LLPS-Hos-a886
IRGQ
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Immunity-related GTPase family Q protein |
| Gene Name: | IRGQ, IRGQ1, FKSG27 |
| Ensembl Gene: | ENSG00000167378.8 |
| Ensembl Protein: | ENSP00000387535.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000422989.5 | ENSP00000387535.1 |
| Ensembl | ENST00000602269.1 | ENSP00000472250.1 |
| Ensembl | ENST00000598324.1 | ENSP00000470686.1 |
| UniProt | Q8WZA9, IRGQ_HUMAN, B2RNP3 | |
| GeneBank | CH471126, BC137020, BC137021, AF322648 | AAL33884.1, AAI37022.1, AAI37021.1, EAW57205.1 |
| RefSeq | NM_001007561.2, XM_005258515.3 | NP_001007562.1, XP_005258572.1 |
| Entrez | 126298 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR AAGPGLFLGE 60 61 LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA LAALARGTPL LAVRNLRPGD 120 121 SQTAAQARDQ TAALLNSAGL GAADLFVLPA NCGSSDGCEE LERLRAALQS QAEALRRLLP 180 181 PAQDGFEVLG AAELEAVREA FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD 240 241 MLLGLDPGDP GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL 300 301 ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK GESLKNAGGG 360 361 GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM KKSGGGDSER AAALSPEDET 420 421 WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL PPAQAGALLL ALPPASPSAA RTKAAALRAG 480 481 AWRPALLASL AAAAAPLPGL GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE 540 541 LAARAHFPGP VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV 600 601 LLQALDEMRA DAEAVLAPPE PAQ 623 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCTCCGC CGCAGGGTGA CGTGACCGCC TTGTTCCTGG GGCCTCCGGG CTTGGGGAAG 60 61 TCCGCGCTGA TCGCAGCGCT GTGCGACAAG GATGTGGAGA CGCTCGAGGC CCCCGAGGGA 120 121 CGGCCGGACT CCGGGGTTCC CAGCCTAAGA GCTGCGGGCC CAGGCCTTTT TCTGGGCGAG 180 181 CTGAGCTGCC CACCCGCAGC GCCGGGGCCC TGGGCGGCGG AAGCCAACGT GCTGGTACTG 240 241 GTGCTGCCCG GACCCGAGGG GAACGGGGAA CCGTTGGCTC CAGCCCTGGG AGAGGCAGCG 300 301 CTGGCCGCCC TGGCCCGAGG GACCCCGCTA CTGGCTGTGC GGAACCTCCG TCCTGGGGAT 360 361 TCACAGACTG CCGCCCAGGC CCGTGATCAG ACAGCAGCTC TGCTGAACAG CGCGGGGTTA 420 421 GGAGCTGCGG ATCTGTTTGT GCTACCGGCG AACTGCGGCA GCAGCGACGG CTGCGAGGAG 480 481 CTAGAGCGCC TCCGGGCGGC GCTGCAGAGC CAGGCAGAAG CGCTGCGGAG GCTCCTGCCA 540 541 CCGGCGCAGG ATGGCTTCGA GGTGTTGGGT GCAGCAGAGC TAGAGGCTGT GCGTGAGGCC 600 601 TTTGAGACCG GCGGCCTTGA GGCTGCGCTG TCGTGGGTGC GCTCAGGCCT GGAGCGCCTG 660 661 GGCAGCGCAC GGCTAGACCT GGCCGTGGCT GGCAAGGCTG ACGTGGGCCT TGTGGTGGAC 720 721 ATGCTGCTTG GATTGGATCC TGGCGACCCA GGCGCTGCGC CTGCTTCGGT CCCCACAGCA 780 781 CCCACTCCCT TCCCAGCCCC AGAGCGCCCG AATGTGGTGC TCTGGACCGT GCCTCTGGGC 840 841 CACACGGGCA CTGCCACCAC CGCGGCCGCC GCCTCTCACC CAACGCACTA CGACGCCCTC 900 901 ATCCTCGTCA CCCCTGGGGC CCCCACTGAG AAGGACTGGG CCCAGGTCCA GGCCTTGCTG 960 961 CTACCAGATG CGCCTCTTGT CTGCGTGCGC ACAGACGGCG AGGGCGAGGA TCCGGAGTGT 1020 1021 CTGGGAGAAG GCAAGATGGA GAATCCCAAG GGCGAGAGCT TAAAGAACGC AGGTGGAGGG 1080 1081 GGATTGGAGA ATGCACTCAG TAAGGGAAGG GAGAAATGTA GCGCTGGATC GCAGAAAGCA 1140 1141 GGCAGCGGGG AAGGTCCTGG GAAAGCTGGC AGCGAGGGTT TGCAGCAGGT TGTCGGCATG 1200 1201 AAGAAATCAG GTGGTGGCGA CTCAGAGCGG GCCGCTGCGT TAAGCCCGGA GGACGAGACG 1260 1261 TGGGAGGTGC TGGAGGAGGC GCCGCCGCCA GTGTTCCCCC TACGGCCTGG CGGACTCCCA 1320 1321 GGGCTATGCG AATGGCTGCG GCGAGCGCTC CCCCCAGCCC AGGCAGGGGC ACTGCTGCTG 1380 1381 GCGTTGCCAC CAGCATCTCC CAGCGCTGCC CGAACCAAGG CTGCGGCGTT GCGAGCCGGG 1440 1441 GCGTGGAGGC CAGCTCTGCT GGCTAGTCTG GCGGCGGCGG CGGCACCACT CCCAGGGCTG 1500 1501 GGCTGGGCAT GCGACGTGGC ACTTCTGCGG GGTCAGCTGG CGGAGTGGCG ACGGGGCCTG 1560 1561 GGGCTGGAAC CCACGGCACT GGCTCGACGT GAGCGTGCCC TGGGCCTGGC TTCTGGAGAG 1620 1621 CTGGCAGCGC GCGCTCATTT CCCAGGCCCG GTGACGCGCG CCGAGGTGGA AGCAAGACTG 1680 1681 GGCGCCTGGG CGGGCGAGGG CACTGCTGGG GGCGCAGCAC TGGGGGCTCT CTCCTTCCTG 1740 1741 TGGCCTGCGG GTGGTGCAGC GGCGACAGGT GGCCTGGGCT ACCGAGCGGC TCACGGCGTC 1800 1801 CTGCTGCAGG CTCTCGATGA GATGCGGGCT GATGCTGAGG CTGTGCTGGC ACCCCCTGAG 1860 1861 CCTGCCCAGT GA 1872 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Domain | ||||
| LCR-eXXXplorer | Gene3D | |||
| Disease | ||||
| ActiveDriverDB | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a874 | Pan troglodytes | 99.52 | 0.0 | 1169 |
| LLPS-Pap-a854 | Pan paniscus | 99.36 | 0.0 | 1164 |
| LLPS-Poa-a849 | Pongo abelii | 98.07 | 0.0 | 1149 |
| LLPS-Rhb-a860 | Rhinopithecus bieti | 98.07 | 0.0 | 1150 |
| LLPS-Mam-a858 | Macaca mulatta | 97.79 | 2e-77 | 251 |
| LLPS-Mal-a859 | Mandrillus leucophaeus | 97.43 | 0.0 | 1140 |
| LLPS-Maf-a871 | Macaca fascicularis | 97.43 | 0.0 | 1139 |
| LLPS-Cea-a873 | Cercocebus atys | 97.27 | 0.0 | 1138 |
| LLPS-Chs-a862 | Chlorocebus sabaeus | 97.27 | 0.0 | 1135 |
| LLPS-Paa-a874 | Papio anubis | 97.11 | 0.0 | 1135 |
| LLPS-Man-a875 | Macaca nemestrina | 96.95 | 0.0 | 1131 |
| LLPS-Nol-a853 | Nomascus leucogenys | 95.51 | 0.0 | 1107 |
| LLPS-Aon-a876 | Aotus nancymaae | 94.86 | 0.0 | 951 |
| LLPS-Caj-a865 | Callithrix jacchus | 94.22 | 0.0 | 940 |
| LLPS-Tut-a454 | Tursiops truncatus | 86.54 | 0.0 | 871 |
| LLPS-Fec-a871 | Felis catus | 85.76 | 0.0 | 840 |
| LLPS-Ict-a858 | Ictidomys tridecemlineatus | 83.63 | 0.0 | 803 |
| LLPS-Caf-a850 | Canis familiaris | 83.46 | 0.0 | 810 |
| LLPS-Bot-a873 | Bos taurus | 83.36 | 0.0 | 800 |
| LLPS-Sus-a872 | Sus scrofa | 83.11 | 0.0 | 686 |
| LLPS-Mup-a840 | Mustela putorius furo | 82.94 | 0.0 | 784 |
| LLPS-Cap-a869 | Cavia porcellus | 81.76 | 0.0 | 803 |
| LLPS-Loa-a843 | Loxodonta africana | 81.25 | 0.0 | 763 |
| LLPS-Otg-a859 | Otolemur garnettii | 80.32 | 0.0 | 736 |
| LLPS-Aim-a832 | Ailuropoda melanoleuca | 78.36 | 0.0 | 587 |
| LLPS-Mum-a872 | Mus musculus | 78.21 | 0.0 | 739 |
| LLPS-Ran-a867 | Rattus norvegicus | 78.21 | 0.0 | 724 |
| LLPS-Mea-a830 | Mesocricetus auratus | 77.08 | 0.0 | 684 |
| LLPS-Ere-a214 | Erinaceus europaeus | 75.28 | 9e-161 | 476 |
| LLPS-Fud-a840 | Fukomys damarensis | 71.92 | 3e-174 | 513 |
| LLPS-Ova-a840 | Ovis aries | 70.09 | 8e-156 | 464 |