LLPS-Hos-a722
TMEM163
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transmembrane protein 163 |
| Gene Name: | TMEM163 |
| Ensembl Gene: | ENSG00000152128.13 |
| Ensembl Protein: | ENSP00000281924.6 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| May bind zinc and other divalent cations and recruit them to vesicular organelles. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000281924.6 | ENSP00000281924.6 |
| UniProt | Q8TC26, TM163_HUMAN, Q53QM3, Q53SV7, Q69YH3, Q9UFG3 | |
| GeneBank | AC110620, AC013718, AL833765, BC026170, AL122044 | AAY24144.1, AAH26170.1, CAB59180.2, AAX93249.1, CAH10592.1 |
| RefSeq | NM_030923.4 | NP_112185.1 |
| Entrez | 81615 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER QVRISESGQF 60 61 SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL ALAVAAFTVS VMRYSASAFG 120 121 FAFDAILDVL SSAIVLWRYS NAAAVHSAHR EYIACVILGV IFLLSSICIV VKAIHDLSTR 180 181 LLPEVDDFLF SVSILSGILC SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA 240 241 EVFKHDSAVW YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE 289 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGCCGG CCGCGGGCAT CCAGCGCCGC AGCTCCCAGG GGCCCACCGT CCCGCCGCCG 60 61 CCCCGGGGCC ACGCGCCACC GGCTGCCGCC CCCGGCCCGG CCCCGCTGAG CTCCCCGGTG 120 121 CGCGAGCCGC CCCAGCTGGA GGAGGAGCGG CAGGTGCGGA TCAGCGAGAG CGGCCAGTTC 180 181 AGCGACGGGC TGGAGGACCG AGGCTTACTA GAAAGCAGCA CCCGCCTGAA ACCTCACGAA 240 241 GCCCAGAACT ACAGGAAGAA GGCATTGTGG GTGTCCTGGT TCTCCATCAT TGTCACCCTG 300 301 GCCCTCGCGG TGGCTGCCTT TACTGTCTCC GTTATGAGGT ACAGCGCCTC TGCTTTTGGG 360 361 TTTGCATTTG ATGCCATCCT GGACGTCCTG TCATCGGCGA TTGTCCTGTG GCGTTACAGC 420 421 AACGCGGCCG CTGTGCACTC TGCCCATAGG GAGTACATAG CCTGTGTCAT CTTGGGGGTG 480 481 ATATTCCTTC TGTCATCCAT ATGTATAGTG GTCAAAGCCA TCCATGACCT CTCAACTAGG 540 541 CTGCTCCCAG AAGTGGACGA TTTCCTGTTC AGTGTCTCCA TTTTAAGTGG GATTCTTTGC 600 601 AGCATCCTGG CCGTGTTGAA GTTCATGCTG GGGAAGGTTC TGACCAGTAG AGCACTCATA 660 661 ACAGATGGGT TTAACTCCCT CGTGGGTGGC GTGATGGGCT TCTCCATTCT TCTGAGCGCG 720 721 GAAGTGTTCA AGCATGACTC GGCGGTCTGG TACCTGGACG GCAGCATAGG CGTTCTGATC 780 781 GGCCTCACCA TATTTGCCTA TGGGGTCAAA CTCCTCATCG ACATGGTGCC GAGGGTGAGG 840 841 CAGACACGTC ACTACGAGAT GTTTGAGTGA 870 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Early endosome membrane | |
Cellular Component | Integral component of synaptic vesicle membrane | |
Molecular Function | Zinc ion binding | |
Biological Process | Zinc ion import into synaptic vesicle |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a711 | Pan troglodytes | 100.0 | 0.0 | 582 |
| LLPS-Mal-a700 | Mandrillus leucophaeus | 100.0 | 2e-155 | 442 |
| LLPS-Chs-a699 | Chlorocebus sabaeus | 100.0 | 3e-122 | 356 |
| LLPS-Gog-a706 | Gorilla gorilla | 99.6 | 3e-179 | 503 |
| LLPS-Cap-a708 | Cavia porcellus | 99.55 | 1e-155 | 443 |
| LLPS-Rhb-a703 | Rhinopithecus bieti | 99.55 | 2e-154 | 439 |
| LLPS-Tut-a379 | Tursiops truncatus | 99.0 | 2e-137 | 395 |
| LLPS-Mup-a689 | Mustela putorius furo | 98.88 | 4e-121 | 353 |
| LLPS-Urm-a648 | Ursus maritimus | 98.65 | 8e-152 | 435 |
| LLPS-Cea-a715 | Cercocebus atys | 98.62 | 0.0 | 574 |
| LLPS-Paa-a712 | Papio anubis | 98.62 | 0.0 | 575 |
| LLPS-Ova-a692 | Ovis aries | 98.34 | 9e-123 | 358 |
| LLPS-Poa-a701 | Pongo abelii | 98.28 | 0.0 | 570 |
| LLPS-Caj-a703 | Callithrix jacchus | 98.27 | 0.0 | 570 |
| LLPS-Nol-a699 | Nomascus leucogenys | 98.27 | 0.0 | 572 |
| LLPS-Dio-a684 | Dipodomys ordii | 98.2 | 1e-109 | 326 |
| LLPS-Ran-a704 | Rattus norvegicus | 96.73 | 1e-167 | 476 |
| LLPS-Eqc-a711 | Equus caballus | 95.5 | 0.0 | 531 |
| LLPS-Man-a716 | Macaca nemestrina | 94.85 | 6e-123 | 362 |
| LLPS-Otg-a703 | Otolemur garnettii | 94.81 | 0.0 | 519 |
| LLPS-Sus-a713 | Sus scrofa | 94.12 | 0.0 | 526 |
| LLPS-Bot-a716 | Bos taurus | 94.12 | 0.0 | 526 |
| LLPS-Loa-a691 | Loxodonta africana | 94.03 | 1e-177 | 501 |
| LLPS-Fec-a713 | Felis catus | 92.73 | 0.0 | 526 |
| LLPS-Orc-a667 | Oryctolagus cuniculus | 92.73 | 0.0 | 537 |
| LLPS-Anp-a577 | Anas platyrhynchos | 91.44 | 7e-147 | 421 |
| LLPS-Meg-a580 | Meleagris gallopavo | 91.16 | 2e-117 | 344 |
| LLPS-Ora-a591 | Ornithorhynchus anatinus | 89.71 | 2e-35 | 132 |
| LLPS-Caf-a695 | Canis familiaris | 89.68 | 6e-154 | 439 |
| LLPS-Tag-a619 | Taeniopygia guttata | 89.64 | 2e-142 | 409 |
| LLPS-Mum-a713 | Mus musculus | 88.24 | 8e-168 | 476 |
| LLPS-Mod-a679 | Monodelphis domestica | 87.54 | 6e-175 | 494 |
| LLPS-Sah-a638 | Sarcophilus harrisii | 87.54 | 1e-175 | 496 |
| LLPS-Fud-a687 | Fukomys damarensis | 86.42 | 2e-156 | 448 |
| LLPS-Anc-a656 | Anolis carolinensis | 86.22 | 2e-119 | 350 |
| LLPS-Mea-a674 | Mesocricetus auratus | 85.83 | 6e-134 | 388 |
| LLPS-Pes-a610 | Pelodiscus sinensis | 85.45 | 7e-167 | 473 |
| LLPS-Gaga-a643 | Gallus gallus | 83.82 | 1e-154 | 442 |
| LLPS-Fia-a631 | Ficedula albicollis | 83.46 | 8e-158 | 450 |
| LLPS-Aon-a715 | Aotus nancymaae | 82.2 | 1e-124 | 363 |
| LLPS-Gaa-a606 | Gasterosteus aculeatus | 80.18 | 4e-127 | 370 |
| LLPS-Scm-a599 | Scophthalmus maximus | 78.51 | 1e-136 | 397 |
| LLPS-Tar-a589 | Takifugu rubripes | 77.69 | 3e-134 | 391 |
| LLPS-Xet-a614 | Xenopus tropicalis | 77.66 | 4e-152 | 436 |
| LLPS-Leo-a620 | Lepisosteus oculatus | 76.51 | 3e-138 | 401 |
| LLPS-Icp-a622 | Ictalurus punctatus | 75.09 | 2e-135 | 393 |
| LLPS-Ten-a588 | Tetraodon nigroviridis | 73.42 | 4e-121 | 357 |
| LLPS-Asm-a619 | Astyanax mexicanus | 73.26 | 2e-129 | 378 |
| LLPS-Orl-a613 | Oryzias latipes | 72.04 | 2e-141 | 409 |
| LLPS-Scf-a601 | Scleropages formosus | 70.93 | 2e-135 | 394 |
| LLPS-Dar-a623 | Danio rerio | 70.38 | 8e-128 | 374 |
| LLPS-Pof-a624 | Poecilia formosa | 69.72 | 1e-139 | 404 |
| LLPS-Xim-a628 | Xiphophorus maculatus | 69.72 | 4e-138 | 403 |
| LLPS-Orn-a620 | Oreochromis niloticus | 63.84 | 6e-125 | 368 |