LLPS-Hos-a637
PYCR2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pyrroline-5-carboxylate reductase 2
Gene Name: PYCR2
Ensembl Gene: ENSG00000143811.18
Ensembl Protein: ENSP00000482845.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSVGFIGAGQ  LAYALARGFT  AAGILSAHKI  IASSPEMNLP  TVSALRKMGV  NLTRSNKETV  60
61    KHSDVLFLAV  KPHIIPFILD  EIGADVQARH  IVVSCAAGVT  ISSVEKKLMA  FQPAPKVIRC  120
121   MTNTPVVVQE  GATVYATGTH  ALVEDGQLLE  QLMSSVGFCT  EVEEDLIDAV  TGLSGSGPAY  180
181   AFMALDALAD  GGVKMGLPRR  LAIQLGAQAL  LGAAKMLLDS  EQHPCQLKDN  VCSPGGATIH  240
241   ALHFLESGGF  RSLLINAVEA  SCIRTRELQS  MADQEKISPA  ALKKTLLDRV  KLESPTVSTL  300
301   TPSSPGKLLT  RSLALGGKKD  320
Nucleotide CDS Sequence (FASTA)
1     ATGAGCGTGG  GCTTCATCGG  GGCCGGCCAG  CTGGCCTATG  CTCTGGCGCG  GGGCTTCACG  60
61    GCCGCAGGCA  TCCTGTCGGC  TCACAAGATA  ATAGCCAGCT  CCCCAGAAAT  GAACCTGCCC  120
121   ACGGTGTCCG  CGCTCAGGAA  GATGGGTGTG  AACCTGACAC  GCAGCAACAA  GGAGACGGTG  180
181   AAGCACAGCG  ACGTCCTGTT  TCTGGCTGTG  AAGCCACATA  TCATCCCCTT  CATCCTGGAT  240
241   GAGATTGGGG  CCGACGTGCA  AGCCAGACAC  ATCGTGGTCT  CCTGTGCGGC  TGGTGTCACC  300
301   ATCAGCTCTG  TGGAGAAGAA  GCTGATGGCA  TTCCAGCCAG  CCCCCAAAGT  GATTCGCTGC  360
361   ATGACCAACA  CACCTGTGGT  AGTGCAGGAA  GGCGCTACAG  TGTACGCCAC  GGGCACCCAT  420
421   GCCCTGGTGG  AGGATGGGCA  GCTCCTGGAG  CAGCTCATGA  GCAGCGTGGG  CTTCTGCACT  480
481   GAGGTGGAAG  AGGACCTCAT  CGATGCCGTC  ACGGGGCTCA  GTGGCAGCGG  GCCTGCCTAT  540
541   GCATTCATGG  CTCTGGACGC  ATTGGCTGAT  GGTGGGGTGA  AGATGGGTTT  GCCACGGCGC  600
601   CTGGCAATCC  AACTCGGGGC  CCAGGCTTTG  CTGGGAGCTG  CCAAGATGCT  GCTGGACTCG  660
661   GAGCAGCATC  CATGCCAGCT  TAAGGACAAT  GTCTGCTCCC  CTGGGGGAGC  CACCATCCAC  720
721   GCCCTGCACT  TTCTAGAGAG  TGGGGGCTTC  CGCTCTCTGC  TCATCAATGC  AGTTGAGGCC  780
781   TCCTGTATCC  GAACACGAGA  GCTACAGTCC  ATGGCCGACC  AAGAAAAGAT  CTCCCCAGCT  840
841   GCCCTTAAGA  AGACCCTCTT  AGACAGAGTG  AAGCTGGAAT  CCCCCACAGT  CTCCACACTG  900
901   ACCCCCTCCA  GCCCAGGGAA  GCTCCTCACA  AGAAGCCTGG  CCCTGGGAGG  CAAGAAGGAC  960
961   TAA  963

▼ KEYWORD

ID
Family
Acetylation
Amino-acid biosynthesis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Leukodystrophy
Mitochondrion
NADP
Oxidoreductase
Phosphoprotein
Proline biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial matrix
Cellular Component
Mitochondrion
Molecular Function
Pyrroline-5-carboxylate reductase activity
Biological Process
Cellular amino acid biosynthetic process
Biological Process
Cellular response to oxidative stress
Biological Process
L-proline biosynthetic process
Biological Process
Proline biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a629Pan troglodytes99.690.0645
LLPS-Pap-a623Pan paniscus99.690.0645
LLPS-Gog-a624Gorilla gorilla98.750.0638
LLPS-Nol-a616Nomascus leucogenys98.750.0640
LLPS-Rhb-a623Rhinopithecus bieti98.440.0640
LLPS-Mal-a619Mandrillus leucophaeus98.120.0637
LLPS-Cea-a634Cercocebus atys98.120.0637
LLPS-Maf-a630Macaca fascicularis98.120.0637
LLPS-Chs-a616Chlorocebus sabaeus97.810.0635
LLPS-Poa-a621Pongo abelii97.50.0635
LLPS-Paa-a629Papio anubis96.880.0623
LLPS-Cas-a542Carlito syrichta96.560.0622
LLPS-Caj-a623Callithrix jacchus96.560.0623
LLPS-Mup-2992Mustela putorius furo96.250.0618
LLPS-Aon-a632Aotus nancymaae95.940.0620
LLPS-Cap-a625Cavia porcellus95.620.0619
LLPS-Sus-a632Sus scrofa95.070.0546
LLPS-Fec-a628Felis catus94.690.0608
LLPS-Myl-a586Myotis lucifugus94.20.0521
LLPS-Caf-a617Canis familiaris94.060.0607
LLPS-Fud-a606Fukomys damarensis94.060.0605
LLPS-Otg-a625Otolemur garnettii94.060.0606
LLPS-Urm-a578Ursus maritimus93.870.0584
LLPS-Aim-a606Ailuropoda melanoleuca93.750.0578
LLPS-Man-a633Macaca nemestrina93.610.0590
LLPS-Tut-a341Tursiops truncatus93.440.0602
LLPS-Loa-a610Loxodonta africana93.420.0595
LLPS-Ict-a622Ictidomys tridecemlineatus93.120.0603
LLPS-Mea-a596Mesocricetus auratus92.810.0603
LLPS-Ran-a625Rattus norvegicus92.50.0601
LLPS-Mum-a632Mus musculus92.190.0600
LLPS-Dio-a607Dipodomys ordii91.449e-170481
LLPS-Anp-2422Anas platyrhynchos90.961e-119351
LLPS-Ova-a617Ovis aries90.940.0578
LLPS-Sah-0865Sarcophilus harrisii88.120.0578
LLPS-Meg-a512Meleagris gallopavo87.821e-121357
LLPS-Bot-a633Bos taurus87.620.0553
LLPS-Mod-3820Monodelphis domestica87.190.0569
LLPS-Fia-a553Ficedula albicollis86.580.0532
LLPS-Lac-2064Latimeria chalumnae83.840.0515
LLPS-Leo-a545Lepisosteus oculatus83.390.0516
LLPS-Tar-2057Takifugu rubripes83.220.0511
LLPS-Pof-a549Poecilia formosa82.836e-179507
LLPS-Asm-a542Astyanax mexicanus82.550.0512
LLPS-Scm-a529Scophthalmus maximus82.214e-179507
LLPS-Dar-3987Danio rerio81.542e-178506
LLPS-Xim-0811Xiphophorus maculatus79.872e-176500
LLPS-Gaga-a567Gallus gallus69.474e-161464
LLPS-Orc-a593Oryctolagus cuniculus64.695e-129379
LLPS-Tag-a546Taeniopygia guttata51.527e-2398.2