LLPS-Mod-a542
ATAT1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Alpha-tubulin N-acetyltransferase 1 |
| Gene Name: | ATAT1, MEC17 |
| Ensembl Gene: | ENSMODG00000015926.3 |
| Ensembl Protein: | ENSMODP00000031752.2 |
| Organism: | Monodelphis domestica |
| Taxa ID: | 13616 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMODT00000033326.2 | ENSMODP00000031752.2 |
| UniProt | F6R6N6, F6R6N6_MONDO | |
| Entrez | 100024215 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEFPFDVDTL FPEPITVLDQ HLRTPARRTG TTTSARVNLQ QQIMTIVDEL GKASAKAQHL 60 61 TGPITSASRM QSNRHVMYVL KDTSARPAGK GAIIGFLKVG YKKLFVLDDR GAHNEVEPLC 120 121 ILDFYIHESL QRHGHGLKLF QYMLEKERVE PHQLAIDRPS EKLLRFLNKH YNLETTVPQV 180 181 NNFVIFEGFF AHQHRSPASS LRATRCSRAA LVDNTPNAPA RKLLPKKAEG EIKPYSSSDR 240 241 EFLKVAVEPP WPLNRAPRRA IPPARPPPRS SSLGNSPDRG PLRPFVPEQE LLRSLRLCPP 300 301 HPTARLLLAT DPGGSPAQRR RTREATPGLM AQNCSYSRYG EPVSAPKTGN QEQRKRGQET 360 361 ESR 363 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGTTCC CGTTCGATGT GGACACCTTG TTCCCGGAGC CGATTACCGT ACTGGACCAA 60 61 CACCTGCGTA CTCCGGCCCG TCGAACCGGA ACCACAACCT CGGCTCGTGT TAATCTCCAG 120 121 CAGCAAATCA TGACTATTGT GGATGAACTG GGAAAGGCAT CAGCCAAGGC GCAGCATCTT 180 181 ACTGGTCCCA TCACCAGTGC TTCCAGAATG CAGAGTAACC GACATGTTAT GTATGTGCTC 240 241 AAGGACACCT CAGCCCGCCC GGCTGGAAAA GGAGCTATTA TTGGCTTTCT CAAAGTTGGA 300 301 TATAAGAAAC TATTTGTACT GGATGATCGT GGGGCTCATA ATGAGGTAGA GCCACTTTGC 360 361 ATACTGGATT TTTATATCCA CGAATCACTG CAACGCCATG GCCACGGGCT GAAACTTTTT 420 421 CAGTATATGT TAGAGAAGGA AAGGGTTGAA CCACATCAAC TAGCTATTGA TCGGCCCTCA 480 481 GAGAAGCTGT TGCGATTCTT AAATAAACAC TACAACCTGG AGACCACAGT ACCACAGGTG 540 541 AACAACTTTG TGATCTTTGA AGGCTTTTTC GCCCACCAGC ACCGGTCCCC TGCTTCCTCT 600 601 CTGAGGGCGA CTCGATGCTC TCGTGCTGCC TTGGTCGATA ACACACCCAA TGCTCCAGCC 660 661 AGAAAACTGC TCCCTAAAAA AGCAGAAGGA GAGATCAAAC CGTATTCTTC TAGTGATCGA 720 721 GAATTTCTAA AGGTGGCTGT AGAGCCTCCA TGGCCTTTGA ACAGGGCCCC CCGACGTGCT 780 781 ATACCCCCAG CCCGACCACC CCCACGGTCC AGCAGCCTGG GCAATTCTCC AGATCGGGGT 840 841 CCCCTCCGTC CCTTTGTGCC AGAGCAAGAG CTGCTACGGT CTCTTCGACT CTGTCCCCCG 900 901 CACCCTACTG CCCGTCTCCT GCTTGCAACT GACCCTGGAG GCAGTCCAGC CCAACGTAGG 960 961 CGAACCAGGG AAGCAACCCC AGGATTGATG GCCCAGAATT GCAGCTACAG TCGATATGGG 1020 1021 GAGCCAGTCT CAGCCCCCAA AACAGGCAAC CAAGAACAGA GGAAGAGGGG ACAGGAAACA 1080 1081 GAGAGTAGGT GA 1092 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Clathrin-coated pit | |
Cellular Component | Cytosol | |
Cellular Component | Focal adhesion | |
Cellular Component | Golgi apparatus | |
Cellular Component | Microtubule | |
Cellular Component | Microtubule bundle | |
Cellular Component | Mitotic spindle | |
Molecular Function | Coenzyme binding | |
Molecular Function | Lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | |
Molecular Function | Tubulin N-acetyltransferase activity | |
Biological Process | Alpha-tubulin acetylation | |
Biological Process | Dentate gyrus development | |
Biological Process | Neuron development | |
Biological Process | Positive regulation of NLRP3 inflammasome complex assembly | |
Biological Process | Regulation of fat cell differentiation | |
Biological Process | Regulation of microtubule cytoskeleton organization | |
Biological Process | Spermatogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a577 | Homo sapiens | 0.0 | 595 | undefined |
| LLPS-Mum-a572 | Mus musculus | 0.0 | 585 | undefined |