LLPS-Mod-a609
TAMM41
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidate cytidylyltransferase, mitochondrial; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog |
| Gene Name: | TAMM41 |
| Ensembl Gene: | ENSMODG00000006153.2 |
| Ensembl Protein: | ENSMODP00000007625.2 |
| Organism: | Monodelphis domestica |
| Taxa ID: | 13616 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMODT00000007778.2 | ENSMODP00000007625.2 |
| UniProt | F7BSM1, F7BSM1_MONDO | |
| RefSeq | XM_007500242.2 | XP_007500304.1 |
| Entrez | 100024953 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSLHTIPGSM ATFRRILANF PDNLSLAFAY GSAVYRQAGP NGGRKNIMLD FVFSVDDPVT 60 61 WHSKNLQKNR NHYSCLRLFG PNVIAKVQNN FGAGIYYNAM IKCDGKLIKY GVISTDTLIK 120 121 DLLTWDTLYV AGRLQKPVRF VSFSENSLLR AALDRNLKSA VTAAFLMLPE SCSEEDLFVQ 180 181 IAGLSYSGDF RMLMGEEKKK VVNIVKPNIP HFRELYCSIL RKDPQVVYKE NQGRLEIDKS 240 241 PEGQFTQLMT LPKTLQQEIS YLMGTPGKNR DVEETLLQVA HDPDCGNVVR QGLSGIVRPS 300 301 SVMQSTKGLL TAGLRKSVIY SSMKLQKMYT GWSKQKS 337 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGCTGC ACACCATTCC GGGCTCGATG GCGACTTTCC GCCGGATCCT GGCCAACTTC 60 61 CCCGATAACC TGAGCCTGGC CTTCGCCTAC GGCTCCGCGG TGTACCGCCA GGCGGGGCCC 120 121 AACGGCGGCC GCAAGAATAT TATGCTGGAC TTTGTGTTTT CAGTAGATGA CCCTGTAACA 180 181 TGGCATTCAA AGAACTTGCA AAAAAACCGC AACCACTACT CTTGCTTAAG ACTTTTTGGA 240 241 CCCAACGTTA TTGCTAAAGT ACAGAATAAC TTTGGAGCAG GAATCTACTA CAACGCCATG 300 301 ATAAAATGTG ACGGTAAGCT TATCAAATAC GGAGTTATTA GCACTGATAC TCTAATTAAG 360 361 GATCTGCTTA CTTGGGATAC CTTATATGTT GCTGGACGCC TGCAAAAGCC GGTGAGATTT 420 421 GTGTCCTTCA GTGAGAACAG TTTGCTCCGG GCTGCACTCG ATCGGAACCT GAAAAGTGCT 480 481 GTCACTGCAG CTTTTCTCAT GCTCCCAGAA AGCTGCTCAG AAGAAGACCT TTTTGTGCAG 540 541 ATCGCTGGAC TCTCCTATTC TGGTGACTTT CGGATGCTGA TGGGAGAGGA GAAAAAAAAG 600 601 GTGGTAAACA TTGTGAAGCC CAACATACCT CACTTTCGTG AACTATATTG TTCCATACTA 660 661 CGTAAAGACC CCCAAGTAGT GTACAAAGAA AATCAAGGCC GACTTGAGAT AGATAAAAGC 720 721 CCAGAAGGTC AATTCACTCA GCTAATGACT TTGCCAAAAA CCCTACAGCA AGAAATAAGT 780 781 TATCTTATGG GCACTCCAGG GAAAAACAGA GATGTAGAAG AAACTTTATT ACAAGTGGCT 840 841 CATGATCCTG ATTGTGGGAA TGTGGTACGG CAAGGACTTT CAGGCATTGT GAGACCTTCT 900 901 AGCGTAATGC AGAGCACCAA AGGGCTCCTA ACAGCTGGTT TGAGAAAATC AGTGATTTAC 960 961 AGTTCAATGA AACTGCAAAA AATGTACACC GGATGGTCAA AGCAGAAATC CTAA 1014 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Lipid biosynthesis | |
Lipid metabolism | |
Magnesium | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Nucleotidyltransferase | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Reference proteome | |
Transferase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Molecular Function | Phosphatidate cytidylyltransferase activity | |
Biological Process | Cardiolipin biosynthetic process | |
Biological Process | CDP-diacylglycerol biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a647 | Homo sapiens | 2e-170 | 491 | undefined |
| LLPS-Mum-a641 | Mus musculus | 0.0 | 514 | undefined |