DrLLPS - Data resource of LLPS

LLPS-Mal-a396
CLU

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Clusterin
Gene Name:	CLU
Ensembl Gene:	ENSMLEG00000035141.1
Ensembl Protein:	ENSMLEP00000021878.1
Organism:	Mandrillus leucophaeus
Taxa ID:	9568
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-a411	P10909	Client	Postsynaptic density	95.55	0.0	887
Mus musculus	LLPS-Mum-a410	Q06890	Client	Postsynaptic density	77.14	0.0	716

▼ FUNCTION

Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMLET00000045382.1	ENSMLEP00000021878.1
UniProt		A0A2K5Z257, A0A2K5Z257_MANLE
RefSeq	XM_011983874.1	XP_011839264.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSDQGSK YVNKEIQNAV NGVKEIKTLI 60 61 EKTNEERKTL LSNLEEAKKK KEDALSETRE SETKLKEFPG VCNETMMALW EECKPCLKQT 120 121 CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWINGDRID SLLEDDRQQT HMMDVMQDRF 180 181 SRASSIMDEL FQDRFFAREP QDSYHFLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF 240 241 HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD 300 301 QCDKCREILS VDCSANNPAQ AQLRRELNES LQVAEKLTRK YNELLQSYQW KMLNTSSLLE 360 361 QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP 420 421 VEVSRKNPKF METVAEKALQ EYRKKQREK 449

Protein Sequence (FASTA)

1     MMKTLLLFVG  LLLTWESGQV  LGDQTVSDNE  LQEMSDQGSK  YVNKEIQNAV  NGVKEIKTLI  60
61    EKTNEERKTL  LSNLEEAKKK  KEDALSETRE  SETKLKEFPG  VCNETMMALW  EECKPCLKQT  120
121   CMKFYARVCR  SGSGLVGRQL  EEFLNQSSPF  YFWINGDRID  SLLEDDRQQT  HMMDVMQDRF  180
181   SRASSIMDEL  FQDRFFAREP  QDSYHFLPFS  LPHRRPHFFF  PKSRIVRSLM  PFSPYEPLNF  240
241   HAMFQPFLEM  IHEAQQAMDI  HFHSPAFQHP  PTEFIREGDD  DRTVCREIRH  NSTGCLRMKD  300
301   QCDKCREILS  VDCSANNPAQ  AQLRRELNES  LQVAEKLTRK  YNELLQSYQW  KMLNTSSLLE  360
361   QLNEQFNWVS  RLANLTQGED  QYYLRVTTVA  SHTSDSDVPS  GVTEVVVKLF  DSDPITVTVP  420
421   VEVSRKNPKF  METVAEKALQ  EYRKKQREK  449

▼ KEYWORD

ID	Family
KW-0143	Chaperone
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0097440	Cellular Component	Apical dendrite
GO:0071944	Cellular Component	Cell periphery
GO:0009986	Cellular Component	Cell surface
GO:0005856	Cellular Component	Cytoskeleton
GO:0005829	Cellular Component	Cytosol
GO:0005743	Cellular Component	Mitochondrial inner membrane
GO:0097418	Cellular Component	Neurofibrillary tangle
GO:0005634	Cellular Component	Nucleus
GO:0099020	Cellular Component	Perinuclear endoplasmic reticulum lumen
GO:0034366	Cellular Component	Spherical high-density lipoprotein particle
GO:0045202	Cellular Component	Synapse
GO:0001540	Molecular Function	Amyloid-beta binding
GO:0050750	Molecular Function	Low-density lipoprotein particle receptor binding
GO:0051787	Molecular Function	Misfolded protein binding
GO:0044877	Molecular Function	Protein-containing complex binding
GO:0048156	Molecular Function	Tau protein binding
GO:0031625	Molecular Function	Ubiquitin protein ligase binding
GO:0051082	Molecular Function	Unfolded protein binding
GO:0000902	Biological Process	Cell morphogenesis
GO:0032286	Biological Process	Central nervous system myelin maintenance
GO:0051131	Biological Process	Chaperone-mediated protein complex assembly
GO:0061077	Biological Process	Chaperone-mediated protein folding
GO:0002434	Biological Process	Immune complex clearance
GO:0001774	Biological Process	Microglial cell activation
GO:0061518	Biological Process	Microglial cell proliferation
GO:1905907	Biological Process	Negative regulation of amyloid fibril formation
GO:1902430	Biological Process	Negative regulation of amyloid-beta formation
GO:1905892	Biological Process	Negative regulation of cellular response to thapsigargin
GO:1905895	Biological Process	Negative regulation of cellular response to tunicamycin
GO:1902230	Biological Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032463	Biological Process	Negative regulation of protein homooligomerization
GO:1903573	Biological Process	Negative regulation of response to endoplasmic reticulum stress
GO:1902004	Biological Process	Positive regulation of amyloid-beta formation
GO:0043065	Biological Process	Positive regulation of apoptotic process
GO:1902998	Biological Process	Positive regulation of neurofibrillary tangle assembly
GO:1901216	Biological Process	Positive regulation of neuron death
GO:0051092	Biological Process	Positive regulation of NF-kappaB transcription factor activity
GO:0045429	Biological Process	Positive regulation of nitric oxide biosynthetic process
GO:0032436	Biological Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464	Biological Process	Positive regulation of protein homooligomerization
GO:0048260	Biological Process	Positive regulation of receptor-mediated endocytosis
GO:1902949	Biological Process	Positive regulation of tau-protein kinase activity
GO:0032760	Biological Process	Positive regulation of tumor necrosis factor production
GO:0017038	Biological Process	Protein import
GO:0050821	Biological Process	Protein stabilization
GO:1900221	Biological Process	Regulation of amyloid-beta clearance
GO:0042127	Biological Process	Regulation of cell population proliferation
GO:1902847	Biological Process	Regulation of neuronal signal transduction
GO:0051788	Biological Process	Response to misfolded protein
GO:0009615	Biological Process	Response to virus

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Hos-a411	Homo sapiens	0.0	887	undefined
LLPS-Mum-a410	Mus musculus	0.0	716	undefined

LLPS-Mal-a396CLU

Protein Sequence

Nucleotide Sequence

LLPS-Mal-a396
CLU