• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mal-2366
P2RX1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: P2X purinoceptor
Gene Name: P2RX1
Ensembl Gene: ENSMLEG00000021130.1
Ensembl Protein: ENSMLEP00000004662.1
Organism: Mandrillus leucophaeus
Taxa ID: 9568
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

Receptor for ATP that acts as a ligand-gated ion channel.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MARRFQEELA  AFLFEYDTPR  MVLVRNKKVG  VIFRLIQLVV  LVYVIGWVFL  YEKGYQTSSG  60
61    LISSVSVKLK  GLAVTQLPGL  GPQVWDVADY  VFPAQGDNSF  VVMTNFIVTP  KQTQGYCAEH  120
121   PEGGICKDDS  GCTPGKAKRK  AQGIRTGKCV  AFNDTLKTCE  IFGWCPVEVD  DDIPRPALLR  180
181   EAENFTLFIK  NSISFPRFKV  NRRNLVEEVN  AAYMKTCLYH  KSLHPLCPVF  QLGYVVQESG  240
241   QNFSTLAEKG  GVVGITIDWH  CDLDWHVRHC  KPIYEFHGLY  EEKNLSPGFN  FRFARHFVEN  300
301   GTNYRHLFKV  FGIRFDILVD  GKAGKFDIIP  TMTTIGSGIG  IFGVATVLCD  LLLLHILPKR  360
361   HYYKQKKFKY  AEDMGPGADE  RDLAATGSTL  GLQENMRTS  399
Nucleotide CDS Sequence (FASTA)
1     ATGGCACGGC  GGTTCCAGGA  GGAGCTGGCC  GCCTTCCTCT  TCGAGTATGA  CACCCCCCGC  60
61    ATGGTGCTGG  TACGCAACAA  GAAGGTGGGC  GTTATCTTCC  GACTGATCCA  GCTGGTGGTC  120
121   CTGGTCTACG  TCATCGGGTG  GGTGTTCCTC  TACGAGAAGG  GCTACCAGAC  CTCGAGCGGC  180
181   CTCATCAGCA  GCGTGTCTGT  GAAACTCAAG  GGCCTGGCCG  TGACCCAGCT  CCCTGGCCTC  240
241   GGCCCCCAGG  TCTGGGACGT  GGCTGACTAC  GTCTTCCCAG  CCCAGGGGGA  CAATTCCTTC  300
301   GTGGTCATGA  CCAATTTCAT  CGTGACCCCA  AAGCAGACTC  AAGGCTACTG  CGCAGAGCAC  360
361   CCAGAAGGGG  GCATATGCAA  GGATGACAGT  GGCTGTACCC  CTGGGAAGGC  CAAGAGGAAG  420
421   GCCCAAGGCA  TCCGCACGGG  CAAGTGTGTG  GCCTTCAACG  ACACCTTGAA  GACATGTGAG  480
481   ATCTTTGGCT  GGTGCCCGGT  GGAGGTGGAT  GACGACATCC  CACGCCCTGC  CCTTCTTCGA  540
541   GAGGCCGAGA  ACTTCACTCT  TTTCATCAAG  AACAGCATCA  GCTTCCCACG  CTTCAAGGTC  600
601   AACAGGCGCA  ACTTGGTGGA  AGAGGTGAAT  GCCGCTTACA  TGAAGACCTG  CCTCTATCAC  660
661   AAGAGCCTGC  ACCCCCTGTG  CCCAGTCTTC  CAGCTTGGCT  ACGTGGTGCA  AGAGTCAGGC  720
721   CAGAACTTCA  GCACCCTGGC  TGAGAAGGGC  GGAGTGGTTG  GCATCACCAT  CGACTGGCAC  780
781   TGTGACCTGG  ACTGGCACGT  ACGACACTGC  AAACCCATCT  ACGAGTTCCA  TGGGCTGTAC  840
841   GAGGAGAAAA  ATCTCTCCCC  AGGCTTCAAC  TTCAGGTTTG  CCAGGCACTT  TGTGGAGAAC  900
901   GGGACCAACT  ACCGTCACCT  CTTCAAGGTG  TTTGGGATTC  GCTTTGACAT  CCTGGTGGAC  960
961   GGCAAGGCCG  GGAAGTTTGA  CATCATCCCC  ACGATGACCA  CCATCGGCTC  TGGAATTGGC  1020
1021  ATCTTCGGGG  TGGCCACAGT  TCTCTGTGAC  CTGCTGCTGC  TTCACATCCT  GCCCAAGAGA  1080
1081  CACTACTACA  AGCAGAAGAA  GTTCAAGTAC  GCTGAGGACA  TGGGGCCAGG  GGCGGATGAG  1140
1141  CGTGACCTCG  CAGCCACCGG  CTCCACCCTG  GGCCTGCAGG  AGAACATGAG  GACGTCCTGA  1200

▼ KEYWORD

ID
Family
Complete proteome
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
External side of plasma membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Postsynaptic membrane
Molecular Function
ATP binding
Molecular Function
Extracellularly ATP-gated cation channel activity
Molecular Function
Purinergic nucleotide receptor activity
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
Ceramide biosynthetic process
Biological Process
Insemination
Biological Process
Platelet activation
Biological Process
Positive regulation of ion transport
Biological Process
Regulation of calcium ion transport
Biological Process
Regulation of vascular smooth muscle contraction
Biological Process
Response to ATP
Biological Process
Serotonin secretion by platelet

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cea-0164Cercocebus atys100.00.0 830
LLPS-Maf-4613Macaca fascicularis99.250.0 827
LLPS-Chs-0820Chlorocebus sabaeus99.250.0 825
LLPS-Man-0763Macaca nemestrina99.250.0 827
LLPS-Mam-2415Macaca mulatta99.00.0 825
LLPS-Gog-1325Gorilla gorilla98.250.0 820
LLPS-Pap-1332Pan paniscus98.250.0 820
LLPS-Pat-0465Pan troglodytes98.250.0 820
LLPS-Nol-4327Nomascus leucogenys98.150.0 780
LLPS-Hos-0503Homo sapiens97.990.0 794
LLPS-Aon-1486Aotus nancymaae94.240.0 768
LLPS-Paa-4678Papio anubis93.730.0 754
LLPS-Otg-3381Otolemur garnettii93.480.0 762
LLPS-Eqc-3072Equus caballus93.390.0 702
LLPS-Caj-2743Callithrix jacchus92.980.0 757
LLPS-Aim-1001Ailuropoda melanoleuca91.480.0 747
LLPS-Mup-0011Mustela putorius furo91.230.0 746
LLPS-Cas-3771Carlito syrichta90.980.0 725
LLPS-Caf-3570Canis familiaris90.980.0 744
LLPS-Cap-4332Cavia porcellus90.980.0 716
LLPS-Urm-1094Ursus maritimus90.980.0 744
LLPS-Fec-4809Felis catus90.980.0 750
LLPS-Sus-0380Sus scrofa90.230.0 715
LLPS-Ova-4237Ovis aries89.970.0 694
LLPS-Mum-3662Mus musculus89.970.0 728
LLPS-Tut-2175Tursiops truncatus89.720.0 727
LLPS-Mea-3520Mesocricetus auratus89.720.0 730
LLPS-Loa-4090Loxodonta africana89.720.0 717
LLPS-Ran-3091Rattus norvegicus89.470.0 721
LLPS-Bot-2745Bos taurus89.470.0 709
LLPS-Orc-3055Oryctolagus cuniculus89.470.0 735
LLPS-Rhb-3331Rhinopithecus bieti89.370.0 802
LLPS-Fud-3347Fukomys damarensis88.970.0 728
LLPS-Myl-3306Myotis lucifugus88.220.0 721
LLPS-Dio-4030Dipodomys ordii87.910.0 716
LLPS-Poa-3156Pongo abelii87.720.0 679
LLPS-Ict-1678Ictidomys tridecemlineatus85.710.0 696
LLPS-Mod-0128Monodelphis domestica76.830.0 514
LLPS-Anp-0746Anas platyrhynchos71.850.0 552
LLPS-Fia-0496Ficedula albicollis71.310.0 546
LLPS-Meg-0567Meleagris gallopavo70.510.0 566
LLPS-Tag-2511Taeniopygia guttata70.110.0 525
LLPS-Pes-1463Pelodiscus sinensis69.980.0 587
LLPS-Gaga-2545Gallus gallus68.670.0 546
LLPS-Lac-0939Latimeria chalumnae64.497e-177 506
LLPS-Xet-2543Xenopus tropicalis60.531e-164 474
LLPS-Ora-0654Ornithorhynchus anatinus59.48e-125 372
LLPS-Orn-1485Oreochromis niloticus56.842e-152 444
LLPS-Leo-0868Lepisosteus oculatus56.05e-153 446
LLPS-Dar-0688Danio rerio55.412e-148 434
LLPS-Asm-2956Astyanax mexicanus55.335e-150 438
LLPS-Ten-0386Tetraodon nigroviridis54.916e-147 430
LLPS-Scf-3300Scleropages formosus54.644e-149 436
LLPS-Gaa-2262Gasterosteus aculeatus54.233e-143 421
LLPS-Pof-3074Poecilia formosa54.232e-145 426
LLPS-Tar-3989Takifugu rubripes53.793e-151 441
LLPS-Orl-1569Oryzias latipes52.93e-146 429
LLPS-Xim-2631Xiphophorus maculatus51.618e-147 431
LLPS-Icp-2184Ictalurus punctatus49.753e-133 395
LLPS-Anc-2422Anolis carolinensis39.894e-98 306
LLPS-Sah-3946Sarcophilus harrisii39.581e-77 252
LLPS-Scm-1731Scophthalmus maximus39.25e-89 282