DrLLPS - Data resource of LLPS

LLPS-Hos-a476
REEP5

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Receptor expression-enhancing protein 5; Polyposis locus protein 1; Protein TB2
Gene Name:	REEP5, C5orf18, DP1, TB2
Ensembl Gene:	ENSG00000129625.12
Ensembl Protein:	ENSP00000421305.2
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613

▼ FUNCTION

May promote functional cell surface expression of olfactory receptors.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000511865.6	ENSP00000421305.2
Ensembl	ENST00000504247.1	ENSP00000421881.1
Ensembl	ENST00000513339.5	ENSP00000425901.1
Ensembl	ENST00000261482.8	ENSP00000261482.4
Ensembl	ENST00000379638.8	ENSP00000368959.4
UniProt		Q00765, REEP5_HUMAN, B7Z681, D3DT04, Q04198, Q5QGT0, Q9BWH9
GeneBank	AK299902, AC008575, M74090, CH471086, BC065926, AY562243, M73547, BC000232, AC008536	BAH13167.1, AAT70688.1, EAW48994.1, AAH65926.1, EAW48995.1, AAA66351.1, AAA60136.1, AAH00232.2
RefSeq	NM_005669.4	NP_005660.4
Entrez	7905

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN 60 61 LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF 120 121 LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN 180 181 LLGEEKKST 189
Nucleotide CDS Sequence (FASTA)
1 ATGTCTGCCC CGCGGCCCGG CGCCCTATTC CTGCTGTCCT GCGCGGTGGG CGCGGACGGC 60 61 GGGGCCCCTG CGGGCGGGCG CGTTGACGGA GGTGTCATCG GACTGGTGGC CTTGTACCTG 120 121 GTGTTCGGTT ATGGAGCCTC TCTCCTCTGC AACCTGATAG GATTTGGCTA CCCAGCCTAC 180 181 ATCTCAATTA AAGCTATAGA GAGTCCCAAC AAAGAAGATG ATACCCAGTG GCTGACCTAC 240 241 TGGGTAGTGT ATGGTGTGTT CAGCATTGCT GAATTCTTCT CTGATATCTT CCTGTCATGG 300 301 TTCCCCTTCT ACTACATGCT GAAGTGTGGC TTCCTGTTGT GGTGCATGGC CCCGAGCCCT 360 361 TCTAATGGGG CTGAACTGCT CTACAAGCGC ATCATCCGTC CTTTCTTCCT GAAGCACGAG 420 421 TCCCAGATGG ACAGTGTGGT CAAGGACCTT AAAGACAAGG CCAAAGAGAC TGCAGATGCC 480 481 ATCACTAAAG AAGCGA 496

▼ KEYWORD

ID	Family
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0256	Endoplasmic reticulum
KW-0472	Membrane
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0071782	Cellular Component	Endoplasmic reticulum tubular network
GO:0016021	Cellular Component	Integral component of membrane

▼ KEGG

hsa:7905

▼ ANNOTATION

Disorder
IUPred2A

Domain
Pfam	InterPro	CDD

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa

Variation
dbSNP	VarCards

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	RAIN
Mentha	PINA	IID	iRefIndex	MIST
DifferentialNET	RNAct

Disease
OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Chs-a464	Chlorocebus sabaeus	100.0	2e-137	390
LLPS-Mam-a464	Macaca mulatta	100.0	2e-137	390
LLPS-Gog-a462	Gorilla gorilla	99.47	1e-135	387
LLPS-Pat-a468	Pan troglodytes	99.43	5e-125	362
LLPS-Poa-a462	Pongo abelii	99.33	5e-105	308
LLPS-Nol-a458	Nomascus leucogenys	98.94	4e-136	387
LLPS-Caj-a464	Callithrix jacchus	98.41	5e-136	387
LLPS-Aon-a473	Aotus nancymaae	98.41	5e-136	387
LLPS-Otg-a468	Otolemur garnettii	98.38	4e-133	380
LLPS-Fud-a453	Fukomys damarensis	96.83	3e-134	382
LLPS-Cap-a466	Cavia porcellus	96.83	3e-134	383
LLPS-Ict-a465	Ictidomys tridecemlineatus	95.77	2e-133	380
LLPS-Mal-a461	Mandrillus leucophaeus	94.71	1e-127	367
LLPS-Cea-a470	Cercocebus atys	94.71	6e-128	367
LLPS-Maf-a470	Macaca fascicularis	94.71	6e-128	367
LLPS-Man-a470	Macaca nemestrina	94.71	6e-128	367
LLPS-Paa-a469	Papio anubis	94.71	6e-128	367
LLPS-Rhb-a464	Rhinopithecus bieti	94.71	7e-128	367
LLPS-Mea-a435	Mesocricetus auratus	94.71	3e-132	378
LLPS-Sah-a432	Sarcophilus harrisii	94.18	6e-132	377
LLPS-Ran-a469	Rattus norvegicus	94.18	1e-131	376
LLPS-Mum-a472	Mus musculus	93.65	4e-131	375
LLPS-Loa-a455	Loxodonta africana	93.65	3e-130	372
LLPS-Anp-a387	Anas platyrhynchos	92.37	8e-76	232
LLPS-Meg-a386	Meleagris gallopavo	92.37	8e-76	232
LLPS-Fec-a468	Felis catus	91.01	3e-126	362
LLPS-Sus-a473	Sus scrofa	91.01	6e-128	367
LLPS-Eqc-a473	Equus caballus	91.01	5e-129	369
LLPS-Bot-a474	Bos taurus	90.8	1e-116	341
LLPS-Ora-a396	Ornithorhynchus anatinus	90.58	1e-125	365
LLPS-Aim-a457	Ailuropoda melanoleuca	89.42	1e-124	358
LLPS-Dio-a458	Dipodomys ordii	88.97	1e-90	271
LLPS-Mod-a450	Monodelphis domestica	88.89	1e-127	366
LLPS-Ova-a460	Ovis aries	88.89	4e-98	290
LLPS-Urm-a429	Ursus maritimus	86.25	2e-99	294
LLPS-Gaga-a420	Gallus gallus	85.19	1e-120	353
LLPS-Caf-a460	Canis familiaris	84.92	4e-75	231
LLPS-Pap-a467	Pan paniscus	84.71	9e-95	285
LLPS-Tag-a404	Taeniopygia guttata	84.66	3e-122	352
LLPS-Pes-a405	Pelodiscus sinensis	84.57	2e-118	343
LLPS-Fia-a410	Ficedula albicollis	83.07	1e-120	348
LLPS-Anc-a435	Anolis carolinensis	80.95	3e-114	332
LLPS-Lac-a413	Latimeria chalumnae	78.19	1e-110	323
LLPS-Xet-a409	Xenopus tropicalis	77.78	2e-112	328
LLPS-Scf-a390	Scleropages formosus	74.47	2e-103	305
LLPS-Dar-a409	Danio rerio	72.73	1e-100	297
LLPS-Orn-a409	Oreochromis niloticus	72.49	1e-102	302
LLPS-Icp-a411	Ictalurus punctatus	72.49	1e-103	305
LLPS-Leo-a412	Lepisosteus oculatus	71.96	3e-91	274
LLPS-Asm-a405	Astyanax mexicanus	71.28	2e-100	296
LLPS-Xim-a417	Xiphophorus maculatus	71.28	2e-91	274
LLPS-Pof-a414	Poecilia formosa	70.74	5e-92	276
LLPS-Orl-a400	Oryzias latipes	70.37	3e-99	294
LLPS-Scm-a393	Scophthalmus maximus	69.84	3e-98	291
LLPS-Tar-a392	Takifugu rubripes	69.31	4e-91	273
LLPS-Ten-a388	Tetraodon nigroviridis	68.05	1e-81	249
LLPS-Gaa-a399	Gasterosteus aculeatus	67.2	2e-95	284
LLPS-Mup-a462	Mustela putorius furo	60.23	4e-74	231
LLPS-Myl-a445	Myotis lucifugus	60.0	7e-75	233
LLPS-Cis-a115	Ciona savignyi	54.97	3e-64	205
LLPS-Drm-a122	Drosophila melanogaster	52.78	6e-55	181
LLPS-Cii-a132	Ciona intestinalis	52.6	7e-62	199
LLPS-Prp-a045	Prunus persica	50.0	3e-28	112

LLPS-Hos-a476REEP5

Protein Sequence

Nucleotide Sequence

LLPS-Hos-a476
REEP5