LLPS-Leo-3141
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Gem-associated protein 2 |
| Ensembl Gene: | ENSLOCG00000009221.1 |
| Ensembl Protein: | ENSLOCP00000011252.1 |
| Organism: | Lepisosteus oculatus |
| Taxa ID: | 7918 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Cajal body, Gemini of cajal body, Nuclear speckle, U body | Predicted from orthologs | (View) |
▼ FUNCTION
| The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLOCT00000011268.1 | ENSLOCP00000011252.1 |
| UniProt | W5MS93, W5MS93_LEPOC | |
| GeneBank | AHAT01003895 | |
| RefSeq | XM_006632142.2, XM_015350252.1, XM_015350253.1, XM_015350254.1 | XP_006632205.1, XP_015205738.1, XP_015205739.1, XP_015205740.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKSDVEELMP RLLPVSEYDT EDIDPNVPPT NPQEYLRQVQ LEAAMCPDVV VAQIDPNKLK 60 61 KKQTVNISLS GCQPAPEGLA PSLRWQQQQV GSFSEVRQRV NKHRQHWKEQ SLDDNVIMPK 120 121 AGDEEGWKKF CLGENVYFER PRTQDPIESD SPSIDYVKVG FPPLLSIVSR FSQVLVTTVL 180 181 EYLINWFVER EFCPELGRWL YALLACIEKP LIPEAHSLLR QLARQCSEVR ARIESQEDEN 240 241 LWALNLLICL VARYFEQIDL ADKD 264 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGTCCG ATGTAGAGGA ACTCATGCCC AGGCTCCTGC CTGTGTCAGA ATACGATACT 60 61 GAAGACATTG ATCCCAACGT ACCTCCAACA AACCCCCAGG AGTATCTGCG ACAGGTTCAG 120 121 CTGGAGGCTG CGATGTGTCC TGATGTCGTT GTTGCCCAAA TTGACCCAAA TAAGCTGAAA 180 181 AAGAAACAGA CTGTGAATAT TTCGCTTTCT GGATGCCAGC CTGCCCCTGA AGGACTTGCC 240 241 CCAAGTCTCA GATGGCAGCA ACAGCAAGTT GGCAGTTTTT CAGAGGTCAG ACAGAGGGTA 300 301 AACAAACATC GGCAGCACTG GAAGGAGCAA TCTCTGGATG ACAATGTGAT CATGCCCAAA 360 361 GCAGGCGATG AAGAAGGGTG GAAGAAGTTC TGCTTGGGCG AGAACGTGTA CTTTGAAAGG 420 421 CCACGCACAC AGGACCCCAT CGAGAGCGAC AGCCCCAGTA TTGATTACGT CAAGGTGGGG 480 481 TTCCCTCCTC TGCTCAGCAT CGTCAGCAGA TTTAGCCAAG TATTAGTTAC TACTGTTCTG 540 541 GAGTATTTGA TCAACTGGTT TGTTGAGAGA GAGTTCTGCC CAGAACTGGG AAGATGGCTT 600 601 TATGCATTGC TGGCCTGTAT TGAAAAACCT CTGATTCCTG AAGCGCATTC CCTCCTCCGA 660 661 CAGCTGGCAA GGCAGTGCTC CGAAGTCCGT GCCAGAATTG AAAGTCAAGA AGATGAAAAT 720 721 CTGTGGGCTC TGAACTTATT GATTTGTCTG GTTGCCAGAT ATTTTGAACA GATCGACCTC 780 781 GCGGATAAAG ACTGA 795 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Cellular Component | SMN complex | |
Cellular Component | Spliceosomal complex | |
Biological Process | Axon extension | |
Biological Process | Spliceosomal complex assembly | |
Biological Process | Spliceosomal snRNP assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Lac-1905 | Latimeria chalumnae | 72.08 | 3e-136 | 392 |
| LLPS-Loa-0671 | Loxodonta africana | 71.86 | 8e-133 | 384 |
| LLPS-Ova-1067 | Ovis aries | 71.21 | 1e-123 | 361 |
| LLPS-Mal-3386 | Mandrillus leucophaeus | 71.1 | 7e-126 | 366 |
| LLPS-Bot-4289 | Bos taurus | 71.1 | 4e-125 | 364 |
| LLPS-Cea-1448 | Cercocebus atys | 71.1 | 7e-126 | 366 |
| LLPS-Maf-0877 | Macaca fascicularis | 71.1 | 8e-126 | 366 |
| LLPS-Mea-1199 | Mesocricetus auratus | 71.1 | 6e-125 | 363 |
| LLPS-Nol-0335 | Nomascus leucogenys | 71.1 | 3e-125 | 364 |
| LLPS-Mam-0744 | Macaca mulatta | 71.1 | 1e-125 | 365 |
| LLPS-Poa-0452 | Pongo abelii | 71.1 | 7e-126 | 366 |
| LLPS-Rhb-3461 | Rhinopithecus bieti | 71.1 | 1e-125 | 365 |
| LLPS-Man-0250 | Macaca nemestrina | 71.1 | 1e-125 | 365 |
| LLPS-Hos-2600 | Homo sapiens | 71.1 | 8e-126 | 366 |
| LLPS-Pat-0079 | Pan troglodytes | 71.1 | 8e-126 | 366 |
| LLPS-Mup-0104 | Mustela putorius furo | 70.77 | 1e-123 | 360 |
| LLPS-Sus-0682 | Sus scrofa | 70.72 | 1e-125 | 366 |
| LLPS-Mum-1550 | Mus musculus | 70.72 | 1e-130 | 378 |
| LLPS-Cas-0830 | Carlito syrichta | 70.72 | 1e-125 | 366 |
| LLPS-Xet-2283 | Xenopus tropicalis | 70.72 | 9e-132 | 381 |
| LLPS-Otg-0277 | Otolemur garnettii | 70.72 | 2e-123 | 360 |
| LLPS-Dio-2318 | Dipodomys ordii | 70.34 | 9e-124 | 360 |
| LLPS-Caj-2791 | Callithrix jacchus | 70.34 | 5e-125 | 364 |
| LLPS-Ict-1094 | Ictidomys tridecemlineatus | 70.34 | 2e-131 | 380 |
| LLPS-Fec-3528 | Felis catus | 70.34 | 7e-125 | 363 |
| LLPS-Anc-0589 | Anolis carolinensis | 70.19 | 3e-131 | 379 |
| LLPS-Fia-1943 | Ficedula albicollis | 70.08 | 9e-131 | 379 |
| LLPS-Mod-2546 | Monodelphis domestica | 70.08 | 2e-133 | 385 |
| LLPS-Ran-1070 | Rattus norvegicus | 69.96 | 1e-123 | 360 |
| LLPS-Aim-1792 | Ailuropoda melanoleuca | 69.7 | 6e-122 | 356 |
| LLPS-Tag-2351 | Taeniopygia guttata | 69.7 | 4e-130 | 376 |
| LLPS-Fud-0538 | Fukomys damarensis | 69.58 | 1e-123 | 360 |
| LLPS-Scf-0497 | Scleropages formosus | 69.38 | 5e-131 | 381 |
| LLPS-Ora-0121 | Ornithorhynchus anatinus | 69.23 | 4e-123 | 359 |
| LLPS-Dar-0213 | Danio rerio | 69.06 | 3e-130 | 377 |
| LLPS-Gaga-0954 | Gallus gallus | 68.94 | 2e-128 | 372 |
| LLPS-Anp-2057 | Anas platyrhynchos | 68.4 | 1e-111 | 328 |
| LLPS-Meg-1262 | Meleagris gallopavo | 68.4 | 9e-113 | 331 |
| LLPS-Sah-1686 | Sarcophilus harrisii | 68.15 | 2e-75 | 234 |
| LLPS-Asm-1848 | Astyanax mexicanus | 68.06 | 7e-129 | 373 |
| LLPS-Caf-1170 | Canis familiaris | 67.8 | 5e-117 | 344 |
| LLPS-Myl-1317 | Myotis lucifugus | 67.69 | 4e-120 | 351 |
| LLPS-Orc-1959 | Oryctolagus cuniculus | 67.68 | 2e-117 | 345 |
| LLPS-Pes-0718 | Pelodiscus sinensis | 67.42 | 4e-127 | 370 |
| LLPS-Orn-3156 | Oreochromis niloticus | 66.79 | 6e-129 | 374 |
| LLPS-Pof-1433 | Poecilia formosa | 66.79 | 3e-124 | 362 |
| LLPS-Icp-0827 | Ictalurus punctatus | 66.38 | 9e-112 | 330 |
| LLPS-Gaa-1413 | Gasterosteus aculeatus | 65.91 | 1e-124 | 363 |
| LLPS-Pap-2139 | Pan paniscus | 65.59 | 6e-116 | 342 |
| LLPS-Cap-0401 | Cavia porcellus | 64.64 | 3e-109 | 323 |
| LLPS-Scm-1306 | Scophthalmus maximus | 64.39 | 5e-120 | 351 |
| LLPS-Ten-1573 | Tetraodon nigroviridis | 64.02 | 1e-120 | 352 |
| LLPS-Urm-1894 | Ursus maritimus | 63.84 | 1e-88 | 271 |
| LLPS-Tar-1869 | Takifugu rubripes | 63.26 | 7e-119 | 348 |
| LLPS-Xim-1975 | Xiphophorus maculatus | 61.36 | 3e-110 | 326 |
| LLPS-Gog-1722 | Gorilla gorilla | 60.46 | 6e-96 | 288 |
| LLPS-Eqc-2819 | Equus caballus | 60.35 | 2e-99 | 300 |
| LLPS-Orl-1180 | Oryzias latipes | 57.77 | 3e-95 | 287 |
| LLPS-Paa-0187 | Papio anubis | 57.03 | 4e-89 | 272 |
| LLPS-Chs-0739 | Chlorocebus sabaeus | 50.57 | 9e-76 | 237 |
| LLPS-Php-1710 | Physcomitrella patens | 36.3 | 2e-15 | 79.7 |
| LLPS-Cis-1216 | Ciona savignyi | 35.96 | 1e-42 | 154 |
| LLPS-Cii-2114 | Ciona intestinalis | 34.0 | 3e-40 | 147 |
| LLPS-Drm-0169 | Drosophila melanogaster | 29.92 | 1e-20 | 92.4 |
| LLPS-Coc-1528 | Corchorus capsularis | 29.57 | 1e-12 | 71.2 |
| LLPS-Viv-1442 | Vitis vinifera | 29.41 | 1e-16 | 80.5 |
| LLPS-Cus-1874 | Cucumis sativus | 28.86 | 6e-17 | 84.7 |
| LLPS-Amt-0965 | Amborella trichopoda | 27.66 | 2e-12 | 70.5 |
| LLPS-Brn-2814 | Brassica napus | 27.6 | 2e-11 | 68.2 |
| LLPS-Sem-1898 | Selaginella moellendorffii | 27.57 | 2e-20 | 92.0 |
| LLPS-Cae-0511 | Caenorhabditis elegans | 27.31 | 5e-21 | 93.6 |
| LLPS-Phv-2260 | Phaseolus vulgaris | 27.04 | 1e-11 | 68.2 |
| LLPS-Via-2198 | Vigna angularis | 26.89 | 1e-11 | 68.2 |
| LLPS-Vir-0843 | Vigna radiata | 26.79 | 1e-06 | 53.1 |
| LLPS-Thc-0158 | Theobroma cacao | 26.74 | 6e-14 | 75.5 |
| LLPS-Brr-2188 | Brassica rapa | 26.59 | 4e-11 | 66.6 |
| LLPS-Gas-1352 | Galdieria sulphuraria | 25.76 | 7e-06 | 50.4 |
| LLPS-Mae-2602 | Manihot esculenta | 24.07 | 5e-14 | 74.3 |