LLPS-Mum-0216
Ppil1

▼ OVERVIEW

Status: Reviewed
Protein Name: Peptidyl-prolyl cis-trans isomerase-like 1
Gene Name: Ppil1
Ensembl Gene: ENSMUSG00000024007.15
Ensembl Protein: ENSMUSP00000115705.2
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus, P-body, Postsynaptic densityPredicted from orthologsN/A(View)

▼ FUNCTION

Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAIPPDTWQ  PPNVYLETSM  GVIVLELYWK  HAPKTCKNFA  ELARRGYYNG  TKFHRIIKDF  60
61    MIQGGDPTGT  GRGGASIYGK  QFEDELHPDL  KFTGAGILAM  ANAGPDTNGS  QFFVTLAPTQ  120
121   WLDGKHTIFG  RVCQGIGMVN  RVGMVETNSQ  DRPVDDVKIL  KAYPSG  166
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGA  TTCCCCCAGA  CACCTGGCAG  CCGCCCAACG  TCTACCTGGA  GACTAGCATG  60
61    GGAGTCATTG  TCCTGGAGCT  ATACTGGAAG  CATGCGCCCA  AGACCTGCAA  GAACTTCGCG  120
121   GAGCTGGCTC  GGCGGGGCTA  CTACAATGGC  ACCAAGTTCC  ACAGGATCAT  CAAGGACTTC  180
181   ATGATCCAAG  GCGGCGACCC  GACAGGCACA  GGTCGAGGTG  GCGCATCTAT  TTATGGCAAA  240
241   CAGTTTGAAG  ATGAGCTTCA  TCCAGACCTG  AAGTTCACTG  GGGCTGGGAT  TCTCGCCATG  300
301   GCCAACGCAG  GACCAGACAC  CAATGGCAGC  CAGTTCTTTG  TGACCCTGGC  CCCCACGCAA  360
361   TGGCTGGACG  GCAAGCATAC  TATTTTTGGC  CGAGTGTGCC  AGGGTATAGG  GATGGTGAAT  420
421   CGAGTGGGCA  TGGTGGAAAC  AAACTCCCAG  GACCGTCCTG  TGGACGACGT  GAAGATTCTT  480
481   AAGGCGTACC  CCTCTGGATA  G  501

▼ KEYWORD

ID
Family
Complete proteome
Isomerase
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome
Rotamase
Spliceosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Catalytic step 2 spliceosome
Cellular Component
Nucleus
Cellular Component
U2-type catalytic step 2 spliceosome
Molecular Function
Cyclosporin A binding
Molecular Function
Disordered domain specific binding
Molecular Function
Peptidyl-prolyl cis-trans isomerase activity
Biological Process
MRNA splicing, via spliceosome
Biological Process
Protein folding
Biological Process
Protein peptidyl-prolyl isomerization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-2044Rattus norvegicus99.41e-111 322
LLPS-Cap-2779Cavia porcellus98.83e-111 321
LLPS-Orc-1364Oryctolagus cuniculus98.197e-111 320
LLPS-Rhb-1226Rhinopithecus bieti98.197e-111 320
LLPS-Pat-0290Pan troglodytes98.197e-111 320
LLPS-Hos-4001Homo sapiens98.197e-111 320
LLPS-Fec-1309Felis catus98.197e-111 320
LLPS-Man-0283Macaca nemestrina98.197e-111 320
LLPS-Cas-0836Carlito syrichta98.197e-111 320
LLPS-Ict-1953Ictidomys tridecemlineatus98.197e-111 320
LLPS-Nol-1770Nomascus leucogenys98.197e-111 320
LLPS-Poa-1502Pongo abelii98.197e-111 320
LLPS-Caf-0386Canis familiaris98.197e-111 320
LLPS-Gog-0971Gorilla gorilla98.197e-111 320
LLPS-Caj-0374Callithrix jacchus98.197e-111 320
LLPS-Mea-3792Mesocricetus auratus98.191e-110 319
LLPS-Maf-3614Macaca fascicularis98.197e-111 320
LLPS-Cea-0794Cercocebus atys98.197e-111 320
LLPS-Aon-0906Aotus nancymaae98.197e-111 320
LLPS-Sus-1726Sus scrofa98.197e-111 320
LLPS-Mal-3020Mandrillus leucophaeus98.197e-111 320
LLPS-Tut-0568Tursiops truncatus98.197e-111 320
LLPS-Bot-0820Bos taurus98.197e-111 320
LLPS-Urm-1543Ursus maritimus98.185e-110 318
LLPS-Aim-2613Ailuropoda melanoleuca98.184e-110 318
LLPS-Ova-0597Ovis aries97.63e-109 315
LLPS-Pap-2010Pan paniscus97.592e-110 318
LLPS-Loa-2734Loxodonta africana97.594e-110 318
LLPS-Myl-1519Myotis lucifugus97.592e-110 318
LLPS-Dio-2527Dipodomys ordii97.593e-110 318
LLPS-Ere-0191Erinaceus europaeus97.175e-62 193
LLPS-Mup-2902Mustela putorius furo96.992e-108 313
LLPS-Otg-1863Otolemur garnettii96.976e-109 315
LLPS-Pes-3059Pelodiscus sinensis95.652e-60 189
LLPS-Mod-0841Monodelphis domestica94.581e-108 314
LLPS-Fud-2402Fukomys damarensis94.581e-103 301
LLPS-Sah-0184Sarcophilus harrisii94.582e-108 313
LLPS-Ora-0691Ornithorhynchus anatinus93.984e-107 310
LLPS-Chs-3727Chlorocebus sabaeus93.04e-54 174
LLPS-Mam-1008Macaca mulatta92.779e-101 294
LLPS-Paa-0216Papio anubis90.363e-97 285
LLPS-Leo-2004Lepisosteus oculatus89.511e-98 289
LLPS-Anc-2480Anolis carolinensis89.364e-48 157
LLPS-Dar-0740Danio rerio87.587e-97 284
LLPS-Tag-2083Taeniopygia guttata87.071e-85 255
LLPS-Icp-0490Ictalurus punctatus86.346e-95 279
LLPS-Orn-0653Oreochromis niloticus85.84e-97 286
LLPS-Asm-0028Astyanax mexicanus85.712e-94 278
LLPS-Lac-1768Latimeria chalumnae84.344e-93 275
LLPS-Xet-1199Xenopus tropicalis84.342e-95 281
LLPS-Fia-1056Ficedula albicollis83.974e-86 256
LLPS-Xim-3301Xiphophorus maculatus83.851e-94 278
LLPS-Eqc-0331Equus caballus83.432e-86 258
LLPS-Scm-1620Scophthalmus maximus83.333e-92 272
LLPS-Orl-1291Oryzias latipes83.337e-94 276
LLPS-Pof-0194Poecilia formosa82.722e-95 280
LLPS-Gaa-0466Gasterosteus aculeatus80.867e-90 266
LLPS-Gaga-3376Gallus gallus80.851e-43 152
LLPS-Tar-1374Takifugu rubripes80.06e-90 266
LLPS-Ten-0798Tetraodon nigroviridis76.976e-81 243
LLPS-Coc-0002Corchorus capsularis74.751e-40 139
LLPS-Drm-0351Drosophila melanogaster74.538e-77 233
LLPS-Ori-1766Oryza indica74.346e-47 157
LLPS-Trr-0617Trichoderma reesei74.03e-67 209
LLPS-Trv-0536Trichoderma virens73.514e-67 208
LLPS-Sem-0625Selaginella moellendorffii73.513e-70 216
LLPS-Mao-0455Magnaporthe oryzae73.333e-69 214
LLPS-Nec-0559Neurospora crassa73.333e-69 214
LLPS-Cis-0886Ciona savignyi73.014e-76 232
LLPS-Fuo-0613Fusarium oxysporum72.734e-64 200
LLPS-Put-0787Puccinia triticina72.733e-62 195
LLPS-Fus-0382Fusarium solani72.673e-68 211
LLPS-Beb-0226Beauveria bassiana72.673e-68 211
LLPS-Sei-0320Setaria italica72.198e-69 213
LLPS-Cii-1362Ciona intestinalis72.153e-71 219
LLPS-Fuv-0709Fusarium verticillioides71.831e-61 194
LLPS-Cus-1597Cucumis sativus71.713e-70 216
LLPS-Orbr-1858Oryza brachyantha71.522e-69 214
LLPS-Amt-0118Amborella trichopoda71.521e-69 215
LLPS-Cogr-0175Colletotrichum graminicola71.332e-67 209
LLPS-Map-0001Magnaporthe poae71.147e-66 205
LLPS-Org-0640Oryza glaberrima71.113e-59 189
LLPS-Sob-0410Sorghum bicolor70.863e-68 211
LLPS-Pot-0732Populus trichocarpa70.863e-69 214
LLPS-Cog-0408Colletotrichum gloeosporioides70.677e-68 210
LLPS-Viv-1856Vitis vinifera70.671e-68 212
LLPS-Asni-0984Aspergillus niger70.672e-67 209
LLPS-Zyt-0231Zymoseptoria tritici70.679e-67 207
LLPS-Dos-0415Dothistroma septosporum70.632e-61 193
LLPS-Mae-1610Manihot esculenta70.25e-67 208
LLPS-Prp-0718Prunus persica70.23e-67 208
LLPS-Mua-1436Musa acuminata70.25e-68 211
LLPS-Lep-1541Leersia perrieri70.27e-68 210
LLPS-Ved-0060Verticillium dahliae70.142e-61 193
LLPS-Orp-0422Oryza punctata70.02e-65 207
LLPS-Orm-0641Oryza meridionalis70.02e-64 205
LLPS-Orr-1028Oryza rufipogon70.01e-65 207
LLPS-Orni-0502Oryza nivara70.01e-65 207
LLPS-Glm-0797Glycine max70.01e-66 207
LLPS-Asc-0814Aspergillus clavatus70.07e-67 207
LLPS-Scc-0208Schizosaccharomyces cryophilus70.06e-65 202
LLPS-Orb-2215Oryza barthii70.03e-65 207
LLPS-Asf-0672Aspergillus flavus70.05e-66 206
LLPS-Orgl-0430Oryza glumaepatula70.03e-65 207
LLPS-Aso-1332Aspergillus oryzae70.05e-66 206
LLPS-Phn-0118Phaeosphaeria nodorum69.933e-59 188
LLPS-Php-0536Physcomitrella patens69.931e-68 212
LLPS-Brd-0059Brachypodium distachyon69.938e-68 210
LLPS-Hea-0429Helianthus annuus69.813e-70 216
LLPS-Usm-0030Ustilago maydis69.88e-63 197
LLPS-Pug-0548Puccinia graminis69.684e-65 203
LLPS-Tum-0161Tuber melanosporum69.595e-61 192
LLPS-Ors-1560Oryza sativa69.543e-66 206
LLPS-Nef-0286Neosartorya fischeri69.332e-67 209
LLPS-Phv-1773Phaseolus vulgaris69.332e-65 204
LLPS-Ast-1079Aspergillus terreus69.331e-65 204
LLPS-Asfu-1103Aspergillus fumigatus69.332e-67 209
LLPS-Hov-0324Hordeum vulgare69.332e-66 207
LLPS-Mel-0084Melampsora laricipopulina69.283e-66 206
LLPS-Scf-0061Scleropages formosus69.145e-66 205
LLPS-Scj-0661Schizosaccharomyces japonicus69.131e-63 199
LLPS-Coo-1030Colletotrichum orbiculare68.831e-64 202
LLPS-Lem-0967Leptosphaeria maculans68.832e-65 204
LLPS-Cae-0246Caenorhabditis elegans68.752e-67 209
LLPS-Miv-0148Microbotryum violaceum68.718e-63 197
LLPS-Met-0114Medicago truncatula68.676e-64 200
LLPS-Spr-0210Sporisorium reilianum68.462e-61 194
LLPS-Thc-0088Theobroma cacao68.426e-67 208
LLPS-Chr-1093Chlamydomonas reinhardtii68.391e-66 207
LLPS-Sol-1133Solanum lycopersicum68.352e-69 214
LLPS-Sot-0110Solanum tuberosum68.352e-69 214
LLPS-Pytr-0333Pyrenophora triticirepentis67.552e-64 202
LLPS-Pyt-0333Pyrenophora teres67.552e-64 202
LLPS-Gas-0656Galdieria sulphuraria67.533e-61 199
LLPS-Brr-0346Brassica rapa67.329e-67 207
LLPS-Bro-1522Brassica oleracea67.321e-66 207
LLPS-Brn-1304Brassica napus67.329e-67 207
LLPS-Tru-1555Triticum urartu67.313e-65 204
LLPS-Tra-1510Triticum aestivum67.314e-66 206
LLPS-Blg-0045Blumeria graminis67.112e-60 191
LLPS-Gag-1134Gaeumannomyces graminis67.11e-63 200
LLPS-Nia-1316Nicotiana attenuata67.097e-68 210
LLPS-Gor-0895Gossypium raimondii66.894e-65 203
LLPS-Scp-0311Schizosaccharomyces pombe66.671e-62 196
LLPS-Crn-0174Cryptococcus neoformans65.368e-61 192
LLPS-Art-0025Arabidopsis thaliana64.22e-65 204
LLPS-Arl-1663Arabidopsis lyrata62.352e-60 191
LLPS-Vir-0444Vigna radiata59.329e-60 191
LLPS-Abg-0388Absidia glauca57.969e-47 156
LLPS-Zem-0157Zea mays57.142e-58 186
LLPS-Osl-0703Ostreococcus lucimarinus56.632e-51 169
LLPS-Via-1866Vigna angularis55.412e-39 144
LLPS-Yal-0889Yarrowia lipolytica53.428e-39 144
LLPS-Asn-1099Aspergillus nidulans52.677e-39 137
LLPS-Dac-2012Daucus carota49.675e-41 149