LLPS-Mao-1355
NPL4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Nuclear protein localization protein 4 |
| Gene Name: | NPL4, MGG_04413 |
| Ensembl Gene: | MGG_04413 |
| Ensembl Protein: | MGG_04413T1 |
| Organism: | Magnaporthe oryzae |
| Taxa ID: | 242507 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | MGG_04413T1 | MGG_04413T1 |
| Ensembl | MGG_04413T0 | MGG_04413T0 |
| UniProt | A4RN19, NPL4_MAGO7, G4MZE9, G4MZF0 | |
| GeneBank | CM001232 | EHA53705.1, EHA53704.1 |
| RefSeq | XM_003713463.1, XM_003713464.1 | XP_003713511.1, XP_003713512.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLLRLRGPDG MLRIELDPKD TFNKLGQELM GKLPPTVDPA TITVSNAPGS QGDKKLLKDI 60 61 AKYKVEAIGL KHGDLIFVDY KHQGAEADGT ANSDGASQPL TSTTNRLNGQ PVLPTEDLPI 120 121 DPLPTPAPGA TIKNPWEVVR QSPLDDRLDK KDGKIPRKRD AMCRHGPKGM CDYCQPLDPF 180 181 DAKFLAEKKI KYLSMHAHLR KINSATNKPE LGSSFIPPLS EPYFRVKHDC PSGHPQWPEG 240 241 ICSKCQPSAI TLQPQPFRMV DHVEFASPSI VDSFINTWRR TGGQRYGIMY GKYSEYEEVP 300 301 LGIKAVVQAI YEPPQVDEVD GVSLNSWDNE KDVNQVARLC GLEPVGAIWT DLLDAGAGDG 360 361 SVVCKRHADS YFLSSLEVCF AARLQAQHPK PSKWSDTGRF GSNFVTCIIS GNEQGEIAIS 420 421 SYQVSNEAVE MVRADIMEPS ADPTVMLVRE EEEDDGSTSR TRYIPDVFYR RINEYGANVQ 480 481 ENAKPSFPVE YLFVTLTHGF PDVAKPMFSD EGAFPIENRE YMGESQEHSA AAKALKVHEK 540 541 ASSGSSKDGM KVSNFHLLCF LHQMSVLSKD EESLLCRVAT QHDLADAFQL RSTTGWQTLM 600 601 AILQSTGERI PKRSRQTDVL AADPAASSYP GRRGIDDSDE RLAKRFASVR LNARGDGRNG 660 661 RDRPSAHET 669 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTATTAA GGTTGCGAGG GCCTGATGGC ATGCTCCGTA TTGAGCTGGA CCCAAAAGAC 60 61 ACTTTCAATA AGCTTGGACA AGAGCTCATG GGCAAGCTAC CGCCCACGGT CGACCCTGCA 120 121 ACAATCACTG TTTCCAATGC GCCAGGATCT CAAGGTGATA AAAAGCTGCT GAAAGATATC 180 181 GCCAAGTACA AGGTGGAAGC TATTGGCTTA AAACACGGAG ACCTCATTTT TGTAGACTAC 240 241 AAACACCAAG GGGCAGAAGC CGATGGGACA GCCAATAGCG ATGGTGCTTC CCAACCCTTG 300 301 ACCTCGACGA CAAACCGCTT GAACGGTCAG CCGGTTCTTC CGACTGAGGA CCTACCCATA 360 361 GACCCGTTGC CCACACCAGC TCCAGGTGCT ACTATCAAAA ACCCGTGGGA GGTTGTCAGG 420 421 CAGTCACCGC TAGATGACAG GCTAGACAAG AAGGATGGAA AGATACCGAG AAAGAGAGAC 480 481 GCCATGTGCC GTCATGGGCC CAAGGGCATG TGCGACTATT GCCAGCCGCT CGACCCCTTT 540 541 GACGCCAAGT TCCTGGCCGA GAAGAAGATC AAGTACCTTT CGATGCACGC CCACCTCCGA 600 601 AAGATCAACT CGGCTACAAA CAAGCCCGAA TTAGGAAGCT CCTTTATCCC TCCACTATCT 660 661 GAGCCCTACT TTCGTGTAAA GCATGACTGC CCATCAGGCC ATCCGCAGTG GCCCGAAGGC 720 721 ATATGCAGCA AATGTCAGCC GAGTGCCATT ACGCTGCAAC CACAACCTTT CCGTATGGTT 780 781 GATCACGTCG AGTTTGCTTC GCCATCTATC GTTGACTCCT TTATCAATAC CTGGCGCCGG 840 841 ACCGGCGGCC AGCGGTACGG AATTATGTAC GGCAAGTATT CAGAGTACGA AGAGGTGCCA 900 901 CTAGGAATTA AGGCGGTCGT GCAGGCAATC TACGAACCCC CACAGGTTGA CGAAGTTGAC 960 961 GGTGTCTCGT TGAACTCGTG GGATAATGAA AAGGATGTCA ACCAAGTGGC GAGATTGTGC 1020 1021 GGCCTAGAGC CAGTGGGCGC CATATGGACA GACTTGCTTG ATGCAGGCGC GGGCGATGGA 1080 1081 TCAGTGGTTT GCAAGCGCCA CGCAGACTCG TACTTTCTCT CATCCCTCGA GGTTTGTTTC 1140 1141 GCAGCACGGC TGCAGGCACA GCACCCGAAG CCGAGCAAGT GGAGTGACAC TGGACGTTTT 1200 1201 GGGTCGAATT TTGTCACATG CATCATCTCG GGTAACGAGC AAGGTGAAAT TGCGATATCG 1260 1261 TCGTATCAGG TTTCGAACGA AGCGGTCGAG ATGGTGCGGG CCGACATTAT GGAGCCATCG 1320 1321 GCAGACCCTA CGGTGATGCT GGTTCGGGAA GAAGAGGAAG ATGACGGATC CACGAGTCGA 1380 1381 ACGCGGTACA TTCCTGACGT ATTCTACCGT CGAATCAACG AGTATGGGGC AAACGTGCAG 1440 1441 GAAAACGCCA AGCCGTCATT CCCAGTCGAG TACCTTTTTG TCACGCTGAC ACATGGTTTC 1500 1501 CCCGATGTGG CAAAGCCCAT GTTTTCGGAT GAGGGTGCTT TCCCGATCGA GAACCGGGAG 1560 1561 TACATGGGCG AGAGCCAAGA GCACAGCGCG GCCGCCAAGG CTCTCAAAGT GCATGAGAAG 1620 1621 GCATCTTCTG GTTCCTCCAA GGACGGGATG AAGGTTTCCA ACTTCCACTT GTTGTGCTTC 1680 1681 TTGCACCAGA TGAGCGTACT TTCAAAGGAT GAGGAGAGCT TGTTATGCCG TGTGGCTACA 1740 1741 CAGCATGACC TGGCCGATGC TTTCCAATTA CGTTCTACTA CGGGTTGGCA GACACTGATG 1800 1801 GCAATTTTAC AATCGACTGG TGAGAGAATC CCCAAGCGAT CCCGGCAAAC TGATGTTTTG 1860 1861 GCTGCAGACC CTGCAGCTTC CTCATACCCA GGCCGCCGTG GAATTGATGA CTCCGATGAA 1920 1921 CGACTTGCTA AGCGTTTTGC CTCCGTTAGG CTGAATGCTC GTGGTGATGG GCGCAACGGC 1980 1981 CGCGATCGCC CGTCTGCTCA TGAGACT 2007 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Nuclear membrane | |
Cellular Component | Nuclear outer membrane-endoplasmic reticulum membrane network | |
Cellular Component | Nucleus | |
Cellular Component | Perinuclear region of cytoplasm | |
Biological Process | MRNA transport | |
Biological Process | Protein transport | |
Biological Process | Ubiquitin-dependent ERAD pathway | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Map-0763 | Magnaporthe poae | 84.1 | 0.0 | 1072 |
| LLPS-Gag-1624 | Gaeumannomyces graminis | 77.1 | 0.0 | 1057 |
| LLPS-Nec-0766 | Neurospora crassa | 74.51 | 0.0 | 971 |
| LLPS-Cog-0485 | Colletotrichum gloeosporioides | 74.35 | 0.0 | 1014 |
| LLPS-Fuo-0998 | Fusarium oxysporum | 71.65 | 0.0 | 969 |
| LLPS-Trr-1490 | Trichoderma reesei | 66.67 | 0.0 | 930 |
| LLPS-Asf-1340 | Aspergillus flavus | 61.64 | 0.0 | 791 |
| LLPS-Blg-1530 | Blumeria graminis | 60.49 | 0.0 | 777 |
| LLPS-Nef-0832 | Neosartorya fischeri | 58.78 | 0.0 | 787 |
| LLPS-Asni-0580 | Aspergillus niger | 58.58 | 0.0 | 791 |
| LLPS-Phn-0192 | Phaeosphaeria nodorum | 58.22 | 0.0 | 753 |
| LLPS-Pyt-1180 | Pyrenophora teres | 57.68 | 0.0 | 777 |
| LLPS-Asc-0019 | Aspergillus clavatus | 57.31 | 0.0 | 753 |
| LLPS-Lem-1014 | Leptosphaeria maculans | 57.27 | 0.0 | 753 |
| LLPS-Pytr-0407 | Pyrenophora triticirepentis | 56.71 | 0.0 | 765 |
| LLPS-Dos-1093 | Dothistroma septosporum | 53.38 | 0.0 | 658 |
| LLPS-Zyt-1501 | Zymoseptoria tritici | 53.06 | 0.0 | 619 |
| LLPS-Yal-1400 | Yarrowia lipolytica | 45.75 | 2e-176 | 522 |
| LLPS-Sac-1573 | Saccharomyces cerevisiae | 45.37 | 5e-180 | 531 |
| LLPS-Spr-0250 | Sporisorium reilianum | 44.01 | 8e-168 | 506 |
| LLPS-Usm-0660 | Ustilago maydis | 43.29 | 2e-166 | 502 |
| LLPS-Miv-0737 | Microbotryum violaceum | 43.11 | 2e-158 | 483 |
| LLPS-Mel-0639 | Melampsora laricipopulina | 42.6 | 8e-171 | 512 |
| LLPS-Asg-0821 | Ashbya gossypii | 40.85 | 1e-153 | 464 |
| LLPS-Crn-0918 | Cryptococcus neoformans | 40.45 | 6e-148 | 453 |
| LLPS-Tag-3050 | Taeniopygia guttata | 40.0 | 6e-84 | 278 |
| LLPS-Mod-0616 | Monodelphis domestica | 38.71 | 6e-95 | 310 |
| LLPS-Scf-3266 | Scleropages formosus | 37.97 | 1e-97 | 320 |
| LLPS-Dar-2036 | Danio rerio | 37.95 | 7e-94 | 310 |
| LLPS-Orl-3191 | Oryzias latipes | 37.88 | 5e-96 | 315 |
| LLPS-Orn-3667 | Oreochromis niloticus | 37.82 | 2e-95 | 313 |
| LLPS-Leo-2038 | Lepisosteus oculatus | 37.76 | 3e-97 | 318 |
| LLPS-Pof-3803 | Poecilia formosa | 37.63 | 5e-96 | 315 |
| LLPS-Paa-3905 | Papio anubis | 37.47 | 7e-95 | 312 |
| LLPS-Xim-2120 | Xiphophorus maculatus | 37.42 | 3e-95 | 313 |
| LLPS-Meg-1949 | Meleagris gallopavo | 37.37 | 2e-97 | 318 |
| LLPS-Fia-3510 | Ficedula albicollis | 37.37 | 7e-97 | 317 |
| LLPS-Aim-1765 | Ailuropoda melanoleuca | 37.37 | 2e-97 | 318 |
| LLPS-Ten-2328 | Tetraodon nigroviridis | 37.32 | 3e-92 | 305 |
| LLPS-Scm-2559 | Scophthalmus maximus | 37.18 | 4e-91 | 302 |
| LLPS-Tar-2401 | Takifugu rubripes | 37.18 | 1e-92 | 306 |
| LLPS-Anp-3159 | Anas platyrhynchos | 37.16 | 3e-97 | 317 |
| LLPS-Eqc-2119 | Equus caballus | 37.16 | 2e-96 | 318 |
| LLPS-Cap-2987 | Cavia porcellus | 37.16 | 3e-97 | 318 |
| LLPS-Asm-1271 | Astyanax mexicanus | 36.97 | 1e-85 | 287 |
| LLPS-Pap-4580 | Pan paniscus | 36.95 | 7e-97 | 317 |
| LLPS-Pat-4070 | Pan troglodytes | 36.95 | 5e-97 | 317 |
| LLPS-Mam-3587 | Macaca mulatta | 36.95 | 1e-96 | 317 |
| LLPS-Nol-4492 | Nomascus leucogenys | 36.95 | 4e-97 | 318 |
| LLPS-Anc-0035 | Anolis carolinensis | 36.95 | 4e-95 | 313 |
| LLPS-Chs-4624 | Chlorocebus sabaeus | 36.95 | 5e-97 | 318 |
| LLPS-Gog-1341 | Gorilla gorilla | 36.95 | 4e-97 | 318 |
| LLPS-Gaa-0415 | Gasterosteus aculeatus | 36.76 | 2e-90 | 301 |
| LLPS-Cea-2884 | Cercocebus atys | 36.74 | 6e-94 | 308 |
| LLPS-Mea-3472 | Mesocricetus auratus | 36.69 | 2e-97 | 319 |
| LLPS-Mum-4762 | Mus musculus | 36.69 | 2e-97 | 318 |
| LLPS-Ran-3917 | Rattus norvegicus | 36.69 | 1e-97 | 319 |
| LLPS-Hos-4707 | Homo sapiens | 36.67 | 3e-95 | 313 |
| LLPS-Sah-3317 | Sarcophilus harrisii | 36.49 | 3e-97 | 318 |
| LLPS-Cae-0144 | Caenorhabditis elegans | 36.33 | 3e-90 | 297 |
| LLPS-Poa-4604 | Pongo abelii | 36.29 | 7e-97 | 317 |
| LLPS-Caj-4074 | Callithrix jacchus | 36.29 | 4e-97 | 318 |
| LLPS-Icp-0495 | Ictalurus punctatus | 36.26 | 5e-75 | 256 |
| LLPS-Aon-4437 | Aotus nancymaae | 36.19 | 2e-87 | 291 |
| LLPS-Lac-1216 | Latimeria chalumnae | 35.76 | 7e-84 | 283 |
| LLPS-Rhb-2387 | Rhinopithecus bieti | 35.76 | 1e-93 | 307 |
| LLPS-Man-0867 | Macaca nemestrina | 35.55 | 8e-85 | 284 |
| LLPS-Mal-2986 | Mandrillus leucophaeus | 35.55 | 1e-84 | 284 |
| LLPS-Otg-4255 | Otolemur garnettii | 34.13 | 2e-80 | 273 |
| LLPS-Pes-0882 | Pelodiscus sinensis | 32.74 | 1e-97 | 319 |
| LLPS-Gaga-2019 | Gallus gallus | 32.69 | 3e-98 | 321 |
| LLPS-Ict-0329 | Ictidomys tridecemlineatus | 32.54 | 2e-99 | 323 |
| LLPS-Sus-4818 | Sus scrofa | 32.32 | 2e-96 | 317 |
| LLPS-Dio-2688 | Dipodomys ordii | 32.25 | 1e-98 | 322 |
| LLPS-Loa-3964 | Loxodonta africana | 32.2 | 1e-98 | 322 |
| LLPS-Mup-0161 | Mustela putorius furo | 32.18 | 5e-98 | 320 |
| LLPS-Bot-0490 | Bos taurus | 31.97 | 5e-98 | 320 |
| LLPS-Myl-0089 | Myotis lucifugus | 31.93 | 1e-96 | 317 |
| LLPS-Ova-4196 | Ovis aries | 31.81 | 1e-97 | 319 |
| LLPS-Xet-3580 | Xenopus tropicalis | 31.76 | 2e-93 | 308 |
| LLPS-Fud-0649 | Fukomys damarensis | 31.75 | 1e-97 | 319 |
| LLPS-Fec-1743 | Felis catus | 31.7 | 7e-98 | 320 |
| LLPS-Caf-0681 | Canis familiaris | 31.7 | 1e-97 | 319 |