LLPS-Hos-a967
SPTBN2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Spectrin beta chain, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein |
| Gene Name: | SPTBN2, KIAA0302, SCA5 |
| Ensembl Gene: | ENSG00000173898.12 |
| Ensembl Protein: | ENSP00000480692.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Probably plays an important role in neuronal membrane skeleton. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000611817.4 | ENSP00000480692.1 |
| Ensembl | ENST00000527010.1 | ENSP00000433631.1 |
| Ensembl | ENST00000533211.5 | ENSP00000432568.1 |
| Ensembl | ENST00000617502.4 | ENSP00000482000.1 |
| Ensembl | ENST00000529997.5 | ENSP00000433593.1 |
| Ensembl | ENST00000309996.6 | ENSP00000311489.2 |
| UniProt | O15020, SPTN2_HUMAN, O14872, O14873 | |
| GeneBank | AF079569, AF026488, AP001157, AB008567, AF026487 | AAC79503.1, AAC79502.1, AAC79504.1, AAC80006.1, BAA32700.2 |
| RefSeq | NM_006946.2, XM_005274192.4, XM_005274193.3, XM_006718671.3, XM_017018174.1, XM_017018175.1, XM_017018176.1, XM_017018177.1, XM_017018178.1 | NP_008877.1, XP_005274249.1, XP_005274250.1, XP_006718734.1, XP_016873663.1, XP_016873664.1, XP_016873665.1, XP_016873666.1, XP_016873667.1 |
| Entrez | 6712 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK 60 61 KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG EILPKPTKGR MRIHCLENVD 120 121 KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD 180 181 ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA 240 241 FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA 300 301 MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT 360 361 EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ 420 421 EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR 480 481 VQAVDAVAAE LAAERYHDIK RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL 540 541 LYLMDWMEEM KGRLQSQDLG RHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCNP 600 601 GKEYRPCDPQ LVSERVAKLE QSYEALCELA AARRARLEES RRLWRFLWEV GEAEAWVREQ 660 661 QHLLASADTG RDLTGALRLL NKHTALRGEM SGRLGPLKLT LEQGQQLVAE GHPGASQASA 720 721 RAAELQAQWE RLEALAEERA QRLAQAASLY QFQADANDME AWLVDALRLV SSPELGHDEF 780 781 STQALARQHR ALEEEIRSHR PTLDALREQA AALPPTLSRT PEVQSRVPTL ERHYEELQAR 840 841 AGERARALEA ALALYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE 900 901 MNTLAAQITA VNDIAEQLLK ANPPGKDRIV NTQEQLNHRW QQFRRLADGK KAALTSALSI 960 961 QNYHLECTET QAWMREKTKV IESTQGLGND LAGVLALQRK LAGTERDLEA IAARVGELTR 1020 1021 EANALAAGHP AQAVAINARL REVQTGWEDL RATMRRREES LGEARRLQDF LRSLDDFQAW 1080 1081 LGRTQTAVAS EEGPATLPEA EALLAQHAAL RGEVERAQSE YSRLRALGEE VTRDQADPQC 1140 1141 LFLRQRLEAL GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM 1200 1201 PGTLQAADAA IKKLEDFMST MDANGERIHG LLEAGRQLVS EGNIHADKIR EKADSIERRH 1260 1261 KKNQDAAQQF LGRLRDNREQ QHFLQDCHEL KLWIDEKMLT AQDVSYDEAR NLHTKWQKHQ 1320 1321 AFMAELAANK DWLDKVDKEG RELTLEKPEL KALVSEKLRD LHRRWDELET TTQAKARSLF 1380 1381 DANRAELFAQ SCCALESWLE SLQAQLHSDD YGKDLTSVNI LLKKQQMLEW EMAVREKEVE 1440 1441 AIQAQAKALA QEDQGAGEVE RTSRAVEEKF RALCQPMRER CRRLQASREQ HQFHRDVEDE 1500 1501 ILWVTERLPM ASSMEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLRER QRALGAAAAG 1560 1561 PELAELQEMW KRLGHELELR GKRLEDALRA QQFYRDAAEA EAWMGEQELH MMGQEKAKDE 1620 1621 LSAQAEVKKH QVLEQALADY AQTIHQLAAS SQDMIDHEHP ESTRISIRQA QVDKLYAGLK 1680 1681 ELAGERRERL QEHLRLCQLR RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS 1740 1741 RDTSTIGQER VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA 1800 1801 YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ ALSPQVQQVQ 1860 1861 DDGHRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR QLLLDTTDKF RFFKAVRELM 1920 1921 LWMDEVNLQM DAQERPRDVS SADLVIKNQQ GIKAEIEARA DRFSSCIDMG KELLARSHYA 1980 1981 AEEISEKLSQ LQARRQETAE KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE 2040 2041 LGCTVDEVES LIKRHEAFQK SAVAWEERFC ALEKLTALEE REKERKRKRE EEERRKQPPA 2100 2101 PEPTASVPPG DLVGGQTASD TTWDGTQPRP PPSTQAPSVN GVCTDGEPSQ PLLGQQRLEH 2160 2161 SSFPEGPGPG SGDEANGPRG ERQTRTRGPA PSAMPQSRST ESAHAATLPP RGPEPSAQEQ 2220 2221 MEGMLCRKQE MEAFGKKAAN RSWQNVYCVL RRGSLGFYKD AKAASAGVPY HGEVPVSLAR 2280 2281 AQGSVAFDYR KRKHVFKLGL QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSASGEPEEP 2340 2341 VVPSTTRGMT RAMTMPPVSP VGAEGPVVLR SKDGRERERE KRFSFFKKNK 2390 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCAGCA CGCTGTCACC CACAGACTTT GACAGCTTGG AAATCCAGGG CCAGTACAGT 60 61 GACATCAACA ACCGCTGGGA CCTTCCTGAC TCGGACTGGG ACAATGACAG CAGCTCGGCC 120 121 CGCCTCTTTG AGAGGTCTCG CATTAAGGCT CTGGCAGATG AACGAGAAGC TGTGCAGAAG 180 181 AAAACCTTCA CCAAGTGGGT AAACTCGCAC CTGGCCCGGG TCACGTGCCG GGTGGGGGAC 240 241 CTGTACAGCG ACCTCCGGGA CGGACGCAAC CTGCTGAGGC TCCTCGAGGT GCTCTCGGGA 300 301 GAGATACTGC CAAAGCCTAC AAAGGGCCGC ATGCGGATCC ACTGCCTGGA GAACGTGGAC 360 361 AAGGCACTGC AGTTCCTCAA GGAGCAGAAA GTGCACTTGG AAAACATGGG CTCCCATGAC 420 421 ATTGTGGACG GAAACCACCG ACTGACCCTT GGGCTGGTCT GGACCATCAT CCTTCGATTC 480 481 CAGATCCAAG ACATCAGTGT GGAGACAGAA GACAACAAGG AGAAGAAGTC AGCCAAGGAT 540 541 GCCCTGCTTC TGTGGTGCCA GATGAAGACT GCAGGTTATC CCAACGTCAA TGTACACAAC 600 601 TTCACCACCA GCTGGAGAGA TGGACTAGCT TTCAACGCCA TCGTGCATAA ACACCGGCCA 660 661 GACCTGCTGG ATTTTGAGTC TCTGAAGAAG TGTAATGCAC ACTATAATCT GCAGAATGCA 720 721 TTCAATCTGG CTGAAAAGGA ACTGGGACTT ACCAAGCTGC TGGATCCCGA AGACGTGAAT 780 781 GTGGACCAGC CAGATGAGAA GTCAATCATT ACCTATGTGG CTACTTACTA CCATTACTTC 840 841 TCCAAGATGA AGGCCCTGGC CGTGGAAGGC AAGAGAATTG GCAAGGTGCT GGACCATGCC 900 901 ATGGAGGCAG AGCGCCTGGT GGAGAAATAC GAGTCCCTGG CCTCGGAGCT GCTGCAGTGG 960 961 ATCGAGCAAA CGATCGTGAC CCTCAATGAC CGGCAGTTGG CCAACTCCCT TAGCGGGGTC 1020 1021 CAGAACCAGC TGCAGTCCTT CAACTCCTAC CGCACCGTGG AGAAGCCGCC CAAGTTTACC 1080 1081 GAGAAAGGGA ACTTGGAAGT GCTGCTCTTC ACCATCCAGA GCAAGCTTCG GGCCAACAAC 1140 1141 CAGAAGGTCT ACACGCCCCG CGAGGGCCGG CTCATCTCGG ACATCAACAA GGCTTGGGAG 1200 1201 CGGCTGGAGA AGGCGGAGCA CGAGCGTGAG CTGGCCCTGC GCACCGAGCT CATCCGCCAG 1260 1261 GAGAAGCTGG AGCAGCTGGC CGCCCGCTTC GACCGCAAGG CTGCCATGCG GGAGACCTGG 1320 1321 CTCAGCGAGA ACCAGCGCCT CGTGTCCCAG GACAACTTTG GGCTGGAGCT GGCAGCTGTC 1380 1381 GAGGCAGCAG TACGGAAGCA CGAAGCCATT GAGACGGACA TCGTGGCCTA CAGCGGCCGG 1440 1441 GTGCAGGCAG TGGACGCCGT GGCTGCAGAG CTGGCCGCCG AGCGCTACCA CGACATCAAG 1500 1501 CGCATCGCCG CTCGGCAGCA CAACGTGGCA CGGCTCTGGG ACTTCTTGCG GCAGATGGTG 1560 1561 GCCGCCCGGC GGGAGCGGCT CCTCCTCAAC CTGGAGCTGC AGAAGGTGTT CCAGGACCTG 1620 1621 CTCTACCTCA TGGACTGGAT GGAAGAGATG AAGGGCCGGC TGCAGTCTCA GGACCTGGGC 1680 1681 AGGCACCTAG CAGGAGTGGA GGACCTGCTG CAGCTGCACG AGCTGGTGGA GGCAGACATC 1740 1741 GCCGTGCAGG CCGAGAGGGT GCGGGCCGTC AGCGCCTCTG CCCTGCGCTT CTGCAACCCA 1800 1801 GGGAAAGAGT ATAGACCTTG CGACCCGCAG CTGGTGTCGG AGCGGGTGGC CAAGCTAGAG 1860 1861 CAGAGCTATG AGGCACTGTG CGAGTTGGCA GCGGCGCGGC GGGCCCGGCT GGAGGAATCA 1920 1921 CGGCGGCTCT GGCGTTTCCT CTGGGAGGTG GGTGAAGCTG AGGCCTGGGT GCGGGAGCAG 1980 1981 CAGCACCTCC TGGCCTCAGC CGACACGGGC CGAGACCTGA CCGGTGCCCT CCGCCTGCTC 2040 2041 AACAAGCACA CAGCCCTGCG GGGCGAGATG AGCGGCCGGC TGGGGCCCCT GAAGCTCACC 2100 2101 CTGGAGCAGG GCCAGCAGTT GGTGGCCGAG GGTCACCCTG GGGCAAGCCA GGCCTCTGCC 2160 2161 CGTGCAGCTG AACTCCAAGC CCAGTGGGAG CGGCTAGAGG CCCTGGCCGA GGAGCGTGCC 2220 2221 CAGCGGCTGG CCCAAGCCGC CAGCCTCTAC CAGTTCCAGG CCGATGCAAA CGACATGGAG 2280 2281 GCCTGGTTGG TTGACGCACT GCGCCTGGTG TCCAGCCCCG AGCTGGGGCA CGACGAGTTC 2340 2341 TCCACGCAGG CTCTAGCCAG GCAGCATCGG GCCCTGGAGG AGGAGATTCG AAGCCACCGG 2400 2401 CCAACCCTGG ACGCCTTGAG GGAACAGGCA GCAGCCCTGC CCCCCACACT GAGCCGCACG 2460 2461 CCCGAGGTGC AGAGCCGGGT GCCCACCCTG GAGCGGCACT ACGAGGAGCT GCAGGCCCGG 2520 2521 GCAGGCGAGC GAGCGCGGGC CTTGGAGGCA GCCCTGGCGC TCTACACCAT GCTCAGCGAG 2580 2581 GCCGGGGCCT GTGGACTCTG GGTGGAGGAG AAGGAGCAGT GGCTCAACGG GCTGGCCCTG 2640 2641 CCTGAACGCC TGGAGGACCT GGAGGTCGTG CAGCAGAGGT TCGAGACCCT GGAGCCTGAA 2700 2701 ATGAACACCC TTGCAGCACA AATCACCGCG GTGAATGACA TTGCCGAGCA GTTACTGAAG 2760 2761 GCCAACCCCC CAGGCAAAGA CCGCATTGTC AACACCCAGG AGCAGCTCAA CCACAGGTGG 2820 2821 CAGCAGTTTC GGCGTCTGGC AGACGGCAAG AAGGCAGCTC TCACCTCAGC CCTGAGCATC 2880 2881 CAGAACTACC ACTTAGAGTG CACGGAGACC CAGGCCTGGA TGAGAGAGAA GACCAAAGTC 2940 2941 ATCGAGTCCA CCCAGGGCCT AGGCAACGAT CTGGCTGGGG TGCTGGCCCT GCAGCGCAAG 3000 3001 CTGGCCGGCA CGGAGCGGGA CCTGGAGGCC ATCGCCGCCC GGGTGGGCGA ACTGACTCGA 3060 3061 GAGGCAAATG CCCTGGCTGC CGGCCATCCC GCTCAGGCAG TGGCCATCAA CGCCCGGCTG 3120 3121 AGAGAGGTGC AGACCGGCTG GGAGGACCTC AGGGCCACCA TGCGGCGTCG AGAAGAGTCG 3180 3181 CTGGGGGAGG CGCGGCGGCT GCAGGACTTC TTGCGCAGCT TGGATGACTT CCAGGCCTGG 3240 3241 CTAGGCCGCA CTCAGACTGC TGTGGCCTCT GAAGAAGGGC CGGCCACCCT GCCTGAGGCA 3300 3301 GAGGCCCTCC TGGCCCAACA TGCAGCCCTG CGGGGAGAGG TGGAGCGGGC CCAGAGCGAG 3360 3361 TATAGCCGGC TGCGAGCCCT GGGCGAGGAG GTGACCCGGG ACCAGGCTGA CCCCCAGTGC 3420 3421 CTCTTCCTAC GACAGCGACT GGAGGCCCTG GGAACTGGCT GGGAGGAGCT GGGCCGAATG 3480 3481 TGGGAGAGCC GGCAAGGTCG CCTGGCCCAG GCCCACGGCT TCCAGGGATT CCTGCGGGAT 3540 3541 GCTCGTCAGG CTGAGGGCGT GCTCAGCAGC CAGGAATATG TTCTGTCTCA CACGGAGATG 3600 3601 CCAGGGACAC TCCAGGCTGC TGATGCTGCC ATTAAAAAAC TGGAGGACTT CATGAGCACC 3660 3661 ATGGACGCCA ATGGGGAACG GATCCACGGG CTCCTGGAGG CTGGCCGCCA GCTGGTATCT 3720 3721 GAAGGCAACA TCCACGCCGA CAAGATTCGG GAAAAGGCAG ACTCCATTGA GAGGAGGCAC 3780 3781 AAGAAGAATC AAGACGCAGC GCAGCAATTT CTGGGCCGTC TTCGGGACAA CCGGGAGCAG 3840 3841 CAGCATTTCC TGCAAGATTG TCACGAGCTG AAGCTCTGGA TCGACGAGAA GATGCTGACA 3900 3901 GCCCAGGACG TGTCCTATGA CGAGGCCCGC AACCTGCATA CTAAGTGGCA GAAGCACCAG 3960 3961 GCATTCATGG CCGAGCTGGC TGCCAACAAA GACTGGCTGG ACAAGGTGGA CAAGGAAGGG 4020 4021 CGAGAGCTCA CCCTTGAGAA GCCAGAGCTG AAAGCCCTGG TGTCGGAGAA GCTGAGAGAC 4080 4081 CTGCACAGGC GCTGGGACGA GCTGGAGACC ACCACCCAAG CCAAGGCCCG CAGCCTCTTT 4140 4141 GATGCCAACC GAGCTGAGCT GTTTGCCCAG AGCTGCTGTG CCCTGGAGAG CTGGCTGGAG 4200 4201 AGCCTGCAGG CCCAGCTGCA CTCGGATGAC TACGGCAAGG ACCTCACCAG CGTCAACATC 4260 4261 CTGCTCAAGA AGCAGCAGAT GCTGGAATGG GAGATGGCTG TGAGAGAGAA GGAGGTGGAG 4320 4321 GCAATCCAGG CCCAGGCCAA AGCACTGGCC CAGGAGGACC AGGGTGCAGG GGAGGTGGAG 4380 4381 AGAACCTCGA GGGCCGTGGA GGAGAAGTTC AGGGCCTTGT GCCAGCCCAT GCGGGAACGC 4440 4441 TGCCGGCGCC TGCAGGCTTC TCGCGAGCAG CACCAGTTCC ACCGCGATGT GGAAGATGAG 4500 4501 ATTTTGTGGG TGACAGAGCG GCTGCCCATG GCCAGCTCCA TGGAGCATGG CAAGGACCTG 4560 4561 CCCAGCGTCC AGCTTCTCAT GAAGAAAAAC CAGACCCTGC AGAAAGAGAT TCAGGGCCAT 4620 4621 GAGCCCCGGA TCGCGGACCT GAGGGAGCGG CAGCGTGCTC TAGGTGCAGC AGCAGCAGGT 4680 4681 CCAGAGCTGG CTGAGCTGCA GGAAATGTGG AAACGCCTGG GCCACGAGCT GGAACTTCGA 4740 4741 GGGAAGCGAC TGGAGGATGC CCTGCGAGCC CAGCAGTTCT ACCGCGATGC CGCCGAGGCG 4800 4801 GAGGCCTGGA TGGGCGAGCA GGAATTACAC ATGATGGGCC AGGAGAAGGC CAAGGATGAG 4860 4861 CTGAGTGCCC AGGCAGAGGT GAAGAAGCAC CAGGTGCTGG AGCAAGCCCT GGCCGACTAC 4920 4921 GCGCAGACCA TCCACCAGCT GGCGGCCAGC AGCCAGGACA TGATTGACCA CGAGCACCCA 4980 4981 GAGAGCACTC GGATATCCAT CCGCCAAGCC CAGGTGGACA AGCTGTATGC CGGCCTGAAG 5040 5041 GAGCTGGCTG GAGAGCGGCG GGAGCGCCTG CAGGAGCACC TCCGGCTGTG CCAGCTCCGC 5100 5101 CGCGAGCTGG ATGACCTGGA ACAGTGGATC CAGGAGCGCG AGGTGGTGGC GGCCTCCCAC 5160 5161 GAGCTGGGCC AGGACTACGA GCATGTGACT ATGCTCCGAG ACAAATTCCG AGAGTTCTCC 5220 5221 CGGGACACAA GCACCATCGG TCAGGAGCGC GTAGATAGCG CCAATGCGCT GGCCAATGGG 5280 5281 CTCATTGCTG GGGGCCATGC TGCACGGGCC ACCGTGGCCG AGTGGAAGGA CAGTCTCAAC 5340 5341 GAGGCCTGGG CTGACCTGCT TGAGCTGCTG GACACACGGG GTCAGGTGCT GGCCGCGGCG 5400 5401 TACGAGCTGC AGCGCTTCCT GCACGGGGCA CGCCAAGCCC TGGCGCGGGT GCAGCACAAG 5460 5461 CAGCAGCAGC TTCCGGACGG GACTGGCCGC GACCTCAACG CTGCCGAGGC CCTGCAGCGC 5520 5521 CGACACTGTG CCTACGAGCA TGACATTCAG GCCCTCAGCC CCCAGGTCCA GCAGGTGCAG 5580 5581 GACGACGGCC ACCGGCTCCA GAAGGCCTAC GCTGGAGACA AGGCTGAGGA GATCGGCCGC 5640 5641 CACATGCAGG CCGTGGCCGA GGCCTGGGCC CAGCTTCAGG GAAGCTCTGC CGCCCGCCGG 5700 5701 CAGCTGCTGC TGGACACCAC AGACAAGTTC CGCTTCTTCA AGGCTGTCCG GGAACTGATG 5760 5761 CTCTGGATGG ATGAGGTCAA CCTGCAGATG GATGCCCAGG AGCGTCCCCG GGATGTGTCC 5820 5821 TCCGCGGATC TAGTCATCAA GAACCAGCAA GGCATCAAGG CAGAGATAGA GGCCCGGGCA 5880 5881 GACCGCTTCT CCTCCTGCAT CGACATGGGG AAGGAGCTGC TGGCCAGGAG CCACTATGCG 5940 5941 GCCGAGGAGA TCTCAGAGAA GCTGTCTCAG CTGCAGGCAC GGCGCCAGGA GACAGCTGAG 6000 6001 AAGTGGCAGG AGAAGATGGA CTGGCTTCAG CTGGTTTTGG AGGTGCTTGT GTTTGGAAGA 6060 6061 GATGCAGGGA TGGCAGAGGC CTGGCTCTGC AGCCAGGAGC CACTGGTGCG CAGCGCTGAG 6120 6121 CTGGGTTGCA CGGTCGACGA AGTTGAGAGC CTCATCAAGC GGCACGAGGC CTTCCAGAAG 6180 6181 TCAGCAGTGG CCTGGGAGGA GCGATTCTGT GCGCTGGAGA AGCTTACTGC GCTAGAGGAG 6240 6241 CGGGAGAAGG AGCGAAAGAG AAAGAGGGAG GAGGAGGAGC GGCGGAAACA GCCGCCTGCT 6300 6301 CCCGAACCCA CAGCCAGTGT GCCTCCAGGG GACCTGGTGG GCGGCCAGAC AGCTTCTGAC 6360 6361 ACCACCTGGG ACGGAACCCA GCCACGGCCA CCACCATCCA CACAAGCACC CAGTGTTAAT 6420 6421 GGAGTCTGCA CAGATGGAGA GCCCTCACAG CCCCTGCTGG GACAACAGAG ACTTGAGCAC 6480 6481 AGCAGCTTCC CCGAAGGGCC GGGACCTGGC TCAGGGGACG AAGCCAATGG GCCCCGGGGA 6540 6541 GAGAGGCAGA CCCGGACTCG GGGCCCGGCC CCATCTGCAA TGCCCCAGAG CAGGTCTACC 6600 6601 GAGTCAGCCC ATGCTGCCAC CCTGCCGCCT CGAGGCCCAG AGCCATCTGC CCAGGAGCAG 6660 6661 ATGGAGGGGA TGCTGTGCCG CAAGCAGGAG ATGGAGGCCT TCGGGAAGAA GGCTGCCAAC 6720 6721 AGGTCCTGGC AGAACGTGTA CTGTGTCCTG CGGCGTGGGA GCCTCGGCTT TTACAAGGAT 6780 6781 GCCAAGGCAG CCAGCGCGGG AGTGCCATAC CACGGAGAAG TGCCTGTCAG CCTGGCCAGG 6840 6841 GCCCAGGGCA GCGTCGCCTT TGATTACCGA AAGCGCAAAC ATGTCTTCAA GCTGGGCTTA 6900 6901 CAGGATGGAA AAGAATATTT ATTCCAGGCC AAGGATGAGG CAGAGATGAG CTCGTGGCTA 6960 6961 CGGGTGGTGA ATGCAGCCAT TGCCACAGCG TCTTCTGCCT CTGGAGAGCC TGAAGAGCCG 7020 7021 GTGGTGCCCA GCACCACCCG GGGCATGACC CGGGCCATGA CCATGCCCCC AGTGTCACCC 7080 7081 GTCGGGGCTG AGGGGCCTGT TGTGCTCCGC AGCAAAGACG GCAGAGAACG AGAGCGAGAA 7140 7141 AAACGCTTCA GCTTCTTTAA GAAGAACAAG TAG 7173 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Actin capping | |
Actin-binding | |
Alternative splicing | |
Complete proteome | |
Cytoplasm | |
Cytoskeleton | |
Disease mutation | |
Neurodegeneration | |
Phosphoprotein | |
Polymorphism | |
Reference proteome | |
Repeat | |
Spinocerebellar ataxia
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Cell junction | |
Cellular Component | Cytosol | |
Cellular Component | Extracellular space | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Neuronal cell body | |
Cellular Component | Parallel fiber to Purkinje cell synapse | |
Cellular Component | Postsynaptic spectrin-associated cytoskeleton | |
Cellular Component | Presynapse | |
Cellular Component | Spectrin | |
Molecular Function | Actin binding | |
Molecular Function | Cadherin binding | |
Molecular Function | Phospholipid binding | |
Molecular Function | Structural constituent of cytoskeleton | |
Molecular Function | Structural constituent of synapse | |
Biological Process | Actin filament capping | |
Biological Process | Adult behavior | |
Biological Process | Antigen processing and presentation of exogenous peptide antigen via MHC class II | |
Biological Process | Axon guidance | |
Biological Process | Cerebellar Purkinje cell layer morphogenesis | |
Biological Process | Endoplasmic reticulum to Golgi vesicle-mediated transport | |
Biological Process | MAPK cascade | |
Biological Process | Multicellular organism growth | |
Biological Process | Postsynapse organization | |
Biological Process | Synapse assembly | |
Biological Process | Vesicle-mediated transport |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a954 | Pan troglodytes | 99.58 | 0.0 | 4850 |
| LLPS-Gog-a944 | Gorilla gorilla | 99.41 | 0.0 | 4839 |
| LLPS-Cea-a952 | Cercocebus atys | 98.91 | 0.0 | 4818 |
| LLPS-Man-a955 | Macaca nemestrina | 98.79 | 0.0 | 4808 |
| LLPS-Mam-a935 | Macaca mulatta | 98.79 | 0.0 | 4811 |
| LLPS-Maf-a951 | Macaca fascicularis | 98.74 | 0.0 | 4808 |
| LLPS-Paa-a954 | Papio anubis | 98.74 | 0.0 | 4809 |
| LLPS-Rhb-a940 | Rhinopithecus bieti | 98.7 | 0.0 | 4799 |
| LLPS-Aon-a956 | Aotus nancymaae | 97.33 | 0.0 | 4737 |
| LLPS-Fec-a951 | Felis catus | 95.94 | 0.0 | 4526 |
| LLPS-Sus-a951 | Sus scrofa | 95.61 | 0.0 | 4442 |
| LLPS-Caf-a929 | Canis familiaris | 95.56 | 0.0 | 4515 |
| LLPS-Eqc-a947 | Equus caballus | 95.44 | 0.0 | 4501 |
| LLPS-Ran-a947 | Rattus norvegicus | 95.02 | 0.0 | 4496 |
| LLPS-Bot-a952 | Bos taurus | 94.95 | 0.0 | 4444 |
| LLPS-Mum-a952 | Mus musculus | 94.9 | 0.0 | 4456 |
| LLPS-Otg-a937 | Otolemur garnettii | 94.9 | 0.0 | 4465 |
| LLPS-Cap-a948 | Cavia porcellus | 94.6 | 0.0 | 4482 |
| LLPS-Orc-a889 | Oryctolagus cuniculus | 93.81 | 0.0 | 4391 |
| LLPS-Loa-a916 | Loxodonta africana | 93.15 | 0.0 | 4425 |
| LLPS-Ora-a780 | Ornithorhynchus anatinus | 74.05 | 0.0 | 1055 |
| LLPS-Cas-a822 | Carlito syrichta | 70.39 | 0.0 | 777 |
| LLPS-Anc-a860 | Anolis carolinensis | 70.04 | 0.0 | 3293 |
| LLPS-Xim-a829 | Xiphophorus maculatus | 69.28 | 0.0 | 2958 |
| LLPS-Scf-a800 | Scleropages formosus | 68.07 | 0.0 | 3210 |
| LLPS-Orn-a823 | Oreochromis niloticus | 67.1 | 0.0 | 3236 |
| LLPS-Asm-a818 | Astyanax mexicanus | 66.89 | 0.0 | 3213 |
| LLPS-Icp-a826 | Ictalurus punctatus | 66.64 | 0.0 | 3184 |
| LLPS-Gaa-a801 | Gasterosteus aculeatus | 66.53 | 0.0 | 3159 |
| LLPS-Pof-a820 | Poecilia formosa | 66.36 | 0.0 | 3179 |
| LLPS-Leo-a813 | Lepisosteus oculatus | 65.81 | 0.0 | 773 |
| LLPS-Lac-a834 | Latimeria chalumnae | 65.31 | 0.0 | 3062 |
| LLPS-Orl-a813 | Oryzias latipes | 64.73 | 0.0 | 3137 |
| LLPS-Scm-a790 | Scophthalmus maximus | 58.84 | 0.0 | 1930 |
| LLPS-Gaga-a853 | Gallus gallus | 58.6 | 0.0 | 788 |
| LLPS-Dar-a830 | Danio rerio | 52.88 | 0.0 | 1342 |