DrLLPS - Data resource of LLPS

LLPS-Mum-0095
Srp19

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Signal recognition particle 19 kDa protein
Gene Name:	Srp19
Ensembl Gene:	ENSMUSG00000014504.16
Ensembl Protein:	ENSMUSP00000072386.3
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs

▼ FUNCTION

Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000072576.9	ENSMUSP00000072386.3
Ensembl	ENSMUST00000142010.1	ENSMUSP00000116373.1
Ensembl	ENSMUST00000119329.7	ENSMUSP00000112826.1
UniProt		Q9D7A6, SRP19_MOUSE
GeneBank	AK009412	BAB26271.1
Entrez	66384

▼ SEQUENCE

Protein Sequence (FASTA)
1 MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNA 60 61 FLEKNKMYSR EWNRDVQFRG RVRVQLKQED GSLCLVQFPS RKSVMLYVAE MIPKLKTRTQ 120 121 KSGGADPSLQ QGEGSKKGKG KKKK 144
Nucleotide CDS Sequence (FASTA)
1 ATGGCTTGCG CGGCCGCGCG GTCCCCGGCC GACCAGGACA GGTTTATTTG TATCTACCCC 60 61 GCTTATTTAA ATAATAAGAA GACCATAGCT GAGGGGAGAC GGATCCCTAT AAGTAAGGCT 120 121 GTAGAAAACC CTACAGCTAC TGAGATTCAA GATGTATGCT CAGCAGTTGG ACTGAATGCC 180 181 TTTCTGGAGA AAAACAAAAT GTACTCCAGA GAATGGAACC GTGATGTTCA GTTTCGAGGC 240 241 AGAGTCCGGG TACAGCTCAA ACAGGAAGAT GGCAGCCTCT GTCTTGTACA GTTCCCGTCA 300 301 CGTAAGTCAG TGATGCTATA TGTAGCAGAA ATGATACCCA AGCTAAAAAC ACGGACACAG 360 361 AAATCAGGAG GTGCCGACCC AAGTCTTCAG CAAGGAGAGG GGAGTAAAAA AGGGAAAGGA 420 421 AAGAAGAAGA AATGA 435

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0733	Signal recognition particle

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005730	Cellular Component	Nucleolus
GO:0048500	Cellular Component	Signal recognition particle
GO:0005786	Cellular Component	Signal recognition particle, endoplasmic reticulum targeting
GO:0008312	Molecular Function	7S RNA binding
GO:0042493	Biological Process	Response to drug
GO:0006617	Biological Process	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0006616	Biological Process	SRP-dependent cotranslational protein targeting to membrane, translocation

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

Mutation
CGAP

Interaction
RISE	RAIN	IID	MIST

Physicochemical
AAindex

Localization
COMPARTMENTS

Expression
ArrayExpress	GXD	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-0056	Rattus norvegicus	98.52	8e-96	280
LLPS-Aon-4005	Aotus nancymaae	96.3	9e-94	275
LLPS-Paa-1955	Papio anubis	96.3	3e-93	273
LLPS-Mup-2316	Mustela putorius furo	96.3	2e-93	273
LLPS-Rhb-0824	Rhinopithecus bieti	96.3	3e-93	273
LLPS-Hos-0420	Homo sapiens	96.3	3e-93	273
LLPS-Pap-1967	Pan paniscus	96.3	3e-93	273
LLPS-Urm-0593	Ursus maritimus	96.3	3e-93	273
LLPS-Pat-1201	Pan troglodytes	96.3	3e-93	273
LLPS-Man-0189	Macaca nemestrina	96.3	3e-93	273
LLPS-Poa-2096	Pongo abelii	96.3	2e-93	273
LLPS-Aim-1420	Ailuropoda melanoleuca	95.56	1e-92	271
LLPS-Fec-2420	Felis catus	95.56	2e-92	271
LLPS-Cas-1314	Carlito syrichta	95.56	2e-92	271
LLPS-Caj-3837	Callithrix jacchus	94.81	2e-92	273
LLPS-Sus-0077	Sus scrofa	94.81	5e-92	270
LLPS-Myl-3028	Myotis lucifugus	94.81	2e-92	271
LLPS-Otg-2018	Otolemur garnettii	94.81	1e-91	269
LLPS-Caf-2165	Canis familiaris	94.81	7e-92	270
LLPS-Fud-0554	Fukomys damarensis	94.07	8e-92	270
LLPS-Ere-0614	Erinaceus europaeus	94.07	1e-91	269
LLPS-Bot-3647	Bos taurus	94.07	1e-91	269
LLPS-Loa-1550	Loxodonta africana	94.07	5e-91	268
LLPS-Ict-4012	Ictidomys tridecemlineatus	94.07	2e-92	271
LLPS-Dio-3186	Dipodomys ordii	93.81	2e-62	194
LLPS-Ova-0720	Ovis aries	93.33	2e-90	266
LLPS-Tut-1060	Tursiops truncatus	93.33	9e-89	262
LLPS-Orc-3138	Oryctolagus cuniculus	92.65	6e-90	265
LLPS-Sah-2352	Sarcophilus harrisii	91.04	1e-38	132
LLPS-Eqc-4301	Equus caballus	90.82	6e-59	188
LLPS-Cea-3590	Cercocebus atys	89.63	7e-83	246
LLPS-Mod-3540	Monodelphis domestica	89.15	4e-82	245
LLPS-Maf-0634	Macaca fascicularis	87.41	5e-78	234
LLPS-Mam-3984	Macaca mulatta	87.41	3e-78	234
LLPS-Mea-2551	Mesocricetus auratus	86.27	4e-25	97.4
LLPS-Meg-1332	Meleagris gallopavo	83.33	5e-71	216
LLPS-Anp-2251	Anas platyrhynchos	83.19	8e-65	200
LLPS-Cap-1012	Cavia porcellus	83.06	2e-69	212
LLPS-Tag-1419	Taeniopygia guttata	82.93	2e-72	220
LLPS-Gaga-3877	Gallus gallus	82.71	5e-75	227
LLPS-Ora-0132	Ornithorhynchus anatinus	81.75	3e-74	226
LLPS-Nol-2311	Nomascus leucogenys	80.74	5e-73	222
LLPS-Pes-3436	Pelodiscus sinensis	80.0	2e-68	209
LLPS-Lac-1658	Latimeria chalumnae	79.37	8e-70	214
LLPS-Mal-2591	Mandrillus leucophaeus	79.26	2e-69	212
LLPS-Gog-0290	Gorilla gorilla	78.52	5e-69	211
LLPS-Anc-0014	Anolis carolinensis	77.44	3e-73	222
LLPS-Xet-2365	Xenopus tropicalis	74.38	7e-61	191
LLPS-Dar-3402	Danio rerio	73.81	8e-63	196
LLPS-Scf-0086	Scleropages formosus	73.64	1e-66	205
LLPS-Leo-0859	Lepisosteus oculatus	73.44	2e-64	200
LLPS-Tar-1163	Takifugu rubripes	73.08	1e-64	201
LLPS-Pof-0061	Poecilia formosa	72.44	3e-64	199
LLPS-Gaa-0611	Gasterosteus aculeatus	71.88	1e-64	200
LLPS-Icp-0807	Ictalurus punctatus	71.43	8e-63	196
LLPS-Ten-1336	Tetraodon nigroviridis	71.32	2e-62	195
LLPS-Xim-1034	Xiphophorus maculatus	71.21	1e-61	193
LLPS-Scm-0222	Scophthalmus maximus	71.07	6e-59	186
LLPS-Asm-1023	Astyanax mexicanus	69.53	4e-59	186
LLPS-Orl-1898	Oryzias latipes	68.42	4e-60	189
LLPS-Orn-3129	Oreochromis niloticus	67.44	6e-61	191
LLPS-Nia-1063	Nicotiana attenuata	54.35	9e-11	59.3
LLPS-Drm-1368	Drosophila melanogaster	53.91	7e-36	127
LLPS-Met-0297	Medicago truncatula	52.78	3e-28	107
LLPS-Amt-1944	Amborella trichopoda	51.85	2e-27	105
LLPS-Via-1828	Vigna angularis	51.69	1e-20	86.3
LLPS-Cus-1023	Cucumis sativus	51.3	1e-28	110
LLPS-Pot-2619	Populus trichocarpa	50.93	1e-28	108
LLPS-Cae-0976	Caenorhabditis elegans	50.85	9e-32	116
LLPS-Php-0863	Physcomitrella patens	50.0	1e-30	113
LLPS-Sot-1672	Solanum tuberosum	50.0	7e-25	98.2
LLPS-Mae-0436	Manihot esculenta	49.57	4e-29	109
LLPS-Tru-0013	Triticum urartu	49.33	1e-14	71.6
LLPS-Gor-0399	Gossypium raimondii	49.07	3e-27	104
LLPS-Hea-0493	Helianthus annuus	49.04	4e-22	93.2
LLPS-Viv-0244	Vitis vinifera	48.7	2e-25	101
LLPS-Mua-1954	Musa acuminata	48.39	2e-29	110
LLPS-Coc-0455	Corchorus capsularis	48.21	5e-29	109
LLPS-Prp-0877	Prunus persica	48.15	2e-24	97.1
LLPS-Glm-0505	Glycine max	47.62	6e-29	108
LLPS-Phv-1745	Phaseolus vulgaris	47.62	6e-29	108
LLPS-Zem-1698	Zea mays	47.62	2e-23	94.7
LLPS-Sei-0758	Setaria italica	47.12	3e-23	94.0
LLPS-Thc-2215	Theobroma cacao	46.83	9e-29	108
LLPS-Orni-0460	Oryza nivara	46.67	5e-23	93.6
LLPS-Ori-0973	Oryza indica	46.67	5e-23	93.6
LLPS-Orgl-0775	Oryza glumaepatula	46.67	5e-23	93.6
LLPS-Sob-2241	Sorghum bicolor	46.67	3e-23	94.0
LLPS-Ors-0847	Oryza sativa	46.67	5e-23	93.6
LLPS-Org-0971	Oryza glaberrima	46.67	5e-23	93.6
LLPS-Art-2593	Arabidopsis thaliana	46.23	4e-24	96.7
LLPS-Orb-1075	Oryza barthii	46.15	1e-22	93.6
LLPS-Brd-0975	Brachypodium distachyon	46.15	1e-23	95.5
LLPS-Lep-0532	Leersia perrieri	46.15	1e-22	93.6
LLPS-Orm-0817	Oryza meridionalis	46.15	2e-22	93.6
LLPS-Orr-0532	Oryza rufipogon	46.15	2e-22	93.6
LLPS-Dac-2182	Daucus carota	45.95	8e-24	95.5
LLPS-Orp-0785	Oryza punctata	45.71	1e-22	92.8
LLPS-Brn-2194	Brassica napus	45.37	4e-24	96.7
LLPS-Bro-2240	Brassica oleracea	45.37	4e-24	96.7
LLPS-Arl-0867	Arabidopsis lyrata	45.28	9e-24	95.9
LLPS-Chr-0607	Chlamydomonas reinhardtii	45.05	3e-23	94.7
LLPS-Sem-0568	Selaginella moellendorffii	44.95	2e-20	86.7
LLPS-Hov-0377	Hordeum vulgare	44.76	7e-21	89.0
LLPS-Brr-1226	Brassica rapa	44.44	2e-23	95.1
LLPS-Orbr-0807	Oryza brachyantha	43.75	4e-22	91.3
LLPS-Tra-2024	Triticum aestivum	42.59	2e-21	89.4
LLPS-Mao-0174	Magnaporthe oryzae	42.47	2e-11	63.9
LLPS-Cogr-0745	Colletotrichum graminicola	41.1	9e-13	66.2
LLPS-Pyt-0174	Pyrenophora teres	40.79	3e-12	65.9
LLPS-Pytr-1285	Pyrenophora triticirepentis	40.79	2e-08	55.1
LLPS-Yal-0429	Yarrowia lipolytica	40.51	2e-12	67.0
LLPS-Chc-0451	Chondrus crispus	39.42	1e-14	71.6
LLPS-Scs-0574	Sclerotinia sclerotiorum	38.36	3e-09	57.8
LLPS-Blg-0986	Blumeria graminis	38.36	3e-10	60.5
LLPS-Map-0474	Magnaporthe poae	37.76	2e-13	68.9
LLPS-Osl-0905	Ostreococcus lucimarinus	37.76	2e-14	69.7
LLPS-Phn-0659	Phaeosphaeria nodorum	37.37	2e-14	72.0
LLPS-Trr-1395	Trichoderma reesei	37.14	1e-13	70.1
LLPS-Trv-0127	Trichoderma virens	36.9	4e-12	65.9
LLPS-Lem-0571	Leptosphaeria maculans	36.84	4e-10	60.5
LLPS-Asg-1047	Ashbya gossypii	36.71	5e-09	56.6
LLPS-Asni-0350	Aspergillus niger	36.7	6e-16	76.3
LLPS-Asf-1114	Aspergillus flavus	36.7	4e-16	76.6
LLPS-Vir-1181	Vigna radiata	36.57	5e-21	90.1
LLPS-Asfu-0524	Aspergillus fumigatus	35.78	2e-16	77.4
LLPS-Asc-0113	Aspergillus clavatus	34.86	2e-16	77.4
LLPS-Nec-1290	Neurospora crassa	34.86	1e-11	65.1
LLPS-Cym-0517	Cyanidioschyzon merolae	34.78	2e-10	59.7
LLPS-Fuv-0626	Fusarium verticillioides	34.75	2e-11	63.9
LLPS-Fuo-0876	Fusarium oxysporum	34.75	1e-11	63.9
LLPS-Tum-0767	Tuber melanosporum	34.67	2e-09	57.8
LLPS-Sac-1580	Saccharomyces cerevisiae	34.57	5e-07	51.2
LLPS-Dos-0458	Dothistroma septosporum	34.52	3e-07	51.6
LLPS-Fus-0271	Fusarium solani	34.15	2e-11	63.5
LLPS-Asn-0900	Aspergillus nidulans	33.96	2e-14	72.0
LLPS-Nef-0532	Neosartorya fischeri	33.94	1e-15	75.1
LLPS-Ast-1308	Aspergillus terreus	33.33	1e-13	69.3
LLPS-Zyt-1434	Zymoseptoria tritici	32.1	4e-07	51.2
LLPS-Abg-0876	Absidia glauca	31.78	8e-11	62.4
LLPS-Crn-0331	Cryptococcus neoformans	31.25	1e-08	56.6
LLPS-Gas-0257	Galdieria sulphuraria	30.48	3e-11	61.6
LLPS-Kop-0857	Komagataella pastoris	30.4	2e-09	58.2
LLPS-Coo-0380	Colletotrichum orbiculare	29.37	1e-11	64.7
LLPS-Beb-0305	Beauveria bassiana	28.44	3e-09	57.8

LLPS-Mum-0095Srp19

Protein Sequence

Nucleotide Sequence

LLPS-Mum-0095
Srp19