LLPS-Mum-0128
Atrip
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | ATR-interacting protein; ATM and Rad3-related-interacting protein |
| Gene Name: | Atrip |
| Ensembl Gene: | ENSMUSG00000025646.9 |
| Ensembl Protein: | ENSMUSP00000124854.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|
▼ FUNCTION
| Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000159614.2 | ENSMUSP00000124854.1 |
| Ensembl | ENSMUST00000045011.8 | ENSMUSP00000044831.2 |
| Ensembl | ENSMUST00000160217.7 | ENSMUSP00000125264.1 |
| Ensembl | ENSMUST00000161521.7 | ENSMUSP00000125615.1 |
| Ensembl | ENSMUST00000128062.2 | ENSMUSP00000118499.2 |
| UniProt | Q8BMG1, ATRIP_MOUSE, E9QLS8 | |
| GeneBank | AC174646, AK031257 | BAC27324.1 |
| RefSeq | NM_172774.3 | NP_766362.2 |
| Entrez | 235610 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGTPAPNSH RKQSGGLEPF PGLSRSIENP PSKRARSFSE TTVPDPEDPF GEHAEFTADD 60 61 LEELDILASQ ALSQCPVAPR NLSSAHKVRR LDGLPNSPIR KSREDIPVKD NFELEVLQIQ 120 121 YKELKEKLKA MEEEILIKNG EIKILRDSLR QTESVLEEQK RSHFLLEQEK TQALSEKEKE 180 181 FSRKLQSLQS ELQFKDAEMN ELRTKSQSNG RTNKPAAPSV SHVSPRKGSS VVLKSEACSP 240 241 HVGKTTFPTK ESFSANTPLF HPCQTEAGHR FLVGQEVSDN KNHSLGGSLM KQDVQQRILA 300 301 DGWMQRKDAQ GSILINLLLK QPLVPGSSLG LCHLLSSCPE VPTGTLLQPP GLSTLPGTSG 360 361 LRTISSSDGP FSPSALREAQ NLAFTGLNLV ARTESSHDGD MAGRRVFPLH QLPGAVHLLP 420 421 LVQFFVGLHC QALQDLAPAK KSGVPGDSAT HTSCMSSGVE ASPEDSIHGL ESFSVASLSV 480 481 LQNLVCHSGA VVCLLLSGMG TEAAAREGNL VQTCADTTSA SREDAHDQDQ HPLLKMLLQL 540 541 MASSSAASGH FQASVLGLCL KVLVKLAENA SSDLLPRFSC VFPVLPQCLG SALPLPCVLL 600 601 AVELLSVLLD HDSLAWQLCS HPEGCLLLRL YMYITSRPDR TASETQWLQL EQEVVWLLAK 660 661 LSVQSPAPAG IGSDCHCNVE AVRALTVMLH RQWLTVRRAG GPRTHQQKQT IRCLRDTVLL 720 721 LHSLSQKDKL FTVHCVEVLH QYDQVMPGVS MLIRALPDVT DCEEAALDDL CAAETDLEDS 780 781 EMDCN 785 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGGGA CCCCCGCACC GAACAGCCAC AGGAAACAGA GTGGCGGCCT GGAGCCTTTC 60 61 CCCGGTCTGT CTCGATCCAT TGAGAACCCT CCGAGCAAGC GGGCCCGGAG CTTCTCTGAG 120 121 ACCACAGTCC CGGACCCCGA AGACCCATTC GGTGAGCACG CGGAATTTAC TGCGGACGAC 180 181 CTAGAGGAAC TCGACATCCT CGCGTCACAG GCCCTGAGCC AGTGTCCCGT CGCGCCTCGG 240 241 AACCTGTCCA GTGCTCATAA GGTCCGCCGA TTAGATGGGT TACCAAATAG TCCTATAAGG 300 301 AAAAGCAGAG AAGATATTCC AGTTAAAGAT AATTTTGAAT TAGAAGTACT TCAGATACAA 360 361 TACAAAGAAC TTAAAGAAAA GCTGAAAGCA ATGGAAGAAG AAATCCTAAT TAAGAATGGA 420 421 GAAATTAAAA TTTTGCGTGA CTCTCTGCGT CAGACAGAAT CCGTTCTAGA AGAACAGAAA 480 481 AGATCACATT TCCTTCTTGA GCAAGAAAAG ACTCAAGCAC TCAGTGAAAA GGAAAAGGAA 540 541 TTCTCCAGAA AGCTCCAATC ACTGCAGTCT GAACTGCAGT TTAAAGACGC AGAAATGAAT 600 601 GAGTTAAGGA CAAAGTCTCA GAGCAACGGA CGAACAAATA AGCCAGCCGC TCCCTCCGTC 660 661 TCCCACGTCA GTCCTAGGAA AGGCTCTTCT GTGGTTCTCA AGTCAGAAGC ATGTTCTCCA 720 721 CATGTTGGAA AAACAACTTT CCCTACAAAA GAATCTTTTA GTGCTAACAC GCCTCTCTTC 780 781 CACCCCTGTC AGACTGAGGC AGGACACAGA TTTCTGGTGG GCCAAGAGGT TTCAGATAAT 840 841 AAAAACCACA GTCTGGGAGG TAGCCTCATG AAGCAAGATG TGCAGCAGAG AATTCTGGCT 900 901 GATGGCTGGA TGCAGAGAAA AGATGCTCAA GGTTCTATTT TGATAAACTT GCTCCTGAAG 960 961 CAACCTTTGG TGCCAGGGTC ATCTCTAGGT CTTTGTCACC TTCTGAGCAG TTGTCCTGAG 1020 1021 GTTCCTACTG GCACCCTCTT GCAGCCACCA GGGCTCAGTA CTTTGCCTGG GACTTCAGGC 1080 1081 CTCAGGACCA TCAGTTCTTC TGATGGGCCA TTTTCCCCCT CTGCCCTGAG AGAAGCACAG 1140 1141 AACTTGGCAT TCACTGGATT AAATCTGGTT GCCAGGACTG AGAGCTCACA TGATGGAGAC 1200 1201 ATGGCAGGCA GAAGAGTCTT CCCGCTCCAC CAGCTTCCTG GAGCTGTGCA TCTCCTTCCT 1260 1261 CTTGTGCAGT TTTTCGTCGG CTTACACTGC CAGGCTCTGC AAGATTTAGC CCCAGCTAAG 1320 1321 AAGAGTGGGG TGCCTGGGGA CTCTGCGACA CATACCTCCT GCATGAGCTC TGGGGTCGAG 1380 1381 GCTAGCCCAG AGGACTCCAT TCATGGCTTG GAGAGCTTTT CTGTGGCATC ACTCAGCGTC 1440 1441 CTTCAGAACC TGGTGTGCCA CAGTGGGGCA GTTGTCTGCC TGTTACTGTC AGGCATGGGG 1500 1501 ACAGAAGCTG CCGCCAGGGA AGGAAACTTG GTCCAGACTT GTGCAGATAC AACCTCAGCC 1560 1561 TCCAGGGAGG ATGCTCATGA CCAAGACCAG CACCCACTGC TAAAGATGCT TCTTCAGCTG 1620 1621 ATGGCTTCCT CCTCTGCAGC ATCAGGTCAT TTTCAAGCCA GTGTCCTGGG CCTGTGCCTC 1680 1681 AAAGTTTTGG TGAAATTAGC AGAAAACGCT TCCTCTGATT TGTTGCCCAG GTTCTCCTGT 1740 1741 GTGTTCCCGG TGTTGCCACA GTGCCTCGGC TCAGCGCTGC CGCTGCCCTG TGTGCTCCTG 1800 1801 GCTGTTGAGC TGCTCTCTGT GCTGCTGGAC CATGACAGCC TAGCATGGCA GCTATGCTCC 1860 1861 CACCCAGAAG GCTGCCTTCT CCTGAGGCTG TACATGTACA TCACATCAAG GCCTGACAGA 1920 1921 ACGGCCTCAG AGACACAGTG GCTTCAGCTG GAACAAGAGG TAGTATGGCT CTTGGCCAAG 1980 1981 CTGAGTGTAC AGAGCCCTGC CCCCGCTGGC ATTGGTTCTG ACTGTCACTG CAATGTAGAG 2040 2041 GCAGTCAGAG CGCTCACTGT GATGTTGCAC AGGCAATGGC TGACGGTGCG GCGGGCAGGA 2100 2101 GGTCCAAGGA CCCACCAGCA GAAGCAGACG ATACGCTGTC TGCGGGACAC TGTGCTGCTG 2160 2161 CTGCATAGCC TATCTCAGAA GGACAAGCTC TTCACTGTGC ACTGTGTCGA GGTCCTGCAT 2220 2221 CAGTACGACC AGGTGATGCC AGGGGTCAGC ATGCTGATTC GAGCCCTTCC TGATGTGACT 2280 2281 GACTGTGAAG AGGCTGCCCT GGATGACCTC TGTGCTGCGG AGACTGATTT GGAAGACTCT 2340 2341 GAGATGGACT GTAACTGA 2358 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | K63-linked polyubiquitin modification-dependent protein binding | |
Biological Process | DNA damage checkpoint | |
Biological Process | DNA repair |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-3845 | Rattus norvegicus | 90.32 | 0.0 | 1261 |
| LLPS-Mea-3885 | Mesocricetus auratus | 82.74 | 0.0 | 1122 |
| LLPS-Mup-2765 | Mustela putorius furo | 74.43 | 0.0 | 837 |
| LLPS-Cea-2920 | Cercocebus atys | 74.32 | 0.0 | 726 |
| LLPS-Hos-2922 | Homo sapiens | 74.12 | 0.0 | 932 |
| LLPS-Otg-1446 | Otolemur garnettii | 74.02 | 0.0 | 939 |
| LLPS-Caj-3377 | Callithrix jacchus | 74.02 | 0.0 | 965 |
| LLPS-Aon-3243 | Aotus nancymaae | 74.02 | 0.0 | 954 |
| LLPS-Eqc-2025 | Equus caballus | 73.96 | 0.0 | 964 |
| LLPS-Tut-1252 | Tursiops truncatus | 73.9 | 0.0 | 952 |
| LLPS-Pap-1385 | Pan paniscus | 73.88 | 0.0 | 912 |
| LLPS-Nol-2148 | Nomascus leucogenys | 73.86 | 0.0 | 930 |
| LLPS-Maf-1523 | Macaca fascicularis | 73.86 | 0.0 | 928 |
| LLPS-Fud-3227 | Fukomys damarensis | 73.68 | 0.0 | 863 |
| LLPS-Aim-1065 | Ailuropoda melanoleuca | 73.64 | 0.0 | 909 |
| LLPS-Pat-4518 | Pan troglodytes | 73.6 | 0.0 | 933 |
| LLPS-Chs-0282 | Chlorocebus sabaeus | 73.6 | 0.0 | 921 |
| LLPS-Paa-2580 | Papio anubis | 73.6 | 0.0 | 925 |
| LLPS-Rhb-3569 | Rhinopithecus bieti | 73.47 | 0.0 | 931 |
| LLPS-Poa-0813 | Pongo abelii | 73.47 | 0.0 | 940 |
| LLPS-Fec-2905 | Felis catus | 73.39 | 0.0 | 920 |
| LLPS-Ict-1491 | Ictidomys tridecemlineatus | 73.39 | 0.0 | 936 |
| LLPS-Sus-4249 | Sus scrofa | 73.39 | 0.0 | 932 |
| LLPS-Caf-1622 | Canis familiaris | 73.27 | 0.0 | 945 |
| LLPS-Loa-2159 | Loxodonta africana | 73.12 | 0.0 | 944 |
| LLPS-Ova-4251 | Ovis aries | 72.98 | 0.0 | 906 |
| LLPS-Bot-0712 | Bos taurus | 72.98 | 0.0 | 904 |
| LLPS-Gog-2132 | Gorilla gorilla | 72.33 | 0.0 | 902 |
| LLPS-Urm-2737 | Ursus maritimus | 71.77 | 0.0 | 601 |
| LLPS-Cap-3916 | Cavia porcellus | 71.23 | 0.0 | 895 |
| LLPS-Mal-3658 | Mandrillus leucophaeus | 70.26 | 0.0 | 853 |
| LLPS-Orc-3394 | Oryctolagus cuniculus | 69.89 | 0.0 | 914 |
| LLPS-Cas-4081 | Carlito syrichta | 69.66 | 0.0 | 868 |
| LLPS-Mam-0228 | Macaca mulatta | 69.57 | 0.0 | 872 |
| LLPS-Man-1548 | Macaca nemestrina | 68.47 | 0.0 | 816 |
| LLPS-Dio-1144 | Dipodomys ordii | 66.78 | 0.0 | 647 |
| LLPS-Myl-1594 | Myotis lucifugus | 66.67 | 0.0 | 687 |
| LLPS-Sah-1747 | Sarcophilus harrisii | 55.34 | 0.0 | 622 |
| LLPS-Mod-3735 | Monodelphis domestica | 53.69 | 0.0 | 622 |
| LLPS-Ora-1652 | Ornithorhynchus anatinus | 47.98 | 4e-169 | 516 |
| LLPS-Anp-0224 | Anas platyrhynchos | 47.51 | 5e-133 | 418 |
| LLPS-Tag-1618 | Taeniopygia guttata | 47.1 | 1e-139 | 436 |
| LLPS-Fia-3120 | Ficedula albicollis | 46.84 | 9e-131 | 412 |
| LLPS-Pes-1708 | Pelodiscus sinensis | 44.06 | 8e-91 | 301 |
| LLPS-Anc-2964 | Anolis carolinensis | 43.61 | 6e-131 | 417 |
| LLPS-Gaga-2114 | Gallus gallus | 43.23 | 9e-140 | 440 |
| LLPS-Xet-1842 | Xenopus tropicalis | 40.32 | 2e-117 | 380 |
| LLPS-Lac-3762 | Latimeria chalumnae | 40.21 | 4e-114 | 371 |
| LLPS-Orn-3286 | Oreochromis niloticus | 40.0 | 1e-21 | 104 |
| LLPS-Tar-0713 | Takifugu rubripes | 39.0 | 9e-25 | 114 |
| LLPS-Scm-4033 | Scophthalmus maximus | 36.61 | 2e-21 | 104 |
| LLPS-Leo-2407 | Lepisosteus oculatus | 36.0 | 2e-80 | 280 |
| LLPS-Ten-2148 | Tetraodon nigroviridis | 35.91 | 2e-18 | 94.7 |
| LLPS-Dar-4169 | Danio rerio | 35.29 | 3e-17 | 90.9 |
| LLPS-Scf-1374 | Scleropages formosus | 34.44 | 5e-64 | 234 |
| LLPS-Icp-1050 | Ictalurus punctatus | 34.33 | 1e-70 | 253 |
| LLPS-Asm-1749 | Astyanax mexicanus | 33.44 | 2e-25 | 116 |
| LLPS-Xim-2978 | Xiphophorus maculatus | 32.84 | 3e-27 | 122 |
| LLPS-Gaa-3639 | Gasterosteus aculeatus | 31.46 | 1e-46 | 182 |
| LLPS-Pof-2152 | Poecilia formosa | 30.79 | 5e-26 | 118 |
| LLPS-Cis-1950 | Ciona savignyi | 26.7 | 2e-06 | 55.1 |