LLPS-Hos-a769
MYO1E
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Unconventional myosin-Ie; Myosin-Ic; Unconventional myosin 1E |
| Gene Name: | MYO1E, MYO1C |
| Ensembl Gene: | ENSG00000157483.8 |
| Ensembl Protein: | ENSP00000453936.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000559412.1 | ENSP00000453936.1 |
| Ensembl | ENST00000559489.1 | ENSP00000453178.1 |
| Ensembl | ENST00000288235.8 | ENSP00000288235.4 |
| Ensembl | ENST00000559269.5 | ENSP00000453232.1 |
| Ensembl | ENST00000560749.1 | ENSP00000454113.1 |
| Ensembl | ENST00000558571.1 | ENSP00000453811.1 |
| UniProt | Q12965, MYO1E_HUMAN, Q14778 | |
| GeneBank | L29139, AC092756, U14391 | AAA62667.1, AAA20902.1 |
| RefSeq | NM_004998.3 | NP_004989.2 |
| Entrez | 4643 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGSKGVYQYH WQSHNVKHSG VDDMVLLSKI TENSIVENLK KRYMDDYIFT YIGSVLISVN 60 61 PFKQMPYFGE KEIEMYQGAA QYENPPHIYA LADNMYRNMI IDRENQCVII SGESGAGKTV 120 121 AAKYIMSYIS RVSGGGTKVQ HVKDIILQSN PLLEAFGNAK TVRNNNSSRF GKYFEIQFSP 180 181 GGEPDGGKIS NFLLEKSRVV MRNPGERSFH IFYQLIEGAS AEQKHSLGIT SMDYYYYLSL 240 241 SGSYKVDDID DRREFQETLH AMNVIGIFAE EQTLVLQIVA GILHLGNISF KEVGNYAAVE 300 301 SEEFLAFPAY LLGINQDRLK EKLTSRQMDS KWGGKSESIH VTLNVEQACY TRDALAKALH 360 361 ARVFDFLVDS INKAMEKDHE EYNIGVLDIY GFEIFQKNGF EQFCINFVNE KLQQIFIELT 420 421 LKAEQEEYVQ EGIRWTPIEY FNNKIVCDLI ENKVNPPGIM SILDDVCATM HAVGEGADQT 480 481 LLQKLQMQIG SHEHFNSWNQ GFIIHHYAGK VSYDMDGFCE RNRDVLFMDL IELMQSSELP 540 541 FIKSLFPENL QADKKGRPTT AGSKIKKQAN DLVSTLMKCT PHYIRCIKPN ETKKPRDWEE 600 601 SRVKHQVEYL GLKENIRVRR AGYAYRRIFQ KFLQRYAILT KATWPSWQGE EKQGVLHLLQ 660 661 SVNMDSDQFQ LGRSKVFIKA PESLFLLEEM RERKYDGYAR VIQKSWRKFV ARKKYVQMRE 720 721 EASDLLLNKK ERRRNSINRN FIGDYIGMEE HPELQQFVGK REKIDFADTV TKYDRRFKGV 780 781 KRDLLLTPKC LYLIGREKVK QGPDKGLVKE VLKRKIEIER ILSVSLSTMQ DDIFILHEQE 840 841 YDSLLESVFK TEFLSLLAKR YEEKTQKQLP LKFSNTLELK LKKENWGPWS AGGSRQVQFH 900 901 QGFGDLAVLK PSNKVLQVSI GPGLPKNSRP TRRNTTQNTG YSSGTQNANY PVRAAPPPPG 960 961 YHQNGVIRNQ YVPYPHAPGS QRSNQKSLYT SMARPPLPRQ QSTSSDRVSQ TPESLDFLKV 1020 1021 PDQGAAGVRR QTTSRPPPAG GRPKPQPKPK PQVPQCKALY AYDAQDTDEL SFNANDIIDI 1080 1081 IKEDPSGWWT GRLRGKQGLF PNNYVTKI 1108 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGAAGCA AAGGTGTCTA CCAGTACCAC TGGCAAAGCC ACAATGTCAA GCACAGTGGT 60 61 GTGGACGACA TGGTGCTACT GTCCAAGATC ACAGAGAACT CCATCGTGGA GAATCTGAAG 120 121 AAGAGATACA TGGATGACTA CATTTTTACA TATATAGGAT CTGTATTAAT CTCAGTCAAC 180 181 CCTTTCAAGC AGATGCCATA TTTTGGGGAA AAGGAAATTG AAATGTACCA AGGAGCGGCA 240 241 CAGTATGAAA ACCCACCACA TATCTATGCC CTTGCAGATA ATATGTACAG AAACATGATC 300 301 ATTGACAGAG AGAACCAGTG CGTCATTATC AGTGGTGAAA GTGGTGCTGG AAAAACAGTG 360 361 GCTGCCAAAT ATATCATGAG CTACATCTCC AGAGTGTCTG GAGGAGGGAC CAAAGTCCAG 420 421 CACGTGAAGG ACATTATCCT GCAGTCCAAC CCGCTGCTGG AGGCCTTCGG GAACGCCAAG 480 481 ACCGTCCGGA ACAACAACTC CAGCCGATTT GGAAAATACT TTGAAATCCA GTTCAGTCCA 540 541 GGTGGGGAAC CAGATGGTGG AAAGATCTCC AACTTCCTTC TGGAAAAATC TAGGGTGGTG 600 601 ATGAGGAACC CAGGAGAGCG GAGTTTTCAC ATATTTTACC AGCTCATCGA GGGCGCCTCT 660 661 GCAGAGCAGA AACACAGCCT TGGCATCACC AGCATGGACT ATTATTACTA CCTGAGCCTC 720 721 TCGGGCTCAT ACAAGGTTGA TGACATTGAC GACAGGCGGG AGTTTCAGGA AACTCTGCAC 780 781 GCCATGAATG TGATTGGGAT CTTTGCAGAA GAGCAAACGC TGGTGTTGCA GATAGTGGCG 840 841 GGTATTCTCC ACCTGGGAAA CATCAGCTTC AAAGAAGTTG GCAACTACGC GGCTGTGGAG 900 901 AGTGAAGAGT TTTTAGCTTT TCCTGCATAT CTGCTAGGGA TAAACCAGGA CCGGTTGAAA 960 961 GAAAAGCTAA CAAGCCGGCA GATGGATAGC AAGTGGGGAG GCAAATCCGA ATCCATCCAC 1020 1021 GTGACCCTCA ACGTAGAGCA GGCCTGTTAC ACCCGGGATG CGCTCGCCAA GGCCCTGCAC 1080 1081 GCCCGGGTCT TTGATTTCTT GGTAGATTCC ATCAATAAAG CCATGGAGAA AGACCATGAA 1140 1141 GAATACAACA TTGGCGTCCT AGACATCTAT GGCTTTGAAA TATTCCAGAA AAATGGCTTT 1200 1201 GAACAGTTTT GTATCAATTT TGTTAATGAA AAACTGCAGC AGATTTTTAT TGAACTGACA 1260 1261 TTAAAGGCAG AACAGGAAGA ATATGTTCAA GAGGGAATAA GATGGACACC CATTGAGTAC 1320 1321 TTTAATAATA AAATCGTATG TGACCTCATA GAGAACAAAG TGAACCCTCC TGGCATCATG 1380 1381 AGCATCCTGG ATGACGTGTG CGCCACGATG CATGCGGTGG GTGAGGGGGC AGATCAGACG 1440 1441 CTGCTCCAGA AACTTCAGAT GCAGATTGGG AGTCATGAGC ACTTCAACAG TTGGAACCAA 1500 1501 GGCTTCATCA TTCATCATTA TGCTGGGAAG GTATCCTATG ACATGGATGG CTTTTGTGAA 1560 1561 AGGAACCGGG ATGTGCTTTT TATGGATCTC ATCGAGCTTA TGCAGAGCAG CGAGCTGCCT 1620 1621 TTCATAAAGT CTTTATTTCC GGAAAATCTG CAGGCTGACA AGAAAGGGCG CCCAACTACT 1680 1681 GCCGGAAGCA AAATAAAGAA ACAAGCCAAT GACCTTGTGA GCACCCTGAT GAAATGTACG 1740 1741 CCCCACTACA TTCGCTGCAT CAAGCCAAAC GAAACCAAGA AGCCCAGAGA CTGGGAGGAA 1800 1801 AGCAGGGTAA AGCATCAAGT CGAATATTTG GGTCTGAAAG AGAACATTCG AGTGAGAAGA 1860 1861 GCTGGCTATG CCTATCGGCG CATCTTCCAA AAATTCCTAC AGAGGTATGC CATTCTGACC 1920 1921 AAAGCCACCT GGCCTTCTTG GCAGGGAGAG GAGAAGCAAG GCGTCCTGCA CCTGCTGCAG 1980 1981 TCGGTCAACA TGGACAGCGA CCAGTTCCAG CTGGGGAGGA GTAAAGTGTT CATCAAAGCC 2040 2041 CCCGAGTCTC TATTTCTTTT AGAAGAGATG AGAGAGAGAA AGTATGATGG GTATGCTCGA 2100 2101 GTGATACAGA AATCATGGAG GAAATTCGTG GCCCGGAAGA AATACGTTCA AATGAGAGAA 2160 2161 GAAGCCTCAG ACCTCTTATT GAACAAGAAG GAGAGAAGGA GAAACAGTAT TAACAGGAAC 2220 2221 TTTATAGGGG ATTATATTGG GATGGAAGAG CACCCAGAAC TCCAGCAGTT CGTGGGCAAG 2280 2281 AGGGAGAAGA TTGATTTCGC AGACACAGTC ACCAAGTATG ACAGGAGGTT CAAGGGTGTA 2340 2341 AAGCGAGACC TGCTCCTTAC CCCAAAGTGC TTGTACTTAA TCGGACGAGA AAAAGTCAAA 2400 2401 CAGGGCCCAG ACAAGGGCCT GGTGAAAGAA GTCCTGAAGC GGAAAATCGA GATAGAACGG 2460 2461 ATCTTGTCTG TGTCCCTCAG TACTATGCAG GATGACATTT TTATTCTCCA TGAGCAAGAG 2520 2521 TATGACAGTT TGCTTGAATC TGTCTTCAAA ACTGAATTCC TAAGCCTCTT AGCAAAGCGT 2580 2581 TACGAGGAGA AGACCCAGAA GCAACTACCT CTGAAATTCA GCAATACGCT TGAACTGAAG 2640 2641 TTGAAAAAGG AAAACTGGGG CCCCTGGAGT GCAGGGGGCT CCCGGCAAGT GCAGTTCCAC 2700 2701 CAAGGGTTTG GGGACCTGGC TGTCCTCAAG CCCAGTAACA AAGTGCTGCA GGTCAGCATC 2760 2761 GGACCTGGAC TGCCCAAGAA CTCCCGTCCT ACCAGAAGGA ACACTACCCA AAATACAGGT 2820 2821 TATTCCAGTG GGACTCAAAA TGCCAACTAC CCAGTGAGAG CTGCCCCTCC TCCCCCAGGA 2880 2881 TACCATCAGA ACGGAGTCAT CAGAAACCAG TATGTGCCAT ATCCCCATGC TCCTGGAAGC 2940 2941 CAGAGGTCCA ATCAGAAAAG CCTGTACACC TCCATGGCCC GCCCGCCCTT GCCTCGGCAG 3000 3001 CAGTCTACCA GTTCAGACCG AGTGTCACAG ACGCCAGAGA GCCTGGATTT CCTCAAGGTC 3060 3061 CCGGACCAGG GAGCTGCAGG GGTCAGGAGA CAAACAACCA GTCGGCCTCC CCCAGCAGGG 3120 3121 GGCAGACCCA AGCCCCAGCC CAAGCCCAAG CCTCAGGTGC CACAGTGCAA GGCTTTGTAT 3180 3181 GCCTATGACG CTCAGGACAC AGACGAACTC AGCTTTAATG CCAATGACAT TATTGATATT 3240 3241 ATCAAAGAAG ATCCTTCTGG CTGGTGGACG GGTCGACTAC GAGGCAAGCA GGGCCTGTTC 3300 3301 CCCAACAACT ATGTGACCAA GATCTGA 3327 |
▼ KEYWORD
ID | Family |
Actin-binding | |
ATP-binding | |
Calmodulin-binding | |
Cell junction | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Cytoskeleton | |
Disease mutation | |
Lipid-binding | |
Motor protein | |
Myosin | |
Nucleotide-binding | |
Phosphoprotein | |
Polymorphism | |
Reference proteome | |
SH3 domain
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Actin cytoskeleton | |
Cellular Component | Adherens junction | |
Cellular Component | Brush border | |
Cellular Component | Cell-cell junction | |
Cellular Component | Clathrin-coated vesicle | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoskeleton | |
Cellular Component | Extracellular exosome | |
Cellular Component | Myosin complex | |
Molecular Function | Actin filament binding | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity, coupled | |
Molecular Function | Calmodulin binding | |
Molecular Function | Microfilament motor activity | |
Molecular Function | Motor activity | |
Molecular Function | Phosphatidylinositol binding | |
Biological Process | Actin filament-based movement | |
Biological Process | Endocytosis | |
Biological Process | Glomerular basement membrane development | |
Biological Process | Glomerular filtration | |
Biological Process | Glomerular visceral epithelial cell development | |
Biological Process | In utero embryonic development | |
Biological Process | Nitrogen compound metabolic process | |
Biological Process | Platelet-derived growth factor receptor signaling pathway | |
Biological Process | Post-embryonic hemopoiesis | |
Biological Process | Vasculogenesis |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CORUM | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-a753 | Gorilla gorilla | 99.64 | 0.0 | 2303 |
| LLPS-Nol-4414 | Nomascus leucogenys | 99.28 | 0.0 | 2288 |
| LLPS-Aon-3878 | Aotus nancymaae | 98.83 | 0.0 | 2284 |
| LLPS-Man-1293 | Macaca nemestrina | 98.29 | 0.0 | 2276 |
| LLPS-Paa-0632 | Papio anubis | 98.29 | 0.0 | 2276 |
| LLPS-Mam-2973 | Macaca mulatta | 98.29 | 0.0 | 2276 |
| LLPS-Caf-1926 | Canis familiaris | 98.19 | 0.0 | 2274 |
| LLPS-Caj-a750 | Callithrix jacchus | 98.1 | 0.0 | 2275 |
| LLPS-Fec-1874 | Felis catus | 97.65 | 0.0 | 2264 |
| LLPS-Otg-a745 | Otolemur garnettii | 97.56 | 0.0 | 2266 |
| LLPS-Loa-2648 | Loxodonta africana | 97.47 | 0.0 | 2259 |
| LLPS-Eqc-a755 | Equus caballus | 97.38 | 0.0 | 2262 |
| LLPS-Urm-3666 | Ursus maritimus | 97.2 | 0.0 | 2261 |
| LLPS-Ict-0652 | Ictidomys tridecemlineatus | 97.2 | 0.0 | 2260 |
| LLPS-Aim-4221 | Ailuropoda melanoleuca | 97.11 | 0.0 | 2255 |
| LLPS-Sus-a757 | Sus scrofa | 96.93 | 0.0 | 2253 |
| LLPS-Mup-a732 | Mustela putorius furo | 96.71 | 0.0 | 2219 |
| LLPS-Mal-4671 | Mandrillus leucophaeus | 96.21 | 0.0 | 2216 |
| LLPS-Mum-a756 | Mus musculus | 96.12 | 0.0 | 2192 |
| LLPS-Fud-0500 | Fukomys damarensis | 96.11 | 0.0 | 2193 |
| LLPS-Cap-a752 | Cavia porcellus | 95.85 | 0.0 | 2192 |
| LLPS-Ova-4044 | Ovis aries | 95.4 | 0.0 | 2184 |
| LLPS-Cea-1901 | Cercocebus atys | 95.29 | 0.0 | 2185 |
| LLPS-Bot-a760 | Bos taurus | 95.13 | 0.0 | 2180 |
| LLPS-Myl-a705 | Myotis lucifugus | 95.1 | 0.0 | 2070 |
| LLPS-Sah-a679 | Sarcophilus harrisii | 94.24 | 0.0 | 2159 |
| LLPS-Orc-a710 | Oryctolagus cuniculus | 93.82 | 0.0 | 2114 |
| LLPS-Mod-a721 | Monodelphis domestica | 92.63 | 0.0 | 2108 |
| LLPS-Gaga-a686 | Gallus gallus | 91.16 | 0.0 | 2097 |
| LLPS-Fia-a673 | Ficedula albicollis | 90.96 | 0.0 | 1963 |
| LLPS-Ran-a749 | Rattus norvegicus | 90.69 | 0.0 | 1832 |
| LLPS-Lac-a667 | Latimeria chalumnae | 85.57 | 0.0 | 1212 |
| LLPS-Meg-a615 | Meleagris gallopavo | 84.74 | 0.0 | 722 |
| LLPS-Orl-a654 | Oryzias latipes | 84.7 | 0.0 | 1664 |
| LLPS-Mea-a719 | Mesocricetus auratus | 84.01 | 0.0 | 1669 |
| LLPS-Xet-a651 | Xenopus tropicalis | 81.92 | 0.0 | 1889 |
| LLPS-Orn-a662 | Oreochromis niloticus | 81.24 | 0.0 | 1853 |
| LLPS-Dar-a664 | Danio rerio | 81.02 | 0.0 | 1883 |
| LLPS-Ten-a628 | Tetraodon nigroviridis | 80.69 | 0.0 | 1870 |
| LLPS-Scf-a643 | Scleropages formosus | 80.66 | 0.0 | 1847 |
| LLPS-Asm-a660 | Astyanax mexicanus | 80.64 | 0.0 | 1885 |
| LLPS-Scm-2542 | Scophthalmus maximus | 80.2 | 0.0 | 1856 |
| LLPS-Icp-a664 | Ictalurus punctatus | 80.0 | 0.0 | 1855 |
| LLPS-Pof-a668 | Poecilia formosa | 79.2 | 0.0 | 1840 |
| LLPS-Xim-a671 | Xiphophorus maculatus | 79.13 | 0.0 | 1826 |
| LLPS-Tar-a628 | Takifugu rubripes | 78.83 | 0.0 | 1856 |
| LLPS-Dio-a727 | Dipodomys ordii | 74.69 | 0.0 | 1250 |
| LLPS-Leo-a660 | Lepisosteus oculatus | 73.73 | 0.0 | 1668 |
| LLPS-Rhb-a748 | Rhinopithecus bieti | 73.05 | 0.0 | 960 |
| LLPS-Gaa-a648 | Gasterosteus aculeatus | 71.73 | 0.0 | 1535 |
| LLPS-Pat-a757 | Pan troglodytes | 66.76 | 0.0 | 1035 |
| LLPS-Pap-a743 | Pan paniscus | 66.76 | 0.0 | 1035 |
| LLPS-Tag-a659 | Taeniopygia guttata | 65.5 | 0.0 | 911 |
| LLPS-Anc-a695 | Anolis carolinensis | 60.16 | 0.0 | 1183 |