LLPS-Lac-0462
NBN
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Nibrin |
| Gene Name: | NBN |
| Ensembl Gene: | ENSLACG00000008266.1 |
| Ensembl Protein: | ENSLACP00000009373.1 |
| Organism: | Latimeria chalumnae |
| Taxa ID: | 7897 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, PML nuclear body, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLACT00000009444.1 | ENSLACP00000009373.1 |
| Ensembl | ENSLACT00000009443.1 | ENSLACP00000009372.1 |
| UniProt | H3AIA1, H3AIA1_LATCH | |
| GeneBank | AFYH01196766, AFYH01196770, AFYH01196768, AFYH01196769, AFYH01196765, AFYH01196767 | |
| RefSeq | XM_006008519.2 | XP_006008581.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWKLIPLTAA GEEPYQLLVG VEYIVGRKNC TILLSDDQSI SRAHAVLTVS HPVVNLGHAA 60 61 RIPVLNIKDT SKYGTFVNEE RMQRESPRSL NSRERVTFGV FESKFRVEYE PMIVCSSCLD 120 121 GPGKVTLNQV VGQLGGHVVN SWMEDCTHLI MPSVKVTVKT ICALICCRPI IKLEYFTELL 180 181 KAIQSKQHLP TLESFFPPVD EPNIQPEALD LTARPERKSI FRGKTFIFLN AKQHKRLSPA 240 241 VTLGGGQVKL VAECSKIESL LESTGNCILD VGTSNSQASI SSSTKKWIES IITSLQSKGL 300 301 RAISEAEIGL AVIFMSTELY CNPQQRDETE TYTATIPGPT LSQSLAIDET TMPAATLNIT 360 361 AYVPDTEPSQ ELDTRMEVSG LQEVKETPEK EQRSRMRSRE ISVVKETPST NSAEVLVTAL 420 421 RSEKERPENS LTSKSASKEQ LSTRETSELG RSNEGSSQSQ SSWLSGDFLL VRKKRERSVD 480 481 EESSSQAKYT RTDREETQSF TTTLQKNSTE KLQRKQCPSL IPSEPFVVEP KQKPSVRGEN 540 541 SGSAFNKSPE AVCVSSEKAA SKKRKEPNDL DDDLLLLAFE SELLEGDADL TDQGTASVMN 600 601 VSRKRRMVPE GKKMKLEETT PAEEISTAKQ SSENSTIRKE ENELAESVKK ERAASKALLA 660 661 GEYDENLPTK LLLIEFKSLV VSRPRAFVQS TTSMEQGQVK NYKRFKKVAY PGAEGLPHII 720 721 GGSDLIAHQS KKNSELEEWL QQEMQEQSQR AREEFLSDDL FRYDPKSVKR RR 772 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGAAGC TGATTCCTTT AACTGCTGCT GGAGAAGAGC CTTATCAATT GTTGGTTGGC 60 61 GTTGAATACA TTGTCGGGCG TAAGAATTGT ACAATTCTTC TTAGCGATGA TCAGTCCATT 120 121 AGCCGAGCTC ATGCAGTTCT CACTGTCAGC CACCCTGTTG TCAACCTGGG ACATGCTGCT 180 181 AGAATTCCTG TGTTAAACAT AAAAGATACT TCCAAGTATG GAACTTTTGT TAACGAGGAG 240 241 CGAATGCAGA GAGAATCTCC CAGGAGTTTA AATTCCAGAG AAAGAGTTAC ATTTGGAGTT 300 301 TTTGAGAGCA AGTTTCGAGT GGAATATGAG CCGATGATTG TCTGCTCCTC ATGTTTAGAT 360 361 GGCCCAGGAA AAGTGACTCT AAATCAGGTG GTTGGGCAGC TGGGGGGCCA TGTAGTCAAC 420 421 AGCTGGATGG AGGACTGTAC TCACCTGATC ATGCCATCAG TTAAAGTCAC TGTCAAGACT 480 481 ATCTGTGCCT TGATTTGCTG CCGGCCAATA ATAAAGCTTG AATATTTCAC TGAGCTTCTC 540 541 AAAGCTATTC AGTCAAAACA GCATCTGCCC ACACTTGAAA GCTTTTTCCC TCCGGTTGAT 600 601 GAACCAAATA TACAGCCTGA AGCCCTGGAT CTGACTGCAC GTCCAGAAAG GAAAAGCATC 660 661 TTCAGAGGGA AGACTTTTAT CTTCCTAAAT GCTAAACAGC ACAAAAGGCT CAGTCCTGCA 720 721 GTTACTCTTG GTGGCGGACA AGTGAAACTA GTTGCAGAAT GCAGTAAAAT TGAATCTCTA 780 781 CTAGAATCAA CTGGAAATTG TATTCTCGAC GTAGGAACCA GTAACTCACA AGCCTCCATT 840 841 TCCAGTTCCA CCAAAAAATG GATTGAGTCC ATTATAACCA GCCTACAGAG CAAAGGTCTC 900 901 CGGGCTATTT CAGAAGCAGA AATCGGGTTA GCAGTGATCT TTATGTCCAC AGAGTTGTAC 960 961 TGTAACCCTC AACAACGTGA TGAGACAGAA ACGTACACAG CCACAATTCC AGGACCAACC 1020 1021 CTTTCCCAGA GTTTGGCTAT TGATGAAACA ACAATGCCCG CTGCCACACT GAACATCACT 1080 1081 GCCTATGTCC CCGACACAGA GCCTTCACAG GAGCTAGATA CAAGAATGGA AGTGAGCGGG 1140 1141 TTACAAGAAG TTAAAGAAAC TCCTGAAAAA GAGCAGAGAA GCAGAATGAG GTCACGGGAA 1200 1201 ATTTCTGTTG TGAAAGAAAC TCCAAGTACA AATAGCGCTG AAGTTCTGGT GACTGCATTA 1260 1261 AGATCTGAGA AGGAAAGACC AGAAAACAGC CTCACTTCTA AAAGTGCCAG TAAGGAGCAG 1320 1321 CTGTCTACTA GAGAAACCTC TGAGCTGGGC AGAAGTAATG AAGGATCTTC ACAGTCACAG 1380 1381 TCCAGTTGGC TGAGTGGTGA TTTCTTGCTG GTACGCAAGA AAAGGGAAAG AAGTGTTGAT 1440 1441 GAGGAAAGCA GTTCTCAAGC TAAATATACA AGAACAGATC GAGAAGAAAC ACAAAGCTTT 1500 1501 ACCACCACTC TTCAGAAAAA CAGCACAGAA AAGCTTCAGA GAAAGCAGTG TCCATCCCTT 1560 1561 ATTCCAAGTG AACCTTTTGT GGTGGAACCA AAGCAGAAAC CCTCAGTCAG AGGTGAAAAC 1620 1621 TCTGGGTCGG CATTTAACAA ATCTCCAGAA GCTGTGTGTG TGAGCAGTGA AAAGGCAGCT 1680 1681 TCGAAAAAAA GAAAAGAGCC AAACGATCTT GATGATGACT TGTTACTGCT GGCTTTTGAA 1740 1741 AGTGAATTAC TTGAAGGGGA TGCTGACCTT ACAGATCAGG GTACAGCCAG TGTTATGAAT 1800 1801 GTAAGCAGGA AAAGAAGGAT GGTGCCAGAG GGAAAAAAGA TGAAGCTGGA AGAAACCACT 1860 1861 CCAGCAGAGG AAATCTCTAC AGCAAAGCAA TCAAGTGAAA ACAGTACTAT ACGGAAAGAA 1920 1921 GAAAATGAAT TAGCTGAATC TGTGAAGAAA GAAAGAGCTG CTTCTAAAGC ACTTCTGGCA 1980 1981 GGTGAATATG ATGAAAACCT TCCTACCAAG CTTCTGCTGA TTGAGTTCAA GTCACTGGTG 2040 2041 GTTAGCCGGC CCAGAGCATT TGTTCAGTCT ACTACAAGTA TGGAACAGGG ACAAGTTAAA 2100 2101 AATTATAAAA GGTTCAAAAA GGTAGCCTAC CCTGGGGCAG AAGGACTCCC ACACATTATT 2160 2161 GGAGGGTCAG ACCTCATTGC TCATCAAAGC AAAAAGAATT CTGAATTGGA GGAGTGGCTA 2220 2221 CAACAGGAAA TGCAGGAGCA AAGTCAACGT GCCAGAGAAG AGTTTCTTTC TGATGACCTC 2280 2281 TTTAGATATG ACCCAAAGTC TGTCAAAAGA AGACGATAG 2319 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome, telomeric region | |
Cellular Component | Mre11 complex | |
Biological Process | Double-strand break repair | |
Biological Process | Meiotic cell cycle | |
Biological Process | Mitotic G2 DNA damage checkpoint | |
Biological Process | Telomere maintenance |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Meg-0443 | Meleagris gallopavo | 62.62 | 3e-20 | 100 |
| LLPS-Cap-0991 | Cavia porcellus | 62.39 | 1e-20 | 101 |
| LLPS-Mod-1863 | Monodelphis domestica | 59.67 | 2e-156 | 480 |
| LLPS-Eqc-1727 | Equus caballus | 59.41 | 2e-17 | 90.9 |
| LLPS-Ora-1993 | Ornithorhynchus anatinus | 57.99 | 7e-121 | 376 |
| LLPS-Fec-1662 | Felis catus | 56.91 | 2e-21 | 103 |
| LLPS-Loa-0990 | Loxodonta africana | 56.6 | 2e-148 | 460 |
| LLPS-Sah-0884 | Sarcophilus harrisii | 56.39 | 1e-154 | 476 |
| LLPS-Ict-3350 | Ictidomys tridecemlineatus | 55.9 | 4e-146 | 450 |
| LLPS-Aim-2639 | Ailuropoda melanoleuca | 55.88 | 5e-150 | 464 |
| LLPS-Urm-1737 | Ursus maritimus | 55.64 | 1e-144 | 450 |
| LLPS-Leo-2603 | Lepisosteus oculatus | 55.14 | 1e-138 | 437 |
| LLPS-Scf-2604 | Scleropages formosus | 53.78 | 2e-108 | 353 |
| LLPS-Asm-1687 | Astyanax mexicanus | 52.35 | 1e-129 | 413 |
| LLPS-Orn-0553 | Oreochromis niloticus | 51.38 | 1e-17 | 92.4 |
| LLPS-Dar-1375 | Danio rerio | 51.08 | 6e-125 | 401 |
| LLPS-Xim-1883 | Xiphophorus maculatus | 50.39 | 7e-111 | 363 |
| LLPS-Ten-2854 | Tetraodon nigroviridis | 50.27 | 3e-105 | 346 |
| LLPS-Icp-2073 | Ictalurus punctatus | 50.13 | 1e-121 | 392 |
| LLPS-Gaga-0573 | Gallus gallus | 49.11 | 2e-141 | 441 |
| LLPS-Tar-0874 | Takifugu rubripes | 48.99 | 9e-101 | 336 |
| LLPS-Scm-1153 | Scophthalmus maximus | 48.89 | 8e-116 | 377 |
| LLPS-Pof-1829 | Poecilia formosa | 48.62 | 5e-17 | 89.7 |
| LLPS-Orl-2981 | Oryzias latipes | 48.08 | 5e-111 | 363 |
| LLPS-Pes-1328 | Pelodiscus sinensis | 48.04 | 0.0 | 590 |
| LLPS-Xet-2022 | Xenopus tropicalis | 47.21 | 5e-25 | 115 |
| LLPS-Cas-1071 | Carlito syrichta | 46.42 | 0.0 | 556 |
| LLPS-Pat-0893 | Pan troglodytes | 45.88 | 0.0 | 554 |
| LLPS-Pap-1210 | Pan paniscus | 45.88 | 0.0 | 554 |
| LLPS-Orc-3546 | Oryctolagus cuniculus | 45.78 | 0.0 | 567 |
| LLPS-Anc-0118 | Anolis carolinensis | 45.78 | 1e-180 | 543 |
| LLPS-Chs-2562 | Chlorocebus sabaeus | 45.62 | 1e-180 | 543 |
| LLPS-Hos-1441 | Homo sapiens | 45.5 | 0.0 | 550 |
| LLPS-Nol-0444 | Nomascus leucogenys | 45.5 | 0.0 | 557 |
| LLPS-Ova-4175 | Ovis aries | 45.49 | 0.0 | 550 |
| LLPS-Bot-0702 | Bos taurus | 45.35 | 0.0 | 569 |
| LLPS-Gaa-1275 | Gasterosteus aculeatus | 45.32 | 1e-114 | 373 |
| LLPS-Rhb-0071 | Rhinopithecus bieti | 45.21 | 1e-179 | 540 |
| LLPS-Fia-2330 | Ficedula albicollis | 45.18 | 5e-172 | 521 |
| LLPS-Myl-0194 | Myotis lucifugus | 45.16 | 2e-167 | 509 |
| LLPS-Mum-1996 | Mus musculus | 45.12 | 3e-21 | 103 |
| LLPS-Mal-3321 | Mandrillus leucophaeus | 45.06 | 3e-179 | 540 |
| LLPS-Cea-2663 | Cercocebus atys | 45.02 | 2e-178 | 538 |
| LLPS-Paa-1715 | Papio anubis | 44.94 | 1e-178 | 538 |
| LLPS-Caj-2741 | Callithrix jacchus | 44.93 | 0.0 | 544 |
| LLPS-Mam-0355 | Macaca mulatta | 44.81 | 1e-177 | 535 |
| LLPS-Maf-0849 | Macaca fascicularis | 44.81 | 1e-177 | 535 |
| LLPS-Man-1786 | Macaca nemestrina | 44.68 | 7e-177 | 533 |
| LLPS-Sus-2079 | Sus scrofa | 44.6 | 1e-180 | 543 |
| LLPS-Otg-1705 | Otolemur garnettii | 44.58 | 6e-172 | 521 |
| LLPS-Tag-1167 | Taeniopygia guttata | 44.53 | 8e-172 | 519 |
| LLPS-Ran-1506 | Rattus norvegicus | 44.42 | 1e-170 | 517 |
| LLPS-Caf-1621 | Canis familiaris | 44.37 | 2e-177 | 535 |
| LLPS-Fud-1158 | Fukomys damarensis | 44.33 | 2e-175 | 529 |
| LLPS-Mup-3936 | Mustela putorius furo | 44.04 | 2e-179 | 540 |
| LLPS-Aon-3698 | Aotus nancymaae | 43.34 | 3e-175 | 529 |
| LLPS-Anp-1154 | Anas platyrhynchos | 43.0 | 7e-156 | 480 |
| LLPS-Poa-0793 | Pongo abelii | 42.84 | 1e-156 | 480 |
| LLPS-Gog-1104 | Gorilla gorilla | 42.82 | 4e-164 | 499 |
| LLPS-Mea-2955 | Mesocricetus auratus | 39.09 | 5e-81 | 276 |
| LLPS-Drm-1031 | Drosophila melanogaster | 30.19 | 2e-32 | 139 |
| LLPS-Orbr-0440 | Oryza brachyantha | 29.86 | 3e-18 | 93.2 |
| LLPS-Php-0642 | Physcomitrella patens | 29.43 | 3e-20 | 100 |
| LLPS-Cii-1700 | Ciona intestinalis | 29.29 | 1e-29 | 123 |
| LLPS-Bro-2692 | Brassica oleracea | 28.57 | 6e-16 | 85.9 |
| LLPS-Vir-0912 | Vigna radiata | 28.5 | 7e-12 | 72.8 |
| LLPS-Abg-0426 | Absidia glauca | 28.47 | 5e-26 | 118 |
| LLPS-Tru-1701 | Triticum urartu | 28.42 | 5e-18 | 92.8 |
| LLPS-Zem-0960 | Zea mays | 28.38 | 6e-16 | 85.9 |
| LLPS-Tra-0229 | Triticum aestivum | 27.93 | 4e-18 | 92.8 |
| LLPS-Mua-0571 | Musa acuminata | 27.91 | 8e-18 | 91.7 |
| LLPS-Hov-0451 | Hordeum vulgare | 27.86 | 1e-17 | 91.3 |
| LLPS-Brd-0998 | Brachypodium distachyon | 27.59 | 2e-17 | 90.5 |
| LLPS-Ors-0616 | Oryza sativa | 27.34 | 2e-17 | 90.9 |
| LLPS-Orm-1487 | Oryza meridionalis | 27.34 | 2e-18 | 93.6 |
| LLPS-Fus-0787 | Fusarium solani | 27.05 | 2e-10 | 68.6 |
| LLPS-Orr-1097 | Oryza rufipogon | 26.99 | 2e-17 | 90.9 |
| LLPS-Ori-1467 | Oryza indica | 26.99 | 2e-17 | 90.5 |
| LLPS-Orni-1389 | Oryza nivara | 26.99 | 2e-17 | 90.9 |
| LLPS-Orgl-0846 | Oryza glumaepatula | 26.99 | 2e-17 | 90.9 |
| LLPS-Glm-0270 | Glycine max | 26.74 | 1e-17 | 91.7 |
| LLPS-Orb-1869 | Oryza barthii | 26.64 | 3e-17 | 90.1 |
| LLPS-Lep-0748 | Leersia perrieri | 26.57 | 7e-17 | 88.6 |
| LLPS-Orp-2138 | Oryza punctata | 26.48 | 8e-18 | 91.7 |
| LLPS-Mae-0429 | Manihot esculenta | 26.43 | 3e-16 | 87.0 |
| LLPS-Via-0543 | Vigna angularis | 26.37 | 2e-16 | 87.4 |
| LLPS-Sei-0970 | Setaria italica | 26.3 | 5e-18 | 92.4 |
| LLPS-Phv-0921 | Phaseolus vulgaris | 26.2 | 2e-17 | 90.9 |
| LLPS-Thc-0664 | Theobroma cacao | 26.03 | 2e-11 | 71.6 |
| LLPS-Met-1596 | Medicago truncatula | 25.99 | 1e-15 | 85.1 |
| LLPS-Pot-1822 | Populus trichocarpa | 25.9 | 1e-16 | 87.8 |
| LLPS-Brr-0842 | Brassica rapa | 25.82 | 2e-19 | 97.1 |
| LLPS-Brn-0951 | Brassica napus | 25.82 | 5e-19 | 95.5 |
| LLPS-Art-2239 | Arabidopsis thaliana | 25.7 | 1e-14 | 81.6 |
| LLPS-Sob-2189 | Sorghum bicolor | 25.69 | 1e-17 | 91.3 |
| LLPS-Nec-0655 | Neurospora crassa | 25.68 | 5e-13 | 77.4 |
| LLPS-Coc-0641 | Corchorus capsularis | 25.09 | 1e-12 | 75.9 |
| LLPS-Sem-1612 | Selaginella moellendorffii | 25.0 | 2e-16 | 87.0 |
| LLPS-Arl-2602 | Arabidopsis lyrata | 25.0 | 9e-14 | 79.0 |
| LLPS-Nia-0314 | Nicotiana attenuata | 24.91 | 2e-16 | 87.4 |
| LLPS-Yal-0548 | Yarrowia lipolytica | 24.66 | 7e-09 | 63.5 |
| LLPS-Gor-0455 | Gossypium raimondii | 24.58 | 1e-15 | 85.1 |
| LLPS-Prp-0462 | Prunus persica | 24.48 | 7e-16 | 85.5 |
| LLPS-Dac-0521 | Daucus carota | 24.06 | 2e-15 | 85.1 |
| LLPS-Sol-0997 | Solanum lycopersicum | 23.97 | 2e-16 | 87.8 |
| LLPS-Amt-0187 | Amborella trichopoda | 23.02 | 4e-10 | 67.0 |
| LLPS-Hea-0132 | Helianthus annuus | 21.97 | 6e-18 | 92.0 |