811e-55 205
LLPS-Dos-0294Dothistroma septosporum30.652e-53 199
LLPS-Scp-0504Schizosaccharomyces pombe30.645e-58 212
LLPS-Scj-0140Schizosaccharomyces japonicus30.576e-62 223
LLPS-Ved-0253Verticillium dahliae30.514e-47 181
LLPS-Fuv-0119Fusarium verticillioides30.495e-58 213
LLPS-Fuo-0206Fusarium oxysporum30.492e-57 211
LLPS-Gag-0306Gaeumannomyces graminis30.336e-53 198
LLPS-Dac-0013Daucus carota30.256e-52 195
LLPS-Beb-0474Beauveria bassiana30.251e-52 197
LLPS-Phn-0482Phaeosphaeria nodorum30.235e-44 171
LLPS-Asn-0757Aspergillus nidulans30.113e-53 199
LLPS-Sot-0120Solanum tuberosum30.061e-50 191
LLPS-Zyt-0341Zymoseptoria tritici29.832e-57 211
LLPS-Lem-0038Leptosphaeria maculans29.796e-47 181
LLPS-Map-0632Magnaporthe poae29.774e-53 199
LLPS-Cus-1065Cucumis sativus29.712e-53 199
LLPS-Glm-0476Glycine max29.553e-49 187
LLPS-Nia-0411Nicotiana attenuata29.532e-49 187
LLPS-Mao-0232Magnaporthe oryzae29.523e-51 194
LLPS-Tra-1466Triticum aestivum29.243e-42 166
LLPS-Pyt-0164Pyrenophora teres29.06e-47 180
LLPS-Via-0447Vigna angularis28.895e-49 186
LLPS-Arl-0307Arabidopsis lyrata28.752e-50 190
LLPS-Mae-1096Manihot esculenta28.654e-51 192
LLPS-Art-0596Arabidopsis thaliana28.627e-50 189
LLPS-Phv-0524Phaseolus vulgaris28.551e-49 188
LLPS-Gas-0446Galdieria sulphuraria28.312e-35 144
LLPS-Sei-0632Setaria italica28.282e-43 169
LLPS-Pot-0877Populus trichocarpa28.182e-51 194
LLPS-Hea-1481Helianthus annuus28.111e-52 195
LLPS-Sac-0475Saccharomyces cerevisiae28.093e-45 175
LLPS-Drm-0492Drosophila melanogaster27.925e-43 169
LLPS-Viv-1340Vitis vinifera27.893e-51 193
LLPS-Hov-0073Hordeum vulgare27.826e-37 150
LLPS-Yal-0204Yarrowia lipolytica27.762e-56 208
LLPS-Tru-0821Triticum urartu27.741e-35 147
LLPS-Bro-1219Brassica oleracea27.721e-48 185
LLPS-Mua-0869Musa acuminata27.694e-38 152
LLPS-Brn-3123Brassica napus27.675e-49 186
LLPS-Osl-0808Ostreococcus lucimarinus27.512e-37 152
LLPS-Crn-0088Cryptococcus neoformans27.432e-39 157
LLPS-Coc-1042Corchorus capsularis27.311e-51 194
LLPS-Met-0105Medicago truncatula27.138e-49 185
LLPS-Sol-0863Solanum lycopersicum26.962e-38 154
LLPS-Asg-0188Ashbya gossypii26.819e-38 152
LLPS-Brr-0278Brassica rapa26.495e-49 186
LLPS-Orbr-1234Oryza brachyantha26.446e-41 162
LLPS-Org-1041Oryza glaberrima26.359e-42 164
LLPS-Lep-0680Leersia perrieri26.272e-38 154
LLPS-Sem-0270Selaginella moellendorffii26.217e-49 184
LLPS-Sob-0622Sorghum bicolor26.23e-39 157
LLPS-Ori-0100Oryza indica26.182e-42 166
LLPS-Ors-1665Oryza sativa26.182e-42 166
LLPS-Brd-0748Brachypodium distachyon26.12e-40 160
LLPS-Zem-0078Zea mays25.762e-34 143
LLPS-Orm-0531Oryza meridionalis25.75e-40 159
LLPS-Chc-0177Chondrus crispus25.695e-26 117
LLPS-Orp-0642Oryza punctata25.431e-36 149
LLPS-Orb-0290Oryza barthii25.347e-37 150
LLPS-Orgl-0491Oryza glumaepatula25.176e-37 150
LLPS-Orni-0005Oryza nivara25.093e-37 151
LLPS-Orr-0456Oryza rufipogon25.093e-37 151
LLPS-Cym-0204Cyanidioschyzon merolae22.651e-1997.1
LLPS-Fec-3773Felis catus21.623e-0757.8
LLPS-Scs-0542Sclerotinia sclerotiorum20.735e-0860.5