LLPS-Hos-a993
RHOG

▼ OVERVIEW

Status: Reviewed
Protein Name: Rho-related GTP-binding protein RhoG
Gene Name: RHOG, ARHG
Ensembl Gene: ENSG00000177105.9
Ensembl Protein: ENSP00000380176.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MQSIKCVVVG  DGAVGKTCLL  ICYTTNAFPK  EYIPTVFDNY  SAQSAVDGRT  VNLNLWDTAG  60
61    QEEYDRLRTL  SYPQTNVFVI  CFSIASPPSY  ENVRHKWHPE  VCHHCPDVPI  LLVGTKKDLR  120
121   AQPDTLRRLK  EQGQAPITPQ  QGQALAKQIH  AVRYLECSAL  QQDGVKEVFA  EAVRAVLNPT  180
181   PIKRGRSCIL  L  191
Nucleotide CDS Sequence (FASTA)
1     ATGCAGAGCA  TCAAGTGCGT  GGTGGTGGGT  GATGGGGCTG  TGGGCAAGAC  GTGCCTGCTC  60
61    ATCTGCTACA  CAACTAACGC  TTTCCCCAAA  GAGTACATCC  CCACCGTGTT  CGACAATTAC  120
121   AGCGCGCAGA  GCGCAGTTGA  CGGGCGCACA  GTGAACCTGA  ACCTGTGGGA  CACTGCGGGC  180
181   CAGGAGGAGT  ATGACCGCCT  CCGTACACTC  TCCTACCCTC  AGACCAACGT  TTTCGTCATC  240
241   TGTTTCTCCA  TTGCCAGTCC  GCCGTCCTAT  GAGAACGTGC  GGCACAAGTG  GCATCCAGAG  300
301   GTGTGCCACC  ACTGCCCTGA  TGTGCCCATC  CTGCTGGTGG  GCACCAAGAA  GGACCTGAGA  360
361   GCCCAGCCTG  ACACCCTACG  GCGCCTCAAG  GAGCAGGGCC  AGGCGCCCAT  CACACCGCAG  420
421   CAGGGCCAGG  CACTGGCCAA  GCAGATCCAC  GCTGTGCGCT  ACCTCGAATG  CTCAGCCCTG  480
481   CAACAGGATG  GTGTCAAGGA  AGTGTTCGCC  GAGGCTGTCC  GGGCTGTGCT  CAACCCCACG  540
541   CCGATCAAGC  GTGGGCGGTC  CTGCATCCTC  TTGTGA  576

▼ KEYWORD

ID
Family
ADP-ribosylation
Cell membrane
Complete proteome
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Prenylation
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell cortex
Cellular Component
Cell projection
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Extracellular exosome
Cellular Component
Focal adhesion
Cellular Component
Plasma membrane
Cellular Component
Secretory granule membrane
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Protein kinase binding
Biological Process
Actin cytoskeleton organization
Biological Process
Actin filament organization
Biological Process
Activation of GTPase activity
Biological Process
Cell chemotaxis
Biological Process
Establishment or maintenance of cell polarity
Biological Process
Neutrophil degranulation
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of protein kinase B signaling
Biological Process
Positive regulation of protein localization to plasma membrane
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Rac protein signal transduction
Biological Process
Regulation of actin cytoskeleton organization
Biological Process
Regulation of cell shape
Biological Process
Regulation of ruffle assembly
Biological Process
Regulation of small GTPase mediated signal transduction
Biological Process
Rho protein signal transduction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a980Pan troglodytes100.02e-140399
LLPS-Pap-a953Pan paniscus100.02e-140399
LLPS-Mum-a977Mus musculus100.02e-140399
LLPS-Gog-a968Gorilla gorilla100.02e-140399
LLPS-Mea-a932Mesocricetus auratus100.02e-140399
LLPS-Ran-a973Rattus norvegicus100.02e-140399
LLPS-Nol-a951Nomascus leucogenys100.02e-140399
LLPS-Mup-a936Mustela putorius furo99.483e-140398
LLPS-Cas-a844Carlito syrichta99.483e-140398
LLPS-Caf-a955Canis familiaris99.483e-139398
LLPS-Mal-a961Mandrillus leucophaeus99.483e-140398
LLPS-Cea-a976Cercocebus atys99.483e-140398
LLPS-Fec-a975Felis catus99.483e-140398
LLPS-Aim-a927Ailuropoda melanoleuca99.483e-140398
LLPS-Poa-a950Pongo abelii99.489e-140397
LLPS-Maf-a976Macaca fascicularis99.483e-140398
LLPS-Caj-a968Callithrix jacchus99.483e-140398
LLPS-Orc-a909Oryctolagus cuniculus99.483e-140398
LLPS-Ict-a961Ictidomys tridecemlineatus99.484e-140398
LLPS-Loa-a943Loxodonta africana99.489e-140397
LLPS-Man-a980Macaca nemestrina99.483e-140398
LLPS-Paa-a980Papio anubis99.483e-140398
LLPS-Mam-a961Macaca mulatta99.483e-140398
LLPS-Myl-a902Myotis lucifugus98.954e-140398
LLPS-Otg-a961Otolemur garnettii98.954e-140398
LLPS-Dio-a937Dipodomys ordii98.951e-139397
LLPS-Eqc-a972Equus caballus98.954e-140398
LLPS-Ere-a248Erinaceus europaeus98.861e-127365
LLPS-Urm-a873Ursus maritimus97.026e-116337
LLPS-Sah-a876Sarcophilus harrisii95.813e-135385
LLPS-Rhb-a968Rhinopithecus bieti95.816e-133379
LLPS-Mod-a934Monodelphis domestica95.292e-134383
LLPS-Ora-a801Ornithorhynchus anatinus88.549e-121348
LLPS-Gaga-a872Gallus gallus84.822e-118349
LLPS-Meg-a772Meleagris gallopavo84.826e-122352
LLPS-Fia-a851Ficedula albicollis83.773e-120347
LLPS-Tag-a833Taeniopygia guttata83.773e-120347
LLPS-Pes-a834Pelodiscus sinensis83.771e-121351
LLPS-Anc-a881Anolis carolinensis83.255e-119344
LLPS-Leo-a834Lepisosteus oculatus80.634e-114332
LLPS-Scf-a819Scleropages formosus80.632e-115335
LLPS-Dar-a851Danio rerio80.13e-114332
LLPS-Pof-a840Poecilia formosa80.11e-111326
LLPS-Icp-a849Ictalurus punctatus80.19e-115333
LLPS-Lac-a850Latimeria chalumnae79.581e-115335
LLPS-Orn-a842Oreochromis niloticus79.585e-112327
LLPS-Tar-a800Takifugu rubripes79.582e-112328
LLPS-Xim-a848Xiphophorus maculatus79.063e-111325
LLPS-Ten-a801Tetraodon nigroviridis78.013e-112327
LLPS-Gaa-a819Gasterosteus aculeatus78.014e-110322
LLPS-Xet-a827Xenopus tropicalis77.491e-108318
LLPS-Scm-a807Scophthalmus maximus76.961e-109321
LLPS-Asm-a839Astyanax mexicanus76.343e-103305
LLPS-Sus-a977Sus scrofa75.923e-108317
LLPS-Orl-a830Oryzias latipes75.929e-108316
LLPS-Ova-a937Ovis aries75.394e-108317
LLPS-Bot-a977Bos taurus72.882e-90271
LLPS-Chs-a966Chlorocebus sabaeus71.359e-94280
LLPS-Aon-a982Aotus nancymaae70.839e-93278
LLPS-Fud-a934Fukomys damarensis70.832e-92277
LLPS-Anp-a778Anas platyrhynchos70.831e-93280
LLPS-Cap-a974Cavia porcellus70.317e-92275
LLPS-Abg-a070Absidia glauca68.573e-88266
LLPS-Cii-a233Ciona intestinalis68.162e-87264
LLPS-Kop-a024Komagataella pastoris66.291e-77241
LLPS-Crn-a031Cryptococcus neoformans62.896e-87263
LLPS-Cae-a124Caenorhabditis elegans61.543e-84256
LLPS-Cis-a197Ciona savignyi59.384e-75233