LLPS-Hos-a703
MPP7

▼ OVERVIEW

Status: Reviewed
Protein Name: MAGUK p55 subfamily member 7
Gene Name: MPP7
Ensembl Gene: ENSG00000150054.18
Ensembl Protein: ENSP00000473899.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 3LRA (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPALSTGSGS  DTGLYELLAA  LPAQLQPHVD  SQEDLTFLWD  MFGEKSLHSL  VKIHEKLHYY  60
61    EKQSPVPILH  GAAALADDLA  EELQNKPLNS  EIRELLKLLS  KPNVKALLSV  HDTVAQKNYD  120
121   PVLPPMPEDI  DDEEDSVKII  RLVKNREPLG  ATIKKDEQTG  AIIVARIMRG  GAADRSGLIH  180
181   VGDELREVNG  IPVEDKRPEE  IIQILAQSQG  AITFKIIPGS  KEETPSKEGK  MFIKALFDYN  240
241   PNEDKAIPCK  EAGLSFKKGD  ILQIMSQDDA  TWWQAKHEAD  ANPRAGLIPS  KHFQERRLAL  300
301   RRPEILVQPL  KVSNRKSSGF  RKSFRLSRKD  KKTNKSMYEC  KKSDQYDTAD  VPTYEEVTPY  360
361   RRQTNEKYRL  VVLVGPVGVG  LNELKRKLLI  SDTQHYGVTV  PHTTRARRSQ  ESDGVEYIFI  420
421   SKHLFETDVQ  NNKFIEYGEY  KNNYYGTSID  SVRSVLAKNK  VCLLDVQPHT  VKHLRTLEFK  480
481   PYVIFIKPPS  IERLRETRKN  AKIISSRDDQ  GAAKPFTEED  FQEMIKSAQI  MESQYGHLFD  540
541   KIIINDDLTV  AFNELKTTFD  KLETETHWVP  VSWLHS  576
Nucleotide CDS Sequence (FASTA)
1     ATGCCAGCTT  TGTCAACGGG  ATCTGGGAGT  GACACTGGTC  TGTATGAGCT  GTTGGCTGCT  60
61    CTGCCAGCCC  AGCTGCAGCC  ACATGTGGAT  AGCCAGGAAG  ACCTGACCTT  CCTCTGGGAT  120
121   ATGTTTGGTG  AAAAAAGCCT  GCATTCATTG  GTAAAGATTC  ATGAAAAACT  ACACTACTAT  180
181   GAGAAGCAGA  GTCCGGTGCC  CATTCTCCAT  GGTGCGGCGG  CCTTGGCCGA  TGATCTGGCC  240
241   GAAGAGCTTC  AGAACAAGCC  ATTAAACAGT  GAGATCAGAG  AGCTGTTGAA  ACTACTGTCA  300
301   AAACCCAATG  TGAAGGCTTT  GCTCTCTGTA  CATGATACTG  TGGCTCAGAA  GAATTACGAC  360
361   CCAGTGTTGC  CTCCTATGCC  TGAAGATATT  GACGATGAGG  AAGACTCAGT  AAAAATAATC  420
421   CGTCTGGTCA  AAAATAGAGA  ACCACTGGGA  GCTACCATTA  AGAAGGATGA  ACAGACCGGG  480
481   GCGATCATTG  TGGCCAGAAT  CATGAGAGGA  GGAGCTGCAG  ATAGAAGTGG  TCTTATTCAT  540
541   GTTGGTGATG  AACTTAGGGA  AGTCAACGGG  ATACCAGTGG  AGGATAAAAG  GCCTGAGGAA  600
601   ATAATACAGA  TTTTGGCTCA  GTCTCAGGGA  GCAATTACAT  TTAAGATTAT  ACCCGGCAGC  660
661   AAAGAGGAGA  CACCATCAAA  AGAAGGCAAG  ATGTTTATCA  AAGCCCTCTT  TGACTATAAT  720
721   CCTAATGAGG  ATAAGGCAAT  TCCATGTAAG  GAAGCTGGGC  TTTCTTTCAA  AAAGGGAGAT  780
781   ATTCTTCAGA  TTATGAGCCA  AGATGATGCA  ACTTGGTGGC  AAGCGAAACA  CGAAGCTGAT  840
841   GCCAACCCCA  GGGCAGGCTT  GATCCCCTCA  AAGCATTTCC  AGGAAAGGAG  ATTGGCTTTG  900
901   AGACGACCAG  AAATATTGGT  TCAGCCCCTG  AAAGTTTCCA  ACAGGAAATC  ATCTGGTTTT  960
961   AGAAAAAGTT  TTCGTCTTAG  TAGAAAAGAT  AAGAAAACAA  ATAAATCCAT  GTATGAATGC  1020
1021  AAGAAGAGTG  ATCAGTACGA  CACAGCTGAC  GTACCCACAT  ACGAAGAAGT  GACACCGTAT  1080
1081  CGGCGACAAA  CTAATGAAAA  ATACAGACTC  GTTGTCTTGG  TTGGTCCCGT  GGGAGTAGGG  1140
1141  CTGAATGAAC  TGAAACGAAA  GCTGCTGATC  AGTGACACCC  AGCACTATGG  CGTGACAGTG  1200
1201  CCCCATACCA  CCAGAGCAAG  AAGAAGCCAG  GAGAGTGATG  GTGTTGAATA  CATTTTCATT  1260
1261  TCCAAGCATT  TGTTTGAGAC  AGATGTACAA  AATAACAAGT  TTATTGAATA  TGGAGAATAT  1320
1321  AAAAACAACT  ACTACGGCAC  AAGTATAGAC  TCAGTTCGGT  CTGTCCTTGC  TAAAAACAAA  1380
1381  GTTTGTTTGT  TGGATGTTCA  GCCTCATACA  GTGAAGCATT  TAAGGACACT  AGAATTTAAG  1440
1441  CCCTATGTGA  TATTTATAAA  GCCTCCATCA  ATAGAGCGTT  TGAGAGAAAC  AAGAAAAAAT  1500
1501  GCAAAGATTA  TTTCAAGCAG  AGATGACCAA  GGTGCTGCAA  AACCCTTCAC  AGAAGAAGAT  1560
1561  TTTCAAGAAA  TGATTAAATC  TGCACAGATA  ATGGAAAGTC  AATATGGTCA  TCTTTTTGAC  1620
1621  AAAATTATAA  TAAATGATGA  CCTCACTGTG  GCATTCAATG  AGCTCAAAAC  AACTTTTGAC  1680
1681  AAATTAGAGA  CAGAGACCCA  TTGGGTGCCA  GTGAGCTGGT  TACATTCATA  A  1731

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Cell junction
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3 domain
Tight junction

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Adherens junction
Cellular Component
Bicellular tight junction
Cellular Component
Cell junction
Cellular Component
MPP7-DLG1-LIN7 complex
Cellular Component
Nucleoplasm
Molecular Function
Cadherin binding
Molecular Function
Molecular adaptor activity
Molecular Function
Protein domain specific binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Signaling adaptor activity
Biological Process
Bicellular tight junction assembly
Biological Process
Establishment of cell polarity
Biological Process
Positive regulation of protein complex assembly
Biological Process
Protein localization to adherens junction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a692Pan troglodytes99.650.01187
LLPS-Pap-a683Pan paniscus99.650.01187
LLPS-Gog-a687Gorilla gorilla99.480.01185
LLPS-Nol-a681Nomascus leucogenys99.130.01182
LLPS-Chs-a680Chlorocebus sabaeus98.960.01178
LLPS-Maf-a694Macaca fascicularis98.960.01178
LLPS-Man-a697Macaca nemestrina98.960.01178
LLPS-Rhb-a685Rhinopithecus bieti98.960.01180
LLPS-Mam-a683Macaca mulatta98.760.01151
LLPS-Paa-a693Papio anubis98.610.01176
LLPS-Caj-a685Callithrix jacchus98.260.01172
LLPS-Fec-a694Felis catus97.740.01169
LLPS-Mup-a671Mustela putorius furo97.570.01166
LLPS-Caf-a676Canis familiaris97.050.01163
LLPS-Urm-a631Ursus maritimus96.70.01161
LLPS-Aim-a664Ailuropoda melanoleuca96.530.01159
LLPS-Cap-a690Cavia porcellus96.180.01152
LLPS-Bot-a697Bos taurus96.180.01153
LLPS-Mea-a655Mesocricetus auratus95.560.01066
LLPS-Ova-a676Ovis aries95.490.01111
LLPS-Ran-a688Rattus norvegicus95.140.01087
LLPS-Loa-a674Loxodonta africana95.070.01022
LLPS-Ict-a685Ictidomys tridecemlineatus94.270.01118
LLPS-Myl-a645Myotis lucifugus94.090.01001
LLPS-Sah-a623Sarcophilus harrisii93.580.01100
LLPS-Aon-a696Aotus nancymaae92.710.01089
LLPS-Mum-a696Mus musculus92.530.01111
LLPS-Ora-a574Ornithorhynchus anatinus92.530.01070
LLPS-Sus-a695Sus scrofa92.360.01064
LLPS-Orc-a652Oryctolagus cuniculus91.850.0971
LLPS-Otg-a685Otolemur garnettii91.030.0983
LLPS-Pes-a593Pelodiscus sinensis90.280.01045
LLPS-Mod-a661Monodelphis domestica90.180.01063
LLPS-Meg-a562Meleagris gallopavo89.930.01034
LLPS-Gaga-a626Gallus gallus89.640.01050
LLPS-Dio-a667Dipodomys ordii87.810.0880
LLPS-Eqc-a692Equus caballus86.470.01094
LLPS-Anc-a637Anolis carolinensis83.760.0995
LLPS-Leo-a604Lepisosteus oculatus83.510.0979
LLPS-Lac-a612Latimeria chalumnae83.160.0988
LLPS-Xet-a597Xenopus tropicalis82.990.0989
LLPS-Scf-a583Scleropages formosus76.860.0806
LLPS-Dar-a606Danio rerio75.520.0910
LLPS-Scm-a581Scophthalmus maximus75.390.0882
LLPS-Gaa-a588Gasterosteus aculeatus74.340.0871
LLPS-Asm-a601Astyanax mexicanus72.550.0853
LLPS-Xim-a609Xiphophorus maculatus71.580.0851
LLPS-Ten-a571Tetraodon nigroviridis70.830.0836
LLPS-Orl-a595Oryzias latipes70.080.0867
LLPS-Icp-a606Ictalurus punctatus65.390.0767
LLPS-Pof-a605Poecilia formosa64.260.0718
LLPS-Tar-a571Takifugu rubripes64.010.0757
LLPS-Orn-a601Oreochromis niloticus61.620.0695
LLPS-Tag-a602Taeniopygia guttata57.120.0662
LLPS-Fia-a613Ficedula albicollis56.760.0661
LLPS-Cea-a696Cercocebus atys54.610.0652
LLPS-Cas-a600Carlito syrichta53.850.0629
LLPS-Poa-a685Pongo abelii53.770.0644
LLPS-Mal-a681Mandrillus leucophaeus52.970.0643
LLPS-Fud-a669Fukomys damarensis50.090.0578