DrLLPS - Data resource of LLPS

LLPS-Mam-0213
ARPC3

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Actin-related protein 2/3 complex subunit 3
Gene Name:	ARPC3
Ensembl Gene:	ENSMMUG00000006492.3
Ensembl Protein:	ENSMMUP00000008550.2
Organism:	Macaca mulatta
Taxa ID:	9544
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0239	O15145	Client	Nucleolus, Postsynaptic density	100.00	2e-131	373
Mus musculus	LLPS-Mum-0648	Q9JM76	Client	Nucleolus, Postsynaptic density	97.75	3e-129	367

▼ FUNCTION

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMMUT00000009101.3	ENSMMUP00000008550.2
UniProt		F7H998, F7H998_MACMU
GeneBank	JV635893, JV044397, JSUE03007754	, AFI34468.1, AFJ71233.1
RefSeq	NM_001260766.1	NP_001247695.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI 60 61 KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP 120 121 ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ 178
Nucleotide CDS Sequence (FASTA)
1 ATGCCGGCTT ACCACTCTTC TCTCATGGAT CCTGACACCA AACTCATCGG AAACATGGCA 60 61 CTGTTACCTA TTAGAAGTCA ATTCAAAGGA CCTGCACCCA GAGAGACAAA AGATACAGAT 120 121 ATTGTGGATG AAGCCATCTA TTACTTCAAG GCCAATGTCT TCTTCAAAAA CTATGAAATT 180 181 AAGAATGAAG CTGATAGGAC CTTGATATAT ATAACTCTCT ATATTTCTGA ATGTCTGAAG 240 241 AAACTCCAAA AGTGCAATTC CAAAAGCCAA GGTGAGAAAG AAATGTATAC ATTGGGAATC 300 301 ACTAATTTTC CCATTCCTGG AGAGCCTGGT TTTCCACTTA ACGCAATTTA TGCCAAACCT 360 361 GCAAACAAAC AGGAAGATGA AGTGATGAGA GCCTATTTAC AACAGCTAAG GCAAGAGACT 420 421 GGACTGAGAC TTTGTGAGAA AGTTTTTGAC CCTCAGAATG ATAAACCTAG CAAGTGGTGG 480 481 ACTTGCTTTG TGAAGAGACA GTTCATGAAC AAGAGTCTTT CAGGACCTGG ACAGTGA 537

▼ KEYWORD

ID	Family
KW-0009	Actin-binding
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005885	Cellular Component	Arp2/3 protein complex
GO:0005737	Cellular Component	Cytoplasm
GO:0003779	Molecular Function	Actin binding
GO:0034314	Biological Process	Arp2/3 complex-mediated actin nucleation

▼ KEGG

mcc:709199

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Otg-3416	Otolemur garnettii	100.0	3e-102	297
LLPS-Fec-2714	Felis catus	100.0	2e-131	373
LLPS-Urm-0837	Ursus maritimus	100.0	2e-131	373
LLPS-Pat-2812	Pan troglodytes	100.0	2e-131	373
LLPS-Hos-0239	Homo sapiens	100.0	2e-131	373
LLPS-Eqc-1259	Equus caballus	100.0	2e-131	373
LLPS-Cap-2396	Cavia porcellus	100.0	2e-131	373
LLPS-Poa-0851	Pongo abelii	100.0	2e-113	327
LLPS-Caj-3009	Callithrix jacchus	100.0	2e-131	373
LLPS-Fud-0378	Fukomys damarensis	100.0	2e-131	373
LLPS-Gog-1872	Gorilla gorilla	100.0	2e-131	373
LLPS-Sus-1199	Sus scrofa	100.0	2e-131	373
LLPS-Maf-3277	Macaca fascicularis	100.0	2e-131	373
LLPS-Mup-1515	Mustela putorius furo	100.0	2e-131	373
LLPS-Mal-1187	Mandrillus leucophaeus	100.0	7e-114	328
LLPS-Paa-1079	Papio anubis	100.0	2e-131	373
LLPS-Ere-0498	Erinaceus europaeus	100.0	9e-130	369
LLPS-Rhb-0034	Rhinopithecus bieti	99.44	8e-131	371
LLPS-Cas-1041	Carlito syrichta	99.44	1e-130	371
LLPS-Caf-0876	Canis familiaris	99.44	4e-130	370
LLPS-Sah-2242	Sarcophilus harrisii	99.43	3e-129	367
LLPS-Orc-0477	Oryctolagus cuniculus	98.88	8e-130	369
LLPS-Mod-3360	Monodelphis domestica	98.88	2e-130	370
LLPS-Cea-1016	Cercocebus atys	98.88	9e-130	369
LLPS-Ova-2535	Ovis aries	98.88	1e-129	369
LLPS-Myl-3786	Myotis lucifugus	98.88	8e-130	369
LLPS-Aim-3475	Ailuropoda melanoleuca	98.88	8e-130	369
LLPS-Tut-1053	Tursiops truncatus	98.86	1e-125	358
LLPS-Loa-0292	Loxodonta africana	97.75	2e-128	365
LLPS-Mum-0648	Mus musculus	97.75	3e-129	367
LLPS-Ran-1256	Rattus norvegicus	97.75	3e-129	367
LLPS-Ora-2002	Ornithorhynchus anatinus	96.63	2e-128	365
LLPS-Aon-1887	Aotus nancymaae	95.51	5e-125	357
LLPS-Gaga-0555	Gallus gallus	94.94	4e-126	359
LLPS-Meg-0022	Meleagris gallopavo	94.89	2e-124	356
LLPS-Tag-0805	Taeniopygia guttata	94.89	2e-124	355
LLPS-Fia-1557	Ficedula albicollis	94.38	7e-124	359
LLPS-Pes-0435	Pelodiscus sinensis	93.82	2e-125	357
LLPS-Nol-1705	Nomascus leucogenys	93.82	8e-120	343
LLPS-Bot-2071	Bos taurus	93.68	1e-127	363
LLPS-Xet-0546	Xenopus tropicalis	93.22	8e-123	352
LLPS-Anc-0194	Anolis carolinensis	91.57	1e-122	350
LLPS-Chs-1603	Chlorocebus sabaeus	90.59	2e-114	330
LLPS-Leo-0754	Lepisosteus oculatus	90.45	2e-122	350
LLPS-Pap-3136	Pan paniscus	90.11	5e-115	331
LLPS-Ict-1364	Ictidomys tridecemlineatus	89.36	6e-86	256
LLPS-Dar-3501	Danio rerio	87.08	2e-118	340
LLPS-Icp-1952	Ictalurus punctatus	87.08	1e-117	338
LLPS-Man-0629	Macaca nemestrina	86.52	6e-112	323
LLPS-Tar-0566	Takifugu rubripes	86.52	5e-92	272
LLPS-Xim-1437	Xiphophorus maculatus	85.44	3e-100	295
LLPS-Pof-3578	Poecilia formosa	85.39	2e-115	332
LLPS-Orn-1821	Oreochromis niloticus	84.27	2e-114	330
LLPS-Gaa-2114	Gasterosteus aculeatus	84.27	7e-115	331
LLPS-Anp-0651	Anas platyrhynchos	83.71	3e-105	306
LLPS-Scf-2573	Scleropages formosus	83.71	7e-115	331
LLPS-Scm-0698	Scophthalmus maximus	82.58	2e-110	320
LLPS-Orl-1241	Oryzias latipes	82.39	6e-109	316
LLPS-Ten-3143	Tetraodon nigroviridis	82.02	7e-112	323
LLPS-Dio-0128	Dipodomys ordii	80.23	4e-93	275
LLPS-Lac-1297	Latimeria chalumnae	76.8	3e-99	291
LLPS-Asm-0185	Astyanax mexicanus	75.28	2e-96	283
LLPS-Cis-2005	Ciona savignyi	60.22	3e-76	233
LLPS-Cii-0233	Ciona intestinalis	60.22	2e-74	228
LLPS-Drm-1590	Drosophila melanogaster	59.55	9e-81	244
LLPS-Cae-1022	Caenorhabditis elegans	53.3	9e-61	193
LLPS-Scc-1460	Schizosaccharomyces cryophilus	53.14	4e-63	199
LLPS-Scp-0618	Schizosaccharomyces pombe	52.57	8e-62	196
LLPS-Abg-1613	Absidia glauca	51.92	2e-51	168
LLPS-Mel-0377	Melampsora laricipopulina	51.23	2e-54	176
LLPS-Amt-1972	Amborella trichopoda	50.34	2e-42	152
LLPS-Scj-0185	Schizosaccharomyces japonicus	50.29	4e-57	184
LLPS-Pug-0987	Puccinia graminis	49.72	2e-57	186
LLPS-Spr-0297	Sporisorium reilianum	48.89	4e-55	179
LLPS-Usm-0764	Ustilago maydis	48.89	2e-57	184
LLPS-Thc-0833	Theobroma cacao	48.0	3e-52	171
LLPS-Yal-0541	Yarrowia lipolytica	48.0	7e-57	183
LLPS-Viv-1002	Vitis vinifera	47.95	1e-50	167
LLPS-Coc-0113	Corchorus capsularis	47.95	1e-47	169
LLPS-Mua-0608	Musa acuminata	47.95	2e-49	165
LLPS-Tra-1179	Triticum aestivum	47.95	2e-50	167
LLPS-Sol-1001	Solanum lycopersicum	47.7	4e-52	171
LLPS-Put-0872	Puccinia triticina	47.69	1e-34	125
LLPS-Met-0446	Medicago truncatula	47.65	6e-51	168
LLPS-Art-2048	Arabidopsis thaliana	47.37	2e-49	164
LLPS-Tru-0456	Triticum urartu	47.37	1e-49	164
LLPS-Prp-0733	Prunus persica	47.37	5e-51	168
LLPS-Brd-0330	Brachypodium distachyon	47.37	6e-50	165
LLPS-Sei-0746	Setaria italica	47.37	9e-50	165
LLPS-Nia-1545	Nicotiana attenuata	47.13	2e-50	167
LLPS-Sot-0614	Solanum tuberosum	47.13	2e-51	169
LLPS-Mae-1465	Manihot esculenta	47.06	4e-51	168
LLPS-Phv-0154	Phaseolus vulgaris	47.06	1e-50	167
LLPS-Zem-2047	Zea mays	47.06	1e-48	163
LLPS-Miv-0004	Microbotryum violaceum	46.93	3e-55	179
LLPS-Orbr-0224	Oryza brachyantha	46.78	3e-49	163
LLPS-Gor-1694	Gossypium raimondii	46.78	2e-50	167
LLPS-Glm-1719	Glycine max	46.78	3e-50	166
LLPS-Cus-0548	Cucumis sativus	46.78	3e-49	164
LLPS-Hov-0079	Hordeum vulgare	46.78	3e-49	166
LLPS-Sob-0581	Sorghum bicolor	46.47	6e-49	163
LLPS-Php-1618	Physcomitrella patens	46.47	1e-54	177
LLPS-Sem-1115	Selaginella moellendorffii	46.47	1e-49	164
LLPS-Kop-0152	Komagataella pastoris	46.29	1e-56	182
LLPS-Dac-0950	Daucus carota	46.24	1e-49	164
LLPS-Org-1493	Oryza glaberrima	46.2	2e-48	161
LLPS-Orm-1314	Oryza meridionalis	46.2	2e-48	161
LLPS-Ori-0508	Oryza indica	46.2	2e-48	161
LLPS-Arl-0878	Arabidopsis lyrata	46.2	8e-48	160
LLPS-Sac-1279	Saccharomyces cerevisiae	46.07	6e-53	173
LLPS-Pot-0595	Populus trichocarpa	45.88	3e-50	166
LLPS-Vir-2080	Vigna radiata	45.88	3e-49	164
LLPS-Hea-0064	Helianthus annuus	45.61	6e-50	165
LLPS-Via-1485	Vigna angularis	45.6	2e-32	119
LLPS-Orni-0874	Oryza nivara	45.35	6e-44	150
LLPS-Cog-1109	Colletotrichum gloeosporioides	44.68	9e-39	137
LLPS-Fus-0222	Fusarium solani	44.27	7e-48	160
LLPS-Pytr-0666	Pyrenophora triticirepentis	44.21	4e-52	171
LLPS-Pyt-0172	Pyrenophora teres	44.21	1e-51	170
LLPS-Ors-1396	Oryza sativa	44.19	2e-32	119
LLPS-Asg-0439	Ashbya gossypii	44.0	8e-50	165
LLPS-Ast-0282	Aspergillus terreus	43.92	2e-48	162
LLPS-Mao-0415	Magnaporthe oryzae	43.75	1e-48	162
LLPS-Tum-0302	Tuber melanosporum	43.68	8e-52	171
LLPS-Lem-1008	Leptosphaeria maculans	43.68	1e-50	167
LLPS-Dos-0228	Dothistroma septosporum	43.39	2e-50	167
LLPS-Zyt-0021	Zymoseptoria tritici	43.39	4e-50	166
LLPS-Asf-1305	Aspergillus flavus	43.39	1e-46	157
LLPS-Aso-0425	Aspergillus oryzae	43.39	1e-46	157
LLPS-Trv-0764	Trichoderma virens	43.23	3e-47	159
LLPS-Scs-0703	Sclerotinia sclerotiorum	43.23	2e-49	164
LLPS-Ved-0551	Verticillium dahliae	43.01	1e-47	160
LLPS-Nec-0304	Neurospora crassa	42.71	6e-47	158
LLPS-Coo-1042	Colletotrichum orbiculare	42.41	3e-45	154
LLPS-Orr-1907	Oryza rufipogon	42.39	2e-40	140
LLPS-Orb-0138	Oryza barthii	42.39	2e-40	140
LLPS-Orgl-0837	Oryza glumaepatula	42.39	2e-40	140
LLPS-Asn-0072	Aspergillus nidulans	42.33	3e-46	156
LLPS-Blg-0571	Blumeria graminis	42.19	3e-47	159
LLPS-Crn-1296	Cryptococcus neoformans	42.13	7e-50	166
LLPS-Trr-1030	Trichoderma reesei	42.11	2e-45	154
LLPS-Cogr-0851	Colletotrichum graminicola	41.97	2e-44	152
LLPS-Asfu-0548	Aspergillus fumigatus	41.8	2e-47	159
LLPS-Asni-0360	Aspergillus niger	41.8	3e-48	161
LLPS-Asc-0912	Aspergillus clavatus	41.71	2e-46	158
LLPS-Fuo-0571	Fusarium oxysporum	41.67	6e-45	153
LLPS-Fuv-1043	Fusarium verticillioides	41.67	7e-45	153
LLPS-Phn-0786	Phaeosphaeria nodorum	41.58	1e-48	162
LLPS-Nef-0223	Neosartorya fischeri	41.28	2e-41	144
LLPS-Map-0206	Magnaporthe poae	41.15	6e-46	155
LLPS-Gag-0782	Gaeumannomyces graminis	41.15	6e-46	155
LLPS-Beb-0400	Beauveria bassiana	39.79	1e-46	157
LLPS-Chr-0243	Chlamydomonas reinhardtii	29.02	9e-26	103

LLPS-Mam-0213ARPC3

Protein Sequence

Nucleotide Sequence

LLPS-Mam-0213
ARPC3