• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mao-1548
TIF1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent RNA helicase eIF4A; Eukaryotic initiation factor 4A; eIF-4A; Translation initiation factor 1
Gene Name: TIF1, TIF41, MGG_04400
Ensembl Gene: MGG_04400
Ensembl Protein: MGG_04400T0
Organism: Magnaporthe oryzae
Taxa ID: 242507
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblMGG_04400T0MGG_04400T0
UniProtA4QVP2, IF4A_MAGO7, G4MKM0
GeneBankCM001231EHA58403.1
RefSeqXM_003710967.1XP_003711015.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADKGLEDVP  EGQIESNYDE  TVDSFDEMNL  KSELLRGIYA  YGFERPSAIQ  QRAIMPVIKG  60
61    HDVIAQAQSG  TGKTATFSIS  VLQKIDTNVK  QCQALILAPT  RELAQQIQKV  VVAIGDFMNI  120
121   ECHACIGGTS  VRDDMKALQD  GPQVVVGTPG  RVHDMIQRRF  LKTDGMKMFV  LDEADEMLSR  180
181   GFTEQIYDIF  QLLPQSTQVV  LLSATMPQDV  LEVTTKFMRD  PVRILVKKDE  LTLEGIKQFY  240
241   IAVEKEEWKL  DTLSDLYETV  TITQAVIFCN  TRRKVDWLTD  KLTARDFTVS  AMHGDMDQAQ  300
301   RDLIMKEFRS  GSSRVLIATD  LLARGIDVQQ  VSLVINYDLP  ANRENYIHRI  GRGGRFGRKG  360
361   VAINFVTADD  VRMMREIEQF  YSTQIEEMPM  NVADLI  396
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGACA  AGGGACTCGA  GGATGTCCCC  GAAGGGCAGA  TCGAGTCCAA  TTACGATGAG  60
61    ACCGTCGACT  CTTTCGACGA  GATGAACCTG  AAGTCGGAGC  TGCTTCGTGG  TATCTATGCC  120
121   TACGGTTTCG  AGCGCCCGTC  TGCTATCCAG  CAGCGCGCTA  TCATGCCCGT  TATCAAGGGC  180
181   CACGATGTCA  TTGCTCAGGC  TCAGTCCGGT  ACCGGCAAGA  CCGCCACTTT  CTCGATCTCG  240
241   GTTCTGCAGA  AGATCGACAC  CAACGTCAAG  CAGTGCCAGG  CCCTGATCCT  TGCCCCGACC  300
301   CGTGAGCTTG  CTCAGCAGAT  CCAGAAGGTC  GTTGTTGCCA  TCGGTGACTT  CATGAACATT  360
361   GAGTGCCACG  CCTGCATTGG  CGGCACCAGC  GTTCGTGATG  ACATGAAGGC  TCTTCAGGAC  420
421   GGCCCCCAGG  TCGTTGTCGG  TACCCCCGGC  CGTGTCCACG  ACATGATCCA  GCGCCGCTTC  480
481   CTCAAGACCG  ACGGCATGAA  GATGTTCGTC  CTTGACGAGG  CCGACGAGAT  GCTTTCGCGT  540
541   GGTTTCACCG  AGCAAATTTA  CGACATCTTC  CAGCTCCTCC  CCCAGTCGAC  TCAGGTTGTC  600
601   CTGCTTTCGG  CCACCATGCC  CCAGGACGTC  CTGGAGGTCA  CGACCAAGTT  CATGCGCGAC  660
661   CCCGTCCGCA  TCCTGGTCAA  GAAGGACGAG  CTTACCCTGG  AGGGTATCAA  GCAGTTCTAC  720
721   ATTGCTGTCG  AGAAGGAAGA  GTGGAAGCTC  GACACCCTCT  CGGACTTGTA  CGAGACTGTC  780
781   ACCATTACCC  AGGCCGTTAT  TTTCTGCAAC  ACCCGCAGAA  AGGTCGACTG  GCTCACGGAC  840
841   AAGCTCACTG  CCCGTGACTT  CACTGTGTCT  GCCATGCACG  GTGACATGGA  CCAGGCTCAG  900
901   CGTGACCTGA  TCATGAAGGA  GTTCCGCTCG  GGTTCGTCCC  GTGTGCTTAT  TGCCACCGAC  960
961   TTGCTCGCTC  GTGGTATCGA  CGTCCAGCAG  GTATCGCTGG  TCATCAACTA  CGACCTGCCC  1020
1021  GCCAACCGTG  AGAACTACAT  CCACAGGATT  GGTCGTGGTG  GTCGTTTCGG  CCGAAAGGGT  1080
1081  GTCGCCATTA  ACTTCGTCAC  CGCCGATGAT  GTGCGCATGA  TGCGCGAGAT  TGAGCAGTTC  1140
1141  TACAGCACGC  AGATTGAGGA  GATGCCTATG  AACGTCGCCG  ACTTGATT  1188

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Cytoplasm
Helicase
Hydrolase
Initiation factor
Nucleotide-binding
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
ATP binding
Molecular Function
ATP-dependent RNA helicase activity
Molecular Function
Translation initiation factor activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cogr-1035Colletotrichum graminicola98.740.0 778
LLPS-Map-0309Magnaporthe poae98.730.0 773
LLPS-Cog-0451Colletotrichum gloeosporioides98.480.0 778
LLPS-Gag-0704Gaeumannomyces graminis98.480.0 771
LLPS-Fuo-0017Fusarium oxysporum98.230.0 774
LLPS-Fuv-1217Fusarium verticillioides98.230.0 774
LLPS-Fus-1205Fusarium solani98.220.0 771
LLPS-Nec-1472Neurospora crassa97.970.0 768
LLPS-Trv-1482Trichoderma virens97.730.0 771
LLPS-Trr-0339Trichoderma reesei97.730.0 772
LLPS-Beb-0407Beauveria bassiana97.210.0 762
LLPS-Coo-0455Colletotrichum orbiculare96.720.0 763
LLPS-Phn-0194Phaeosphaeria nodorum96.460.0 762
LLPS-Scs-0229Sclerotinia sclerotiorum96.460.0 760
LLPS-Pytr-0699Pyrenophora triticirepentis96.210.0 758
LLPS-Pyt-0800Pyrenophora teres96.210.0 758
LLPS-Ved-0239Verticillium dahliae93.70.0 738
LLPS-Nef-0114Neosartorya fischeri93.40.0 736
LLPS-Asc-1469Aspergillus clavatus93.150.0 735
LLPS-Asfu-0400Aspergillus fumigatus93.090.0 731
LLPS-Blg-0118Blumeria graminis92.930.0 741
LLPS-Tum-0606Tuber melanosporum92.680.0 722
LLPS-Asf-1130Aspergillus flavus92.070.0 721
LLPS-Asn-0694Aspergillus nidulans91.620.0 731
LLPS-Asni-0716Aspergillus niger91.370.0 725
LLPS-Aso-0030Aspergillus oryzae86.840.0 714
LLPS-Scp-0609Schizosaccharomyces pombe86.680.0 671
LLPS-Scj-1227Schizosaccharomyces japonicus86.420.0 670
LLPS-Ast-0957Aspergillus terreus86.40.0 717
LLPS-Scc-1071Schizosaccharomyces cryophilus86.160.0 667
LLPS-Abg-1766Absidia glauca84.910.0 662
LLPS-Mel-0769Melampsora laricipopulina81.980.0 642
LLPS-Spr-0452Sporisorium reilianum81.750.0 654
LLPS-Usm-0562Ustilago maydis81.750.0 653
LLPS-Miv-1473Microbotryum violaceum81.070.0 638
LLPS-Gaa-1592Gasterosteus aculeatus78.030.0 611
LLPS-Lac-1643Latimeria chalumnae77.890.0 603
LLPS-Put-0968Puccinia triticina77.860.0 603
LLPS-Mam-1480Macaca mulatta77.840.0 608
LLPS-Eqc-0161Equus caballus77.840.0 607
LLPS-Cap-1449Cavia porcellus77.840.0 608
LLPS-Caf-2831Canis familiaris77.840.0 608
LLPS-Poa-0769Pongo abelii77.840.0 608
LLPS-Ict-0382Ictidomys tridecemlineatus77.840.0 608
LLPS-Nol-1872Nomascus leucogenys77.840.0 608
LLPS-Cas-0113Carlito syrichta77.840.0 608
LLPS-Loa-2282Loxodonta africana77.840.0 608
LLPS-Man-0241Macaca nemestrina77.840.0 608
LLPS-Fec-1541Felis catus77.840.0 608
LLPS-Mod-0560Monodelphis domestica77.840.0 607
LLPS-Pap-0552Pan paniscus77.840.0 608
LLPS-Urm-1221Ursus maritimus77.840.0 608
LLPS-Pat-2795Pan troglodytes77.840.0 608
LLPS-Hos-0639Homo sapiens77.840.0 608
LLPS-Orc-2473Oryctolagus cuniculus77.840.0 608
LLPS-Otg-1452Otolemur garnettii77.840.0 608
LLPS-Bot-1221Bos taurus77.840.0 608
LLPS-Aim-0711Ailuropoda melanoleuca77.840.0 608
LLPS-Mal-2259Mandrillus leucophaeus77.840.0 608
LLPS-Paa-1394Papio anubis77.840.0 608
LLPS-Ran-0005Rattus norvegicus77.840.0 608
LLPS-Aon-0787Aotus nancymaae77.840.0 608
LLPS-Cea-2370Cercocebus atys77.840.0 608
LLPS-Sus-0086Sus scrofa77.840.0 608
LLPS-Mum-4271Mus musculus77.840.0 608
LLPS-Maf-2353Macaca fascicularis77.840.0 608
LLPS-Caj-2333Callithrix jacchus77.840.0 608
LLPS-Fud-0629Fukomys damarensis77.840.0 608
LLPS-Gog-0745Gorilla gorilla77.840.0 608
LLPS-Scf-0272Scleropages formosus77.780.0 612
LLPS-Dio-3485Dipodomys ordii77.650.0 559
LLPS-Mup-0432Mustela putorius furo77.650.0 559
LLPS-Chs-0017Chlorocebus sabaeus77.650.0 559
LLPS-Rhb-0719Rhinopithecus bieti77.610.0 608
LLPS-Tut-1572Tursiops truncatus77.610.0 608
LLPS-Myl-0612Myotis lucifugus77.610.0 608
LLPS-Ere-0487Erinaceus europaeus77.610.0 608
LLPS-Mea-1224Mesocricetus auratus77.60.0 602
LLPS-Xet-0198Xenopus tropicalis77.580.0 608
LLPS-Dar-1037Danio rerio77.530.0 609
LLPS-Leo-0027Lepisosteus oculatus77.530.0 609
LLPS-Sah-0483Sarcophilus harrisii77.440.0 602
LLPS-Ova-0374Ovis aries77.410.0 603
LLPS-Pes-0010Pelodiscus sinensis77.380.0 603
LLPS-Gaga-1395Gallus gallus77.320.0 608
LLPS-Icp-0901Ictalurus punctatus77.270.0 605
LLPS-Cii-0503Ciona intestinalis77.00.0 594
LLPS-Tag-1189Taeniopygia guttata76.90.0 609
LLPS-Anp-1216Anas platyrhynchos76.90.0 609
LLPS-Fia-0701Ficedula albicollis76.90.0 609
LLPS-Anc-1175Anolis carolinensis76.770.0 609
LLPS-Asm-0154Astyanax mexicanus76.770.0 602
LLPS-Xim-0442Xiphophorus maculatus76.650.0 604
LLPS-Orl-1072Oryzias latipes76.650.0 602
LLPS-Orn-0422Oreochromis niloticus76.590.0 602
LLPS-Scm-0767Scophthalmus maximus76.560.0 592
LLPS-Cis-1713Ciona savignyi76.420.0 595
LLPS-Tar-1057Takifugu rubripes76.340.0 597
LLPS-Pof-2955Poecilia formosa76.260.0 601
LLPS-Crn-0653Cryptococcus neoformans75.440.0 601
LLPS-Chc-0540Chondrus crispus74.350.0 581
LLPS-Yal-1088Yarrowia lipolytica73.480.0 589
LLPS-Drm-0038Drosophila melanogaster72.610.0 573
LLPS-Gor-1076Gossypium raimondii72.440.0 550
LLPS-Mae-0189Manihot esculenta72.440.0 550
LLPS-Brr-1101Brassica rapa72.180.0 554
LLPS-Brn-1648Brassica napus72.180.0 554
LLPS-Hea-1728Helianthus annuus72.180.0 552
LLPS-Sac-0302Saccharomyces cerevisiae72.010.0 559
LLPS-Bro-2410Brassica oleracea71.920.0 553
LLPS-Met-0986Medicago truncatula71.920.0 551
LLPS-Sol-1984Solanum lycopersicum71.920.0 549
LLPS-Meg-2838Meleagris gallopavo71.90.0 553
LLPS-Cae-0890Caenorhabditis elegans71.760.0 560
LLPS-Chr-0131Chlamydomonas reinhardtii71.240.0 557
LLPS-Arl-0954Arabidopsis lyrata70.710.0 553
LLPS-Gas-0524Galdieria sulphuraria70.290.0 555
LLPS-Ten-0477Tetraodon nigroviridis70.10.0 550
LLPS-Dos-0759Dothistroma septosporum69.420.0 558
LLPS-Zyt-1297Zymoseptoria tritici68.920.0 555
LLPS-Osl-0029Ostreococcus lucimarinus68.660.0 551
LLPS-Php-1299Physcomitrella patens67.680.0 551