LLPS-Hos-a492
ATXN10
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Ataxin-10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein |
| Gene Name: | ATXN10, SCA10 |
| Ensembl Gene: | ENSG00000130638.16 |
| Ensembl Protein: | ENSP00000391117.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000435026.5 | ENSP00000391117.1 |
| Ensembl | ENST00000252934.9 | ENSP00000252934.4 |
| Ensembl | ENST00000381061.8 | ENSP00000370449.4 |
| Ensembl | ENST00000640901.1 | ENSP00000491659.1 |
| Ensembl | ENST00000402380.3 | ENSP00000385624.3 |
| UniProt | Q9UBB4, ATX10_HUMAN, A6NLC4, B4DG05, O14998, O15009, Q6I9X4 | |
| GeneBank | CR456568, Z93784, Z95331, AF119662, AK294348, Z84478, BC007508, CR457381, AL050282 | AAF17219.1, AAH07508.1, CAG33662.1, BAG57616.1, CAB43383.1, CAG30454.1 |
| RefSeq | NM_001167621.1, NM_013236.3 | NP_001161093.1, NP_037368.1 |
| Entrez | 25814 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAPRPPPAR LSGVMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSSHA 60 61 VELACRDPSQ VENLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLILLFRE 120 121 LRVEQESLLT AFRCGLQFLG NIASRNEDSQ SIVWVHAFPE LFLSCLNHPD KKIVAYSSMI 180 181 LFTSLNHERM KELEENLNIA IDVIDAYQKH PESEWPFLII TDLFLKSPEL VQAMFPKLNN 240 241 QERVTLLDLM IAKITSDEPL TKDDIPVFLR HAELIASTFV DQCKTVLKLA SEEPPDDEEA 300 301 LATIRLLDVL CEMTVNTELL GYLQVFPGLL ERVIDLLRVI HVAGKETTNI FSNCGCVRAE 360 361 GDISNVANGF KSHLIRLIGN LCYKNKDNQD KVNELDGIPL ILDNCNISDS NPFLTQWVIY 420 421 AIRNLTEDNS QNQDLIAKME EQGLADASLL KKVGFEVEKK GEKLILKSTR DTPKP 475 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 60 61 CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGAGAA 120 121 ACAGCACCCA GGACTATCTT CCAAAGAGTT CTGGATATCC TAAAGAAATC TTCTCATGCT 180 181 GTTGAGCTTG CCTGCAGAGA TCCATCCCAA GTGGAAAACC TGGCTTCCAG TCTGCAGTTA 240 241 ATAACAGAAT GCTTCAGGTG TCTTCGCAAT GCTTGCATAG AGTGTTCTGT GAACCAGAAT 300 301 TCAATCAGGA ACTTGGATAC GATTGGTGTT GCTGTTGATT TGATTCTTCT GTTTCGTGAA 360 361 CTGCGAGTGG AACAGGAATC TCTGTTGACA GCTTTTCGCT GTGGCCTGCA GTTTTTAGGC 420 421 AACATTGCCT CACGGAATGA AGATTCCCAG TCTATTGTTT GGGTGCATGC TTTCCCAGAA 480 481 CTGTTTTTGT CTTGCTTAAA TCATCCGGAC AAAAAAATTG TTGCCTACTC TTCAATGATT 540 541 TTGTTTACAT CCCTTAATCA TGAAAGAATG AAAGAACTGG AGGAGAACCT CAATATTGCA 600 601 ATTGATGTCA TAGATGCTTA CCAAAAACAT CCTGAATCAG AATGGCCGTT CTTGATTATT 660 661 ACAGACCTCT TTCTGAAAAG CCCGGAATTG GTACAAGCCA TGTTTCCCAA ACTGAACAAT 720 721 CAAGAAAGAG TTACACTGTT AGACCTTATG ATAGCCAAGA TAACGAGTGA TGAGCCACTC 780 781 ACCAAGGATG ACATCCCTGT GTTTTTGCGG CATGCTGAGT TGATTGCAAG CACCTTTGTG 840 841 GATCAGTGCA AGACTGTGCT CAAGCTGGCC TCTGAGGAGC CTCCTGATGA TGAGGAGGCA 900 901 CTGGCTACAA TTAGGCTTCT CGACGTCCTG TGCGAAATGA CTGTGAATAC TGAGCTGCTC 960 961 GGCTATCTGC AGGTTTTCCC TGGCTTGCTG GAAAGAGTGA TTGATCTTTT GCGGGTGATT 1020 1021 CATGTAGCTG GAAAAGAAAC CACAAACATC TTCAGTAATT GTGGTTGCGT GAGAGCAGAA 1080 1081 GGTGACATCT CCAATGTGGC CAATGGGTTT AAGTCTCATC TCATTCGTCT GATTGGAAAT 1140 1141 CTGTGTTACA AGAATAAAGA TAACCAAGAC AAGGTAAATG AGCTGGATGG TATCCCGTTG 1200 1201 ATCCTGGACA ACTGCAACAT CAGTGACAGT AACCCCTTTC TGACCCAGTG GGTGATATAT 1260 1261 GCCATCCGAA ACCTTACCGA AGACAACAGC CAAAACCAAG ATTTGATTGC AAAGATGGAG 1320 1321 GAACAGGGGC TGGCAGATGC ATCCCTACTT AAAAAAGTGG GTTTTGAAGT TGAAAAGAAA 1380 1381 GGCGAAAAGC TGATCCTGAA ATCTACTAGA GACACCCCTA AGCCATGA 1428 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Dendrite | |
Cellular Component | Extracellular space | |
Cellular Component | Membrane | |
Cellular Component | Neuronal cell body | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Plasma membrane | |
Molecular Function | Enzyme binding | |
Molecular Function | Identical protein binding | |
Biological Process | Cilium assembly | |
Biological Process | Nervous system development | |
Biological Process | Neuron projection development | |
Biological Process | Protein homotrimerization |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a483 | Pan troglodytes | 99.58 | 0.0 | 966 |
| LLPS-Pap-a483 | Pan paniscus | 99.58 | 0.0 | 966 |
| LLPS-Gog-a478 | Gorilla gorilla | 99.37 | 0.0 | 965 |
| LLPS-Poa-a477 | Pongo abelii | 99.16 | 0.0 | 959 |
| LLPS-Chs-a478 | Chlorocebus sabaeus | 98.74 | 0.0 | 959 |
| LLPS-Man-a486 | Macaca nemestrina | 98.62 | 0.0 | 877 |
| LLPS-Maf-a486 | Macaca fascicularis | 98.53 | 0.0 | 957 |
| LLPS-Mam-a480 | Macaca mulatta | 98.53 | 0.0 | 957 |
| LLPS-Mal-a475 | Mandrillus leucophaeus | 98.4 | 0.0 | 878 |
| LLPS-Rhb-a479 | Rhinopithecus bieti | 98.32 | 0.0 | 957 |
| LLPS-Nol-a472 | Nomascus leucogenys | 98.32 | 0.0 | 956 |
| LLPS-Paa-a484 | Papio anubis | 98.11 | 0.0 | 954 |
| LLPS-Cea-a486 | Cercocebus atys | 97.68 | 0.0 | 952 |
| LLPS-Caj-a480 | Callithrix jacchus | 95.79 | 0.0 | 939 |
| LLPS-Aon-a489 | Aotus nancymaae | 95.79 | 0.0 | 939 |
| LLPS-Otg-a484 | Otolemur garnettii | 91.58 | 0.0 | 744 |
| LLPS-Caf-a475 | Canis familiaris | 90.49 | 0.0 | 880 |
| LLPS-Eqc-a489 | Equus caballus | 89.77 | 0.0 | 891 |
| LLPS-Fec-a483 | Felis catus | 89.64 | 0.0 | 877 |
| LLPS-Aim-a472 | Ailuropoda melanoleuca | 88.97 | 0.0 | 795 |
| LLPS-Bot-a490 | Bos taurus | 88.61 | 0.0 | 874 |
| LLPS-Ova-a475 | Ovis aries | 88.3 | 0.0 | 802 |
| LLPS-Fud-a467 | Fukomys damarensis | 87.33 | 0.0 | 784 |
| LLPS-Cap-a481 | Cavia porcellus | 87.1 | 0.0 | 845 |
| LLPS-Mup-a475 | Mustela putorius furo | 86.07 | 0.0 | 781 |
| LLPS-Urm-a442 | Ursus maritimus | 86.06 | 0.0 | 785 |
| LLPS-Sus-a488 | Sus scrofa | 85.65 | 0.0 | 848 |
| LLPS-Ere-a128 | Erinaceus europaeus | 84.83 | 0.0 | 771 |
| LLPS-Ran-a484 | Rattus norvegicus | 84.63 | 0.0 | 835 |
| LLPS-Orc-a461 | Oryctolagus cuniculus | 84.36 | 0.0 | 827 |
| LLPS-Mum-a488 | Mus musculus | 82.95 | 0.0 | 825 |
| LLPS-Cas-a430 | Carlito syrichta | 81.07 | 0.0 | 630 |
| LLPS-Myl-a458 | Myotis lucifugus | 79.47 | 0.0 | 621 |
| LLPS-Ict-a480 | Ictidomys tridecemlineatus | 77.06 | 0.0 | 677 |
| LLPS-Dio-a472 | Dipodomys ordii | 73.32 | 0.0 | 629 |
| LLPS-Mea-a451 | Mesocricetus auratus | 68.28 | 0.0 | 613 |
| LLPS-Sah-a445 | Sarcophilus harrisii | 63.01 | 0.0 | 569 |
| LLPS-Mod-a465 | Monodelphis domestica | 58.88 | 0.0 | 575 |
| LLPS-Pes-a416 | Pelodiscus sinensis | 58.06 | 3e-180 | 521 |
| LLPS-Ten-a400 | Tetraodon nigroviridis | 57.66 | 4e-35 | 134 |
| LLPS-Anp-a398 | Anas platyrhynchos | 55.48 | 5e-169 | 493 |
| LLPS-Anc-a447 | Anolis carolinensis | 55.38 | 5e-164 | 481 |
| LLPS-Gaga-a433 | Gallus gallus | 55.25 | 0.0 | 533 |
| LLPS-Lac-a427 | Latimeria chalumnae | 54.39 | 1e-73 | 240 |
| LLPS-Fia-a421 | Ficedula albicollis | 53.91 | 1e-133 | 402 |
| LLPS-Tag-a416 | Taeniopygia guttata | 53.16 | 2e-174 | 508 |
| LLPS-Ora-a406 | Ornithorhynchus anatinus | 50.0 | 7e-53 | 184 |