LLPS-Hos-a645
LNPK

▼ OVERVIEW

Status: Unreviewed
Protein Name: Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor lunapark
Gene Name: LNPK, KIAA1715, LNP
Ensembl Gene: ENSG00000144320.13
Ensembl Protein: ENSP00000272748.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGGLFSRWRT  KPSTVEVLES  IDKEIQALEE  FREKNQRLQK  LWVGRLILYS  SVLYLFTCLI  60
61    VYLWYLPDEF  TARLAMTLPF  FAFPLIIWSI  RTVIIFFFSK  RTERNNEALD  DLKSQRKKIL  120
121   EEVMEKETYK  TAKLILERFD  PDSKKAKECE  PPSAGAAVTA  RPGQEIRQRT  AAQRNLSPTP  180
181   ASPNQGPPPQ  VPVSPGPPKD  SSAPGGPPER  TVTPALSSNV  LPRHLGSPAT  SVPGMEMGLP  240
241   HIAQAGLEHL  SSSDLSTSTS  QSAGITGLHP  PGPPLARPIL  PRERGALDRI  VEYLVGDGPQ  300
301   NRYALICQQC  FSHNGMALKE  EFEYIAFRCA  YCFFLNPARK  TRPQAPRLPE  FSFEKRQVVE  360
361   GSSSVGPLPS  GSVLSSDNQF  NEESLEHDVL  DDNTEQTDDK  IPATEQTNQV  IEKASDSEEP  420
421   EEKQETENEE  ASVIETNSTV  PGADSIPDPE  LSGESLTAE  459
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGGAT  TATTTTCTCG  ATGGAGGACA  AAACCTTCAA  CTGTAGAAGT  TCTAGAAAGT  60
61    ATAGATAAGG  AAATTCAAGC  ATTGGAAGAA  TTTAGGGAAA  AAAATCAGAG  ATTACAAAAA  120
121   TTATGGGTTG  GAAGATTAAT  TCTGTATTCC  TCAGTTCTCT  ATCTGTTTAC  ATGCTTAATT  180
181   GTATATTTGT  GGTATCTTCC  TGATGAATTT  ACAGCAAGAC  TTGCCATGAC  ACTCCCATTT  240
241   TTTGCTTTTC  CATTGATCAT  CTGGAGCATA  AGAACAGTAA  TTATTTTCTT  CTTTTCCAAG  300
301   AGAACAGAAA  GAAATAATGA  AGCATTGGAT  GATTTAAAAT  CCCAGAGGAA  AAAAATACTT  360
361   GAAGAAGTCA  TGGAAAAAGA  AACTTACAAG  ACGGCTAAAT  TAATTCTTGA  AAGGTTTGAT  420
421   CCGGACTCAA  AGAAAGCAAA  GGAGTGTGAG  CCGCCATCTG  CTGGAGCAGC  TGTAACTGCA  480
481   AGACCTGGAC  AAGAGATTCG  TCAGCGAACT  GCAGCTCAAA  GAAACCTTTC  TCCAACACCA  540
541   GCAAGCCCTA  ACCAGGGCCC  TCCTCCACAA  GTTCCAGTAT  CTCCTGGACC  ACCAAAGGAC  600
601   AGTTCTGCCC  CTGGTGGACC  CCCAGAAAGG  ACTGTTACTC  CAGCCCTATC  ATCAAATGTG  660
661   TTACCAAGAC  ATCTTGGATC  CCCTGCTACT  TCAGTGCCTG  GAATGGGTCT  TCATCCTCCA  720
721   GGTCCACCTT  TAGCAAGACC  TATTCTCCCC  CGAGAACGAG  GTGCTTTGGA  TAGAATTGTT  780
781   GAATATTTGG  TTGGTGATGG  TCCACAAAAC  AGGTATGCAC  TTATATGTCA  GCAGTGTTTT  840
841   TCTCATAATG  GCATGGCTTT  GAAGGAAGAA  TTTGAATACA  TTGCTTTTCG  ATGTGCCTAC  900
901   TGTTTTTTCT  TGAACCCTGC  AAGAAAAACC  AGACCTCAGG  CTCCAAGACT  TCCTGAGTTT  960
961   AGTTTTGAGA  AGAGGCAGGT  GGTGGAAGGT  TCAAGTTCAG  TTGGTCCCTT  GCCATCAGGA  1020
1021  AGTGTGCTTT  CATCAGACAA  CCAGTTTAAT  GAAGAATCTT  TAGAACACGA  TGTTCTTGAT  1080
1081  GATAATACAG  AGCAGACAGA  TGACAAAATA  CCAGCTACAG  AACAGACAAA  CCAAGTGATT  1140
1141  GAAAAAGCAT  CTGACTCAGA  GGAACCAGAG  GAGAAACAAG  AGACTGAGAA  TGAGGAAGCC  1200
1201  TCAGTGATTG  AAACCAACTC  CACAGTTCCT  GGAGCTGATT  CTATTCCTGA  TCCTGAACTA  1260
1261  AGTGGAGAAT  CTTTGACGGC  AGAGTAG  1287

▼ KEYWORD

ID
Family
Alternative splicing
Coiled coil
Complete proteome
Developmental protein
Disease mutation
Endoplasmic reticulum
Epilepsy
Lipoprotein
Membrane
Mental retardation
Metal-binding
Myristate
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Endoplasmic reticulum tubular network
Cellular Component
Endoplasmic reticulum tubular network membrane
Cellular Component
Integral component of endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Nucleoplasm
Molecular Function
Identical protein binding
Molecular Function
Metal ion binding
Biological Process
Blood coagulation
Biological Process
Embryonic digit morphogenesis
Biological Process
Embryonic forelimb morphogenesis
Biological Process
Endoplasmic reticulum organization
Biological Process
Endoplasmic reticulum tubular network maintenance
Biological Process
Endoplasmic reticulum tubular network organization
Biological Process
Limb development
Biological Process
Positive regulation of endoplasmic reticulum tubular network organization
Biological Process
Regulation of chondrocyte differentiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-a632Gorilla gorilla100.00.0938
LLPS-Pap-a630Pan paniscus99.560.0935
LLPS-Pat-a637Pan troglodytes99.350.0932
LLPS-Mal-a625Mandrillus leucophaeus97.390.0914
LLPS-Cea-a641Cercocebus atys97.170.0914
LLPS-Maf-a637Macaca fascicularis97.170.0911
LLPS-Man-a640Macaca nemestrina97.170.0911
LLPS-Paa-a636Papio anubis97.170.0912
LLPS-Rhb-a631Rhinopithecus bieti97.170.0912
LLPS-Mam-a627Macaca mulatta96.950.0910
LLPS-Aon-a640Aotus nancymaae96.080.0894
LLPS-Caj-a630Callithrix jacchus95.860.0843
LLPS-Aim-a613Ailuropoda melanoleuca95.323e-159459
LLPS-Nol-a624Nomascus leucogenys90.430.0830
LLPS-Chs-a623Chlorocebus sabaeus90.410.0835
LLPS-Poa-a628Pongo abelii90.00.0827
LLPS-Otg-a632Otolemur garnettii86.210.0777
LLPS-Ict-a629Ictidomys tridecemlineatus84.780.0751
LLPS-Fec-a636Felis catus84.750.0754
LLPS-Eqc-a635Equus caballus84.280.0754
LLPS-Caf-a623Canis familiaris84.10.0728
LLPS-Urm-a584Ursus maritimus84.10.0753
LLPS-Mup-a618Mustela putorius furo83.660.0724
LLPS-Cas-a549Carlito syrichta83.590.0750
LLPS-Ova-a625Ovis aries83.440.0742
LLPS-Loa-a617Loxodonta africana82.790.0732
LLPS-Orc-a599Oryctolagus cuniculus82.680.0703
LLPS-Ran-a631Rattus norvegicus82.20.0634
LLPS-Bot-a641Bos taurus82.140.0727
LLPS-Sus-a639Sus scrofa81.480.0722
LLPS-Fud-a612Fukomys damarensis80.910.0738
LLPS-Myl-a592Myotis lucifugus80.850.0731
LLPS-Mum-a639Mus musculus78.740.0689
LLPS-Mea-a603Mesocricetus auratus78.520.0697
LLPS-Dio-a613Dipodomys ordii77.290.0600
LLPS-Mod-a607Monodelphis domestica75.00.0651
LLPS-Sah-a573Sarcophilus harrisii75.00.0658
LLPS-Cap-a632Cavia porcellus73.297e-132394
LLPS-Tag-a553Taeniopygia guttata72.934e-175503
LLPS-Anp-a518Anas platyrhynchos72.853e-180517
LLPS-Gaga-a574Gallus gallus69.420.0531
LLPS-Fia-a560Ficedula albicollis68.520.0545
LLPS-Ora-a529Ornithorhynchus anatinus67.510.0560
LLPS-Anc-a588Anolis carolinensis65.841e-175506
LLPS-Pes-a544Pelodiscus sinensis65.280.0559
LLPS-Meg-a517Meleagris gallopavo63.614e-142420
LLPS-Leo-a553Lepisosteus oculatus60.761e-155458
LLPS-Orl-a543Oryzias latipes60.392e-137410
LLPS-Xet-a553Xenopus tropicalis59.647e-163476
LLPS-Tar-a526Takifugu rubripes58.785e-135406
LLPS-Scf-a534Scleropages formosus58.434e-138412
LLPS-Dar-a557Danio rerio58.24e-140418
LLPS-Icp-a555Ictalurus punctatus57.625e-137411
LLPS-Lac-a558Latimeria chalumnae57.353e-151446
LLPS-Scm-a535Scophthalmus maximus57.33e-143427
LLPS-Orn-a551Oreochromis niloticus56.692e-138412
LLPS-Pof-a555Poecilia formosa55.592e-127385
LLPS-Asm-a548Astyanax mexicanus54.553e-140418
LLPS-Xim-a561Xiphophorus maculatus54.473e-121369