LLPS-Hos-a487
ACTN4

▼ OVERVIEW

Status: Reviewed
Protein Name: Alpha-actinin-4; Non-muscle alpha-actinin 4
Gene Name: ACTN4
Ensembl Gene: ENSG00000130402.11
Ensembl Protein: ENSP00000439497.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 1YDI (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVDYHAANQS  YQYGPSSAGN  GAGGGGSMGD  YMAQEDDWDR  DLLLDPAWEK  QQRKTFTAWC  60
61    NSHLRKAGTQ  IENIDEDFRD  GLKLMLLLEV  ISGERLPKPE  RGKMRVHKIN  NVNKALDFIA  120
121   SKGVKLVSIG  AEEIVDGNAK  MTLGMIWTII  LRFAIQDISV  EETSAKEGLL  LWCQRKTAPY  180
181   KNVNVQNFHI  SWKDGLAFNA  LIHRHRPELI  EYDKLRKDDP  VTNLNNAFEV  AEKYLDIPKM  240
241   LDAEDIVNTA  RPDEKAIMTY  VSSFYHAFSG  AQKAETAANR  ICKVLAVNQE  NEHLMEDYEK  300
301   LASDLLEWIR  RTIPWLEDRV  PQKTIQEMQQ  KLEDFRDYRR  VHKPPKVQEK  CQLEINFNTL  360
361   QTKLRLSNRP  AFMPSEGKMV  SDINNGWQHL  EQAEKGYEEW  LLNEIRRLER  LDHLAEKFRQ  420
421   KASIHEAWTD  GKEAMLKHRD  YETATLSDIK  ALIRKHEAFE  SDLAAHQDRV  EQIAAIAQEL  480
481   NELDYYDSHN  VNTRCQKICD  QWDALGSLTH  SRREALEKTE  KQLEAIDQLH  LEYAKRAAPF  540
541   NNWMESAMED  LQDMFIVHTI  EEIEGLISAH  DQFKSTLPDA  DREREAILAI  HKEAQRIAES  600
601   NHIKLSGSNP  YTTVTPQIIN  SKWEKVQQLV  PKRDHALLEE  QSKQQSNEHL  RRQFASQANV  660
661   VGPWIQTKME  EIGRISIEMN  GTLEDQLSHL  KQYERSIVDY  KPNLDLLEQQ  HQLIQEALIF  720
721   DNKHTNYTME  HIRVGWEQLL  TTIARTINEV  ENQILTRDAK  GISQEQMQEF  RASFNHFDKD  780
781   HGGALGPEEF  KACLISLGYD  VENDRQGEAE  FNRIMSLVDP  NHSGLVTFQA  FIDFMSRETT  840
841   DTDTADQVIA  SFKVLAGDKN  FITAEELRRE  LPPDQAEYCI  ARMAPYQGPD  AVPGALDYKS  900
901   FSTALYGESD  L  911
Nucleotide CDS Sequence (FASTA)
1     ATGGTGGACT  ACCACGCGGC  GAACCAGTCG  TACCAGTACG  GCCCCAGCAG  CGCGGGCAAT  60
61    GGCGCTGGCG  GCGGGGGCAG  CATGGGCGAC  TACATGGCCC  AGGAGGACGA  CTGGGACCGG  120
121   GACCTGCTGC  TGGACCCGGC  CTGGGAGAAG  CAGCAGCGCA  AGACCTTCAC  GGCATGGTGC  180
181   AACTCCCACC  TGCGGAAGGC  AGGCACACAG  ATCGAGAACA  TTGATGAGGA  CTTCCGAGAC  240
241   GGGCTCAAGC  TCATGCTGCT  CCTGGAGGTC  ATATCAGGGG  AGCGGTTACC  TAAGCCGGAG  300
301   CGGGGGAAGA  TGAGAGTGCA  CAAAATCAAC  AATGTGAACA  AAGCGCTGGA  CTTTATTGCC  360
361   AGCAAAGGCG  TCAAGCTGGT  CTCCATCGGG  GCAGAAGAGA  TTGTGGACGG  CAACGCAAAG  420
421   ATGACCCTGG  GAATGATCTG  GACCATCATC  CTTAGGTTCG  CCATCCAGGA  CATCTCCGTG  480
481   GAAGAGACCT  CGGCCAAGGA  AGGGCTCCTT  CTCTGGTGCC  AGAGAAAGAC  AGCCCCGTAT  540
541   AAGAACGTCA  ATGTGCAGAA  CTTCCACATC  AGCTGGAAGG  ATGGTCTTGC  CTTCAATGCC  600
601   CTGATCCACC  GGCACAGACC  AGAGCTGATT  GAGTATGACA  AGCTGAGGAA  GGACGACCCT  660
661   GTCACCAACC  TGAACAATGC  CTTCGAAGTG  GCTGAGAAAT  ACCTCGACAT  CCCCAAGATG  720
721   CTGGATGCAG  AGGACATCGT  GAACACGGCC  CGGCCCGACG  AGAAGGCCAT  AATGACCTAT  780
781   GTGTCCAGCT  TCTACCATGC  CTTTTCAGGA  GCGCAGAAGG  CTGAAACTGC  CGCCAACCGG  840
841   ATCTGTAAGG  TGCTGGCTGT  CAACCAAGAG  AACGAGCACC  TGATGGAGGA  CTACGAGAAG  900
901   CTGGCCAGCG  ACCTCCTGGA  GTGGATCCGG  CGCACCATCC  CCTGGCTGGA  GGACCGTGTG  960
961   CCCCAAAAGA  CTATCCAGGA  GATGCAGCAG  AAGCTGGAGG  ACTTCCGCGA  CTACCGGCGT  1020
1021  GTGCACAAGC  CGCCCAAGGT  GCAGGAGAAG  TGCCAGCTGG  AGATCAACTT  CAACACGCTG  1080
1081  CAGACCAAGC  TGCGCCTCAG  CAACCGGCCC  GCCTTCATGC  CCTCCGAGGG  CAAGATGGTC  1140
1141  TCGGACATCA  ACAATGGCTG  GCAGCACTTG  GAGCAGGCTG  AGAAGGGCTA  CGAGGAGTGG  1200
1201  CTGCTGAATG  AGATCCGCAG  GCTGGAGCGG  CTCGACCACC  TGGCAGAGAA  GTTCCGGCAG  1260
1261  AAGGCCTCCA  TCCACGAGGC  CTGGACTGAC  GGGAAGGAAG  CCATGCTGAA  GCACCGGGAC  1320
1321  TACGAGACGG  CCACACTATC  GGACATCAAA  GCCCTCATTC  GCAAGCACGA  GGCCTTCGAG  1380
1381  AGCGACCTGG  CTGCGCACCA  GGACCGCGTG  GAGCAGATCG  CCGCCATTGC  CCAGGAGCTC  1440
1441  AACGAGCTGG  ATTACTACGA  CTCCCACAAT  GTCAACACCC  GGTGCCAGAA  GATCTGTGAC  1500
1501  CAGTGGGACG  CCCTCGGCTC  TCTGACACAT  AGTCGCAGGG  AAGCCCTGGA  GAAAACAGAG  1560
1561  AAGCAGCTGG  AGGCCATCGA  CCAGCTGCAC  CTGGAATACG  CCAAGCGCGC  GGCCCCCTTC  1620
1621  AACAACTGGA  TGGAGAGCGC  CATGGAGGAC  CTCCAGGACA  TGTTCATCGT  CCATACCATC  1680
1681  GAGGAGATTG  AGGGCCTGAT  CTCAGCCCAT  GACCAGTTCA  AGTCCACCCT  GCCGGACGCC  1740
1741  GATAGGGAGC  GCGAGGCCAT  CCTGGCCATC  CACAAGGAGG  CCCAGAGGAT  CGCTGAGAGC  1800
1801  AACCACATCA  AGCTGTCGGG  CAGCAACCCC  TACACCACCG  TCACCCCGCA  AATCATCAAC  1860
1861  TCCAAGTGGG  AGAAGGTGCA  GCAGCTGGTG  CCAAAACGGG  ACCATGCCCT  CCTGGAGGAG  1920
1921  CAGAGCAAGC  AGCAGTCCAA  CGAGCACCTG  CGCCGCCAGT  TCGCCAGCCA  GGCCAATGTT  1980
1981  GTGGGGCCCT  GGATCCAGAC  CAAGATGGAG  GAGATCGGGC  GCATCTCCAT  TGAGATGAAC  2040
2041  GGGACCCTGG  AGGACCAGCT  GAGCCACCTG  AAGCAGTATG  AACGCAGCAT  CGTGGACTAC  2100
2101  AAGCCCAACC  TGGACCTGCT  GGAGCAGCAG  CACCAGCTCA  TCCAGGAGGC  CCTCATCTTC  2160
2161  GACAACAAGC  ACACCAACTA  TACCATGGAG  CACATCCGCG  TGGGCTGGGA  GCAGCTGCTC  2220
2221  ACCACCATTG  CCCGCACCAT  CAACGAGGTG  GAGAACCAGA  TCCTCACCCG  CGACGCCAAG  2280
2281  GGCATCAGCC  AGGAGCAGAT  GCAGGAGTTC  CGGGCGTCCT  TCAACCACTT  CGACAAGGAT  2340
2341  CATGGCGGGG  CGCTGGGGCC  CGAGGAGTTC  AAGGCCTGCC  TCATCAGCCT  GGGCTACGAC  2400
2401  GTGGAGAACG  ACCGGCAGGG  TGAGGCCGAG  TTCAACCGCA  TCATGAGCCT  GGTCGACCCC  2460
2461  AACCATAGCG  GCCTTGTGAC  CTTCCAAGCC  TTCATCGACT  TCATGTCGCG  GGAGACCACC  2520
2521  GACACGGACA  CGGCTGACCA  GGTCATCGCT  TCCTTCAAGG  TCTTAGCAGG  GGACAAGAAC  2580
2581  TTCATCACAG  CTGAGGAGCT  GCGGAGAGAG  CTGCCCCCCG  ACCAGGCCGA  GTACTGCATC  2640
2641  GCCCGCATGG  CGCCATACCA  GGGCCCTGAC  GCCGTGCCCG  GTGCCCTCGA  CTACAAGTCC  2700
2701  TTCTCCACGG  CCTTGTATGG  CGAGAGCGAC  CTGTGA  2736

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Metal-binding
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Brush border
Cellular Component
Cell-cell junction
Cellular Component
Cortical cytoskeleton
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Cellular Component
Extracellular region
Cellular Component
Extracellular space
Cellular Component
Focal adhesion
Cellular Component
Neuron projection
Cellular Component
Nuclear body
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Platelet alpha granule lumen
Cellular Component
Protein-containing complex
Cellular Component
Pseudopodium
Cellular Component
Ribonucleoprotein complex
Cellular Component
Stress fiber
Cellular Component
Z disc
Molecular Function
Actin binding
Molecular Function
Actin filament binding
Molecular Function
Calcium ion binding
Molecular Function
Chromatin DNA binding
Molecular Function
Integrin binding
Molecular Function
Ion channel binding
Molecular Function
Nuclear hormone receptor binding
Molecular Function
Nuclear receptor transcription coactivator activity
Molecular Function
Nucleoside binding
Molecular Function
Protein homodimerization activity
Molecular Function
Protein N-terminus binding
Molecular Function
Retinoic acid receptor binding
Molecular Function
RNA binding
Molecular Function
RNA polymerase II regulatory region sequence-specific DNA binding
Molecular Function
Transcription coactivator activity
Biological Process
Actin filament bundle assembly
Biological Process
Bicellular tight junction assembly
Biological Process
Negative regulation of cellular component movement
Biological Process
Negative regulation of substrate adhesion-dependent cell spreading
Biological Process
Peroxisome proliferator activated receptor signaling pathway
Biological Process
Platelet degranulation
Biological Process
Positive regulation of cell migration
Biological Process
Positive regulation of cellular component movement
Biological Process
Positive regulation of NIK/NF-kappaB signaling
Biological Process
Positive regulation of pinocytosis
Biological Process
Positive regulation of sodium:proton antiporter activity
Biological Process
Protein localization to bicellular tight junction
Biological Process
Protein transport
Biological Process
Regulation of apoptotic process
Biological Process
Regulation of nucleic acid-templated transcription
Biological Process
Response to hypoxia
Biological Process
Retinoic acid receptor signaling pathway
Biological Process
Tumor necrosis factor-mediated signaling pathway
Biological Process
Vesicle transport along actin filament

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Chs-a473Chlorocebus sabaeus100.00.01900
LLPS-Mam-a475Macaca mulatta100.00.01900
LLPS-Otg-a479Otolemur garnettii99.20.01820
LLPS-Sus-a483Sus scrofa99.120.01888
LLPS-Caf-a470Canis familiaris99.010.01886
LLPS-Mup-a471Mustela putorius furo98.950.01769
LLPS-Fud-a462Fukomys damarensis98.870.01827
LLPS-Cap-a476Cavia porcellus98.790.01885
LLPS-Orc-a457Oryctolagus cuniculus98.660.01535
LLPS-Bot-a485Bos taurus98.640.01664
LLPS-Mea-a446Mesocricetus auratus98.610.0885
LLPS-Ran-a479Rattus norvegicus98.460.01879
LLPS-Aim-a467Ailuropoda melanoleuca98.350.01877
LLPS-Myl-a454Myotis lucifugus98.250.01739
LLPS-Cea-a481Cercocebus atys97.850.01889
LLPS-Maf-a481Macaca fascicularis97.850.01889
LLPS-Pap-a478Pan paniscus97.850.01889
LLPS-Paa-a479Papio anubis97.850.01889
LLPS-Rhb-a475Rhinopithecus bieti97.850.01889
LLPS-Gog-a473Gorilla gorilla97.530.01882
LLPS-Nol-a467Nomascus leucogenys97.530.01882
LLPS-Man-a481Macaca nemestrina97.530.01882
LLPS-Aon-a484Aotus nancymaae97.420.01880
LLPS-Ova-a470Ovis aries96.70.01755
LLPS-Fec-a478Felis catus96.680.01879
LLPS-Ict-a475Ictidomys tridecemlineatus96.570.01874
LLPS-Mod-a460Monodelphis domestica96.380.01830
LLPS-Mum-a483Mus musculus96.350.01863
LLPS-Mal-a470Mandrillus leucophaeus96.320.01777
LLPS-Eqc-a484Equus caballus96.140.01864
LLPS-Pes-a413Pelodiscus sinensis95.450.01718
LLPS-Sah-a440Sarcophilus harrisii94.630.01675
LLPS-Gaga-a430Gallus gallus92.550.01452
LLPS-Xet-a419Xenopus tropicalis91.840.01656
LLPS-Cas-a427Carlito syrichta91.250.01595
LLPS-Anc-a444Anolis carolinensis91.120.01741
LLPS-Scf-a400Scleropages formosus86.290.01655
LLPS-Asm-a415Astyanax mexicanus85.640.01639
LLPS-Dar-a420Danio rerio84.240.01638
LLPS-Icp-a421Ictalurus punctatus83.80.01452
LLPS-Xim-3249Xiphophorus maculatus83.640.01607
LLPS-Pof-a422Poecilia formosa83.320.01598
LLPS-Tar-1646Takifugu rubripes82.990.01575
LLPS-Orn-a419Oreochromis niloticus82.890.01584
LLPS-Gaa-a408Gasterosteus aculeatus82.370.01571
LLPS-Ten-a397Tetraodon nigroviridis82.110.01560
LLPS-Scm-a403Scophthalmus maximus80.60.01571
LLPS-Orl-a411Oryzias latipes80.60.01573
LLPS-Lac-a423Latimeria chalumnae79.030.01439
LLPS-Poa-a472Pongo abelii77.10.01420
LLPS-Dio-a468Dipodomys ordii76.540.01146
LLPS-Leo-a423Lepisosteus oculatus74.810.01226
LLPS-Caj-a475Callithrix jacchus74.240.01381
LLPS-Pat-a478Pan troglodytes73.670.01383
LLPS-Loa-a464Loxodonta africana72.580.01401
LLPS-Urm-a437Ursus maritimus71.560.01299
LLPS-Anp-a395Anas platyrhynchos62.639e-149453