LLPS-Hos-a691
LIN7C

▼ OVERVIEW

Status: Reviewed
Protein Name: Protein lin-7 homolog C
Gene Name: LIN7C, MALS3, VELI3
Ensembl Gene: ENSG00000148943.11
Ensembl Protein: ENSP00000435353.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 3LRA (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAALGEPVRL  ERDICRAIEL  LEKLQRSGEV  PPQKLQALQR  VLQSEFCNAV  REVYEHVYET  60
61    VDISSSPEVR  ANATAKATVA  AFAASEGHSH  PRVVELPKTE  EGLGFNIMGG  KEQNSPIYIS  120
121   RIIPGGIADR  HGGLKRGDQL  LSVNGVSVEG  EHHEKAVELL  KAAQGKVKLV  VRYTPKVLEE  180
181   MESRFEKMRS  AKRRQQT  197
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGC  TAGGGGAACC  CGTGCGGCTG  GAGAGAGATA  TTTGTAGAGC  AATTGAATTA  60
61    TTGGAAAAAC  TACAAAGGAG  TGGAGAAGTA  CCACCACAGA  AACTTCAGGC  TTTGCAAAGA  120
121   GTCCTTCAAA  GTGAATTCTG  CAATGCTGTG  AGAGAGGTAT  ATGAACATGT  CTATGAGACT  180
181   GTGGACATCA  GTAGCAGTCC  TGAAGTGAGA  GCGAACGCTA  CTGCAAAGGC  TACTGTTGCT  240
241   GCATTTGCTG  CCAGTGAAGG  ACATTCTCAT  CCTCGAGTTG  TTGAGCTACC  AAAAACAGAA  300
301   GAGGGCCTTG  GATTCAATAT  TATGGGAGGC  AAAGAACAAA  ACTCTCCAAT  CTATATATCC  360
361   CGAATAATTC  CAGGTGGAAT  TGCTGATAGA  CATGGGGGCC  TCAAACGTGG  AGATCAACTC  420
421   CTCTCTGTTA  ATGGAGTGAG  TGTTGAAGGA  GAACATCATG  AAAAAGCTGT  AGAACTGCTG  480
481   AAAGCCGCAC  AAGGAAAGGT  TAAATTAGTG  GTACGATACA  CACCCAAAGT  CTTAGAAGAA  540
541   ATGGAGTCGC  GCTTTGAAAA  AATGAGATCA  GCAAAACGCA  GGCAACAGAC  CTAA  594

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Cell junction
Cell membrane
Complete proteome
Direct protein sequencing
Exocytosis
Membrane
Postsynaptic cell membrane
Protein transport
Reference proteome
Synapse
Synaptosome
Tight junction
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Basolateral plasma membrane
Cellular Component
Bicellular tight junction
Cellular Component
Cell-cell junction
Cellular Component
Cytoplasm
Cellular Component
Glutamatergic synapse
Cellular Component
MPP7-DLG1-LIN7 complex
Cellular Component
Neuron projection
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic membrane
Cellular Component
Presynapse
Cellular Component
Synapse
Molecular Function
Cytoskeletal protein binding
Molecular Function
L27 domain binding
Molecular Function
PDZ domain binding
Molecular Function
Protein domain specific binding
Biological Process
Exocytosis
Biological Process
Maintenance of epithelial cell apical/basal polarity
Biological Process
Morphogenesis of an epithelial sheet
Biological Process
Neurotransmitter secretion
Biological Process
Protein localization to basolateral plasma membrane
Biological Process
Protein transport

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a680Pan troglodytes100.01e-140400
LLPS-Myl-a635Myotis lucifugus100.03e-138393
LLPS-Mal-a669Mandrillus leucophaeus100.01e-140400
LLPS-Cea-a685Cercocebus atys100.01e-140400
LLPS-Aon-a684Aotus nancymaae100.01e-140400
LLPS-Otg-a674Otolemur garnettii100.01e-140400
LLPS-Fec-a682Felis catus100.01e-140400
LLPS-Sus-a684Sus scrofa100.02e-131376
LLPS-Ran-a676Rattus norvegicus100.01e-140400
LLPS-Aim-a652Ailuropoda melanoleuca100.01e-140400
LLPS-Chs-a668Chlorocebus sabaeus100.01e-140400
LLPS-Pap-a671Pan paniscus100.01e-140400
LLPS-Poa-a673Pongo abelii100.01e-140400
LLPS-Ict-a673Ictidomys tridecemlineatus100.01e-140400
LLPS-Mum-a685Mus musculus100.01e-140400
LLPS-Loa-a662Loxodonta africana100.01e-140400
LLPS-Paa-a681Papio anubis100.01e-140400
LLPS-Dio-a654Dipodomys ordii100.01e-140400
LLPS-Mam-a671Macaca mulatta100.01e-140400
LLPS-Rhb-a673Rhinopithecus bieti100.01e-140400
LLPS-Maf-a682Macaca fascicularis100.01e-140400
LLPS-Mea-a643Mesocricetus auratus100.01e-140400
LLPS-Nol-a670Nomascus leucogenys100.01e-140400
LLPS-Man-a685Macaca nemestrina100.01e-140400
LLPS-Cap-a679Cavia porcellus99.498e-140397
LLPS-Eqc-a680Equus caballus99.493e-140399
LLPS-Bot-a686Bos taurus99.486e-136388
LLPS-Tut-a366Tursiops truncatus98.981e-137392
LLPS-Fud-a658Fukomys damarensis98.982e-139396
LLPS-Urm-a620Ursus maritimus98.421e-131377
LLPS-Caj-a674Callithrix jacchus96.915e-131375
LLPS-Anc-a624Anolis carolinensis96.862e-131376
LLPS-Orl-a584Oryzias latipes96.514e-116341
LLPS-Orn-a589Oreochromis niloticus96.452e-135387
LLPS-Pof-a596Poecilia formosa95.947e-135385
LLPS-Icp-a595Ictalurus punctatus95.941e-135388
LLPS-Xim-a598Xiphophorus maculatus95.947e-135385
LLPS-Gaa-a577Gasterosteus aculeatus95.433e-122353
LLPS-Scf-a572Scleropages formosus95.432e-121351
LLPS-Tar-a561Takifugu rubripes95.197e-113329
LLPS-Lac-a603Latimeria chalumnae94.925e-120347
LLPS-Dar-a595Danio rerio94.05e-132378
LLPS-Cas-a588Carlito syrichta92.132e-52172
LLPS-Gog-a675Gorilla gorilla92.132e-52172
LLPS-Ova-a665Ovis aries86.212e-88265
LLPS-Ora-a564Ornithorhynchus anatinus83.727e-36130
LLPS-Xet-a587Xenopus tropicalis81.823e-105310
LLPS-Ten-a560Tetraodon nigroviridis79.612e-71223
LLPS-Asm-a589Astyanax mexicanus70.923e-80246