• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-1772
PPIB

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Peptidyl-prolyl cis-trans isomerase
Gene Name: PPIB
Ensembl Gene: ENSMODG00000010819.2
Ensembl Protein: ENSMODP00000013555.1
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLRLTERNMK  LLVVAAFVLG  SVLFLLLPGF  SVADEKKKGP  KVTTKVYFDL  QIGEENAGRI  60
61    VIGLFGKTTP  KTVENFVVLT  TGEKGFGFKG  SKFHRVIKDF  MIQGGDFTRG  DGTGGKSIYG  120
121   DRFPDENFKL  KHYGPGWVSM  ANAGKDTNGS  QFFITTVKTP  WLDGKHVVFG  KVLEGMDVVR  180
181   KVENTKTDGR  DKPLKDVTIA  DCGTIEVEKP  FAIAKE  216
Nucleotide CDS Sequence (FASTA)
1     ACCGAGCGGA  ACATGAAGCT  GCTCGTGGTG  GCCGCCTTCG  TCTTGGGCTC  GGTGCTTTTC  60
61    TTGCTCTTGC  CGGGATTCTC  CGTGGCAGAC  GAGAAGAAGA  AGGGGCCCAA  AGTAACCACC  120
121   AAGGTATATT  TTGATCTTCA  AATTGGTGAG  GAAAATGCAG  GTCGAATTGT  CATCGGTCTC  180
181   TTTGGGAAGA  CAACTCCAAA  GACAGTGGAA  AATTTTGTGG  TTTTGACCAC  AGGAGAGAAA  240
241   GGTTTTGGCT  TCAAGGGCAG  CAAATTTCAC  CGTGTGATCA  AGGACTTCAT  GATTCAAGGT  300
301   GGAGACTTCA  CTCGTGGTGA  TGGCACAGGA  GGAAAGAGCA  TCTATGGCGA  TCGTTTCCCT  360
361   GACGAGAACT  TCAAACTGAA  GCACTACGGA  CCTGGCTGGG  TGAGCATGGC  CAATGCCGGC  420
421   AAGGACACCA  ATGGCTCCCA  GTTCTTCATC  ACCACTGTCA  AAACTCCGTG  GCTGGATGGC  480
481   AAACATGTGG  TGTTTGGCAA  AGTTCTAGAA  GGCATGGATG  TGGTACGAAA  GGTGGAAAAC  540
541   ACCAAGACAG  ATGGGCGGGA  CAAGCCCCTG  AAGGACGTGA  CAATAGCTGA  CTGTGGCACG  600
601   ATTGAAGTGG  AGAAGCCTTT  TGCCATTGCC  AAGGATGAGT  GG  642

▼ KEYWORD

ID
Family
Complete proteome
Isomerase
Reference proteome
Rotamase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum chaperone complex
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Protein-containing complex
Molecular Function
Cyclosporin A binding
Molecular Function
Peptidyl-prolyl cis-trans isomerase activity
Molecular Function
RNA polymerase binding
Molecular Function
Unfolded protein binding
Biological Process
Bone development
Biological Process
Chaperone-mediated protein folding
Biological Process
Positive regulation by host of viral genome replication
Biological Process
Positive regulation of multicellular organism growth
Biological Process
Protein peptidyl-prolyl isomerization
Biological Process
Protein refolding
Biological Process
Protein stabilization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-0445Anas platyrhynchos99.195e-73 224
LLPS-Sah-0750Sarcophilus harrisii94.771e-95 283
LLPS-Gaga-0223Gallus gallus93.992e-102 302
LLPS-Fia-0545Ficedula albicollis93.024e-93 278
LLPS-Tag-0076Taeniopygia guttata91.161e-95 285
LLPS-Anc-0443Anolis carolinensis89.474e-99 294
LLPS-Bot-0109Bos taurus88.893e-118 342
LLPS-Ova-1363Ovis aries88.895e-118 342
LLPS-Sus-0088Sus scrofa88.431e-116 338
LLPS-Loa-0074Loxodonta africana88.431e-117 341
LLPS-Myl-2435Myotis lucifugus87.965e-117 339
LLPS-Scf-1161Scleropages formosus87.832e-99 295
LLPS-Cas-0022Carlito syrichta87.642e-91 273
LLPS-Aim-2390Ailuropoda melanoleuca87.044e-115 334
LLPS-Mup-0614Mustela putorius furo87.047e-116 336
LLPS-Xet-0029Xenopus tropicalis87.042e-115 335
LLPS-Otg-0284Otolemur garnettii87.044e-116 337
LLPS-Dio-1234Dipodomys ordii87.022e-109 320
LLPS-Scm-1098Scophthalmus maximus87.023e-60 192
LLPS-Cap-0334Cavia porcellus86.575e-115 334
LLPS-Ict-0460Ictidomys tridecemlineatus86.575e-115 334
LLPS-Fec-1924Felis catus86.479e-109 319
LLPS-Ora-0696Ornithorhynchus anatinus86.265e-102 301
LLPS-Fud-2014Fukomys damarensis86.122e-107 314
LLPS-Aon-1503Aotus nancymaae86.118e-115 334
LLPS-Caj-0187Callithrix jacchus86.118e-115 334
LLPS-Urm-0027Ursus maritimus86.113e-113 330
LLPS-Pat-2286Pan troglodytes86.115e-115 334
LLPS-Pes-1004Pelodiscus sinensis86.056e-80 243
LLPS-Ran-0437Rattus norvegicus85.652e-113 330
LLPS-Mal-0201Mandrillus leucophaeus85.651e-114 333
LLPS-Paa-0312Papio anubis85.651e-114 333
LLPS-Mum-0639Mus musculus85.654e-113 330
LLPS-Maf-0916Macaca fascicularis85.651e-114 333
LLPS-Cea-0842Cercocebus atys85.651e-114 333
LLPS-Gog-2899Gorilla gorilla85.651e-114 333
LLPS-Poa-0314Pongo abelii85.651e-114 333
LLPS-Mam-0097Macaca mulatta85.651e-114 333
LLPS-Pap-0853Pan paniscus85.658e-114 331
LLPS-Hos-1474Homo sapiens85.651e-114 333
LLPS-Man-0745Macaca nemestrina85.651e-114 333
LLPS-Rhb-2617Rhinopithecus bieti85.651e-114 333
LLPS-Mea-1016Mesocricetus auratus85.195e-113 329
LLPS-Chs-0554Chlorocebus sabaeus85.198e-114 331
LLPS-Caf-0901Canis familiaris85.166e-89 269
LLPS-Leo-0202Lepisosteus oculatus83.331e-113 331
LLPS-Eqc-0740Equus caballus83.266e-107 317
LLPS-Dar-1076Danio rerio83.173e-105 309
LLPS-Orc-2705Oryctolagus cuniculus82.954e-106 312
LLPS-Icp-0124Ictalurus punctatus81.943e-108 317
LLPS-Pof-1099Poecilia formosa81.942e-108 318
LLPS-Xim-0055Xiphophorus maculatus81.022e-106 313
LLPS-Orn-1516Oreochromis niloticus81.022e-108 318
LLPS-Orl-0307Oryzias latipes79.639e-105 308
LLPS-Ten-0793Tetraodon nigroviridis78.77e-101 298
LLPS-Tar-1918Takifugu rubripes78.671e-99 295
LLPS-Gaa-1762Gasterosteus aculeatus73.396e-103 304
LLPS-Ere-0526Erinaceus europaeus72.624e-65 206
LLPS-Cae-1813Caenorhabditis elegans72.078e-71 221
LLPS-Drm-0080Drosophila melanogaster71.822e-74 230
LLPS-Nol-2026Nomascus leucogenys71.761e-104 307
LLPS-Cis-0544Ciona savignyi71.433e-79 243
LLPS-Fus-0079Fusarium solani71.13e-65 207
LLPS-Chr-1108Chlamydomonas reinhardtii70.739e-62 198
LLPS-Sei-0622Setaria italica70.592e-63 204
LLPS-Mua-0819Musa acuminata70.599e-62 199
LLPS-Fuv-0142Fusarium verticillioides69.949e-66 210
LLPS-Asn-1099Aspergillus nidulans69.713e-65 207
LLPS-Sot-1150Solanum tuberosum69.412e-59 194
LLPS-Hov-1158Hordeum vulgare69.411e-61 201
LLPS-Met-1797Medicago truncatula69.419e-62 199
LLPS-Tra-2527Triticum aestivum69.412e-62 201
LLPS-Sol-1671Solanum lycopersicum69.414e-60 195
LLPS-Tru-0418Triticum urartu69.412e-62 201
LLPS-Prp-0394Prunus persica69.11e-61 200
LLPS-Glm-2347Glycine max69.053e-59 193
LLPS-Amt-0172Amborella trichopoda68.861e-58 191
LLPS-Lep-0403Leersia perrieri68.822e-61 198
LLPS-Brd-1141Brachypodium distachyon68.827e-61 197
LLPS-Zem-0760Zea mays68.829e-61 197
LLPS-Phv-1358Phaseolus vulgaris68.821e-58 192
LLPS-Nia-0534Nicotiana attenuata68.823e-60 196
LLPS-Fuo-0689Fusarium oxysporum68.791e-64 207
LLPS-Nec-0156Neurospora crassa68.783e-67 214
LLPS-Abg-1657Absidia glauca68.568e-68 216
LLPS-Zyt-0030Zymoseptoria tritici68.542e-62 199
LLPS-Php-0188Physcomitrella patens68.422e-59 194
LLPS-Cii-0408Ciona intestinalis68.292e-78 241
LLPS-Orp-1471Oryza punctata68.245e-61 197
LLPS-Orbr-0936Oryza brachyantha68.245e-61 197
LLPS-Sob-1746Sorghum bicolor68.247e-61 197
LLPS-Map-0157Magnaporthe poae67.989e-61 196
LLPS-Cus-1207Cucumis sativus67.861e-60 197
LLPS-Arl-0034Arabidopsis lyrata67.867e-60 194
LLPS-Bro-1908Brassica oleracea67.863e-59 193
LLPS-Via-0309Vigna angularis67.654e-59 193
LLPS-Orgl-0115Oryza glumaepatula67.659e-61 197
LLPS-Orb-1009Oryza barthii67.658e-61 197
LLPS-Ori-0875Oryza indica67.658e-61 197
LLPS-Orni-1471Oryza nivara67.658e-61 197
LLPS-Orm-0428Oryza meridionalis67.651e-60 197
LLPS-Orr-0141Oryza rufipogon67.658e-61 197
LLPS-Org-0878Oryza glaberrima67.658e-61 197
LLPS-Ors-1785Oryza sativa67.658e-61 197
LLPS-Viv-0670Vitis vinifera67.611e-59 194
LLPS-Hea-0660Helianthus annuus67.582e-60 196
LLPS-Aso-0029Aspergillus oryzae67.481e-54 179
LLPS-Brn-0435Brassica napus67.444e-60 196
LLPS-Coc-0576Corchorus capsularis67.443e-59 193
LLPS-Brr-1719Brassica rapa67.444e-60 196
LLPS-Coo-0029Colletotrichum orbiculare67.424e-63 204
LLPS-Asm-0622Astyanax mexicanus67.382e-65 207
LLPS-Sem-1891Selaginella moellendorffii67.275e-58 189
LLPS-Scp-0530Schizosaccharomyces pombe67.22e-67 213
LLPS-Art-0788Arabidopsis thaliana66.673e-57 190
LLPS-Gor-1345Gossypium raimondii66.281e-57 189
LLPS-Gas-1091Galdieria sulphuraria65.841e-49 166
LLPS-Asfu-0416Aspergillus fumigatus65.845e-52 172
LLPS-Lac-2486Latimeria chalumnae65.713e-73 228
LLPS-Cogr-1295Colletotrichum graminicola65.646e-67 211
LLPS-Kop-0620Komagataella pastoris65.06e-61 196
LLPS-Trr-0248Trichoderma reesei64.921e-62 200
LLPS-Dac-1320Daucus carota64.672e-57 193
LLPS-Scj-0218Schizosaccharomyces japonicus64.531e-60 195
LLPS-Pot-0912Populus trichocarpa64.535e-56 185
LLPS-Usm-0289Ustilago maydis64.52e-54 179
LLPS-Trv-0867Trichoderma virens64.478e-64 206
LLPS-Pyt-0239Pyrenophora teres64.14e-63 204
LLPS-Mae-0983Manihot esculenta64.042e-59 194
LLPS-Chc-0255Chondrus crispus63.862e-56 184
LLPS-Tut-0947Tursiops truncatus63.731e-68 216
LLPS-Mao-0281Magnaporthe oryzae63.642e-64 205
LLPS-Dos-0440Dothistroma septosporum63.52e-67 213
LLPS-Thc-0674Theobroma cacao63.482e-61 199
LLPS-Vir-0720Vigna radiata63.163e-53 177
LLPS-Ved-0524Verticillium dahliae63.03e-66 209
LLPS-Cog-0486Colletotrichum gloeosporioides63.01e-64 207
LLPS-Miv-0079Microbotryum violaceum62.893e-61 197
LLPS-Nef-1294Neosartorya fischeri62.739e-49 163
LLPS-Yal-0625Yarrowia lipolytica62.692e-62 200
LLPS-Pytr-0447Pyrenophora triticirepentis62.562e-63 202
LLPS-Osl-0446Ostreococcus lucimarinus62.52e-62 200
LLPS-Asni-0113Aspergillus niger62.39e-62 200
LLPS-Spr-0473Sporisorium reilianum62.015e-55 181
LLPS-Beb-0820Beauveria bassiana61.03e-63 202
LLPS-Asc-0176Aspergillus clavatus60.895e-61 196
LLPS-Gag-0423Gaeumannomyces graminis60.615e-58 189
LLPS-Scs-0057Sclerotinia sclerotiorum60.05e-60 196
LLPS-Crn-0500Cryptococcus neoformans59.721e-63 207
LLPS-Blg-0822Blumeria graminis59.35e-55 181
LLPS-Scc-0600Schizosaccharomyces cryophilus57.691e-59 193
LLPS-Mel-0792Melampsora laricipopulina57.362e-54 179
LLPS-Put-0804Puccinia triticina57.073e-53 177
LLPS-Asg-0434Ashbya gossypii56.544e-54 178
LLPS-Sac-1189Saccharomyces cerevisiae55.289e-57 186
LLPS-Pug-0073Puccinia graminis52.437e-54 179