LLPS-Mam-3595
KATNA1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Katanin p60 ATPase-containing subunit A1 |
| Gene Name: | KATNA1, EGK_15265 |
| Ensembl Gene: | ENSMMUG00000004646.3 |
| Ensembl Protein: | ENSMMUP00000045233.1 |
| Organism: | Macaca mulatta |
| Taxa ID: | 9544 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMMUT00000074826.1 | ENSMMUP00000045233.1 |
| Ensembl | ENSMMUT00000006570.3 | ENSMMUP00000006180.3 |
| Ensembl | ENSMMUT00000006571.3 | ENSMMUP00000006181.3 |
| UniProt | G7MQ57, G7MQ57_MACMU | |
| GeneBank | JSUE03031942, JSUE03031943, JSUE03031947, CM001256, JSUE03031946, JU474131, JSUE03031945, JSUE03031944 | , EHH18621.1, AFH30935.1 |
| RefSeq | XM_015137142.1, XM_015137143.1, XM_015137144.1, XM_015137145.1 | XP_014992628.1, XP_014992629.1, XP_014992630.1, XP_014992631.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSLLMISENV KLAREYALLG NYDSAMVYYQ GVLDQMNKYL YSVKDTYLQQ KWQQVWQEIN 60 61 VEAKHVKDIM KTLESFKLDS TPLKAAQHDL PASEGEVWSM PVPVERRPSP GPRKRQSSQY 120 121 SDSKSHGNRP GTTVRVHRSS AQNLHNDRGK AVRCREKKEQ NKGREEKNKS PAAVTEPETN 180 181 KFDSTGYDKD LVEALERDII SQNPNVRWDD IADLVEAKKL LKEAVVLPMW MPEFFKGIRR 240 241 PWKGVLMVGP PGTGKTLLAK AVATECKTTF FNVSSSTLTS KYRGESEKLV RLLFEMARFY 300 301 SPATIFIDEI DSICSRRGTS EEHEASRRVK AELLVQMDGV GGASENDDPS KMVMVLAATN 360 361 FPWDIDEALR RRLEKRIYIP LPSAKGREEL LRISLRELEL ADDVDLASIA ENMEGYSGAD 420 421 ITNVCRDASL MAMRRRIEGL TPEEIRNLSK EEMHMPTTME DFEMALKKVS KSVSAADIER 480 481 YEKWIFEFGS C 491 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGTCTTC TTATGATTAG TGAGAATGTA AAATTGGCTC GTGAATATGC ATTGCTGGGA 60 61 AACTATGACT CTGCGATGGT CTATTATCAG GGAGTTCTTG ACCAAATGAA CAAGTATCTG 120 121 TACTCAGTCA AAGATACATA CCTCCAGCAA AAATGGCAAC AGGTTTGGCA GGAAATAAAT 180 181 GTGGAAGCTA AACATGTTAA AGATATCATG AAAACACTAG AGAGCTTTAA ACTAGACAGC 240 241 ACTCCCTTGA AGGCAGCACA GCATGACCTT CCAGCTTCTG AGGGAGAAGT CTGGTCCATG 300 301 CCTGTACCTG TTGAACGAAG ACCCTCACCA GGACCTAGAA AACGCCAGTC TTCTCAGTAC 360 361 AGTGACTCTA AATCACATGG TAATCGTCCA GGTACAACTG TCAGAGTTCA CCGTTCATCT 420 421 GCACAGAATC TTCACAATGA CAGAGGGAAA GCTGTTCGTT GTCGTGAAAA GAAAGAACAG 480 481 AATAAAGGAA GAGAGGAAAA GAACAAATCA CCTGCTGCAG TAACAGAACC AGAGACAAAT 540 541 AAATTTGACA GTACCGGATA TGATAAAGAC TTAGTAGAAG CTTTGGAAAG AGATATAATT 600 601 TCCCAGAATC CCAATGTTCG ATGGGATGAT ATCGCTGATT TAGTAGAAGC TAAGAAGTTG 660 661 CTTAAGGAAG CTGTAGTGTT ACCAATGTGG ATGCCTGAAT TCTTTAAGGG CATTAGAAGA 720 721 CCATGGAAGG GAGTACTGAT GGTCGGCCCA CCTGGCACGG GGAAGACGCT CCTTGCTAAA 780 781 GCAGTAGCTA CAGAATGCAA GACAACATTC TTCAATGTCT CTTCATCAAC TCTGACTTCC 840 841 AAATACAGAG GAGAATCTGA GAAGCTTGTT CGTCTTCTGT TTGAAATGGC TCGATTTTAT 900 901 TCTCCAGCCA CCATATTTAT TGATGAGATA GACTCCATTT GTAGTCGCCG AGGGACTTCT 960 961 GAAGAACATG AAGCAAGCAG AAGGGTGAAA GCGGAGCTGC TGGTTCAAAT GGATGGTGTT 1020 1021 GGAGGTGCTT CTGAAAATGA TGACCCTTCC AAAATGGTTA TGGTTCTGGC AGCTACTAAT 1080 1081 TTTCCCTGGG ATATAGATGA GGCTTTAAGA CGACGCCTTG AGAAACGAAT CTATATTCCT 1140 1141 TTGCCATCAG CAAAAGGCAG GGAGGAGCTA TTACGAATAA GTCTACGTGA GCTGGAATTG 1200 1201 GCTGATGATG TTGACCTTGC AAGTATAGCA GAAAACATGG AAGGTTATNN NNNNNNNNNN 1260 1261 NNNNNNNNTT TTCTTTGGAT TACAAATTCA CATATGTACC AGTTAAGTCT TAAGGAGGCT 1320 1321 TGA 1323 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Cellular Component | Midbody | |
Cellular Component | Mitotic spindle pole | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity | |
Molecular Function | Isomerase activity | |
Molecular Function | Microtubule binding | |
Molecular Function | Microtubule-severing ATPase activity | |
Molecular Function | Protein heterodimerization activity | |
Biological Process | Cell cycle | |
Biological Process | Cell division | |
Biological Process | Cytoplasmic microtubule organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mal-2328 | Mandrillus leucophaeus | 100.0 | 0.0 | 988 |
| LLPS-Man-0051 | Macaca nemestrina | 100.0 | 0.0 | 873 |
| LLPS-Paa-1399 | Papio anubis | 99.8 | 0.0 | 985 |
| LLPS-Rhb-4021 | Rhinopithecus bieti | 99.69 | 0.0 | 640 |
| LLPS-Chs-3702 | Chlorocebus sabaeus | 99.53 | 0.0 | 838 |
| LLPS-Pat-3024 | Pan troglodytes | 99.39 | 0.0 | 982 |
| LLPS-Pap-1904 | Pan paniscus | 99.39 | 0.0 | 982 |
| LLPS-Nol-1483 | Nomascus leucogenys | 99.39 | 0.0 | 980 |
| LLPS-Gog-1795 | Gorilla gorilla | 99.21 | 2e-165 | 481 |
| LLPS-Hos-2387 | Homo sapiens | 99.19 | 0.0 | 981 |
| LLPS-Aon-1012 | Aotus nancymaae | 98.98 | 0.0 | 978 |
| LLPS-Cas-0964 | Carlito syrichta | 98.98 | 0.0 | 978 |
| LLPS-Poa-1531 | Pongo abelii | 98.98 | 0.0 | 977 |
| LLPS-Caj-0414 | Callithrix jacchus | 98.78 | 0.0 | 971 |
| LLPS-Otg-1197 | Otolemur garnettii | 98.17 | 0.0 | 967 |
| LLPS-Maf-2487 | Macaca fascicularis | 98.0 | 0.0 | 879 |
| LLPS-Mup-0346 | Mustela putorius furo | 97.96 | 0.0 | 968 |
| LLPS-Ict-1238 | Ictidomys tridecemlineatus | 97.96 | 0.0 | 968 |
| LLPS-Caf-1471 | Canis familiaris | 97.76 | 0.0 | 967 |
| LLPS-Urm-0178 | Ursus maritimus | 97.56 | 0.0 | 964 |
| LLPS-Orc-2494 | Oryctolagus cuniculus | 97.35 | 0.0 | 963 |
| LLPS-Fec-2103 | Felis catus | 97.35 | 0.0 | 961 |
| LLPS-Sus-2208 | Sus scrofa | 97.15 | 0.0 | 961 |
| LLPS-Bot-1822 | Bos taurus | 97.15 | 0.0 | 958 |
| LLPS-Myl-2429 | Myotis lucifugus | 96.95 | 0.0 | 957 |
| LLPS-Eqc-3307 | Equus caballus | 96.83 | 0.0 | 917 |
| LLPS-Fud-2251 | Fukomys damarensis | 96.54 | 0.0 | 943 |
| LLPS-Ova-3644 | Ovis aries | 96.36 | 0.0 | 952 |
| LLPS-Cap-2590 | Cavia porcellus | 95.93 | 0.0 | 941 |
| LLPS-Aim-0771 | Ailuropoda melanoleuca | 95.74 | 0.0 | 949 |
| LLPS-Sah-1142 | Sarcophilus harrisii | 94.73 | 0.0 | 934 |
| LLPS-Mod-2994 | Monodelphis domestica | 94.52 | 0.0 | 931 |
| LLPS-Ran-0321 | Rattus norvegicus | 93.89 | 0.0 | 927 |
| LLPS-Mum-3049 | Mus musculus | 92.87 | 0.0 | 915 |
| LLPS-Ora-0665 | Ornithorhynchus anatinus | 91.68 | 0.0 | 898 |
| LLPS-Loa-3376 | Loxodonta africana | 89.92 | 0.0 | 877 |
| LLPS-Anp-1815 | Anas platyrhynchos | 89.25 | 0.0 | 877 |
| LLPS-Meg-0849 | Meleagris gallopavo | 88.64 | 0.0 | 871 |
| LLPS-Gaga-0388 | Gallus gallus | 88.44 | 0.0 | 870 |
| LLPS-Tag-2657 | Taeniopygia guttata | 88.24 | 0.0 | 869 |
| LLPS-Pes-1548 | Pelodiscus sinensis | 88.03 | 0.0 | 866 |
| LLPS-Fia-0078 | Ficedula albicollis | 88.03 | 0.0 | 865 |
| LLPS-Anc-0925 | Anolis carolinensis | 87.63 | 0.0 | 855 |
| LLPS-Tar-2027 | Takifugu rubripes | 80.57 | 2e-179 | 514 |
| LLPS-Xet-0557 | Xenopus tropicalis | 78.8 | 0.0 | 766 |
| LLPS-Scf-2187 | Scleropages formosus | 78.09 | 0.0 | 732 |
| LLPS-Dar-4208 | Danio rerio | 76.67 | 0.0 | 725 |
| LLPS-Asm-3315 | Astyanax mexicanus | 76.02 | 0.0 | 722 |
| LLPS-Icp-1581 | Ictalurus punctatus | 75.86 | 0.0 | 724 |
| LLPS-Leo-1740 | Lepisosteus oculatus | 75.79 | 0.0 | 713 |
| LLPS-Scm-1751 | Scophthalmus maximus | 75.1 | 0.0 | 720 |
| LLPS-Gaa-3177 | Gasterosteus aculeatus | 74.9 | 0.0 | 726 |
| LLPS-Xim-2519 | Xiphophorus maculatus | 74.13 | 0.0 | 691 |
| LLPS-Orn-1322 | Oreochromis niloticus | 73.59 | 0.0 | 707 |
| LLPS-Orl-1870 | Oryzias latipes | 72.27 | 0.0 | 659 |
| LLPS-Ten-1297 | Tetraodon nigroviridis | 71.26 | 0.0 | 676 |
| LLPS-Php-1434 | Physcomitrella patens | 68.95 | 4e-144 | 432 |
| LLPS-Mea-0942 | Mesocricetus auratus | 68.42 | 0.0 | 621 |
| LLPS-Cea-0110 | Cercocebus atys | 68.22 | 0.0 | 622 |
| LLPS-Bro-1156 | Brassica oleracea | 67.79 | 1e-138 | 409 |
| LLPS-Dio-0651 | Dipodomys ordii | 67.61 | 0.0 | 618 |
| LLPS-Pof-0947 | Poecilia formosa | 67.34 | 0.0 | 624 |
| LLPS-Orgl-0734 | Oryza glumaepatula | 66.56 | 4e-142 | 419 |
| LLPS-Cis-0514 | Ciona savignyi | 62.35 | 0.0 | 585 |
| LLPS-Chr-0962 | Chlamydomonas reinhardtii | 59.88 | 5e-122 | 375 |
| LLPS-Dac-1529 | Daucus carota | 57.44 | 4e-139 | 416 |
| LLPS-Lac-1765 | Latimeria chalumnae | 56.39 | 3e-123 | 372 |
| LLPS-Drm-0183 | Drosophila melanogaster | 52.1 | 2e-172 | 506 |
| LLPS-Thc-1932 | Theobroma cacao | 51.87 | 2e-158 | 470 |
| LLPS-Mae-0944 | Manihot esculenta | 51.83 | 3e-161 | 474 |
| LLPS-Gor-0858 | Gossypium raimondii | 51.83 | 2e-163 | 480 |
| LLPS-Cus-0563 | Cucumis sativus | 51.15 | 7e-164 | 481 |
| LLPS-Coc-0729 | Corchorus capsularis | 51.06 | 5e-159 | 469 |
| LLPS-Sem-1395 | Selaginella moellendorffii | 50.78 | 4e-159 | 469 |
| LLPS-Met-0966 | Medicago truncatula | 50.78 | 4e-154 | 457 |
| LLPS-Brn-3223 | Brassica napus | 50.58 | 1e-157 | 465 |
| LLPS-Brd-0394 | Brachypodium distachyon | 50.49 | 8e-157 | 463 |
| LLPS-Prp-0397 | Prunus persica | 50.38 | 1e-161 | 475 |
| LLPS-Amt-0631 | Amborella trichopoda | 50.28 | 9e-158 | 466 |
| LLPS-Phv-0638 | Phaseolus vulgaris | 50.28 | 2e-158 | 468 |
| LLPS-Zem-1424 | Zea mays | 50.19 | 3e-159 | 469 |
| LLPS-Nia-0561 | Nicotiana attenuata | 50.0 | 3e-152 | 451 |
| LLPS-Art-0049 | Arabidopsis thaliana | 49.91 | 5e-160 | 471 |
| LLPS-Hea-0639 | Helianthus annuus | 49.81 | 9e-157 | 463 |
| LLPS-Orni-1227 | Oryza nivara | 49.81 | 2e-159 | 470 |
| LLPS-Sol-0030 | Solanum lycopersicum | 49.81 | 3e-154 | 457 |
| LLPS-Ori-0739 | Oryza indica | 49.81 | 2e-159 | 470 |
| LLPS-Pot-1766 | Populus trichocarpa | 49.81 | 8e-156 | 461 |
| LLPS-Glm-0109 | Glycine max | 49.8 | 5e-150 | 444 |
| LLPS-Orb-0026 | Oryza barthii | 49.79 | 4e-140 | 428 |
| LLPS-Orr-0073 | Oryza rufipogon | 49.79 | 6e-143 | 427 |
| LLPS-Sot-1309 | Solanum tuberosum | 49.71 | 1e-152 | 452 |
| LLPS-Mua-0147 | Musa acuminata | 49.7 | 4e-145 | 436 |
| LLPS-Arl-1358 | Arabidopsis lyrata | 49.62 | 3e-159 | 470 |
| LLPS-Tra-0574 | Triticum aestivum | 49.52 | 8e-157 | 463 |
| LLPS-Tru-1688 | Triticum urartu | 49.52 | 7e-157 | 464 |
| LLPS-Ors-0171 | Oryza sativa | 49.51 | 7e-157 | 463 |
| LLPS-Orp-0513 | Oryza punctata | 49.51 | 5e-157 | 464 |
| LLPS-Org-0429 | Oryza glaberrima | 49.51 | 7e-157 | 463 |
| LLPS-Brr-0621 | Brassica rapa | 49.44 | 3e-156 | 462 |
| LLPS-Hov-0723 | Hordeum vulgare | 49.43 | 1e-155 | 460 |
| LLPS-Orm-0783 | Oryza meridionalis | 49.42 | 1e-148 | 459 |
| LLPS-Sob-0126 | Sorghum bicolor | 49.34 | 8e-157 | 463 |
| LLPS-Sei-0290 | Setaria italica | 49.33 | 2e-154 | 457 |
| LLPS-Viv-0434 | Vitis vinifera | 49.24 | 9e-157 | 463 |
| LLPS-Usm-0594 | Ustilago maydis | 48.99 | 3e-78 | 259 |
| LLPS-Lep-0248 | Leersia perrieri | 48.96 | 5e-157 | 464 |
| LLPS-Orbr-0771 | Oryza brachyantha | 48.94 | 6e-157 | 464 |
| LLPS-Via-1963 | Vigna angularis | 48.03 | 9e-156 | 461 |
| LLPS-Vir-1151 | Vigna radiata | 46.77 | 3e-148 | 442 |
| LLPS-Ved-0260 | Verticillium dahliae | 46.69 | 3e-83 | 270 |
| LLPS-Coo-1010 | Colletotrichum orbiculare | 46.67 | 3e-80 | 263 |
| LLPS-Cog-0741 | Colletotrichum gloeosporioides | 46.67 | 7e-80 | 262 |
| LLPS-Asn-0968 | Aspergillus nidulans | 46.34 | 2e-79 | 261 |
| LLPS-Trr-0807 | Trichoderma reesei | 46.34 | 2e-81 | 266 |
| LLPS-Fus-0219 | Fusarium solani | 46.18 | 5e-80 | 262 |
| LLPS-Nec-1292 | Neurospora crassa | 46.04 | 1e-77 | 256 |
| LLPS-Cogr-1560 | Colletotrichum graminicola | 46.04 | 3e-79 | 260 |
| LLPS-Trv-0993 | Trichoderma virens | 46.04 | 2e-81 | 266 |
| LLPS-Cae-0147 | Caenorhabditis elegans | 45.43 | 2e-82 | 270 |
| LLPS-Ast-0832 | Aspergillus terreus | 45.26 | 4e-79 | 260 |
| LLPS-Fuv-1141 | Fusarium verticillioides | 45.14 | 1e-80 | 264 |
| LLPS-Fuo-0279 | Fusarium oxysporum | 45.14 | 1e-80 | 264 |
| LLPS-Crn-0895 | Cryptococcus neoformans | 44.71 | 1e-78 | 259 |
| LLPS-Asc-0067 | Aspergillus clavatus | 44.65 | 5e-78 | 257 |
| LLPS-Beb-1235 | Beauveria bassiana | 44.54 | 6e-81 | 265 |
| LLPS-Asni-0022 | Aspergillus niger | 44.35 | 3e-78 | 258 |
| LLPS-Mao-0131 | Magnaporthe oryzae | 43.02 | 4e-79 | 259 |
| LLPS-Asf-0380 | Aspergillus flavus | 42.47 | 2e-78 | 258 |
| LLPS-Cii-1541 | Ciona intestinalis | 38.79 | 1e-84 | 278 |