LLPS-Mea-a534
Atat1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Alpha-tubulin N-acetyltransferase 1 |
| Gene Name: | Atat1, ATAT1, MEC17 |
| Ensembl Gene: | ENSMAUG00000014788.1 |
| Ensembl Protein: | ENSMAUP00000015274.1 |
| Organism: | Mesocricetus auratus |
| Taxa ID: | 10036 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMAUT00000019199.1 | ENSMAUP00000015274.1 |
| Ensembl | ENSMAUT00000019203.1 | ENSMAUP00000015278.1 |
| UniProt | A0A1U8CQP2, A0A1U8CQP2_MESAU | |
| RefSeq | , XM_013126372.1 | , XP_012981826.1, XP_012981826.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTILDEL GKASAKAQRL 60 61 PAPITSASRM QSNRHVVYIL KDTSARPAGK GAILGFLKVG YKKLFVLDDR EAHNEVEPLC 120 121 ILDFYIHESV QRHGHGRELF QHMLQKERVE PHQLAIDRPS PKLLKFLNKH YNLETTVPQV 180 181 NNFVIFEGFF AHQHRPPTPS LRASRHSRAA EVDPTPAAPA RKLPPKRAEG DIKPYSSSDR 240 241 EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPDRG PLRPFVPEQE LLRSLRLCPP 300 301 HPAARLLLAS DPGSSPAQRR RTSSLPRSDE SRY 333 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Clathrin-coated pit | |
Cellular Component | Cytoplasm | |
Cellular Component | Focal adhesion | |
Cellular Component | Microtubule | |
Cellular Component | Spindle | |
Molecular Function | Tubulin N-acetyltransferase activity | |
Biological Process | Alpha-tubulin acetylation | |
Biological Process | Neuron development | |
Biological Process | Regulation of microtubule cytoskeleton organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a577 | Homo sapiens | 0.0 | 630 | undefined |
| LLPS-Mum-a572 | Mus musculus | 0.0 | 631 | undefined |