• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Man-0120
KPNA4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit alpha
Gene Name: KPNA4
Ensembl Gene: ENSMNEG00000041168.1
Ensembl Protein: ENSMNEP00000036089.1
Organism: Macaca nemestrina
Taxa ID: 9545
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear pore complex, Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADNEKLDNQ  RLKNFKNKGR  DLETMRRQRN  EVVVELRKNK  RDEHLLKRRN  VPHEDICEDS  60
61    DIDGDYRVQN  TSLEAIVQNA  SSDNQGIQLS  AVQAARKLLS  SDRNPPIDDL  IKSGILPILV  120
121   HCLERDDNPS  LQFEAAWALT  NIASGTSEQT  QAVVQSNAVP  LFLRLLHSPH  QNVCEQAVWA  180
181   LGNIIGDGPQ  CRDYVISLGV  VKPLLSFISP  SIPITFLRNV  TWVMVNLCRH  KDPPPPMETI  240
241   QEILPALCVL  IHHTDVNILV  DTVWALSYLT  DAGNEQIQMV  IDSGIVPHLV  PLLSHQEVKV  300
301   QTAALRAVGN  IVTGTDEQTQ  VVLNCDALSH  FPALLTHPKE  KINKEAVWFL  SNITAGNQQQ  360
361   VQAVIDANLV  PMIIHLLDKG  DFGTQKEAAW  AISNLTISGR  KDQVAYLIQQ  NVIPPFCNLL  420
421   TVKDAQVVQV  VLDGLSNILK  MAEDEAETIG  NLIEECGGLE  KIEQLQNHEN  EDIYKLAYEI  480
481   IDQFFSSDDI  DEDPSLVPEA  IQGGTFGFNS  SANVPTEGFQ  F  521
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGACA  ACGAGAAACT  GGACAACCAA  CGGCTCAAGA  ATTTCAAGAA  CAAAGGCCGC  60
61    GACTTGGAGA  CTATGAGAAG  ACAACGAAAT  GAAGTTGTAG  TTGAATTAAG  GAAGAATAAA  120
121   AGAGATGAAC  ATCTCTTAAA  GAGAAGGAAT  GTACCACATG  AAGATATCTG  TGAAGACTCT  180
181   GATATAGATG  GTGATTATAG  AGTGCAAAAT  ACCTCTCTAG  AAGCTATTGT  TCAAAATGCT  240
241   TCAAGTGATA  ACCAAGGAAT  TCAGTTAAGC  GCAGTTCAAG  CTGCTAGGAA  GCTTTTGTCC  300
301   AGTGATCGCA  ATCCACCAAT  TGATGACTTA  ATAAAATCTG  GAATATTGCC  CATTTTAGTC  360
361   CATTGTCTTG  AAAGAGATGA  CAATCCTTCT  TTGCAGTTTG  AAGCTGCATG  GGCTTTGACA  420
421   AACATTGCAT  CTGGAACTTC  TGAACAAACT  CAAGCCGTAG  TTCAGTCCAA  TGCTGTGCCA  480
481   CTTTTCCTGA  GGCTTCTCCA  TTCACCCCAT  CAGAATGTCT  GTGAGCAAGC  AGTGTGGGCA  540
541   TTGGGAAACA  TCATAGGTGA  TGGGCCCCAG  TGTAGAGATT  ATGTCATAAG  TCTTGGAGTT  600
601   GTGAAACCTT  TACTTTCCTT  CATAAGTCCA  TCTATTCCTA  TAACATTCTT  AAGAAATGTT  660
661   ACTTGGGTTA  TGGTCAACTT  ATGTCGCCAC  AAAGACCCAC  CACCACCAAT  GGAAACCATT  720
721   CAGGAGATTC  TTCCAGCCCT  TTGTGTTTTA  ATTCATCACA  CAGACGTAAA  TATATTGGTA  780
781   GATACAGTCT  GGGCCCTCTC  TTACCTTACT  GATGCTGGCA  ATGAACAAAT  ACAGATGGTA  840
841   ATAGACTCTG  GAATAGTTCC  TCATTTGGTT  CCTCTGCTCA  GCCACCAGGA  AGTTAAAGTT  900
901   CAGACTGCTG  CACTTAGAGC  TGTGGGCAAC  ATTGTTACTG  GAACTGATGA  GCAAACACAA  960
961   GTAGTTTTGA  ACTGTGATGC  TCTTTCACAC  TTCCCAGCAC  TCCTGACACA  TCCCAAAGAG  1020
1021  AAAATTAATA  AAGAAGCAGT  GTGGTTCCTC  TCCAACATCA  CTGCAGGAAA  TCAGCAGCAG  1080
1081  GTACAGGCAG  TAATTGATGC  CAATCTTGTA  CCAATGATAA  TACACCTTTT  GGATAAGGGG  1140
1141  GATTTTGGCA  CTCAAAAAGA  AGCTGCTTGG  GCCATAAGTA  ACTTAACAAT  TAGTGGAAGG  1200
1201  AAAGATCAAG  TGGCTTACCT  TATCCAGCAA  AATGTTATCC  CACCTTTTTG  CAACTTGCTG  1260
1261  ACTGTAAAAG  ATGCACAAGT  TGTGCAAGTA  GTACTCGATG  GACTAAGTAA  TATATTAAAA  1320
1321  ATGGCTGAAG  ATGAGGCAGA  AACCATAGGC  AATCTTATAG  AAGAATGTGG  AGGACTGGAG  1380
1381  AAAATTGAAC  AACTTCAAAA  TCATGAAAAT  GAAGACATCT  ACAAATTGGC  CTATGAGATC  1440
1441  ATTGATCAGT  TCTTCTCTTC  AGATGATATT  GATGAAGACC  CTAGCCTTGT  TCCAGAGGCG  1500
1501  ATTCAAGGCG  GAACGTTTGG  TTTCAATTCA  TCTGCCAATG  TACCAACAGA  AGGGTTCCAG  1560
1561  TTTTAG  1566

▼ KEYWORD

ID
Family
Complete proteome
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nuclear membrane
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Protein transporter activity
Biological Process
Protein import into nucleus
Biological Process
Response to hydrogen peroxide

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-2301Homo sapiens100.00.01032
LLPS-Pap-0231Pan paniscus100.00.01032
LLPS-Pat-0055Pan troglodytes100.00.01032
LLPS-Nol-0486Nomascus leucogenys100.00.01032
LLPS-Poa-0826Pongo abelii100.00.01032
LLPS-Mam-0407Macaca mulatta100.00.01032
LLPS-Gog-1579Gorilla gorilla100.00.0 981
LLPS-Maf-1050Macaca fascicularis100.00.01032
LLPS-Cea-1220Cercocebus atys100.00.0 978
LLPS-Mal-1405Mandrillus leucophaeus100.00.0 983
LLPS-Paa-1646Papio anubis100.00.01012
LLPS-Fec-1854Felis catus99.810.01030
LLPS-Cas-1346Carlito syrichta99.810.01030
LLPS-Ict-0003Ictidomys tridecemlineatus99.810.01028
LLPS-Caj-1870Callithrix jacchus99.810.01030
LLPS-Aon-3236Aotus nancymaae99.810.01030
LLPS-Mup-0163Mustela putorius furo99.810.01030
LLPS-Tut-0962Tursiops truncatus99.80.0 981
LLPS-Mod-1385Monodelphis domestica99.620.01028
LLPS-Sus-0775Sus scrofa99.620.01028
LLPS-Fud-0575Fukomys damarensis99.60.0 981
LLPS-Bot-0607Bos taurus99.60.0 988
LLPS-Urm-1930Ursus maritimus99.590.0 942
LLPS-Eqc-1866Equus caballus99.40.0 988
LLPS-Chs-1725Chlorocebus sabaeus99.40.0 976
LLPS-Sah-2195Sarcophilus harrisii99.40.0 980
LLPS-Aim-2303Ailuropoda melanoleuca99.40.0 984
LLPS-Dio-1216Dipodomys ordii99.40.0 980
LLPS-Orc-1104Oryctolagus cuniculus99.230.01024
LLPS-Pes-1936Pelodiscus sinensis99.040.01022
LLPS-Gaga-1562Gallus gallus99.040.01023
LLPS-Myl-1100Myotis lucifugus99.040.01016
LLPS-Mum-1132Mus musculus98.850.01021
LLPS-Ran-0978Rattus norvegicus98.850.01022
LLPS-Ova-0447Ovis aries98.820.0 988
LLPS-Meg-2294Meleagris gallopavo98.80.0 977
LLPS-Tag-1023Taeniopygia guttata98.60.0 976
LLPS-Rhb-3039Rhinopithecus bieti98.460.01009
LLPS-Loa-1396Loxodonta africana98.430.0 989
LLPS-Leo-2858Lepisosteus oculatus97.690.01004
LLPS-Asm-1756Astyanax mexicanus96.930.0 999
LLPS-Cap-0943Cavia porcellus96.740.0 988
LLPS-Lac-3235Latimeria chalumnae96.60.0 957
LLPS-Icp-1558Ictalurus punctatus96.550.0 996
LLPS-Scf-2669Scleropages formosus96.550.01001
LLPS-Fia-2245Ficedula albicollis96.320.0 978
LLPS-Anp-1189Anas platyrhynchos96.270.0 961
LLPS-Mea-2049Mesocricetus auratus96.180.0 939
LLPS-Caf-1703Canis familiaris96.150.0 988
LLPS-Gaa-0402Gasterosteus aculeatus95.790.0 986
LLPS-Orl-0313Oryzias latipes95.590.0 993
LLPS-Otg-2321Otolemur garnettii95.40.0 967
LLPS-Dar-1414Danio rerio95.390.0 987
LLPS-Scm-1193Scophthalmus maximus95.010.0 986
LLPS-Xim-3218Xiphophorus maculatus94.820.0 983
LLPS-Pof-2307Poecilia formosa94.630.0 980
LLPS-Anc-3117Anolis carolinensis94.440.0 926
LLPS-Orn-0895Oreochromis niloticus93.410.0 973
LLPS-Xet-0985Xenopus tropicalis91.950.0 946
LLPS-Tar-1503Takifugu rubripes91.750.0 940
LLPS-Ten-0504Tetraodon nigroviridis91.570.0 940
LLPS-Ora-0178Ornithorhynchus anatinus87.630.0 843
LLPS-Ere-0115Erinaceus europaeus86.770.0 678
LLPS-Cii-1885Ciona intestinalis73.90.0 735
LLPS-Drm-0105Drosophila melanogaster69.920.0 660
LLPS-Cis-0296Ciona savignyi65.710.0 613
LLPS-Cae-0053Caenorhabditis elegans63.330.0 605
LLPS-Scj-0572Schizosaccharomyces japonicus48.21e-150 449
LLPS-Trr-0178Trichoderma reesei46.516e-150 448
LLPS-Trv-1149Trichoderma virens46.512e-150 449
LLPS-Gas-0099Galdieria sulphuraria46.266e-151 450