• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Met-1471
25495172

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Formate dehydrogenase, mitochondrial
Gene Name: 25495172, MTR_6g007170, MtrunA17_Chr6g0450811
Ensembl Gene: MTR_6g007170
Ensembl Protein: KEH24845
Organism: Medicago truncatula
Taxa ID: 3880
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAMKRAASTL  ITASSKISSL  SSPSSIITRD  LHASGGKKKI  VGVFYKGGEY  ASLNPNFVGC  60
61    VEGALGIREW  LESQGHEYIV  TDDKEGLNSE  LEKHIPDLNV  LISTPFHPAY  VTAERIKKAK  120
121   NLELLLTAGI  GSDHIDLNAA  AAAGLTVAEV  TGSNTVSVAE  DELMRILILV  RNFLPGYHQA  180
181   ITGEWNVAGI  AHRAYDLEGK  TVGTVGAGRI  GKLLLQRLKP  FNCNLLYHDR  LKMEPELEKE  240
241   IGAQFEEDLD  AMLPKCDIIV  MNMPLTDKTR  GLFDKNRIAK  LKKGVLIVNN  ARGALMDTQA  300
301   VADACSSGHV  AGYSGDVWFP  QPAPKDHPWR  YMPNHAMTPH  ISGTTIDAQL  RYAAGVKDML  360
361   EKHFKGEDFP  EQNYIVKEGQ  LASQYR  386
Nucleotide CDS Sequence (FASTA)
1     ATGGCTATGA  AACGTGCTGC  TTCCACCTTG  ATCACTGCTT  CTTCAAAGAT  TTCATCACTT  60
61    TCTTCACCTT  CTTCCATCAT  CACCAGAGAC  CTTCATGCCT  CTGGTGGAAA  GAAGAAGATT  120
121   GTAGGTGTGT  TCTACAAAGG  CGGCGAATAT  GCTTCCTTGA  ATCCCAATTT  TGTTGGATGT  180
181   GTTGAAGGAG  CATTAGGTAT  ACGCGAGTGG  TTGGAATCAC  AAGGACATGA  ATACATTGTC  240
241   ACTGATGACA  AAGAAGGACT  CAATTCTGAA  CTTGAGAAGC  ACATTCCTGA  TCTCAATGTC  300
301   CTGATATCCA  CACCATTTCA  CCCTGCCTAT  GTCACTGCGG  AAAGAATTAA  GAAAGCTAAG  360
361   AATTTAGAGC  TGCTTTTAAC  TGCCGGCATT  GGTTCTGATC  ACATTGATCT  CAATGCTGCG  420
421   GCTGCTGCTG  GTTTAACCGT  CGCAGAGGTC  ACAGGAAGCA  ACACTGTGTC  GGTTGCTGAG  480
481   GACGAGCTCA  TGAGAATTCT  CATTCTTGTG  AGGAATTTCT  TGCCTGGTTA  CCATCAGGCT  540
541   ATTACCGGAG  AATGGAATGT  TGCTGGAATT  GCACATAGAG  CCTATGATCT  TGAAGGAAAG  600
601   ACAGTTGGAA  CGGTTGGTGC  GGGACGAATC  GGGAAGCTTT  TACTCCAAAG  GCTGAAACCC  660
661   TTTAACTGTA  ACCTTTTATA  TCATGATAGA  CTTAAGATGG  AGCCTGAATT  GGAGAAAGAA  720
721   ATTGGAGCTC  AGTTTGAGGA  GGATCTTGAT  GCTATGCTAC  CAAAATGCGA  CATTATTGTT  780
781   ATGAACATGC  CTCTCACTGA  TAAGACAAGA  GGATTGTTTG  ACAAAAATAG  AATTGCCAAG  840
841   TTGAAGAAAG  GTGTCTTGAT  TGTCAACAAT  GCTCGCGGAG  CACTTATGGA  TACACAAGCA  900
901   GTTGCTGATG  CTTGTTCCAG  TGGACACGTT  GCAGGTTACA  GTGGTGATGT  TTGGTTCCCA  960
961   CAACCAGCTC  CAAAAGATCA  TCCATGGCGC  TACATGCCTA  ATCATGCTAT  GACTCCTCAT  1020
1021  ATTTCTGGAA  CTACCATTGA  TGCACAGTTA  CGTTATGCTG  CTGGAGTCAA  AGATATGCTT  1080
1081  GAGAAGCACT  TTAAGGGTGA  AGACTTTCCT  GAACAGAACT  ACATTGTGAA  GGAGGGTCAA  1140
1141  TTGGCAAGCC  AATACCGGTG  A  1161

▼ KEYWORD

ID
Family
Complete proteome
Mitochondrion
NAD
Oxidoreductase
Pyruvate
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Formate dehydrogenase (NAD+) activity
Molecular Function
NAD binding
Molecular Function
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
Formate catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Glm-1574Glycine max90.450.0 671
LLPS-Cus-1547Cucumis sativus89.390.0 647
LLPS-Phv-1892Phaseolus vulgaris88.290.0 656
LLPS-Orm-2054Oryza meridionalis88.270.0 659
LLPS-Ors-0509Oryza sativa87.990.0 655
LLPS-Orp-0969Oryza punctata87.990.0 655
LLPS-Orr-0621Oryza rufipogon87.990.0 657
LLPS-Ori-2392Oryza indica87.990.0 657
LLPS-Orni-0988Oryza nivara87.990.0 657
LLPS-Orgl-0584Oryza glumaepatula87.990.0 657
LLPS-Lep-0267Leersia perrieri87.990.0 659
LLPS-Org-1432Oryza glaberrima87.710.0 654
LLPS-Orb-2046Oryza barthii87.710.0 654
LLPS-Viv-2427Vitis vinifera87.430.0 660
LLPS-Orbr-1368Oryza brachyantha87.430.0 657
LLPS-Sei-2059Setaria italica87.430.0 635
LLPS-Gor-1037Gossypium raimondii87.150.0 661
LLPS-Via-1590Vigna angularis87.040.0 649
LLPS-Vir-2056Vigna radiata87.040.0 650
LLPS-Thc-2450Theobroma cacao86.870.0 659
LLPS-Tra-0191Triticum aestivum86.870.0 655
LLPS-Sob-2017Sorghum bicolor86.760.0 628
LLPS-Brd-1550Brachypodium distachyon86.590.0 654
LLPS-Tru-1517Triticum urartu86.310.0 650
LLPS-Zem-0684Zea mays86.310.0 630
LLPS-Hov-1776Hordeum vulgare86.310.0 651
LLPS-Pot-2685Populus trichocarpa86.270.0 645
LLPS-Amt-0352Amborella trichopoda86.270.0 643
LLPS-Coc-2288Corchorus capsularis86.030.0 650
LLPS-Dac-0716Daucus carota86.030.0 641
LLPS-Mua-1316Musa acuminata85.750.0 640
LLPS-Mae-2135Manihot esculenta85.20.0 645
LLPS-Sol-2030Solanum lycopersicum84.360.0 633
LLPS-Sot-0309Solanum tuberosum84.360.0 636
LLPS-Nia-0181Nicotiana attenuata84.080.0 634
LLPS-Hea-0452Helianthus annuus83.80.0 645
LLPS-Prp-0637Prunus persica83.570.0 624
LLPS-Brr-2865Brassica rapa83.050.0 612
LLPS-Arl-0117Arabidopsis lyrata83.050.0 595
LLPS-Art-1293Arabidopsis thaliana82.770.0 592
LLPS-Brn-0871Brassica napus82.770.0 610
LLPS-Bro-1785Brassica oleracea82.450.0 612
LLPS-Sem-2407Selaginella moellendorffii67.424e-180 513
LLPS-Php-0919Physcomitrella patens66.765e-173 496
LLPS-Gas-1273Galdieria sulphuraria56.792e-139 410
LLPS-Aso-0854Aspergillus oryzae56.021e-134 398
LLPS-Asf-0575Aspergillus flavus56.022e-134 397
LLPS-Mel-1344Melampsora laricipopulina55.656e-133 393
LLPS-Pytr-0941Pyrenophora triticirepentis55.495e-129 382
LLPS-Pyt-1510Pyrenophora teres54.642e-129 385
LLPS-Phn-0770Phaeosphaeria nodorum54.371e-133 395
LLPS-Lem-1574Leptosphaeria maculans54.086e-126 375
LLPS-Mao-1514Magnaporthe oryzae54.066e-132 393
LLPS-Asni-1246Aspergillus niger53.853e-129 383
LLPS-Ast-0173Aspergillus terreus53.831e-134 399
LLPS-Cogr-0817Colletotrichum graminicola53.84e-127 378
LLPS-Cog-0162Colletotrichum gloeosporioides53.523e-130 388
LLPS-Asn-0794Aspergillus nidulans53.522e-129 384
LLPS-Coo-0437Colletotrichum orbiculare53.523e-125 375
LLPS-Gag-0654Gaeumannomyces graminis53.53e-127 380
LLPS-Crn-1590Cryptococcus neoformans53.412e-127 379
LLPS-Kop-0933Komagataella pastoris53.241e-126 376
LLPS-Map-1113Magnaporthe poae53.152e-127 379
LLPS-Nef-0210Neosartorya fischeri53.012e-132 393
LLPS-Asfu-1654Aspergillus fumigatus53.017e-127 379
LLPS-Beb-0925Beauveria bassiana52.883e-129 385
LLPS-Asc-1391Aspergillus clavatus52.735e-132 392
LLPS-Yal-0566Yarrowia lipolytica52.695e-126 375
LLPS-Fus-0431Fusarium solani52.686e-120 359
LLPS-Fuo-0147Fusarium oxysporum52.684e-125 372
LLPS-Fuv-1183Fusarium verticillioides52.682e-125 373
LLPS-Trv-0502Trichoderma virens52.69e-129 382
LLPS-Trr-0708Trichoderma reesei52.391e-126 377
LLPS-Nec-0536Neurospora crassa52.392e-118 356
LLPS-Zyt-1229Zymoseptoria tritici52.043e-129 385
LLPS-Dos-0356Dothistroma septosporum51.633e-128 382
LLPS-Spr-1023Sporisorium reilianum50.428e-121 362
LLPS-Ved-0900Verticillium dahliae50.429e-114 343
LLPS-Miv-0328Microbotryum violaceum50.03e-118 355
LLPS-Usm-0282Ustilago maydis49.583e-118 355
LLPS-Sac-1549Saccharomyces cerevisiae46.23e-105 322
LLPS-Cis-1656Ciona savignyi35.383e-29 119
LLPS-Leo-2604Lepisosteus oculatus34.881e-32 132
LLPS-Asm-1851Astyanax mexicanus33.332e-32 132
LLPS-Orl-2157Oryzias latipes33.217e-32 130
LLPS-Xet-1083Xenopus tropicalis33.068e-28 118
LLPS-Drm-1167Drosophila melanogaster32.948e-29 119
LLPS-Ora-2954Ornithorhynchus anatinus32.828e-30 124
LLPS-Scp-1259Schizosaccharomyces pombe32.573e-27 114
LLPS-Cii-0671Ciona intestinalis32.444e-33 133
LLPS-Hos-2297Homo sapiens32.435e-31 127
LLPS-Pat-0447Pan troglodytes32.437e-31 127
LLPS-Pap-3852Pan paniscus32.437e-31 127
LLPS-Loa-2685Loxodonta africana32.431e-31 129
LLPS-Man-2098Macaca nemestrina32.438e-31 127
LLPS-Rhb-1166Rhinopithecus bieti32.431e-30 127
LLPS-Poa-0195Pongo abelii32.435e-31 127
LLPS-Mam-3273Macaca mulatta32.437e-31 127
LLPS-Nol-4555Nomascus leucogenys32.438e-31 127
LLPS-Chs-3657Chlorocebus sabaeus32.435e-31 127
LLPS-Maf-1155Macaca fascicularis32.437e-31 127
LLPS-Caj-4768Callithrix jacchus32.434e-30 125
LLPS-Paa-4070Papio anubis32.436e-31 127
LLPS-Sah-2963Sarcophilus harrisii32.34e-29 122
LLPS-Anc-3176Anolis carolinensis32.222e-28 120
LLPS-Abg-0571Absidia glauca32.146e-30 122
LLPS-Scm-3793Scophthalmus maximus32.123e-32 132
LLPS-Orn-0907Oreochromis niloticus32.076e-34 136
LLPS-Aon-3320Aotus nancymaae32.062e-29 123
LLPS-Otg-4112Otolemur garnettii32.052e-29 123
LLPS-Orc-1371Oryctolagus cuniculus32.052e-30 125
LLPS-Ten-2761Tetraodon nigroviridis32.058e-31 127
LLPS-Cas-2437Carlito syrichta32.054e-31 127
LLPS-Mum-3332Mus musculus32.053e-30 125
LLPS-Dar-2742Danio rerio31.691e-30 126
LLPS-Gaa-3041Gasterosteus aculeatus31.682e-31 128
LLPS-Icp-1894Ictalurus punctatus31.673e-33 134
LLPS-Ran-4467Rattus norvegicus31.669e-30 124
LLPS-Mal-4622Mandrillus leucophaeus31.661e-27 118
LLPS-Fud-2521Fukomys damarensis31.641e-29 124
LLPS-Meg-2509Meleagris gallopavo31.586e-31 127
LLPS-Tar-1518Takifugu rubripes31.581e-27 118
LLPS-Scc-1217Schizosaccharomyces cryophilus31.531e-25 110
LLPS-Bot-3221Bos taurus31.522e-29 122
LLPS-Pof-3926Poecilia formosa31.467e-33 133
LLPS-Xim-3288Xiphophorus maculatus31.464e-33 133
LLPS-Urm-3734Ursus maritimus31.271e-28 120
LLPS-Cea-3379Cercocebus atys31.272e-27 117
LLPS-Dio-1652Dipodomys ordii31.273e-29 122
LLPS-Aim-3542Ailuropoda melanoleuca31.271e-28 120
LLPS-Mup-2395Mustela putorius furo31.272e-28 120
LLPS-Scf-0250Scleropages formosus31.137e-31 128
LLPS-Sus-3383Sus scrofa31.058e-29 121
LLPS-Cap-2232Cavia porcellus31.022e-30 126
LLPS-Fec-2791Felis catus30.893e-28 119
LLPS-Tum-1557Tuber melanosporum30.718e-25 108
LLPS-Ova-3645Ovis aries30.651e-27 118
LLPS-Mod-3886Monodelphis domestica30.634e-30 125
LLPS-Cae-1837Caenorhabditis elegans30.583e-26 111
LLPS-Ict-0923Ictidomys tridecemlineatus30.465e-30 124
LLPS-Eqc-4526Equus caballus30.361e-29 123
LLPS-Gog-3373Gorilla gorilla30.296e-28 119
LLPS-Tag-2478Taeniopygia guttata30.142e-25 107
LLPS-Anp-2638Anas platyrhynchos30.16e-25 106
LLPS-Caf-0716Canis familiaris30.032e-28 120
LLPS-Asg-0711Ashbya gossypii30.07e-29 120
LLPS-Cym-1006Cyanidioschyzon merolae29.632e-28 118
LLPS-Chc-0953Chondrus crispus29.534e-32 128
LLPS-Fia-1154Ficedula albicollis28.975e-28 116
LLPS-Pes-0050Pelodiscus sinensis28.881e-31 125
LLPS-Mea-4281Mesocricetus auratus28.462e-26 112
LLPS-Myl-4310Myotis lucifugus28.242e-33 132
LLPS-Gaga-0790Gallus gallus26.164e-29 120