LLPS-Ict-a874
CHRM1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Muscarinic acetylcholine receptor |
| Gene Name: | CHRM1 |
| Ensembl Gene: | ENSSTOG00000004514.3 |
| Ensembl Protein: | ENSSTOP00000004039.2 |
| Organism: | Ictidomys tridecemlineatus |
| Taxa ID: | 43179 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSSTOT00000004499.3 | ENSSTOP00000004039.2 |
| UniProt | I3M4D2, I3M4D2_ICTTR | |
| GeneBank | AGTP01066691, AGTP01066690 | |
| RefSeq | XM_005331467.2, XM_005331468.1 | XP_005331524.1, XP_005331525.1 |
| Entrez | 101959071 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNTSAPPAVS PNITVLAPGK GPWQLAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 60 61 NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 120 121 FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 180 181 QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 240 241 SERSQPGAEG SPETPPGRCC RCCRTPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 300 301 VIKMPMVDPE AQAPTKQPPK SSPNTVKRPT RKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 360 361 KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 420 421 CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC 460 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAACACCT CAGCCCCACC CGCCGTCAGC CCCAACATCA CTGTTCTGGC CCCGGGGAAG 60 61 GGTCCCTGGC AACTGGCCTT CATCGGGATC ACCACGGGCC TCCTGTCACT GGCCACCGTG 120 121 ACAGGCAACC TGCTGGTACT CATCTCCTTC AAGGTCAACA CGGAGCTCAA GACAGTCAAT 180 181 AACTACTTCC TGCTGAGCCT CGCCTGTGCC GACCTCATCA TTGGCACCTT CTCCATGAAC 240 241 CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCCCTGG GCACGCTGGC CTGTGACCTC 300 301 TGGCTAGCCC TGGACTATGT GGCCAGCAAT GCCTCGGTCA TGAATCTGCT TCTCATCAGC 360 361 TTTGACCGCT ACTTCTCTGT GACCCGGCCC CTGAGCTACC GCGCCAAGCG CACACCCCGC 420 421 CGGGCAGCTC TGATGATCGG CCTGGCCTGG CTGGTCTCCT TCGTCCTCTG GGCCCCGGCC 480 481 ATCCTCTTCT GGCAGTACCT GGTAGGGGAG CGGACAGTGC TGGCCGGCCA GTGTTACATC 540 541 CAGTTCCTGT CCCAACCCAT CATCACCTTC GGCACCGCCA TGGCCGCCTT CTACCTCCCG 600 601 GTCACAGTCA TGTGCACCCT GTACTGGCGC ATTTACCGGG AGACGGAGAA CCGGGCTCGG 660 661 GAGCTGGCGG CCCTGCAGGG CTCTGAAACA CCAGGCAAAG GAGGCGGCAG CAGCAGCAGC 720 721 TCAGAGAGGT CGCAGCCAGG TGCCGAGGGC TCACCAGAGA CTCCCCCGGG CCGCTGCTGT 780 781 CGCTGTTGCC GGACCCCCAG GCTGCTGCAG GCCTATAGCT GGAAGGAGGA AGAGGAAGAG 840 841 GACGAAGGCT CCATGGAGTC CCTCACATCT TCAGAGGGTG AGGAACCAGG CTCTGAAGTG 900 901 GTGATCAAGA TGCCCATGGT GGACCCCGAG GCCCAGGCCC CCACCAAGCA GCCCCCAAAG 960 961 AGCTCCCCGA ATACGGTCAA GAGGCCCACC CGGAAAGGGC GAGATCGAGC TGGCAAGGGC 1020 1021 CAGAAGCCCC GCGGGAAGGA GCAGCTGGCC AAGAGGAAGA CCTTCTCACT GGTCAAGGAG 1080 1081 AAGAAGGCGG CTCGGACCCT GAGCGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCG 1140 1141 TACAACATCA TGGTGCTGGT GTCCACCTTC TGCAAGGACT GTGTTCCCGA GACCCTGTGG 1200 1201 GAGCTGGGCT ACTGGCTGTG CTACGTCAAC AGCACCATCA ACCCCATGTG CTACGCACTC 1260 1261 TGCAACAAAG CTTTCCGGGA CACCTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGCGA 1320 1321 CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAGTGC 1380 1381 TGA 1383 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Cholinergic synapse | |
Cellular Component | Integral component of postsynaptic membrane | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | G protein-coupled acetylcholine receptor activity | |
Molecular Function | Neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | |
Biological Process | Cognition | |
Biological Process | Entrainment of circadian clock | |
Biological Process | G protein-coupled acetylcholine receptor signaling pathway | |
Biological Process | Phototransduction, visible light | |
Biological Process | Positive regulation of ion transport | |
Biological Process | Regulation of locomotion | |
Biological Process | Saliva secretion |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a902 | Homo sapiens | 0.0 | 938 | undefined |
| LLPS-Mum-a888 | Mus musculus | 0.0 | 935 | undefined |