LLPS-Hos-a929
TMEM126A
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Transmembrane protein 126A |
| Gene Name: | TMEM126A |
| Ensembl Gene: | ENSG00000171202.6 |
| Ensembl Protein: | ENSP00000436723.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000531366.5 | ENSP00000436723.1 |
| Ensembl | ENST00000528105.5 | ENSP00000436590.1 |
| Ensembl | ENST00000525353.5 | ENSP00000431993.1 |
| Ensembl | ENST00000304511.6 | ENSP00000306887.2 |
| Ensembl | ENST00000532180.1 | ENSP00000434357.1 |
| UniProt | Q9H061, T126A_HUMAN, B2R570, E9PI16 | |
| GeneBank | AK312081, BC007875, AL136941, AP000642, CH471076 | AAH07875.1, CAB66875.1, EAW75102.1, BAG35017.1 |
| RefSeq | NM_001244735.1, NM_032273.3 | NP_001231664.1, NP_115649.1 |
| Entrez | 84233 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MENHKSNNKE NITIVDISRK INQLPEAERN LLENGSVYVG LNAALCGLIA NSLFRRILNV 60 61 TKARIAAGLP MAGIPFLTTD LTYRCFVSFP LNTGDLDCET CTITRSGLTG LVIGGLYPVF 120 121 LAIPVNGGLA ARYQSALLPH KGNILSYWIR TSKPVFRKML FPILLQTMFS AYLGSEQYKL 180 181 LIKALQLSEP GKEIH 195 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAAATC ATAAATCCAA TAATAAGGAA AACATAACAA TTGTTGATAT ATCCAGAAAA 60 61 ATTAACCAGC TTCCAGAAGC AGAAAGGAAT CTACTTGAAA ATGGATCGGT TTATGTTGGA 120 121 TTAAATGCTG CTCTTTGTGG CCTCATAGCA AACAGTCTTT TTCGACGCAT CTTGAATGTG 180 181 ACAAAGGCTC GCATAGCTGC TGGCTTACCA ATGGCAGGGA TACCTTTTCT TACAACAGAC 240 241 TTAACTTACA GATGTTTTGT AAGTTTTCCT TTGAATACAG GTGATTTGGA TTGTGAAACC 300 301 TGTACCATAA CACGGAGTGG ACTGACTGGT CTTGTTATTG GTGGTCTATA CCCTGTTTTC 360 361 TTGGCTATAC CTGTAAATGG TGGTCTAGCA GCCAGGTATC AATCAGCTCT GTTACCACAC 420 421 AAAGGGAACA TCTTAAGTTA CTGGATTAGA ACTTCTAAGC CTGTCTTTAG AAAGATGTTA 480 481 TTTCCTATTT TGCTCCAGAC TATGTTTTCA GCATACCTTG GGTCTGAACA ATATAAACTA 540 541 CTTATAAAGG CCCTTCAGTT ATCTGAACCT GGCAAAGAAA TTCACTGA 588 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Domain | ||||
| CDD | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a917 | Pan troglodytes | 100.0 | 1e-140 | 399 |
| LLPS-Pap-a896 | Pan paniscus | 100.0 | 1e-140 | 399 |
| LLPS-Gog-a908 | Gorilla gorilla | 98.46 | 2e-138 | 394 |
| LLPS-Poa-a889 | Pongo abelii | 96.94 | 2e-135 | 387 |
| LLPS-Nol-a895 | Nomascus leucogenys | 96.43 | 3e-134 | 383 |
| LLPS-Rhb-a901 | Rhinopithecus bieti | 93.88 | 1e-130 | 374 |
| LLPS-Cea-a916 | Cercocebus atys | 91.84 | 3e-128 | 368 |
| LLPS-Maf-a913 | Macaca fascicularis | 91.84 | 3e-127 | 365 |
| LLPS-Chs-a904 | Chlorocebus sabaeus | 91.33 | 1e-126 | 364 |
| LLPS-Paa-a917 | Papio anubis | 90.82 | 2e-127 | 366 |
| LLPS-Man-a919 | Macaca nemestrina | 90.82 | 6e-126 | 362 |
| LLPS-Mal-a902 | Mandrillus leucophaeus | 90.31 | 2e-126 | 363 |
| LLPS-Orc-a854 | Oryctolagus cuniculus | 81.38 | 5e-108 | 317 |
| LLPS-Ova-a879 | Ovis aries | 80.81 | 4e-100 | 296 |
| LLPS-Bot-a915 | Bos taurus | 80.81 | 3e-101 | 300 |
| LLPS-Caj-a907 | Callithrix jacchus | 80.54 | 5e-96 | 286 |
| LLPS-Caf-a891 | Canis familiaris | 80.1 | 6e-109 | 319 |
| LLPS-Cas-a787 | Carlito syrichta | 79.29 | 2e-101 | 300 |
| LLPS-Otg-a902 | Otolemur garnettii | 78.17 | 4e-106 | 312 |
| LLPS-Mup-a879 | Mustela putorius furo | 77.66 | 7e-99 | 293 |
| LLPS-Tut-a482 | Tursiops truncatus | 77.55 | 3e-97 | 289 |
| LLPS-Myl-a848 | Myotis lucifugus | 77.27 | 1e-97 | 290 |
| LLPS-Urm-a821 | Ursus maritimus | 77.16 | 3e-98 | 292 |
| LLPS-Aim-a871 | Ailuropoda melanoleuca | 77.16 | 3e-105 | 310 |
| LLPS-Eqc-a910 | Equus caballus | 77.16 | 4e-97 | 289 |
| LLPS-Ere-a227 | Erinaceus europaeus | 76.25 | 4e-79 | 242 |
| LLPS-Sus-a913 | Sus scrofa | 76.14 | 3e-95 | 284 |
| LLPS-Aon-a919 | Aotus nancymaae | 76.12 | 2e-100 | 297 |
| LLPS-Dio-a879 | Dipodomys ordii | 75.26 | 3e-99 | 294 |
| LLPS-Loa-a880 | Loxodonta africana | 74.87 | 1e-102 | 303 |
| LLPS-Ict-a899 | Ictidomys tridecemlineatus | 74.62 | 2e-95 | 285 |
| LLPS-Cap-a911 | Cavia porcellus | 74.49 | 2e-99 | 295 |
| LLPS-Fec-a913 | Felis catus | 74.11 | 9e-90 | 270 |
| LLPS-Fud-a879 | Fukomys damarensis | 73.6 | 4e-101 | 299 |
| LLPS-Mum-a914 | Mus musculus | 70.92 | 9e-97 | 288 |
| LLPS-Ran-a908 | Rattus norvegicus | 69.9 | 1e-93 | 280 |
| LLPS-Ora-a751 | Ornithorhynchus anatinus | 67.8 | 9e-73 | 228 |
| LLPS-Mea-a870 | Mesocricetus auratus | 67.01 | 8e-89 | 268 |
| LLPS-Sah-a822 | Sarcophilus harrisii | 63.02 | 1e-79 | 245 |
| LLPS-Mod-a875 | Monodelphis domestica | 60.32 | 8e-82 | 250 |
| LLPS-Pes-a778 | Pelodiscus sinensis | 56.38 | 2e-69 | 219 |
| LLPS-Lac-a804 | Latimeria chalumnae | 54.07 | 7e-62 | 200 |
| LLPS-Icp-a799 | Ictalurus punctatus | 53.11 | 4e-56 | 184 |
| LLPS-Scf-a771 | Scleropages formosus | 52.57 | 1e-52 | 176 |
| LLPS-Asm-a791 | Astyanax mexicanus | 51.05 | 4e-40 | 144 |
| LLPS-Xim-a802 | Xiphophorus maculatus | 50.3 | 3e-43 | 150 |