LLPS-Hos-a547
RAB11FIP5
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Rab11 family-interacting protein 5 |
| Gene Name: | RAB11FIP5, GAF1, KIAA0857, RIP11 |
| Ensembl Gene: | ENSG00000135631.16 |
| Ensembl Protein: | ENSP00000258098.6 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000258098.6 | ENSP00000258098.6 |
| Ensembl | ENST00000486777.6 | ENSP00000489752.1 |
| UniProt | Q9BXF6, RFIP5_HUMAN, O94939, Q9P0M1 | |
| GeneBank | AF153085, BC035013, AF334812, AB020664 | AAH35013.1, BAA74880.1, AAF34356.1, AAK20892.1 |
| RefSeq | NM_015470.2 | NP_056285.1 |
| Entrez | 26056 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALVRGAEPA AGPSRWLPTH VQVTVLRARG LRGKSSGAGS TSDAYTVIQV GREKYSTSVV 60 61 EKTHGCPEWR EECSFELPPG ALDGLLRAQE ADAGPAPWAA SSAAACELVL TTMHRSLIGV 120 121 DKFLGQATVA LDEVFGAGRA QHTQWYKLHS KPGKKEKERG EIEVTIQFTR NNLSASMFDL 180 181 SMKDKPRSPF SKIRDKMKGK KKYDLESASA ILPSSAIEDP DLGSLGKMGK AKGFFLRNKL 240 241 RKSSLTQSNT SLGSDSTLSS ASGSLAYQGP GAELLTRSPS RSSWLSTEGG RDSAQSPKLF 300 301 THKRTYSDEA NQMRVAPPRA LLDLQGHLDA ASRSSLCVNG SHIYNEEPQG PVRHRSSISG 360 361 SLPSSGSLQA VSSRFSEEGP RSTDDTWPRG SRSNSSSEAV LGQEELSAQA KVLAPGASHP 420 421 GEEEGARLPE GKPVQVATPI VASSEAVAEK EGARKEERKP RMGLFHHHHQ GLSRSELGRR 480 481 SSLGEKGGPI LGASPHHSSS GEEKAKSSWF GLREAKDPTQ KPSLDVSPQV ESDPAALPHH 540 541 LPCSPWAPAP PTPAPTAAPM LSTNLFAAAS PAAATAAAAA TTAAPEATPP GLLGLTNPFL 600 601 TSLQSNPFFE ELIADIALNS PSPAPSLPSA SRASPTPLAS PGKALPEWDN TFNVFAASRL 660 661 RPEARSEILA PAGVGLEAAG LQDPGPGAMT AKAAEPQGEP GGGGGGGGGG GGRGGSSVWL 720 721 EPRVPLDLGP NHQSASAADP GLLGSVGAGL PSSSAQLQLR ASGSEPDREL PAPEVEAGQS 780 781 PADSGTSLFS SPEVISVWER LPGPESAAEG QDDESSRGEN QLCPDVETAD DAWPWDVVTI 840 841 SPAAETASLV FRGESDEPAP QVQPESPETV SPKGSEGLPP PEPEPKPEWV SDKGLQPSTP 900 901 PPKPPRLFTP SRSQEEEEEK AAVGLSNRGP ETEGEDASPS ALVVGPPETK EEGEKRESEE 960 961 SDSCSSATLL GQPGLEELVE DASPPVSGPC LSAPASCPEG PAPIPCHSKS LALQSQHIWG 1020 1021 TPEVGEGPEA PEAQGQDPVG EGLGSLSATS QQADVWVSKE DALNPFLFQG SRDPPSLSSA 1080 1081 SPPGSRESSI HSGPEELPTP PEPDFPPPPL PPWASHHRGG PSPPCSPLSE AWPLTTSSAP 1140 1141 PGEPALLPGP HEPSPPGGSP ALLREDLAAA TPASPLVLLP LETRPAEEPQ PSASPHPVKP 1200 1201 LSAAPVEGSP DRKQSRSSLS IALSSGLEKL KTVTSGSIQP VTQAPQAGQM VDTKRLKDSA 1260 1261 VLDQSAKYYH LTHDELISLL LQRERELSQR DEHVQELESY IDRLLVRIME TSPTLLQIPP 1320 1321 GPPK 1324 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCCTGG TGCGGGGCGC GGAGCCGGCG GCGGGGCCTT CCCGCTGGCT GCCCACGCAC 60 61 GTCCAGGTGA CGGTGCTGCG GGCCCGCGGG CTGCGGGGCA AGAGCTCGGG AGCGGGCAGC 120 121 ACCAGCGACG CGTACACGGT GATCCAGGTG GGCCGCGAGA AGTACAGTAC GTCGGTGGTG 180 181 GAGAAGACGC ACGGCTGCCC CGAGTGGCGT GAGGAGTGCT CCTTCGAGCT GCCGCCGGGG 240 241 GCCCTGGATG GCCTGCTGCG GGCGCAGGAG GCCGACGCGG GCCCGGCGCC CTGGGCCGCG 300 301 AGCTCCGCCG CCGCCTGCGA GCTGGTGCTC ACCACCATGC ACCGCTCGCT CATCGGCGTC 360 361 GACAAGTTCC TGGGCCAGGC CACGGTGGCG CTGGACGAGG TCTTCGGCGC AGGCCGCGCC 420 421 CAGCACACGC AGTGGTACAA GCTGCACTCC AAGCCAGGCA AGAAGGAGAA GGAACGCGGC 480 481 GAGATTGAAG TCACCATCCA GTTCACGCGC AACAACCTGA GCGCCAGTAT GTTTGACCTG 540 541 TCCATGAAGG ACAAGCCAAG GTCTCCCTTC AGCAAGATCA GGGACAAGAT GAAGGGCAAG 600 601 AAGAAGTATG ATCTGGAATC TGCCTCTGCC ATCCTCCCAA GCAGCGCCAT AGAGGATCCT 660 661 GACCTGGGCA GCCTGGGCAA GATGGGCAAA GCCAAAGGCT TCTTCCTCCG CAACAAGCTG 720 721 CGCAAGTCGT CCCTGACCCA GTCCAACACC TCGCTGGGCT CGGACAGCAC CCTGTCCTCA 780 781 GCCAGCGGGA GCTTGGCCTA CCAGGGACCT GGCGCCGAAC TCCTCACCCG CTCACCAAGC 840 841 CGTAGCAGCT GGCTGTCCAC TGAAGGGGGC AGGGACTCTG CACAGTCCCC CAAGCTGTTC 900 901 ACCCATAAGA GGACCTACAG CGATGAGGCC AACCAGATGC GAGTGGCTCC TCCTCGGGCC 960 961 CTTCTGGACC TTCAGGGCCA CCTGGATGCT GCCTCCCGCT CTTCGCTCTG TGTCAATGGG 1020 1021 AGCCACATTT ACAATGAGGA GCCCCAGGGC CCTGTGCGGC ACCGCAGCTC CATCTCGGGC 1080 1081 TCGCTTCCAT CCTCTGGCTC CTTGCAAGCT GTCTCTTCCC GGTTCTCCGA GGAGGGGCCT 1140 1141 CGTTCCACAG ATGACACCTG GCCCAGAGGC AGTCGTAGCA ACAGCAGCTC AGAGGCAGTG 1200 1201 CTTGGACAGG AGGAGCTGAG TGCTCAGGCT AAAGTCCTGG CCCCTGGGGC CAGCCACCCT 1260 1261 GGAGAGGAGG AGGGGGCCCG GCTACCAGAG GGCAAGCCAG TCCAGGTTGC CACACCCATA 1320 1321 GTGGCCTCCT CTGAGGCTGT GGCAGAGAAG GAGGGAGCCC GGAAGGAGGA ACGCAAGCCC 1380 1381 CGGATGGGTC TCTTCCACCA CCACCACCAA GGCCTAAGTC GGAGCGAGTT GGGTCGCCGA 1440 1441 AGCTCTCTGG GGGAAAAGGG GGGTCCCATC CTGGGGGCCT CCCCACATCA CTCATCCAGT 1500 1501 GGGGAGGAAA AGGCCAAGAG TAGCTGGTTT GGCTTGAGAG AAGCCAAGGA CCCGACTCAG 1560 1561 AAACCCAGTC CCCACCCCGT GAAGCCCCTC AGTGCCGCCC CTGTGGAGGG CAGCCCCGAC 1620 1621 AGGAAGCAGT CCCGCTCCAG TCTGAGCATA GCCCTGAGCA GTGGGCTGGA GAAGCTCAAA 1680 1681 ACAGTCACAT CTGGGAGCAT TCAGCCTGTG ACCCAGGCCC CCCAGGCTGG CCAGATGGTG 1740 1741 GACACCAAAA GGCTGAAGGA CTCAGCTGTG CTGGACCAGT CGGCCAAGTA CTACCACCTG 1800 1801 ACCCACGATG AGCTCATCAG CCTGCTCCTG CAGCGGGAGC GGGAGCTGAG CCAGCGGGAC 1860 1861 GAGCATGTGC AGGAGCTGGA GAGCTACATC GACCGGCTGC TGGTGCGGAT CATGGAGACC 1920 1921 TCACCCACGC TGCTGCAGAT CCCCCCGGGC CCCCCCAAAT AG 1962 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Early endosome | |
Cellular Component | Early endosome membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Mitochondrial outer membrane | |
Cellular Component | Recycling endosome | |
Cellular Component | Recycling endosome membrane | |
Cellular Component | Secretory granule | |
Cellular Component | Transport vesicle membrane | |
Molecular Function | Gamma-tubulin binding | |
Molecular Function | Rab GTPase binding | |
Biological Process | Cellular response to acidic pH | |
Biological Process | Insulin secretion involved in cellular response to glucose stimulus | |
Biological Process | Negative regulation of adiponectin secretion | |
Biological Process | Regulated exocytosis | |
Biological Process | Regulation of protein localization to cell surface |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Chs-a530 | Chlorocebus sabaeus | 99.04 | 0.0 | 969 |
| LLPS-Pat-a539 | Pan troglodytes | 99.02 | 0.0 | 2563 |
| LLPS-Pap-a537 | Pan paniscus | 98.99 | 0.0 | 2279 |
| LLPS-Mam-a531 | Macaca mulatta | 98.67 | 2e-41 | 155 |
| LLPS-Gog-a533 | Gorilla gorilla | 98.57 | 0.0 | 2541 |
| LLPS-Nol-a525 | Nomascus leucogenys | 97.51 | 0.0 | 947 |
| LLPS-Paa-a538 | Papio anubis | 96.75 | 0.0 | 2490 |
| LLPS-Poa-a531 | Pongo abelii | 96.67 | 0.0 | 1046 |
| LLPS-Cea-a542 | Cercocebus atys | 96.61 | 0.0 | 2487 |
| LLPS-Rhb-a532 | Rhinopithecus bieti | 96.61 | 0.0 | 2492 |
| LLPS-Maf-a541 | Macaca fascicularis | 96.46 | 0.0 | 2483 |
| LLPS-Man-a541 | Macaca nemestrina | 96.38 | 0.0 | 2482 |
| LLPS-Mal-a529 | Mandrillus leucophaeus | 96.33 | 0.0 | 2284 |
| LLPS-Caj-a534 | Callithrix jacchus | 91.54 | 0.0 | 1986 |
| LLPS-Aon-a542 | Aotus nancymaae | 91.31 | 0.0 | 1972 |
| LLPS-Sus-a543 | Sus scrofa | 91.01 | 0.0 | 919 |
| LLPS-Aim-a521 | Ailuropoda melanoleuca | 91.0 | 0.0 | 868 |
| LLPS-Orc-a512 | Oryctolagus cuniculus | 89.1 | 0.0 | 822 |
| LLPS-Urm-a492 | Ursus maritimus | 88.42 | 0.0 | 602 |
| LLPS-Dio-a522 | Dipodomys ordii | 85.36 | 0.0 | 781 |
| LLPS-Eqc-a542 | Equus caballus | 83.72 | 0.0 | 1824 |
| LLPS-Cap-a535 | Cavia porcellus | 83.43 | 0.0 | 777 |
| LLPS-Fec-a539 | Felis catus | 83.13 | 0.0 | 1790 |
| LLPS-Otg-a537 | Otolemur garnettii | 81.95 | 0.0 | 1784 |
| LLPS-Fud-a518 | Fukomys damarensis | 81.82 | 0.0 | 624 |
| LLPS-Caf-a527 | Canis familiaris | 80.51 | 0.0 | 1791 |
| LLPS-Ict-a534 | Ictidomys tridecemlineatus | 80.12 | 0.0 | 1729 |
| LLPS-Myl-a504 | Myotis lucifugus | 79.8 | 0.0 | 1707 |
| LLPS-Mup-a529 | Mustela putorius furo | 79.7 | 0.0 | 1709 |
| LLPS-Bot-a544 | Bos taurus | 78.07 | 0.0 | 1667 |
| LLPS-Sah-a487 | Sarcophilus harrisii | 77.78 | 7e-51 | 202 |
| LLPS-Loa-a520 | Loxodonta africana | 77.2 | 0.0 | 1725 |
| LLPS-Mea-a505 | Mesocricetus auratus | 74.74 | 0.0 | 1582 |
| LLPS-Mum-a542 | Mus musculus | 72.75 | 0.0 | 1546 |
| LLPS-Ran-a537 | Rattus norvegicus | 71.33 | 0.0 | 1305 |
| LLPS-Ova-a529 | Ovis aries | 66.86 | 0.0 | 1234 |
| LLPS-Tag-a463 | Taeniopygia guttata | 61.29 | 7e-19 | 92.8 |
| LLPS-Fia-a467 | Ficedula albicollis | 58.94 | 2e-53 | 203 |
| LLPS-Pes-a456 | Pelodiscus sinensis | 53.04 | 9e-87 | 300 |
| LLPS-Gaga-a483 | Gallus gallus | 50.61 | 4e-115 | 404 |