LLPS-Mum-0232
Bbs4

▼ OVERVIEW

Status: Reviewed
Protein Name: Bardet-Biedl syndrome 4 protein homolog
Gene Name: Bbs4
Ensembl Gene: ENSMUSG00000025235.8
Ensembl Protein: ENSMUSP00000026265.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A15784680

▼ FUNCTION

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAEVKLGMKT  QVPASVESQK  PRSKKAPDFP  IVEKQNWLIH  LHYIRKDYEA  CKAVIKEQLQ  60
61    ETQGLCEYAI  YVQALIFRLE  GNIQESLELF  QTCAVLSPQC  ADNLKQVARS  LFLLGKHKAA  120
121   TEVYNEAAKL  NQKDWEICHN  LGVCYTYLKQ  FNKAQDQLHS  ALQLNKHDLT  YIMLGKIHLL  180
181   QGDLDKAIEI  YKKAVEFSPE  NTELLTTLGL  LYLQLGVYQK  AFEHLGNALT  YDPANYKAIL  240
241   AAGSMMQTHG  DFDVALTKYR  VVACAIPESP  PLWNNIGMCF  FGKKKYVAAI  SCLKRANYLA  300
301   PFDWKILYNL  GLVHLTMQQY  ASAFHFLSAA  INFQPKMGEL  YMLLAVALTN  LEDIENARRA  360
361   YVEAVRLDKC  NPLVNLNYAV  LLYNQGEKKS  ALAQYQEMEK  KVNFLKDNSP  LEFDSEMVEM  420
421   AQKLGAALQV  GEALVWTKPV  KDPKTKHRTN  SGSKSATLQQ  PLGSIQALGQ  AMSSAAAYRK  480
481   ILSGAVGAQL  PKPPSLPLEP  EPEPTVEASP  TEASEQKKEK  520
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGAAG  TGAAGCTTGG  GATGAAAACT  CAGGTTCCTG  CATCTGTTGA  ATCTCAAAAA  60
61    CCTAGGTCAA  AAAAAGCTCC  AGACTTCCCT  ATTGTGGAGA  AACAGAACTG  GCTGATCCAT  120
121   CTCCACTATA  TCCGGAAGGA  TTATGAAGCT  TGCAAGGCTG  TGATCAAAGA  ACAGCTTCAG  180
181   GAGACTCAGG  GGCTATGTGA  ATATGCTATC  TATGTCCAAG  CACTGATTTT  TCGCCTGGAA  240
241   GGAAATATCC  AAGAATCCCT  AGAACTCTTT  CAGACATGTG  CTGTTCTCAG  CCCACAGTGT  300
301   GCTGATAATC  TCAAGCAGGT  GGCCAGATCT  TTGTTTCTTC  TGGGAAAACA  CAAAGCTGCC  360
361   ACTGAAGTAT  ATAATGAAGC  AGCTAAACTT  AACCAGAAAG  ACTGGGAGAT  CTGCCATAAC  420
421   CTGGGAGTGT  GCTACACTTA  CCTGAAGCAG  TTCAACAAGG  CACAAGACCA  ACTGCACAGT  480
481   GCCCTCCAGC  TTAACAAGCA  TGACCTGACT  TACATAATGT  TGGGGAAGAT  CCATTTACTG  540
541   CAGGGAGACC  TGGATAAAGC  CATCGAGATC  TACAAGAAAG  CAGTAGAGTT  CTCACCAGAA  600
601   AATACTGAAC  TTCTTACAAC  TTTAGGATTG  CTCTACTTGC  AGCTTGGTGT  GTACCAGAAG  660
661   GCATTTGAAC  ATCTTGGGAA  TGCACTGACC  TACGACCCTG  CCAACTACAA  GGCCATCTTG  720
721   GCAGCAGGCA  GCATGATGCA  GACTCATGGG  GACTTTGATG  TCGCCCTTAC  CAAATACAGA  780
781   GTTGTAGCCT  GTGCTATTCC  AGAAAGTCCT  CCACTTTGGA  ATAACATTGG  AATGTGTTTC  840
841   TTTGGCAAGA  AGAAATATGT  GGCAGCTATC  AGCTGCCTAA  AACGAGCCAA  CTACTTGGCA  900
901   CCCTTCGACT  GGAAGATTCT  GTACAACCTG  GGCCTTGTCC  ATTTGACTAT  GCAGCAGTAT  960
961   GCATCAGCAT  TCCATTTTCT  CAGTGCAGCC  ATCAACTTCC  AGCCAAAGAT  GGGGGAACTC  1020
1021  TACATGCTCT  TGGCTGTGGC  TCTGACCAAC  CTGGAAGATA  TAGAGAATGC  CAGAAGAGCT  1080
1081  TATGTAGAAG  CTGTTCGCCT  GGATAAGTGT  AACCCTTTAG  TAAACCTGAA  CTATGCTGTG  1140
1141  CTGCTGTATA  ACCAGGGTGA  GAAGAAGAGC  GCCCTGGCTC  AGTACCAGGA  GATGGAGAAG  1200
1201  AAGGTCAACT  TTCTCAAGGA  CAACAGCCCT  CTGGAATTTG  ACTCTGAGAT  GGTAGAGATG  1260
1261  GCTCAGAAGT  TGGGAGCTGC  CCTTCAGGTG  GGAGAGGCAC  TGGTCTGGAC  CAAACCAGTC  1320
1321  AAAGATCCCA  AGACAAAGCA  CCGGACCAAT  TCAGGCAGCA  AATCTGCTAC  TCTCCAGCAG  1380
1381  CCTCTGGGTT  CCATTCAAGC  TCTAGGACAG  GCGATGTCTT  CAGCAGCTGC  ATACAGAAAG  1440
1441  ATCCTTTCAG  GTGCTGTAGG  AGCCCAGCTC  CCAAAGCCAC  CATCACTGCC  ACTGGAGCCA  1500
1501  GAGCCAGAGC  CCACTGTGGA  AGCAAGTCCA  ACAGAAGCAT  CAGAACAAAA  GAAAGAAAAA  1560
1561  TAG  1563

▼ KEYWORD

ID
Family
Cell membrane
Cell projection
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Flagellum
Membrane
Protein transport
Reference proteome
Repeat
TPR repeat
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
BBSome
Cellular Component
Centriolar satellite
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Ciliary basal body
Cellular Component
Ciliary membrane
Cellular Component
Ciliary transition zone
Cellular Component
Cilium
Cellular Component
Cytosol
Cellular Component
Membrane
Cellular Component
Motile cilium
Cellular Component
Non-motile cilium
Cellular Component
Nucleus
Cellular Component
Pericentriolar material
Cellular Component
Photoreceptor connecting cilium
Cellular Component
Photoreceptor inner segment
Cellular Component
Photoreceptor outer segment
Molecular Function
Alpha-tubulin binding
Molecular Function
Beta-tubulin binding
Molecular Function
Dynactin binding
Molecular Function
Microtubule motor activity
Molecular Function
RNA polymerase II repressing transcription factor binding
Biological Process
Adult behavior
Biological Process
Brain morphogenesis
Biological Process
Centrosome cycle
Biological Process
Cerebral cortex development
Biological Process
Cilium assembly
Biological Process
Dendrite development
Biological Process
Face development
Biological Process
Fat cell differentiation
Biological Process
Fat pad development
Biological Process
Hippocampus development
Biological Process
Leptin-mediated signaling pathway
Biological Process
Maintenance of protein location in nucleus
Biological Process
Microtubule anchoring at centrosome
Biological Process
Microtubule cytoskeleton organization
Biological Process
Mitotic cytokinesis
Biological Process
Negative regulation of actin filament polymerization
Biological Process
Negative regulation of appetite by leptin-mediated signaling pathway
Biological Process
Negative regulation of gene expression
Biological Process
Negative regulation of GTPase activity
Biological Process
Negative regulation of systemic arterial blood pressure
Biological Process
Neural tube closure
Biological Process
Neuron migration
Biological Process
Non-motile cilium assembly
Biological Process
Photoreceptor cell maintenance
Biological Process
Photoreceptor cell outer segment organization
Biological Process
Positive regulation of cilium assembly
Biological Process
Positive regulation of multicellular organism growth
Biological Process
Protein localization
Biological Process
Protein localization to centrosome
Biological Process
Protein localization to cilium
Biological Process
Protein localization to organelle
Biological Process
Protein localization to photoreceptor outer segment
Biological Process
Protein transport
Biological Process
Regulation of cilium beat frequency involved in ciliary motility
Biological Process
Regulation of cytokinesis
Biological Process
Regulation of lipid metabolic process
Biological Process
Regulation of non-motile cilium assembly
Biological Process
Regulation of stress fiber assembly
Biological Process
Response to leptin
Biological Process
Retina homeostasis
Biological Process
Retinal rod cell development
Biological Process
Sensory perception of smell
Biological Process
Social behavior
Biological Process
Spermatid development
Biological Process
Striatum development
Biological Process
Ventricular system development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4141Rattus norvegicus96.730.0 934
LLPS-Mea-3010Mesocricetus auratus94.230.0 907
LLPS-Ict-0495Ictidomys tridecemlineatus91.380.0 858
LLPS-Aim-3808Ailuropoda melanoleuca91.020.0 840
LLPS-Eqc-0993Equus caballus90.30.0 845
LLPS-Dio-1226Dipodomys ordii89.670.0 837
LLPS-Chs-2830Chlorocebus sabaeus89.490.0 837
LLPS-Caj-4504Callithrix jacchus89.210.0 821
LLPS-Man-0987Macaca nemestrina88.670.0 854
LLPS-Maf-2512Macaca fascicularis88.650.0 874
LLPS-Mal-1075Mandrillus leucophaeus88.510.0 551
LLPS-Cea-0007Cercocebus atys88.510.0 551
LLPS-Paa-1752Papio anubis88.460.0 872
LLPS-Gog-0632Gorilla gorilla88.460.0 872
LLPS-Pat-0461Pan troglodytes88.460.0 871
LLPS-Hos-0772Homo sapiens88.460.0 871
LLPS-Rhb-1083Rhinopithecus bieti88.220.0 549
LLPS-Loa-0248Loxodonta africana88.140.0 837
LLPS-Aon-2786Aotus nancymaae87.880.0 863
LLPS-Sus-1461Sus scrofa87.880.0 860
LLPS-Nol-2242Nomascus leucogenys87.880.0 857
LLPS-Mam-0447Macaca mulatta87.720.0 842
LLPS-Cas-1429Carlito syrichta87.690.0 865
LLPS-Otg-1701Otolemur garnettii87.550.0 855
LLPS-Fec-3401Felis catus87.50.0 855
LLPS-Ova-1560Ovis aries87.470.0 809
LLPS-Caf-3092Canis familiaris87.080.0 820
LLPS-Mod-3951Monodelphis domestica86.930.0 813
LLPS-Pap-2012Pan paniscus86.90.0 840
LLPS-Myl-3260Myotis lucifugus86.550.0 804
LLPS-Sah-2974Sarcophilus harrisii86.390.0 767
LLPS-Bot-1982Bos taurus86.150.0 835
LLPS-Urm-2760Ursus maritimus85.987e-166 480
LLPS-Orc-3992Oryctolagus cuniculus85.570.0 797
LLPS-Fud-1295Fukomys damarensis84.960.0 825
LLPS-Cap-0584Cavia porcellus84.830.0 736
LLPS-Ora-1082Ornithorhynchus anatinus83.920.0 780
LLPS-Scf-3382Scleropages formosus83.670.0 583
LLPS-Tag-2086Taeniopygia guttata83.240.0 608
LLPS-Poa-2865Pongo abelii83.110.0 817
LLPS-Pes-2789Pelodiscus sinensis82.280.0 763
LLPS-Mup-1982Mustela putorius furo81.960.0 726
LLPS-Lac-3681Latimeria chalumnae79.320.0 714
LLPS-Asm-3895Astyanax mexicanus79.170.0 691
LLPS-Icp-0153Ictalurus punctatus77.160.0 676
LLPS-Fia-2391Ficedula albicollis76.950.0 718
LLPS-Anc-0183Anolis carolinensis76.890.0 701
LLPS-Dar-2307Danio rerio76.30.0 699
LLPS-Anp-0886Anas platyrhynchos76.140.0 714
LLPS-Orn-0570Oreochromis niloticus75.60.0 673
LLPS-Orl-0343Oryzias latipes74.780.0 671
LLPS-Xet-3001Xenopus tropicalis74.490.0 523
LLPS-Gaa-3854Gasterosteus aculeatus74.00.0 685
LLPS-Meg-0966Meleagris gallopavo73.956e-154 451
LLPS-Scm-0672Scophthalmus maximus73.880.0 667
LLPS-Xim-2599Xiphophorus maculatus73.740.0 676
LLPS-Pof-1873Poecilia formosa73.240.0 685
LLPS-Gaga-0151Gallus gallus72.520.0 718
LLPS-Ten-1256Tetraodon nigroviridis71.960.0 669
LLPS-Leo-2758Lepisosteus oculatus70.480.0 696
LLPS-Tar-0020Takifugu rubripes68.590.0 659
LLPS-Cii-1263Ciona intestinalis59.242e-165 484
LLPS-Chr-0171Chlamydomonas reinhardtii54.932e-121 370
LLPS-Drm-1282Drosophila melanogaster35.733e-60 212
LLPS-Cae-1076Caenorhabditis elegans34.996e-49 181
LLPS-Gas-0325Galdieria sulphuraria31.531e-0552.4
LLPS-Cus-1167Cucumis sativus28.511e-0655.5
LLPS-Dac-1586Daucus carota27.962e-0655.1
LLPS-Thc-0015Theobroma cacao27.25e-0757.0
LLPS-Hea-1415Helianthus annuus26.994e-0653.9
LLPS-Amt-2030Amborella trichopoda26.999e-0652.8
LLPS-Mae-2158Manihot esculenta26.678e-0756.2
LLPS-Tra-0835Triticum aestivum25.737e-0756.2
LLPS-Glm-1849Glycine max24.776e-1066.2
LLPS-Phv-0551Phaseolus vulgaris24.771e-1068.2
LLPS-Trr-1549Trichoderma reesei24.757e-0653.1
LLPS-Vir-1797Vigna radiata24.467e-1065.9
LLPS-Met-0893Medicago truncatula24.153e-1067.4
LLPS-Gor-0990Gossypium raimondii24.075e-0756.6
LLPS-Ors-0937Oryza sativa23.949e-0652.8
LLPS-Tum-0822Tuber melanosporum23.856e-0756.2
LLPS-Via-2349Vigna angularis23.812e-0758.2
LLPS-Zem-1870Zea mays23.813e-0654.3
LLPS-Sob-0543Sorghum bicolor23.812e-0654.7
LLPS-Orp-1507Oryza punctata23.815e-0653.9
LLPS-Osl-0162Ostreococcus lucimarinus23.731e-0862.0
LLPS-Coc-0232Corchorus capsularis23.732e-0654.7
LLPS-Art-3100Arabidopsis thaliana23.538e-0962.8
LLPS-Lep-2181Leersia perrieri23.475e-0653.9
LLPS-Orni-0237Oryza nivara23.479e-0652.8
LLPS-Ori-1521Oryza indica23.479e-0652.8
LLPS-Orb-1814Oryza barthii23.478e-0652.8
LLPS-Orr-1588Oryza rufipogon23.478e-0652.8
LLPS-Orm-1678Oryza meridionalis23.471e-0552.8
LLPS-Orbr-2175Oryza brachyantha23.472e-0654.7
LLPS-Sei-0011Setaria italica23.332e-0757.8
LLPS-Arl-0144Arabidopsis lyrata23.222e-0861.6
LLPS-Brn-0228Brassica napus23.229e-0859.3
LLPS-Bro-1112Brassica oleracea23.227e-0859.7
LLPS-Brr-0573Brassica rapa23.229e-0859.3
LLPS-Mua-0940Musa acuminata23.212e-0654.7
LLPS-Prp-1146Prunus persica23.216e-0653.1
LLPS-Nia-2513Nicotiana attenuata22.732e-0654.7
LLPS-Orgl-0847Oryza glumaepatula22.427e-0859.7
LLPS-Sol-0129Solanum lycopersicum22.291e-0655.8
LLPS-Php-0123Physcomitrella patens22.134e-0653.9
LLPS-Sot-0821Solanum tuberosum21.59e-0652.8