LLPS-Hos-a872
TVP23A
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Golgi apparatus membrane protein TVP23 homolog A |
| Gene Name: | TVP23A, FAM18A |
| Ensembl Gene: | ENSG00000166676.15 |
| Ensembl Protein: | ENSP00000411972.2 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000456096.6 | ENSP00000411972.2 |
| Ensembl | ENST00000573360.5 | ENSP00000458488.1 |
| Ensembl | ENST00000575135.5 | ENSP00000460567.1 |
| Ensembl | ENST00000572428.5 | ENSP00000460822.1 |
| Ensembl | ENST00000619408.1 | ENSP00000482095.1 |
| Ensembl | ENST00000612195.4 | ENSP00000482891.1 |
| Ensembl | ENST00000572102.5 | ENSP00000461067.1 |
| Ensembl | ENST00000299866.12 | ENSP00000299866.8 |
| Ensembl | ENST00000649981.1 | ENSP00000497634.1 |
| UniProt | A6NH52, TV23A_HUMAN, B2RUV4, B7ZW18 | |
| GeneBank | AK294418, BC146882, BC171817, BC146886, AC074136 | BAG57667.1, AAI46883.1, AAI46887.1, AAI71817.1 |
| RefSeq | NM_001079512.3, XM_006720944.3, XM_011522654.2, XM_017023649.1 | NP_001072980.1, XP_006721007.1, XP_011520956.1, XP_016879138.1 |
| Entrez | 780776 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKQALVDDTE DVSLDFGNEE ELAFRKAKIR HPLATFFHLF FRVSAIVTYV SCDWFSKSFV 60 61 GCFVMVLLLL SLDFWSVKNV TGRLLVGLRW WNQIDEDGKS HWIFEARKVS PNSIAATEAE 120 121 ARIFWLGLII CPMIWIVFFF STLFSLKLKW LALVVAGISL QAANLYGYIL CKMGGNSDIG 180 181 KVTASFLSQT VFQTACPGDF QKPGLEGLEI HQH 213 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGCAGG CCCTGGTGGA CGATACCGAG GATGTGTCCC TGGACTTTGG AAACGAGGAG 60 61 GAGCTGGCCT TTAGGAAAGC CAAGATCAGA CACCCCTTGG CCACCTTTTT CCACCTGTTT 120 121 TTCCGAGTGA GTGCCATCGT CACCTACGTG AGCTGCGACT GGTTCAGCAA GAGCTTTGTG 180 181 GGCTGTTTTG TCATGGTGCT GCTCCTCCTG TCCCTGGACT TCTGGTCTGT GAAGAATGTA 240 241 ACCGGAAGAC TCCTGGTGGG CCTTCGATGG TGGAACCAGA TAGATGAAGA TGGGAAGAGC 300 301 CACTGGATCT TTGAAGCCAG GAAGGTCTCT CCGAATAGCA TTGCTGCCAC AGAAGCTGAA 360 361 GCACGAATCT TCTGGCTGGG CCTCATAATC TGCCCCATGA TATGGATTGT GTTTTTTTTT 420 421 AGCACCTTAT TTTCCTTGAA GCTAAAGTGG CTGGCTCTGG TGGTTGCTGG GATCTCTCTC 480 481 CAAGCTGCAA ACCTGTATGG CTACATCCTT TGTAAGATGG GAGGCAACAG TGACATTGGC 540 541 AAGGTCACAG CCAGTTTCCT GTCCCAGACA GTGTTCCAGA CGGCCTGCCC AGGTGACTTT 600 601 CAGAAGCCTG GCCTCGAGGG GCTGGAGATT CACCAGCATT AG 642 |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Domain | ||||
| SMART | LCR-eXXXplorer | CDD | ||
| Disease | ||||
| ActiveDriverDB | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Proteomics | ||||
| THPA | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| MethyCancer | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-a840 | Pan paniscus | 98.59 | 2e-152 | 431 |
| LLPS-Pat-a860 | Pan troglodytes | 98.12 | 6e-152 | 429 |
| LLPS-Poa-a835 | Pongo abelii | 98.12 | 3e-151 | 428 |
| LLPS-Caj-a851 | Callithrix jacchus | 97.16 | 6e-148 | 424 |
| LLPS-Mal-a845 | Mandrillus leucophaeus | 96.24 | 5e-149 | 422 |
| LLPS-Cea-a859 | Cercocebus atys | 96.24 | 5e-149 | 422 |
| LLPS-Chs-a848 | Chlorocebus sabaeus | 96.24 | 9e-149 | 421 |
| LLPS-Paa-a860 | Papio anubis | 96.24 | 5e-149 | 422 |
| LLPS-Maf-a857 | Macaca fascicularis | 95.77 | 5e-147 | 417 |
| LLPS-Man-a861 | Macaca nemestrina | 95.77 | 5e-147 | 417 |
| LLPS-Mam-a844 | Macaca mulatta | 95.77 | 5e-147 | 417 |
| LLPS-Orc-a803 | Oryctolagus cuniculus | 95.31 | 6e-130 | 373 |
| LLPS-Rhb-a847 | Rhinopithecus bieti | 95.31 | 1e-146 | 416 |
| LLPS-Otg-a845 | Otolemur garnettii | 92.42 | 4e-142 | 404 |
| LLPS-Mup-a826 | Mustela putorius furo | 92.02 | 1e-142 | 406 |
| LLPS-Loa-a829 | Loxodonta africana | 92.02 | 1e-142 | 406 |
| LLPS-Eqc-a855 | Equus caballus | 91.98 | 1e-139 | 399 |
| LLPS-Cap-a856 | Cavia porcellus | 91.94 | 1e-137 | 394 |
| LLPS-Myl-a799 | Myotis lucifugus | 91.8 | 2e-121 | 351 |
| LLPS-Caf-a837 | Canis familiaris | 91.55 | 8e-142 | 404 |
| LLPS-Aim-a818 | Ailuropoda melanoleuca | 91.55 | 7e-142 | 404 |
| LLPS-Bot-a859 | Bos taurus | 91.08 | 7e-144 | 409 |
| LLPS-Tut-a447 | Tursiops truncatus | 90.61 | 3e-142 | 407 |
| LLPS-Ova-a826 | Ovis aries | 90.22 | 1e-121 | 353 |
| LLPS-Dio-a826 | Dipodomys ordii | 89.37 | 6e-134 | 384 |
| LLPS-Fud-a828 | Fukomys damarensis | 89.25 | 2e-136 | 390 |
| LLPS-Cas-a738 | Carlito syrichta | 88.83 | 1e-122 | 355 |
| LLPS-Fec-a857 | Felis catus | 88.26 | 2e-136 | 390 |
| LLPS-Mum-a858 | Mus musculus | 88.26 | 8e-135 | 387 |
| LLPS-Sus-a858 | Sus scrofa | 87.98 | 3e-124 | 360 |
| LLPS-Urm-a772 | Ursus maritimus | 87.85 | 8e-132 | 379 |
| LLPS-Mea-a816 | Mesocricetus auratus | 87.79 | 2e-134 | 385 |
| LLPS-Ran-a852 | Rattus norvegicus | 87.32 | 2e-135 | 388 |
| LLPS-Ict-a844 | Ictidomys tridecemlineatus | 87.14 | 9e-127 | 366 |
| LLPS-Pes-a732 | Pelodiscus sinensis | 85.33 | 2e-110 | 323 |
| LLPS-Ere-a208 | Erinaceus europaeus | 85.25 | 3e-70 | 219 |
| LLPS-Nol-a840 | Nomascus leucogenys | 83.57 | 7e-121 | 350 |
| LLPS-Mod-a820 | Monodelphis domestica | 81.86 | 2e-127 | 368 |
| LLPS-Lac-a757 | Latimeria chalumnae | 80.41 | 9e-112 | 327 |
| LLPS-Fia-a759 | Ficedula albicollis | 80.32 | 5e-106 | 314 |
| LLPS-Gog-a853 | Gorilla gorilla | 80.28 | 5e-112 | 327 |
| LLPS-Tag-a741 | Taeniopygia guttata | 78.89 | 2e-99 | 296 |
| LLPS-Gaga-a773 | Gallus gallus | 75.59 | 2e-111 | 327 |
| LLPS-Scf-a727 | Scleropages formosus | 74.74 | 3e-103 | 306 |
| LLPS-Anp-a696 | Anas platyrhynchos | 74.0 | 2e-99 | 296 |
| LLPS-Leo-a744 | Lepisosteus oculatus | 73.43 | 1e-106 | 314 |
| LLPS-Meg-a691 | Meleagris gallopavo | 73.37 | 8e-91 | 273 |
| LLPS-Xet-a733 | Xenopus tropicalis | 72.51 | 3e-111 | 326 |
| LLPS-Orn-a749 | Oreochromis niloticus | 67.37 | 2e-79 | 245 |
| LLPS-Asm-a746 | Astyanax mexicanus | 65.66 | 2e-87 | 267 |
| LLPS-Gaa-a730 | Gasterosteus aculeatus | 65.64 | 2e-83 | 255 |
| LLPS-Scm-a716 | Scophthalmus maximus | 62.37 | 5e-77 | 239 |
| LLPS-Ora-a705 | Ornithorhynchus anatinus | 60.42 | 3e-80 | 247 |
| LLPS-Icp-a753 | Ictalurus punctatus | 58.42 | 5e-76 | 236 |
| LLPS-Anc-a778 | Anolis carolinensis | 58.33 | 7e-84 | 256 |
| LLPS-Aon-a862 | Aotus nancymaae | 58.33 | 9e-80 | 246 |
| LLPS-Orl-a743 | Oryzias latipes | 57.54 | 1e-71 | 225 |
| LLPS-Sah-a771 | Sarcophilus harrisii | 56.65 | 9e-70 | 219 |
| LLPS-Pof-a752 | Poecilia formosa | 55.56 | 9e-73 | 228 |
| LLPS-Dar-a753 | Danio rerio | 55.21 | 2e-73 | 229 |
| LLPS-Xim-a756 | Xiphophorus maculatus | 54.36 | 5e-68 | 216 |
| LLPS-Ten-a707 | Tetraodon nigroviridis | 54.21 | 5e-73 | 228 |
| LLPS-Tar-a709 | Takifugu rubripes | 53.97 | 5e-73 | 228 |
| LLPS-Drm-a187 | Drosophila melanogaster | 50.26 | 1e-56 | 187 |